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| 1 | Density functional theory study on the insertion reaction mechanism of dibromocarbene with formaldehyde显示文摘The insertion reaction mechanism of CBr2 with CH3CH2O has been studied by using the B3LYP/6-311G(d) and CCSD(T)/6-311G(d) at single point. The geometries of reactions,transition state and products were completely optimized. All the transition state is verified by the vibrational analysis and the internal re-action coordinate (IRC) calculations. The results show that reaction (1) is the dominant reaction path,which proceeds via two steps: i) two reactants form an intermediate (IM1),which is an exothermal re-action of 8.62 kJ·mol?1 without energy barrier; ii) P1 is obtained via the TS1 and the H-shift,in which the energy barrier is 44.53 kJ·mol?1. The statistical thermodynamics and Eyring transition state theory with Wigner correction are used to study the thermodynamic and kinetic characters of this reaction in temperature range from 100 to 2200 K. The results show that the appropriate reaction temperature ranges from 200 to 1900 K at 1.0 atm,in which the reaction has a bigger spontaneity capability,equi-librium constant (K) and higher rate constant (k). | LI ZhiFeng LUE LingLing KANG JingWan LU XiaoQuan | 2007 | Chinese Science Bulletin2007，52，15： | 8 |
| 2 | Atmospheric correction of HJ-1A/B CCD images over Chinese coastal waters using MODIS-Terra aerosol data显示文摘This paper demonstrates an atmospheric correction method to process HJ-1A/B CCD images over Chinese coastal waters with the aid of MODIS-Terra aerosol information.Based on the assumption of zero water-leaving radiance at the two near-infrared (NIR)bands or the shortwave infrared(SWIR)bands,the atmospheric aerosol optical depth(AOD)is firstly retrieved from MODIS-Terra with a simple extension of the NIR-SWIR combined atmospheric correction approach embedded in SeaDAS (SeaWiFS data analysis system).Then the'turbid'and'non-turbid'waters are separated by the turbid water index.Maximum probability of AOD at 551 nm band is derived based on the NIR information over'non-turbid'waters and FLAASH model is selected to do the atmospheric correction of the HJ-1A/B CCD imagery using the AOD values of highest probabilities as input.Similarly,according to the histogram of the AOD distribution at 551 nm band,the studied turbid water area is divided into several blocks and HJ-1A/B CCD imagery is corrected with the corresponding AOD values displayed with the highest frequency in each block.This method has been applied to several HJ-1A/B images over Chinese coastal waters and validated by synchronous in-situ data.The results have shown that this method is effective in the atmospheric correction process of HJ-1A/B CCD images for ocean color remote sensing study and application in the coastal waters. | TIAN LiQiao 1,LU JianZhong 1,CHEN XiaoLing 1,2,3,YU ZhiFeng 1,XIAO JingJing 1,QIU Feng 1 & ZHAO Xi 1 1 State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan 430079,China 2Key Laboratory of Poyang Lake Wetland and Watershed Research,Ministry of Education,Jiangxi Normal University,Nanchang 330022,China 3 The Key Laboratory of Poyang Lake Environment and Resource Utilization,Ministry of Education,Nanchang University,Nanchang 330031,China | 2010 | Science China(Technological Sciences)2010，53，S1： | 8 |
| 3 | A general alternate loading technique and its applications in the inverse designs of centrifugal and mixed-flow pump impellers显示文摘For the inverse designs of centrifugal and mixed-flow pump impellers,clarifying the generation process of secondary flows and putting forward corresponding suppression measures is an important approach to improve the impeller performance.In this paper,to provide a better qualitative insight into the generation mechanism of secondary flows in the impeller,a simple kinematic equation is derived based on the ideal assumptions,which indicates that the potential rothalpy gradient(PRG)is the most important dynamic source