|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Isolation and characterization of H7N9 viruses from live poultry markets--Implication of the source of current H7N9 infection in humans显示文摘On March 31, 2013, the National Health and Family Planning Commission announced that human infections with a previously undescribed influenza A (H7N9) virus had occurred in Shanghai and Anhui Province, China. To investigate the possible origins of the H7N9 viruses causing these human infections, we collected 970 samples, including drinking water, soil, and cloacal and tracheal swabs of poultry from live poultry markets and poultry farms in Shanghai and Anhui Province. Twenty samples were positive for the H7N9 influenza virus. Notably, all 20 viruses were isolated from samples collected from live poultry markets in Shanghai. Phylogenetic analyses showed that the six internal genes of these novel human H7N9 viruses were derived from avian H9N2 viruses, but the ancestor of their HA and NA genes is uncertain. When we examined the phylogenetic relationship between the H7N9 isolates from live poultry markets and the viruses that caused the human infections, we found that they shared high homology across all eight gene segments. We thus identified the direct avian origin of the H7N9 influenza viruses that caused the human infections. Importantly, we observed that the H7N9 viruses isolated from humans had acquired critical mutations that made them more 'human-like'. It is therefore imperative to take strong measures to control the spread of H7N9 viruses in birds and humans to prevent further threats to human health. | SHI JianZhong DENG GuoHua LIU PeiHong ZHOU JinPing GUAN LiZheng LI WenHui LI XuYong GUO Jing WANG GuoJun FAN Jun WANG JinLiang LI YuanYuan JIANG YongPing LIU LiLing TIAN GuoBin LI ChengJun CHEN HuaLan | 2013 | Chinese Science Bulletin2013，58，16： | 85 |
| 2 | Natural variation in Ghd7.1 plays an important role in grain yield and adaptation in rice显示文摘 | Wenhao Yan Haiyang Liu Xiangchun Zhou Qiuping Li Jia Zhang Li Lu Touming Liu Haijun Liu Chengjun Zhang Zhanyi Zhang Guojing Shen Wen Yao Huaxia Chen Sibin Yu Weibo Xie Yongzhong Xing | 2013 | Cell Research2013，23，7： | 39 |
| 3 | Minichromosome maintenance complex component 7 has an important rolein the invasion of papillary urothelial neoplasia显示文摘 | Bingxin Guan Xiaoying Wang Jingyan Yang Chengjun Zhou Yan Meng | 2015 | Oncology Letters2015，，2： | 1 |
| 4 | Analysis of a mechanical vapor recompression wastewater distillation system显示文摘 | Yasu Zhou Chengjun Shi Guoqiang Dong | 2014 | Desalination2014，，： | 1 |
| 5 | Analysis of a mechanical vapor recompression wastewater distil- lation system显示文摘 | Zhou Yasu Shi Chengjtm Dong Chengjun | 2014 | Desalination2014，353，： | 1 |
| 6 | Experiment on fractional frequency transmission system显示文摘 | Wang Xifan Cao Chengjun Zhou Zhichao | 2006 | IEEE Transactions on Power Systems2006，21，1： | 1 |
| 7 | Enhanced conductivity in polybenzoxazoles doped with carboxylated multi-walled carbon nanotubes 显示文摘 | Zhou Chengjun Wang Shanfeng Zhuang Qixin etal | 2008 | Carbon2008，46，9： | 1 |
| 8 | Silencing Id-1 inhibits lymphangiogenesis through down-regulation of VEGF-C in oral squamous cell carcinoma显示文摘 | Zuoqing Dong Fengcai Wei Chengjun Zhou Tomoki Sumida Hiroyuki Hamakawa Yingwei Hu Shaohua Liu | 2010 | Oral Oncology2010，，1： | 1 |
| 9 | Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma显示文摘 | Zuoqing Dong Shaohua Liu Chengjun Zhou Tomoki sumida Hiroyuki Hamakawa Zhenggang Chen Pei Liu Fengcai Wei | 2009 | Oral Oncology2009，，3： | 1 |
| 10 | in situ preparation and continuous fiber spinning of poly(p-phenylene benzobisoxazole) composites with oligo-hydroxya mide-functionalized multi-walled carbon nanotubes 显示文摘 | Zhou Chengjun Wang Shanfeng Zhang Yi | 2008 | Polymer2008，49，10： | 1 |
| 11 | Enhanced conductivity in poly benzoxazoles doped with carboxylated multi-walled carbon nanotubes 显示文摘 | Zhou Chengjun Wang Shanfeng Zhuang Qixin et a l | 2008 | Carbon2008，46，9： | 1 |
| 12 | Deoxycholic acidmodified chitooligosaccharide/mP EG-PDLLA mixed micelles loaded with paclitaxel for enhanced antitumor efficacy显示文摘 | Chengjun Jiang Hangxiang Wang Xiaomin Zhang Zhibin Sun Feng Wang Jun Cheng Haiyang Xie Bo Yu Lin Zhou | 2014 | International Journal of Pharmaceutics2014，475，12： | 1 |
