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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Function of lncRNAs and approaches to lncRNA-protein interactions显示文摘Long non-coding RNAs(lncRNAs),which represent a new frontier in molecular biology,play important roles in regulating gene expression at epigenetic,transcriptional and post-transcriptional levels.More and more lncRNAs have been found to play important roles in normal cell physiological activities,and participate in the development of varieties of tumors and other diseases.Previously,we have only been able to determine the function of lncRNAs through multiple mechanisms,including genetic imprinting,chromatin remodeling,splicing regulation,mRNA decay,and translational regulation.Application of technological advances to research into the function of lncRNAs is extremely important.The major tools for exploring lncRNAs include microarrays,RNA sequencing(RNA-seq),Northern blotting,real-time quantitative reverse transcription-polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),RNA interference(RNAi),RNA-binding protein immunoprecipitation(RIP),chromatin isolation by RNA purification(ChIRP),crosslinking-immunopurification(CLIP),and bioinformatic prediction.In this review,we highlight the functions of lncRNAs,and advanced methods to research lncRNA-protein interactions. | ZHU JuanJuan FU HanJiang WU YongGe ZHENG XiaoFei | 2013 | Science China(Life Sciences)2013，56，10： | 54 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | Panax notogiseng saponin inhibits ischemia-induced apoptosis by activating PI3K/Akt signal pathway in cardiomyocytes显示文摘The panax notoginseng saponin(PNS) had been clinically used for the treatment of cardiovascular diseases and stroke in China.It had been demonstrated that PNS could protect cardiomyocytes from injury induced by ischemi- a,but the underlying molecular mechanisms of this protective effect were still unclear.This study was aimed to investigate the protective effect and molecular mechanisms of PNS on apoptosis in H9c2 cells in vitro and rat myocardial ischemia injury model in vivo.Annexin-V/PI assay shew that PNS could protect H9c2 cells from apoptosis induced by serum, glucose and oxygen deprivation(SGOD) in a dose-dependent manner.However,the anti-apoptotic effect of PNS was reversed by LY294002,a specific PI3K inhibitor.This antiapoptotic effect of PNS was confirmed by JC-1,a specific probe of mitochondrial membrane potential staining.PNS could significantly increase phos-Akt in H9c2 cells by Western blot assays and its effect could be inhibited by LY294002.Furthermore,PNS could improve ischemic-induced left ventricular function as reflected by EF,LVDd and LVDs.PNS could also inhibited cellular apoptosis in myocardial tissues in ischemic rats by TUNEL assay.PNS administration also increased the expression of phos-Akt in rat ischemic myocardial tissues.These results suggested that PNS could protect myocardial cells from apoptosis induced by ischemia in vitro model and in vivo model through activating-PI3K/Akt signal pathway which may be meaningful for further understanding the molecular mechanisms of cardiac protection of PNS.And the results might be useful in treatment of myocardial ischemia in future. | YANG Min,CHEN Shao-Xian,LIU Ju-Li,LIU Xiao-Ying,FU Yong-Heng,ZHANGMeng-zhen,LIN Qiu-Xiong,ZHU Jie-Ning, SHAN Zhi-Xin,YU Xi-yong (Medical Research Center,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510100,China) | 2011 | 岭南心血管病杂志2011，17，S1： | 47 |