that actively induces secondary vortical flows.Induced by the natural adverse PRG on the S1 and S2 stream surfaces,two typical secondary flows,H-S and P-S secondary flows,are clearly presented.To specially suppress these typical secondary flows,a general alternate loading technique(GALT)is proposed,aiming to adjust the real blade loadingδp to control the PRG features.At the blade fore part,theδp on the hub streamline should be slowly increased to avoid breakneck growth of the potential rothalpy to reduce adverse streamwise PRG on the S2 streamsurface.At the blade middle part,theδp should be moderately decreased to reduce adverse streamwise PRG on the S1 streamsurface.At the blade aft part,the difference in theδp between the shroud and hub streamlines should be decreased faster to control the exit uniformity.By applying the GALT to the impeller designs of three typical pump types in hydraulic engineering,the organizational effect of the PRG on fundamental flow structures is proven.The GALT can effectively control the PRG distributions and suppress the secondary flows,thereby widening the pump’s high-efficiency zone,improving flow uniformity and suppressing pressure fluctuations.Compared with the current Z-G method and the ALT,the GALT can meet the requirements of'de-experience'better,thereby enabling the designers to obtain good products explicitly and quickly. | WANG ChaoYue WANG FuJun AN DongSen YAO ZhiFeng XIAO RuoFu LU Li HE ChengLian ZOU ZhiChao | 2021 | Science China(Technological Sciences)2021，64，4： | 7 |
| 4 | Metal halide perovskite nanocrystals and their applications in optoelectronic devices显示文摘In recent years, metal halide perovskite nanocrystals (NCs) have been favored by manyresearchers due to their unique properties including long carrier diffusion length, highcarrier mobility, tunable emission wavelength, and narrow full width at half maximum,making them great application potentials in optoelectronic devices. The photoluminescencequantum yields of perovskite NCs are nearly 100%, and the device efficiencyof perovskite NC-based light-emitting diodes (LEDs) has been improvedsignificantly from below 0.1% to over 20%. In addition, perovskite NC-based solarcells and photodetectors have also developed rapidly in recent years. Here, we summarizethe synthesis and the basic optoelectronic properties of metal halide perovskiteNCs and introduce their applications in LEDs, solar cells, and photodetectors. | Po Lu Min Lu Hua Wang Ning Sui Zhifeng Shi William W.Yu Yu Zhang | 2019 | InfoMat2019，1，4： | 7 |
| 5 | Density functional theory calculation on the C―H bond insertion reaction of dibromocarbene with acetaldehyde显示文摘The insertion reaction mechanism of CBr_2 with CH_3CH_O has been studied by using the B3LYP/6-31G(d) method. The geometries of reactions, transition state and products were completely optimized. All the energy of the species was obtained at the CCSD(T)/6-31G(d) level. All the transition state is verified by the vibrational analysis and the internal reaction coordinate (IRC) calculations. The results show that the propionaldehyde (~HP1) is the main product of CH_2 insertion with CH_3CH_O. The calculated results indicated that all the major pathways of the reaction were obtained on the singlet potential energy surface. The singlet CBr_2 not only can insert the C_α-H [reaction I(1)]) but also can react with C_β-H [reaction II(1)]. The statistical thermodynamics and Eyring transition state theory with Wigner correc- tion are used to study the thermodynamic and kinetic characters of I(1) and II(1) in temperature range from 100 to 2200 K. The results show that the appropriate reaction temperature rang is 250 to 1750 K and 250 to 1600 K at 1.0 atm for I(1) and II(1) respectively. The rate constant and equilibrium constant are distinct in the range from 250 to 1000 K so that I(1) more easily occurs, while the reactions are not selected in the temperature range of 1000-1600 | LI ZhiFeng YANG Sheng LU LingLing LU XiaoQuan KANG JingWan | 2008 | Chinese Science Bulletin2008，53，5： | 4 |