| 13 | Electro-chemo-mechanical analysis of the effect of bending deformation on the interface of flexible solid-state battery显示文摘Flexible solid-state battery has several unique characteristics including high flexibility,easy portability,and high safety,which may have broad application prospects in new technology products such as rollup displays,power implantable medical devices,and wearable equipments.The interfacial mechanical and electrochemical problems caused by bending deformation,resulting in the battery damage and failure,are particularly interesting.Herein,a fully coupled electro-chemo-mechanical model is developed based on the actual solid-state battery structure.Concentration-dependent material parameters,stress-dependent diffusion,and potential shift are considered.According to four bending forms(k=8/mm,0/mm,-8/mm,and free),the results show that the negative curvature bending is beneficial to reducing the plastic strain during charging/discharging,while the positive curvature is detrimental.However,with respect to the electrochemical performance,the negative curvature bending creates a negative potential shift,which causes the battery to reach the cut-off voltage earlier and results in capacity loss.These results enlighten us that suitable electrode materials and charging strategy can be tailored to reduce plastic deformation and improve battery capacity for different forms of battery bending. | Yutao SHI Chengjun XU Bingbing CHEN Jianqiu ZHOU Rui CAI | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，2： | 1 |
| 14 | Electrospun Polyethylene Oxide/Cellulose Nanocrystal Composite Nanofibrous Mats with Homogeneous and Heterogeneous Microstructures显示文摘 | Chengjun Zhou Raymond Chu Rhonna Wu Qinglin Wu | | 0，，： | 1 |
| 15 | Analysis of a mechanical vapor recompression wastewater distillation system 显示文摘 | Yasu Zhou Chengjun Shi Guoqiang Dong | 2014 | Desalina- tion2014，353，： | 1 |
| 16 | Co-extrusion technology for functioned nature fiber reinforced polymercomposites显示文摘 | Huang Runzhou Zhou Chengjun Zhang Yang | 2013 | Advanced Materials Research2013，773，： | 1 |
| 17 | Generation and application of replication-competent Venus-expressing H5N1,H7N9,and H9N2 influenza A viruses显示文摘The generation and application of replication-competent influenza A virus(IAV) expressing a reporter gene represent a valuable tool to elucidate the mechanism of viral pathogenesis and establish new countermeasures to combat the threat of influenza. Here, replication-competent IAVs with a neuraminidase(NA) segment harboring a fluorescent reporter protein, Venus, were generated in the background of H5N1, H7N9, and H9N2 influenza viruses, the three subtypes of viruses with imminent pandemic potential. All three reporter viruses maintained virion morphology, replicated with similar or slightly reduced titers relative to their parental viruses, and stably expressed the fluorescent signal for at least two passages in embryonated chicken eggs. As a proof of concept, we demonstrated that these reporter viruses,used in combination with a high-content imaging system, can serve as a convenient and rapid tool for the screening of antivirals and host factors involved in the virus life cycle. Moreover, the reporter viruses demonstrated similar growth properties and tissue tropism as their parental viruses in mice, among which the H7N9 NA-Venus virus could potentially be used in ex vivo studies to better understand H7N9 pathogenesis or to develop novel therapeutics. | guangwen wang jie zhang fandi kong qibing li jinliang wang shujie ma yuhui zhao libin liang junping li nan sun lizheng guan yuan zhou chenchen zhou shanyu huang zhigao bu li jiang hualan chen chengjun li | 2018 | Science Bulletin2018，63，3： | 1 |