| 5 | An Exploratory Analysis of Vegetation Strategies to Reduce Shallow Landslide Activity on Loess Hillslopes, Northeast Qinghai-Tibet Plateau, China显示文摘Heavy summer rainfall induces significant soil erosion and shallow landslide activity on the loess hillslopes of the Xining Basin at the northeast margin of the Qinghai-Tibet Plateau. This study examines the mechanical effects of five native shrubs that can be used to reduce shallow landslide activity. We measured single root tensile resistance and shear resistance, root anatomical structure and direct shear and triaxial shear for soil without roots and five root- soil composite systems. Results show that Atriplex canescens (Pursh) Nutt. possessed the strongest roots, followed by Caragana korshinskii Kom., Zygophyllum xanthoxylon (Bunge) Maxim., Nitraria tangutorum Bobr. and Lycium chinense Mill. Single root strength and shear resistance relationships with root diameter are characterized by power or exponential relations, consistent with the Mohr- Coulomb law. Root mechanical strength reflects their anatomical structure, especially the percentage of phloem and xylem cells, and the degree and speed of periderm lignifications. The cohesion force of root- soil composite systems is notably higher than that of soil without roots, with increasing amplitudes of cohesion force for A. canescens, C. korshinskii, Z. xanthoxylon, N. tangutorum and L. chinense of 75.9%, 75.1%, 36.2%, 24.6% and 17.0 % respectively. When subjected to shear forces, the soil without root samples show much greater lateral deformation thanthe root-soil composite systems, reflecting the restraining effects of roots. Findings from this paper indicate that efforts to reduce shallow landslides in this region by enhancing root reinforcement will be achieved most effectively using A. canescens and C. korshinskii. | HU Xia-song BRIERLEY Gary ZHU Hai-li LI Guo-rong FU Jiang-tao MAO Xiao-qing YU Qin-qin QIAO Na | 2013 | Journal of Mountain Science2013，10，4： | 41 |
| 6 | GS6, A Member of the GRAS Gene Family,Negatively Regulates Grain Size in Rice显示文摘Grain size is an important yield related trait in rice.Intensive arti cial selection for grain size during domestication is evidenced by the larger grains of most of today’s cultivars compared with their wild relatives.However,the molecular genetic control of rice grain size is still not well characterized.Here,we report the identi cation and cloning of Grain Size 6(GS6),which plays an important role in reducing grain size in rice.A premature stop at the t348 position in the coding sequence(CDS)of GS6 increased grain width and weight signi cantly.Alignment of the CDS regions of GS6 in 90 rice materials revealed three GS6alleles.Most japonica varieties(95%)harbor the Type I haplotype,and 62.9%of indica varieties harbor the Type II haplotype.Association analysis revealed that the Type I haplotype tends to increase the width and weight of grains more than either of the Type II or Type III haplotypes.Further investigation of genetic diversity and the evolutionary mechanisms of GS6showed that the GS6gene was strongly selected in japonica cultivars.In addition,a'ggc'repeat region identi ed in the region that encodes the GRAS domain of GS6 played an important historic role in the domestication of grain size in rice.Knowledge of the function of GS6might aid efforts to elucidate the molecular mechanisms that control grain development and evolution in rice plants,and could facilitate the genetic improvement of rice yield. | Lianjun Sun Xiaojiao Li Yongcai Fu Zuofeng Zhu Lubin Tan Fengxia Liu Xianyou Sun Xuewen Sun Chuanqing Sun | 2013 | Journal of Integrative Plant Biology2013，55，10： | 44 |