| 6 | In vitro Inhibitory Activity of Shisandra chinensis and Polygonatum sibiricum against Vibrio harveyi and Its Biofilms显示文摘[Objective] This study aimed to analyze the in vitro inhibitory activity of Shisandra chinensis and Polygonatum sibiricum against Vibrio harveyi and its biofilms. [Result] By agar diffusion test,in vitro inhibitory activity of S.chinensis and P. sibiricum against V. harveyi was investigated. The minimal inhibitory concentration(MIC) a nd minimal bactericidal concentration(MBC) of S.chinensis and P.sibiricum against V.harveyi were determined by doubling dilution method. The inhibitory activity of S. chinensis and P.sibiricum on the formation of V.harveyi biofilms was evaluated by modified MTT assay. [Result]Both S.chinensis and P.sibiricum had inhibitory activity against V.harveyi. The inhibition zone diameter of S.chinensis against V.harveyi was 17.95 mm; MIC and MBC of S.chinensis were both 3.125 mg / ml. The inhibition zone diameter of P. sibiricum against V.harveyi was 12.22 mm; MIC and MBC of P.sibiricum were 3.125 and 6. 250 mg / ml,respectively. When the concentration was higher than 6. 25 mg / ml,S.chinensis decoction had extremely significant inhibitory activity against V.harveyi( P < 0. 01); when the concentration was higher than 3. 125 mg / ml,P. sibiricum had extremely significant inhibitory activity against V. harveyi(P <0. 01). [Conclusion]S.chinensis and P.sibiricum could significantly inhibit V.harveyi and its biofilms. | Zhifeng HUANG Huanying PANG Yang HUANG Yucong HUANG Yishan LU Jichang JIAN | 2016 | Agricultural Biotechnology2016，5，4： | 4 |
| 7 | Highly sensitive solar-blind deep ultraviolet photodetector based on graphene/PtSe_(2)/β-Ga_(2)O_(3)2D/3D Schottky junction with ultrafast speed显示文摘There is an emerging need for high-sensitivity solar-blind deep ultraviolet(DUV)photodetectors with an ultra-fast response speed.Although nanoscale devices based on Ga_(2)O_(3)nanostructures have been developed,their practical applications are greatly limited by their slow response speed as well as low specific detectivity.Here,the successful fabrication of two-/three-dimensional(2D/3D)graphene(Gr)/PtSe2/β-Ga_(2)O_(3)Schottky junction devices for high-sensitivity solar-blind DUV photodetectors is demonstrated.Benefitting from the high-quality 2D/3D Schottky junction,the vertically stacked structure,and the superior-quality transparent graphene electrode for effective carrier collection,the photodetector is highly sensitive to DUV light illumination and achieves a high responsivity of 76.2 mA/W,a large on/off current ratio of~105,along with an ultra-high ultraviolet(UV)/visible rejection ratio of 1.8×104.More importantly,it has an ultra-fast response time of 12µs and a remarkable specific detectivity of~1013 Jones.Finally,an excellent DUV imaging capability has been identified based on the Gr/PtSe2/β-Ga_(2)O_(3)Schottky junction photodetector,demonstrating its great potential application in DUV imaging systems. | Di Wu Zhihui Zhao Wei Lu Lukas Rogée Longhui Zeng Pei Lin Zhifeng Shi Yongtao Tian Xinjian Li Yuen Hong Tsang | 2021 | Nano Research2021，14，6： | 4 |
| 8 | Effect of pulsatile perfusion during cardiopulmonary bypass in terms of radial artery sphygmogram显示文摘OBJECTIVE: To investigate a quantitative method for using radial artery pulse waveforms to assess the effect of pulsatile flow during cardiopulmonary bypass(CPB).METHODS: A total of 34 adults with heart disease who underwent open-heart surgery between April2010 and January 2011 were randomized into a pulsatile perfusion group(n=17) and a non-pulsatile perfusion group(n=17). Radial arterial pulse waveforms of pulsatile and non-pulsatile perfusion patients were observed and compared before and during CPB.RESULTS: No pulse waveform could be detected at patients' radial artery in both groups when the aorta was cross-clamped. Pulse waveforms could be detected at pulsatile perfusion patients' radial artery, but