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| 1 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 2 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 3 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 4 | Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines显示文摘Hepatitis B virus(HBV) infection is one of the most serious and prevalent viral diseases in the world. Although several anti-HBV drugs have been used clinically, their side and adverse effects limit treatment efficacy. Therefore, it is necessary to identify novel potential anti-HBV agents. The flavonol quercetin has shown activity against some retroviruses, but its effect on HBV remains unclear. In the present study, quercetin was incubated with Hep G2.2.15 cells, as well as Hu H-7 cells transfected with an HBV plasmid. Quercetin was shown to significantly reduce Hepatitis B surface antigen(HBs Ag) and Hepatitis B e antigen(HBe Ag), secretion and HBV genomic DNA levels in both cell lines. In addition, co-incubation with lamivudine(3TC), entecavir(ETV), or adefovir(Ade) further enhanced the quercetin-induced inhibition of HBV replication. This inhibition was partially associated with decreased heat shock proteins and HBV transcription levels. The results indicate that quercetin inhibited HBV antigen secretion and genome replication in human hepatoma cell lines, which suggests that quercetin may be a potentially effective anti-HBV agent. | Zhikui Cheng Ge Sun Wei Guo Yayun Huang Weihua Sun Fei Zhao Kanghong Hu | 2015 | Virologica Sinica2015，30，4： | 20 |
| 5 | Metabolic changes in cancer: beyond the Warburg effect显示文摘改变的新陈代谢是癌症房间的特点之一。在癌症房间的最著名的新陈代谢的反常是 Warburg 效果,它甚至面对氧表明增加的 glycolysis。然而,肿瘤相关的新陈代谢的畸形没被限制到在葡萄糖发酵和氧化 phosphorylation 之间的改变的平衡。象 p53 和 c-myc 那样的关键肿瘤基因被发现是新陈代谢的主人管理者。象 succinate 脱氢酶, fumarate hydratase, pyruvate kinase,和 isocitrate 脱氢酶变化或表示水平改变那样的新陈代谢的酶都被连接到 tumorigenesis。在这评论,我们介绍一些联系癌症的新陈代谢的混乱和他们的分子的 tumorigenic 机制的当前的理解。 | Weihua Wu Shimin Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，1： | 15 |
| 6 | Using eye tracking to evaluate the usability of animated maps显示文摘Cartographic animation has been developed and widely used in geo-visualisation and many other areas in recent years.The usability of animated maps is a key characteristic affecting map users’effectiveness and efficiency in accomplishing tasks.In this paper,an eye tracking approach was proposed as a visual analytics method to evaluate the usability of animated maps by capturing participants’eye movement data and quantitatively analysing the accuracy(effectiveness)and response time(efficiency)of users’task completion.In the study,a set of animated traffic maps represented by three important visual variables(colour hue,size and frequency)was used for the usability evaluation.The experimental results showed that the usability of these three visual variables for cartographic animation affects the usability of animated maps.Red,yellow,and aqua were found to convey map information more effectively than other colour hues.Size was found to be more usable than colour hues for both animated maps and static maps.Usability was not found to be proportional to the playback rate of animated maps.Furthermore,the usability of the frequency,colour hue,and size was found to be related to the display’s size.We hope that the analysis approach presented in this paper and the results of this study will be of help in the design of cartographic animation displays with better usability. | DONG WeiHua LIAO Hua XU Fang LIU Zhao ZHANG ShaoBo | 2014 | Science China Earth Sciences2014，57，3： | 14 |
| 7 | COVID-19 Super Spreading Event Amongst Elderly Individuals—Jilin Province,China,January 2021显示文摘Summary What is already known on this topic?Clusters of COVID-19 cases often happened in small settings(e.g.,families,offices,school,or workplaces)that facilitate person-to-person virus transmission,especially from a common exposure.What is added by this report?On January 10 and 11,2021,an individual gave three product promotional lectures in Tonghua City. | Laishun Yao Mingyu Luo Tiewu Jia Xingang Zhang Zhulin Hou Feng Gao Xin Wang Xiaogang Wu Weihua Cheng Guoqian Li Jing Lu Bing Zhao Tao Li Enfu Chen Dapeng Yin Biao Huang | 2021 | China CDC weekly2021，3，10： | 13 |
| 8 | Fault diagnosis for distillation process based on CNN–DAE显示文摘Distillation is the most widely used operation for liquid mixture separation in the chemical industry. It is of great importance to detect and diagnose faults in distillation process. Due to the strong feedback and coupling of processes in a distillation column, it is difficult to use deep auto-encoders(DAEs) alone to achieve good results in detecting and diagnosing faults, in terms of accuracy and efficiency. This paper proposes a hybrid fault-diagnosis model based on convolutional neural networks(CNNs) and DAEs, by integrating the powerful capability of CNN in feature extraction and of DAE in classification. A case study was carried out with the distillation process of depropanization. It is shown that the proposed hybrid model is of good performance compared to other models, in terms of the accuracy of fault detection in such a process. Also, with the increase of structural layers of the CNN–DAE model, the diagnostic accuracy will be improved, with an optimal accuracy of 92.2%. | Chuankun Li Dongfeng Zhao Shanjun Mu Weihua Zhang Ning Shi Lening Li | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 12 |
| 9 | Heat treatment effect on electrochemical properties of spinel Li_4Ti_5O_(12)显示文摘阳极材料 Li4Ti5O12 在 800 牰灯牥祴洠湡条浥 h | LI Yue ZHAO Hailei TIAN Zhihong QIU Weihua LI Xue | 2008 | Rare Metals2008，27，2： | 11 |