| 7 | A three-dimensional variational ocean data assimilation system:Scheme and preliminary results显示文摘A new 3DVAR-based Ocean Variational Analysis System (OVALS) is developed. OVALS is capable of assimilating in situ sea water temperature and salinity observations and satellite altimetry data. As a component of OVALS, a new variational scheme is proposed to assimilate the sea surface height data. This scheme considers both the vertical correlation of background errors and the nonlinear temperature-salinity relationship which is derived from the generalization of the linear balance constraints to the nonlinear in the 3DVAR. By this scheme, the model temperature and salinity fields are directly adjusted from the altimetry data. Additionally, OVALS can assimilate the temperature and salinity profiles from the ARGO floats which have been implemented in recent years and some temperature and salinity data such as from expendable bathythermograph, moored ocean buoys, etc. A 21-year assimilation experiment is carried out by using OVALS and the Tropical Pacific circulation model. The results show that the assimilation system may effectively improve the estimations of temperature and salinity by assimilating all kinds of observations. Moreover, the root mean square errors of temperature and salinity in the upper depth less than 420 m reach 0.63℃ and 0.34 psu. | ZHU Jiang1,2, ZHOU Guangqing1, YAN Changxiang1, FU Weiwei1 & YOU Xiaobao1,3 1. International Center for Climate and Environment Sciences, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China 2. Jiangsu Key Laboratory of Meteorological Disaster, Nanjing University of Information Science and Technology, Nanjing 210044, China 3. Beijing Institute of Applied Meteorology, Beijing 100029, China | 2006 | Science China Earth Sciences2006，49，11： | 35 |
| 8 | Identification and mapping of genes for improving yield from Chinese common wild rice (O.rufipogon Griff.) using advanced backcross QTL analysis显示文摘To identify useful genes from wild rice which have been lost or weakened in cultivated rice has become more and more important for modern breeding strategy. In this study, a BC4 population derived from 94W1, an accession of common wild rice (Oryza rufipogon Griff.) from Dongxiang in Jiangxi Province of China, as the donor, and a high-yielding Indica cultivar (O. sativa L.), 'Guichao 2', as the recipient, was used to identify quantitative trait loci (QTL) associated with yield and its components. Based on the analysis for the genotype of BC4F1 population with 87 SSR markers distributed throughout the genome and investigation of the plant height, yield and yield components of BC4F2, a total of 52 QTLs, were detected. Of 7 QTLs associated with grain yield per plant, 2 QTLs on chromosome 2 and chromosome 11 for grain yield, explaining 16% and 11% of the phenotypic variance respectively, were identified. The alleles from Dongxiang common wild rice in those two loci could increase the yield of 'Guichao 2' by | Dejun Li Chuanqing Sun Yongcai Fu Cheng Li Zuofeng Zhu Liang Chen Hongwei Cai Xiangkun Wang | 2002 | Chinese Science Bulletin2002，47，18： | 39 |
| 9 | Detection of nighttime sea fog/stratus over the Huang-hai Sea using MTSAT-1R IR data显示文摘A dual channel difference (DCD) method is applied to detect nighttime sea fog/stratus over the Huanghai Sea using the infrared (IR) data of shortwave (3.5–4.0 μm) and longwave (10.3–11.3 μm) channels from the Multi-functional Transport Satellite (MTSAT)-1R, i.e., shortwave minus longwave brightness temperature difference (SLTD). Twenty-four sea fog events over the Huanghai Sea during March to July of 2006 and 2007 are chosen to determine a suitable value of SLTD for nighttime sea fog/stratus detection, and it is found that the value of –5.5––2.5°C can be taken as a criterion. Two case examples of sea fog events are especially demonstrated in detail utilizing the criterion, and the results show that the derived sea fog/stratus coverage is quite reasonable. This coverage information is very helpful to analyze the formation and evolution of sea fog/stratus during night and can provide sea fog researchers with observational evidences for model results verification. However, more efforts are needed to further obtain vertical extent information of sea fog/stratus and attempt to discriminate between sea fog and stratus. | GAO Shanhong WU Wei ZHU Leilei FU Gang HUANG Bin | 2009 | Acta Oceanologica Sinica2009，28，2： | 36 |