could not be detected at non-pulsatile perfusion patients' radial artery during CPB. Additionally, patients' pulse waveforms during pulsatile perfusion were lower than those before the operation.CONCLUSION: Our findings indicate that radial artery sphygmogram can be used as a valid indicator to evaluate the effectiveness of pulsatile perfusion during CPB. | Zhifeng Zhang Jiatuo Xu Enyuan Zhu Qi Zhang Lu Yu Yongbing Qiu Jianguo Tang Zhaofu Fei Xin Li Liping Tu Chouping Han Ying Liu Zhen Guo Changle Zhou Meiyu Shi Yingxin Qian Yimin Bao Xinming Ji | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
| 9 | Mixing of Enriched Lithospheric Mantle-Derived and Crustal Magmas: Evidence from the Habo Cenozoic Porphyry in Western Yunnan显示文摘New zircon U–Pb ages, whole-rock geochemistry and zircon Hf isotopes from the Habo porphyry Western Yunnan, China, were determined to provide constraints on the timing of uplift of the Eastern Tibetan Plateau. The intrusive rocks consist of shoshonitic porphyry(syenite porphyry and monzonite porphyry). Zircon laser ablation inductively coupled plasma mass spectrometry(LA-ICPMS) U–Pb dating indicates coeval emplacement ages of ~35 Ma. The porphyries have alkaline affinities, enrichment in large ion lithophile elements(LILEs) and light rare earth elements(LREEs)(e.g., Rb, Th, U, Pb), with depletion of high field strength elements(HFSEs)(e.g., Nb, Ti, Ta) and weak Eu anomalies. They display uniform Lu–Hf isotopic compositions with negative zircon εHf(t) values ranging from-3.9 to-0.6. The chemical characteristics of the syenite porphyries indicated that they most likely originated from the lower crust, with mantle-derived material involved in their generation. Geochemically, the monzonite porphyries are similar to the syenite porphyries; however, the lower MgO contents suggest that they were produced by different degrees of partial melting of the same lower crust source. Combined with the geochemical and isotopic data in this paper, imply that the alkali-rich porphyries of the Habo polymetallic deposit were derived from the partial melting of lower crust, enriched by mantle magma, formed in a conversion stage from stress extrusion(a strike-slip shear process) to local stress relaxation(a strike-slip pull-apart process) at the Ailaoshao tectonic zone. | XIA Bin LU Ye YUAN Yajuan CHEN Weiyan ZHANG Xiao XU Chi YU Shengrui WAN Zhifeng | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 2 |
| 10 | Salvianolic acid B dry powder inhaler for the treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF)is a serious and fatal pulmonary inflammatory disease with an increasing incidenceworldwide.The drugs nintedanib and pirfenidone,are listed as conditionally recommended drugs in the“Evidence-Based Guidelines for the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis”.However,these two drugs have many adverse reactions in clinical application.Salvianolic acid B(Sal B),a water-soluble component of Salvia miltiorrhiza,could alleviate bleomycin-induced peroxidative stress damage,and prevent or delay the onset of IPF by regulating inflammatory factors and fibrotic cytokines during the disease’s progression.However,Sal B is poorly absorbed orally,and patient compliance is poor when administered intravenously.Therefore,there is an urgent need to find a new non-injection route of drug delivery.In this study,Sal B was used as model drug and l-leucine(LL)as excipient to prepare Sal B dry powder inhaler(Sal B-DPI)by spray drying method.Modern preparation evaluation methods were used to assess the quality of Sal B-DPI.Sal B-DPI is promising for the treatment of IPF,according to studies on pulmonary irritation evaluation,in vivo and in vitro pharmacodynamics,metabolomics,pharmacokinetics,and lung tissue distribution. | Peng Lu Jiawei Li Chuanxin Liu Jian Yang Hui Peng Zhifeng Xue Zhidong Liu | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，3： | 2 |