| 18 | Recent advancements in the diagnosis and treatment of acral melanoma显示文摘Acral melanoma(AM)is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate,largely due to the inconspicuous nature of early-stage lesions,which can lead to late diagnosis.Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas,early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities,including clinical examination,dermoscopy,histopathology,molecular testing,radiological imaging,and blood tests.While surgery is the preferred method of treatment for AM,other therapeutic options may be employed based on the stage and underlying etiology of the disease.Immune checkpoint inhibitors,molecular targeted therapy,radiotherapy,chemotherapy,and oncolytic virotherapy represent promising advanced treatment options for AM.In this review,we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM,highlighting the importance of early detection and the prompt,individualized management of this challenging disease. | Ahmad ALHASKAWI Sohaib Hasan Abdullah EZZI Yanzhao DONG Haiying ZHOU Zewei WANG Jingtian LAI Chengjun YAO Vishnu Goutham KOTA Mohamed Hasan Abdulla Hasan ABDULLA Hui LU | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，2： | 0 |
| 19 | Spatial Inhomogeneity of Atmospheric CO_(2) Concentration and Its Uncertainty in CMIP6 Earth System Models显示文摘This paper provides a systematic evaluation of the ability of 12 Earth System Models(ESMs)participating in the Coupled Model Intercomparison Project Phase 6(CMIP6)to simulate the spatial inhomogeneity of the atmospheric carbon dioxide(CO_(2))concentration.The multi-model ensemble mean(MME)can reasonably simulate the increasing trend of CO_(2) concentration from 1850 to 2014,compared with the observation data from the Scripps CO_(2) Program and CMIP6 prescribed data,and improves upon the CMIP5 MME CO_(2) concentration(which is overestimated after 1950).The growth rate of CO_(2) concentration in the northern hemisphere(NH)is higher than that in the southern hemisphere(SH),with the highest growth rate in the mid-latitudes of the NH.The MME can also reasonably simulate the seasonal amplitude of CO_(2) concentration,which is larger in the NH than in the SH and grows in amplitude after the 1950s(especially in the NH).Although the results of the MME are reasonable,there is a large spread among ESMs,and the difference between the ESMs increases with time.The MME results show that regions with relatively large CO_(2) concentrations(such as northern Russia,eastern China,Southeast Asia,the eastern United States,northern South America,and southern Africa)have greater seasonal variability and also exhibit a larger inter-model spread.Compared with CMIP5,the CMIP6 MME simulates an average spatial distribution of CO_(2) concentration that is much closer to the site observations,but the CMIP6-inter-model spread is larger.The inter-model differences of the annual means and seasonal cycles of atmospheric CO_(2) concentration are both attributed to the differences in natural sources and sinks of CO_(2) between the simulations. | Chengjun XIE Tongwen WU Jie ZHANG Kalli FURTADO Yumeng ZHOU Yanwu ZHANG Fanghua WU Weihua JIE He ZHAO Mengzhe ZHENG | 2023 | Advances in Atmospheric Sciences2023，40，11： | 0 |
| 20 | Research on Cooling Effectiveness in Stepped Slot Film Cooling Vane显示文摘As one of the most important developments in air cooling technology for hot parts of the aero-engine,film cooling technology has been widely used.Film cooling hole structure exists mainly in areas that have high temperature,uneven cooling effectiveness issues when in actual use.The first stage turbine vanes of the aero-engine consume the largest portion of cooling air,thereby the research on reducing the amount of cooling air has the greatest potential.A new stepped slot film cooling vane with a high cooling effectiveness and a high cooling uniformity was researched initially.Through numerical methods,the affecting factors of the cooling effectiveness of a vane with the stepped slot film cooling structure were researched.This paper focuses on the cooling effectiveness and the pressure loss in different blowing ratio conditions,then the most reasonable and scientific structure parameter can be obtained by analyzing the results.The results show that 1.0 mm is the optimum slot width and 10.0 is the most reasonable blowing ratio.Under this condition,the vane achieved the best cooling result and the highest cooling effectiveness,and also retained a low pressure loss. | LI Yulong WU Hong ZHOU Feng RONG Chengjun | 2016 | Journal of Thermal Science2016，25，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员