| 10 | Ginsenoside Rbl protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening显示文摘 | Hong-liang KONG Zhan-quan LI Ying-jun ZHAO Shu-mei ZHAO Li ZHU Tong LI Yao FU Hui-jun LI | 2010 | Acta Pharmacologica Sinica2010，31，6： | 35 |
| 11 | A study on relationship of nitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis显示文摘AIM To study relationship of injury induced bynitric oxide,oxidation,peroxidation,lipoperoxidation with chronic cholecystitis.METHODS The values of plasma nitric oxide(P-NO),plasma vitamin C(P-VC),plasma vitamin E(P-VE),plasma β-carotene(P-β-CAR),plasmalipoperoxides(P-LPO),erythrocyte superoxidedismutase(E-SOD),erythrocyte catalase(E-CAT),erythrocyte glutathione peroxidase(E-GSH-Px)activities and erythrocyte lipoperoxides(E-LPO)level in 77 patients with chronic cholecystitisand 80 healthy control subjects were determined,differences of the above average values betweenthe patient group and the control group anddifferences of the average values betweenpreoperative and postoperative patients wereanalyzed and compared,linear regression andcorrelation of the disease course with the abovedetermination values as well as the stepwiseregression and correlation of the course with thevalues were analyzed.RESULTS Compared with the control group,theaverage values of P-NO,P-LPO,E-LPO weresignificantly increased(P<0.01),and of P-VC, P-VE,P-β-CAR,E-SOD,E-CAT and E-GSH-Pxdecreased(P<0.01)in the patient group.Theanalysis of the linear regression and correlationshowed that with prolonging of the course,thevalues of P-NO,P-LPO and E-LPO in the patientswere gradually ascended and the values of P-VC,P-VE,P-β-CAR,E-SOD,E-CAT and E-GSH-Pxdescended(P<0.01).The analysis of thestepwise regression and correlation indicated thatthe correlation of the course with P-NO,P-VE andP-β-CAR values was the closest.Compared withthe preoperative patients,the average values of P-NO,P-LPO and E-LPO were significantlydecreased(P<0.01)and the average values of P-VC,E-SOD,E-CAT and E-GSH-Px in postoperativepatients increased(P<0.01)in postoperativepatients.But there was no significant difference inthe average values of P-VE,P-β-CAR preoperativeand postoperative patients.CONCLUSION Chronic cholecystitis could inducethe increase of nitric oxide,oxidation,peroxidation and lipoperoxidation. | Jun Fu Zhou Dong Cai You Gen Zhu Jin Lu Yang Cheng Hong Peng Yang Hai Yu | 2000 | World Journal of Gastroenterology2000，6，4： | 36 |
| 12 | Different treatment strategies and molecular features between right-sided and left-sided colon cancers显示文摘The colon is derived from the embryological midgut and hindgut separately,with the right colon and left colon having different features with regards to both anatomical and physiological characteristics.Cancers located in the right and left colon are referred to as right colon cancer(RCC) and left colon cancer(LCC),respectively,based on their apparent anatomical positions.Increasing evidence supports the notion that not only are there differences in treatment strategies when dealing with RCC and LCC,but molecular features also vary between them,not to mention the distinguishing clinical manifestations.Disease-free survival after radical surgery of both RCC and LCC are similar.In the treatment of RCC,the benefit gained from adjuvant FOLFIRI chemotherapy is superior,or at least similar,to LCC,but inferior to LCC if FOLFOX regimen is applied.On the other hand,metastatic LCC exhibits longer survival than that of