| 11 | Single-cell RNA sequencing reveals Nestin+active neural stem cells outside the central canal after spinal cord injury显示文摘Neural stem cells(NSCs)in the spinal cord hold great potential for repair after spinal cord injury(SCI).The ependyma in the central canal(CC)region has been considered as the NSCs source in the spinal cord.However,the ependyma function as NSCs after SCI is still under debate.We used Nestin as a marker to isolate potential NSCs and their immediate progeny,and characterized the cells before and after SCI by single-cell RNA-sequencing(scRNA-seq).We identified two subgroups of NSCs:the subgroup located within the CC cannot prime to active NSCs after SCI,while the subgroup located outside the CC were activated and exhibited the active NSCs properties after SCI.We demonstrated the comprehensive dynamic transcriptome of NSCs from quiescent to active NSCs after SCI.This study reveals that Nestin+cells outside CC were NSCs that activated upon SCI and may thus serve as endogenous NSCs for regenerative treatment of SCI in the future. | Muya Shu Xiaoyu Xue Hu Nie Xianming Wu Minghan Sun Lianyong Qiao Xing Li Bai Xu Zhifeng Xiao Yannan Zhao Yongheng Fan Bing Chen Jixiang Zhang Ya Shi Yaming Yang Falong Lu Jianwu Dai | 2022 | Science China(Life Sciences)2022，65，2： | 2 |
| 12 | Comprehensive metabolic profiling of Alismatis Rhizoma triterpenes in rats based on characteristic ions and a triterpene database显示文摘Alismatis Rhizoma(AR)is widely used in Chinese medicine,and its major bioactive components,triterpenes,reportedly possess various pharmacological activities.Therefore,it is very important to study the metabolism of triterpenes in vivo.However,the metabolism of AR triterpene extract has not been comprehensively elucidated due to its complex chemical components and metabolic pathways.In this study,an ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method,which was based on the characteristic ions from an established database of known triterpenes,was used to analyze the major metabolites in rats following the oral administration of Alismatis Rhizoma extracts(ARE).As a result,a total of 233 constituents,with 85 prototype compounds and 148 metabolites,were identified for the first time.Hydrogenation,oxidation,sulfate and glucuronidation conjugation were the major metabolic pathways for triterpenes in AR.In addition,the mutual in vivo transformation of known ARE triterpenes was discovered and confirmed for the first time.Those results provide comprehensive insights into the metabolism of AR in vivo,which will be useful for future studies on its pharmacodynamics and pharmacokinetics.Moreover,this established strategy may be useful in metabolic studies of similar compounds. | Lu Wang Sen Li Jiaxin Li Zhongzhe Cheng Yulin Feng Hui Ouyang Zhifeng Du Hongliang Jiang | 2021 | Journal of Pharmaceutical Analysis2021，11，1： | 2 |
| 13 | Curcumin delivery by methoxy polyethylene glycol-poly(caprolactone) nanoparticles inhibits the growth of C6 glioma cells显示文摘 | Junfei Shao Donghui Zheng Zhifeng Jiang Huae Xu Yong Hu Xiaolin Li Xiaowei Lu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，4： | 2 |
| 14 | 10E8-like neutralizing antibodies against HIV-1 induced using a precisely designed conformational peptide as a vaccine prime显示文摘Recent studies have demonstrated that the membrane-proximal external region(MPER)of human immunodeficiency virus 1(HIV-1)glycoprotein 41 contains a series of epitopes for human monoclonal antibodies,including 2F5,Z13e1,4E10,and10E8,which were isolated from HIV-1-infected individuals and show broad neutralizing activities.This suggests that MPER is a good target for the development of effective HIV-1 vaccines.However,many studies have shown that it is difficult to induce antibodies with similar broad neutralizing activities using MPER-based peptide antigens.Here,we report that 10E8-like neutralizing antibodies with effective anti-HIV-1 activity were readily induced using a precisely designed conformational immunogenic peptide containing the 10E8-specific epitope.This immunogenic peptide(designated