RCC in a palliative chemotherapy setting.For KRAS wild-type cancers,LCC benefits more from cetuximab treatment than RCC.Moreover,advanced LCC shows a higher sensitivity to bevacizumab treatment in comparison with advanced RCC.Significant varieties exist at the molecular level between RCC and LCC,which may serve as the cause of all apparent differences.With respect to carcinogenesis mechanisms,RCC is associated with known gene types,such as MMR,KRAS,BRAF,and mi RNA-31,while LCC is associated with CIN,p53,NRAS,mi RNA-146 a,mi RNA-147 b,and mi RNA-1288.Regarding protein expression,RCC is related to GNAS,NQO1,telomerase activity,P-PDH,and annexin A10,while LCC is related to Topo I,TS,and EGFR.In addition,separated pathways dominate progressionto relapse in RCC and LCC.Therefore,RCC and LCC should be regarded as two heterogeneous entities,with this heterogeneity being used to stratify patients in order for them to have the optimal,current,and novel therapeutic strategies in clinical practice.Additional research is needed to uncover further differences between RCC and LCC. | Hong Shen Jiao Yang Qing Huang Meng-Jie Jiang Yi-Nuo Tan Jian-Fei Fu Li-Zhen Zhu Xue-Feng Fang Ying Yuan | 2015 | World Journal of Gastroenterology2015，21，21： | 33 |
| 13 | Most common SLC25A13 mutation in 400 Chinese infants with intrahepatic cholestasis显示文摘AIM:To establish the real time fluorescence polymerase chain reaction(RT-PCR) with dual labeled probes for fast detection of SLC25A13 gene mutation 851del4.METHODS:Four hundred infants(< 1 year of age) with unexplained intrahepatic cholestasis from 18 provinces or municipalities in China were enrolled in this study for detecting their SLC25A13 gene mutation 851del4.Suitable primers and fluorescence-labeled probes for detecting SLC25A13 gene mutation 841del4 were designed.Normal and mutant sequences were detected by PCR with two fluorescence-labeled probes.After a single RT-PCR,results were obtained by analyzing the take-off curves.Twenty-four positive and 14 negative samples were retested by direct sequencing.RESULTS:Eight homozygous and 30 heterozygous mutations were detected in 46 mutant alleles with a 851del4 mutation rate of 5.8%(46/800).Twenty-six and 20 mutant alleles were observed respectively,in 474 and 242 alleles from the intermediate and southern areas of China.No mutant allele was detected in 84 alleles from northern China.Twenty-four positive samples including 4 homozygous and 20 heterozygous mutations,and 14 negative samples were retested by direct sequencing,which confirmed that the accuracy of RTPCR was 100%.CONCLUSION:RT-PCR can detect the mutation 851del4 in infants with intrahepatic cholestasis with an accuracy of 100%. | Fu, Hai-Yan Zhang, Shao-Ren Yu, Hui Wang, Xiao-Hong Zhu, Qi-Rong Wang, Jian-She | 2010 | World Journal of Gastroenterology2010，16，18： | 29 |
| 14 | Endoscopic treatment of difficult extrahepatic bile duct stones, EPBD or EST: An anatomic view显示文摘Large bile duct stone(> 10 mm) or multiple stones(≥ 3) are challenging for endoscopists. Endoscopic sphincterotomy(EST) is a routine therapeutic endoscopic retrograde cholangiopancreatography(ERCP) procedure usually used. It is safe and effective, but severe perforation or massive bleeding are the main causes of mortality. Because of the permanent destroy ofOddi sphincter, the use of EST is still controversial. Endoscopic papillary balloon dilation(EPBD) gives another way to open the sphincter. Less incidence of bleeding, perforation and partly preserving the Oddi sphincter's function are the main advantages. But high incidence of post-ERCP pancreatitis becomes a predominant problem. According to the anatomical feature of Oddi sphincter, limited EST + EPBD seems a more reasonable procedure. Compared to the former two procedures, it makes the stone extraction process much easier with lower incidences of short-term and long-term complications. | Jun Ding Fu Li Hong-Yi Zhu Xi-Wen Zhang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 29 |
| 15 | Development of Oryza rufipogon and O. sativa Introgression Lines and Assessment for Yield-related Quantitative Trait Loci显示文摘基因渗入线人口有效地在印射量的特点 loci (QTL ) 被使用,识别有利基因,发现隐藏的遗传变异,评估处于多重条件的 QTL 的行动或相互作用并且提供为植物繁殖和基因研究的有利试验性的材料。在这研究,先进回交和连续 selfing 策略被用来开发基因渗入线(IL ) ,它源于 Oryza rufipogon Griff 的就职。从 Yuanjiang 县镇定,中国的云南省,著名计算机生产厂商他施主,和精英 indica 栽培变种 Teqing (O。sativa L.) ,接受者。从 O 的 Introgressionsegments。rufipogon 用 179 次多态的简单顺序重复(SSR ) 被屏蔽在每 IL 的染色体的标记。基因渗入线人口带的 Introgressed 片断包含了盖住整个 O 的 120 IL。rufipogon 染色体。同型结合的 O 的吝啬的数字。rufipogonsegments 每基因渗入线是大约 3.88。introgressed 片断的平均长度是近似的 25.5 厘米,并且有的大约 20.8% 这些片断缩放不到 10 厘米。eachIL 的染色体怀有 O 的 chromosomal 碎片。rufipogon 从 0.54% ~ 23.7%,与 5.79% 的全面一般水准。在每个地点, O 的替换的比率。rufipogon 等位基因有范围 of1.67-9.33,与 5.50 的一般水准。大量改变在词法并且 yield-relatedtraits 也在基因渗入线人口被发现。用单个点的分析,为产量和产量构成因素的 37 通常认为的 QTL 的一个总数与解释 phenotypic 的 7%-20% 在二个地点被检测。十九 QTL (51.4%) 在两个地点被检测,并且从在十五 loci (40.5%) 的 O.rufipogon 的等位基因在 Teging 背景改进了收益和产量构成因素。这些 O。rufipogon-O。sativa 基因渗入线将为从普通野米饭识别并且使用有利基因用作遗传物质…… | Lubin Tan | 2007 | Journal of Integrative Plant Biology2007，49，6： | 28 |
| 16 | Use of Controlled Release Fertilizer for Increasing N Efficiency of Direct Seeding Rice显示文摘Field trials on a silt-loamy paddy soil derived from shallow-sea deposit in direct seeding rice fields were conducted in Zhejiang, China, in 1996 to compare N efficiency of controlled release fertilizers (LP fertilizers) with the conventional urea. Six treatments including CK (no N fertilizer), conventional urea and different types of LP fertilizers at different rates were designed for two succeeding crops of early and late rice. A blend of different types of LP fertilizers as a single preplant 'co-situs' application released N in a rate and amount synchronizing with uptake pattern of direct seeding rice. A single preplant application of the LP fertilizers could meet the N requirement of rice for the whole growth period without need of topdressing. Using LP fertilizer blends, equivalent grain yields could be maintained even if the N fertilization rates were reduced by 25%~50% compared with the conventional urea. Agronomic efficiency of the LP fertilizers was 13.6%~ 86.4% higher than that of the conventional urea in early rice and 100%~164.1% in late rice, depending on the amounts of the LP fertilizers applied. N fertilizer recovery rate increased from 27.4% for the conventional application of urea to 41.7%~54.l% for the single preplant 'co-situs' application of the LP fertilizers. Use of the LP fertilizers was promising if the increase in production costs due to the high LP fertilizer prices could be compensated by increase in yield and N efficiency, reduction in labor costs and improvement in environment. | FU JIANRONG, ZHU YUANHONG and JIANG LINA Institute of Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021 (China) | 2001 | Pedosphere2001，11，4： | 27 |
| 17 | DNA methylation changes detected by methylation-sensitive amplified polymorphism in two contrasting rice genotypes under salt stress显示文摘DNA methylation,one of the most important epigenetic phenomena,plays a vital role in tuning gene expression during plant development as well as in response to environmental stimuli.In the present study,a methylation-sensitive amplified polymorphism(MSAP) analysis was performed to profile DNA methylation changes in two contrasting rice genotypes under salt stress.Consistent with visibly different phenotypes in response to salt stress,epigenetic markers classified as stable inter-cultivar DNA methylation differences were determined between salt-tolerant FL478 