T10HE)contains a 15-mer MPER-derived 10E8-specific epitope fused to T-helper-cell epitopes from tetanus toxin(tt),which showed a significantly stabilized-helix structure after a series of modifications,including substitution with an(S)--(2-pentenyl)alanine containing an olefin-bearing tether and ruthenium-catalyzed olefin metathesis,compared with the unmodified T10E peptide.The stabilized-helix structure of T10HE did not affect its capacity to bind the 10E8 antibody,as evaluated with an enzyme linked immunosorbent assay(ELISA)and surface plasmon resonance binding assay(SPR assay).The efficacies of the T10HE and T10E epitope vaccines were evaluated after a standard vaccination procedure in which the experimental mice were primed with either the T10HE or T10E immunogen and boosted with HIV-1 JRFL pseudoviruses.Higher titers of 10E8-like antibodies were induced by T10HE than that by T10E.More importantly,the antibodies induced by T10HE showed enhanced antiviral potency against HIV-1 strains with both X4 and R5 tropism and a greater degree of broad neutralizing activity than the antibodies induced by T10E.These results indicate that a 10E8-epitope-based structure-specific peptide immunogen can elicit neutralizing antibodies when used as a vaccine prime. | YU Yang TONG Pei LI Yu LU ZhiFeng CHEN YingHua | 2014 | Science China(Life Sciences)2014，57，1： | 2 |
| 15 | Mid-trimester fetal blood derived adherent cells share characteristics similar to mesenchymal stem cells but fullterm umbilical cord blood does not显示文摘 | Lu Minjun Xiao Zhifeng Shen L | 2003 | British Hematology2003，124，5： | 1 |
| 16 | Effect of uneven noise source and/or station distribution on estimating the azimuth anisotropy of surface waves显示文摘With the development of the dense array,the surface wave velocity and azimuthal anisotropy under the array can be directly obtained by beamforming the noise cross-correlation functions(NCFs). However, the retrieval of the Green's function by cross-correlating the seismic noise requires that the noise source has a uniform distribution. For the case with uneven noise source, the azimuthal dependence on the sources in the expression for the spatial coherence function, which corresponds to the NCF in the time domain,has the same form as the azimuthal dependence of the surface wave velocity in weakly anisotropic media. Therefore, the uneven noise source will affect the surface wave anisotropy extraction. In this study, three passive seismic methods, i.e.,beamforming, SPAC(spatial autocorrelation), and NCF, are compared to demonstrate that an uneven source distribution and uneven station distribution have equivalent effects on the outcome from each method. A beamforming method is proposed to directly extract the velocity and azimuthal anisotropy of surface waves. The effect of uneven noise source and/or station distribution on estimating the azimuth anisotropy of surface waves was investigated using data from the ChinArray Phase Ⅱ. A method for correcting the apparent anisotropy in beamforming results caused by an uneven station distribution is suggested. | Laiyu Lu Kaiming Wang Zhifeng Ding | 2018 | Earthquake Science2018，31，4： | 1 |
| 17 | An Effective Object-level XML Keyword Search 显示文摘 | Bao Zhifeng Lu Jiaheng Ling Tok Wang | 2010 | Computer Science2010，5981，： | 1 |
| 18 | Microstructure and Mechanical Property of In Situ Synthesized Multiple-Reinforced (TiB + TiC + La2 O3 )/Ti Composites 显示文摘 | Yang Zhifeng Lu Weijie Zhao Lin | 2008 | Journal of AUoys and Compounds2008，455，12： | 1 |
| 19 | Microstructure and Tensile Properties of In-Situ Synthesized (TiC + TiB + Nd2O3 )/Ti-alloy Composites at Elevated Temperature 显示文摘 | Yang Zhifeng Lu Weijie Qin Jining | 2006 | Materials Science and Engineering: A2006，425，12： | 1 |
| 20 | Extended XMLtree pattern matching: theories and algorithms 显示文摘 | Lu Jiaheng Ling T W Bao Zhifeng | 2011 | IEEETransactions on Knowledge and Data Engineering2011，23，3： | 1 |
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