and salt-sensitive IR29.In addition,most tissue-specific DNA methylation loci were conserved,while many of the growth stage-dependent DNA methylation loci were dynamic between the two genotypes.Strikingly,salt stress induced a decrease in DNA methylation specifically in roots at the seedling stage that was more profound in IR29 than in the FL478.This result may indicate that demethylation of genes is an active epigenetic response to salt stress in roots at the seedling stage,and helps to further elucidate the implications of DNA methylation in crop growth and development. | Wensheng Wang Xiuqin Zhao Yajiao Pan Linghua Zhu Binying Fu Zhikang Li | 2011 | Journal of Genetics and Genomics2011，38，9： | 25 |
| 18 | An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain显示文摘The nature of brain interstitial fluid (ISF) has long been a subject of controversy. Most of the previous studies on brain ISF were carried out in vitro. In the present study, a novel method was developed to characterize ISF in the living rat brain by magnetic resonance (MR) imaging using gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer. Sprague Dawley rats (n=8) were subjected to MR scanning before and after the introduction of Gd-DTPA into the caudate nucleus. A one-way drainage of brain ISF was demonstrated on the dynamic MR images. According to the traditional diffusion model, the diffusion and clearance rate constants of the tracer within brain extracellular space (ECS) were derived as (3.38±1.07)×10-4 mm 2 s-1 and (7.60±4.18)×10-5 s-1 . Both diffusion and bulk flow contributed to the drainage of ISF from the caudate nucleus, which demonstrated an ISF-cerebrospinal fluid confluence in the subarachnoid space at the lateral and ventral surface of the brain cortex at 3 h after the injection. By using this newly developed method, the brain ECS and ISF can be quantitatively measured simultaneously in the living brain, which will enhance the understanding of ISF and improve the efficiency of drug therapy via the brain interstitium. | HAN HongBin LI Kai YAN JunHao ZHU Kai FU Yu | 2012 | Science China(Life Sciences)2012，55，9： | 25 |
| 19 | A mouse model for HBV immunotolerance and immunotherapy显示文摘一个适当小动物模型的缺乏仍然是一个主要障碍因为学习 immunotolerance 和 immunopathogenesis 由肝炎 B 病毒(HBV ) 导致了感染。在这研究,我们与 recombinant 在感染以后与持续 HBV viremia 报导一个老鼠模型带一个可复制的 HBV 染色体(AAV/HBV ) 的联系 adeno 的病毒(AAV ) 。类似于临床的 HBV 搬运人,感染 AAV/HBV 的老鼠为对 HBV 表面抗原(HBsAg ) 的抗体是 sero 否定的。有面对铝助手疫苗的常规 HBV 的免疫没能在这些老鼠对 HBV 得到有免疫力的回答。为了识别一支疫苗,那能潜在地围绕这忍耐, TLR9 收缩筋 CpG 作为一个助手被加到 HBsAg。有 HBsAg/CpG 的老鼠的种痘导致了 viremia,而且强壮的抗体生产和 T 房间回答的不仅清理。而且, DNA 复制和 HBV 的蛋白质表示显著地在 AAV/HBV-infected 鼠标的肝被减少。因此, AAV/HBV-infected 老鼠可以作为一个柔韧的模型被使用调查 HBV immunotolerance 并且为开发新奇免疫疗法根除的内在的机制 HBV 感染。 | Dan Yang Longchao Liu Danming Zhu Hua Peng Lishan Su Yang-Xin Fu Liguo Zhang | 2014 | Cellular & Molecular Immunology2014，11，1： | 25 |
| 20 | A highly active oxygen evolution electrocatalyst: Ultrathin CoNi double hydroxide/CoO nanosheets synthesized via interface-directed assembly显示文摘成本效率、稳定的氧进化 electrocatalyst 为改进精力存储和变换效率是必要的。此处, 2D nanosheets 与随机 cross-linked CoNi 分层的双氢氧化物(LDH ) 并且小咕咕叫 nanocrystals 被设计并且综合经由在在空中的 situ 减小和 interfacedirected 汇编。CoNi LDH/CoO nanosheets 的形成被归因于界面的紧张驾驶的含水的 metaloxide 簇的强壮的挤出。获得了松开、多孔的 nanosheets 由于众多的缺点的存在展出了低 crystallinity。由于在金属 3d 和 O 2p 之间的轨道的杂交, orbitals,和电子在在场的 CoNi LDH 通过 NiOCo,很多个公司和 Ni 原子在金属原子之间转一个高 +3 原子价。在氧进化反应(OER ) 的高密度的这些唯一的特征结果活跃地点,改进与的亲密关系哦 和催化剂,并且为离子吸附和运输导致一个大可存取的表面区域和可渗透的隧道。因此,产生 nanosheets 向 OER 展出了高催化的活动。CoNi LDH/CoO 在碱的媒介展示了 1.48 V 的一个低发作潜力,并且在 10 妈据獥漠 ? 楬桧 ?L 潳灲楴湯漠 ? 桴 ? 的当前的密度要求了仅仅 300 mV 的过电位 ?? 潢瑴浯摥琠慲獮業瑴湡散吗?? | Jun Wu Zhiyu Ren Shichao Du Lingjun Kong Bowen Liu Wang Xi Jiaqing Zhu Honggang Fu | 2016 | Nano Research2016，9，3： | 25 |
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