| 10 | Abnormal Rich-Club Organization Associated with Compromised Cognitive Function in Patients with Schizophrenia and Their Unaffected Parents显示文摘Schizophrenia is considered to be a disorder of brain connectivity, which might result from a disproportionally impaired rich-club organization. The rich-club is composed of highly interconnected hub regions that play crucial roles in integrating information between different brain regions. Few studies have yet investigated whether the structural rich-club organization is impaired in patients and their first-degree relatives. In this study, we established a weighted network model of white matter connections using diffusion tensor imaging of 19 patients and 39 unaffected parents, 22 young healthy controls for the patients, and 25 old healthy controls for the parents. Feeder edges between rich-club nodes and non-rich-club nodes were significantly decreased in both schizophrenic patients and their unaffected parents compared with controls.Furthermore, the feeder edges showed significant positive correlations with the scores in Category Fluency Test—animal naming in the unaffected parents. Specific feeder edges exhibited discriminative power with accuracy of 84.4% in distinguishing unaffected parents from old healthy controls. Our findings suggest that impaired richclub organization, especially impaired feeder edges, may be related to familial vulnerability to schizophrenia,possibly reflecting a genetic predisposition for schizophrenia. | Xin Zhao Lin Tian Jun Yan Weihua Yue Hao Yan Dai Zhang | 2017 | Neuroscience Bulletin2017，33，4： | 8 |
| 11 | 小鼠骨骼肌挫伤后基因表达的时间进程(英文)显示文摘Background:Though the mechanisms of skeletal muscle regeneration are deeply understood,those involved in muscle contusion,one of the most common muscle injuries in sports medicine clinics,are not.The objective of this study is to explore the mechanisms involved in muscle regeneration after contusion injury.Methods:In this study,a total of 72 mice were used.Eight of them were randomly chosen for the control group,while the rest were subjected to muscle contusion.Subsequently,their gastrocnemius muscles were harvested at different time points.The changes in muscle morphology were assessed by hematoxylin and eosin(HE) stain.In addition,the gene expression was analyzed by real-time polymerase chain reaction.Results:The data showed that the expression of many genes,i.e.,specific markers of immune cells and satellite cells,regulatory factors for muscle regeneration,cytokines,and chemokines,increased in the early stages of recovery,especially in the first 3 days.Furthermore,there were strict rules in the expression of these genes.However,almost all the genes returned to normal at 14 days post-injury.Conclusion:The sequence of immune cells invaded after muscle contusion was neutrophils,M1 macrophages and M2 macrophages.Some CC(CCL2,CCL3,and CCL4) and CXC(CXCL10) chemokines may be involved in the chemotaxis of these immune cells.HGF may be the primary factor to activate the satellite cells after muscle contusion.Moreover,2 weeks are needed to recover when acute contusion happens as used in this study. | Weihua Xiao Yu Liu Beibei Luo Linlin Zhao Xiaoguang Liu Zhigang Zeng Peijie Chen | 2016 | Journal of Sport and Health Science2016，5，1： | 8 |
| 12 | Aerodynamic performances and vehicle dynamic response of high-speed trains passing each other显示文摘Based on the aerodynamics and vehicle dynamics,the aerodynamic performances and vehicle dynamic characteristics of two high-speed trains passing each other on the ground,embankment and bridge are studied.Firstly,a train aerodynamic model and a vehicle dynamic model are established.Through the simulation of the two models,the pressure waves,aerodynamic forces,and vehicle dynamic responses are obtained.Then,the pressure waves and aerodynamic forces on different foundations are compared.The results show that the variation trends of pressure wave and aerodynamic forces of trains passing each other on different foundations are almost similar.The peak-to-peak differences in pressure wave and aerodynamic force are below 4% and 3% in three cases in open air.Besides,the differences of security indexes,including coefficient of derailment,wheel unloading rate,the wheelset lateral force,and the wheelrail vertical force,are below 2% among the three cases;the differences of comfort indexes,including the lateral acceleration and the vertical acceleration,are also below 2%.It is concluded that the dynamic performances of trains passing each other are influenced little by different foundations in open air. | Yinghui ZHAO Jiye ZHANG Tian LI Weihua ZHANG | 2012 | Journal of Modern Transportation2012，20，1： | 7 |
| 13 | Atomic mobilities and diffusivities in Al alloys显示文摘Knowledge of diffusivity is a prerequisite for understanding many scientific and technological disciplines.In this paper,firstly major experimental methods,which are employed to provide various diffusivity data,are briefly described.Secondly,the fundamentals of various computational methods,including first-principles method,embedded atomic method/molecular dynamic simulation,semi-empirical approaches,and phenomenological DICTRA technique,are demonstrated.Diffusion models recently developed for order/disorder transitions and stoichiometric compounds are also briefly depicted.Thirdly,a newly established diffusivity database for liquid,fcc_A1,L12,bcc_A2,bcc_B2,and intermetallic phases in the multicomponent Al alloys is presented via a few case studies in binary,ternary and quaternary systems.And the integration of various computational techniques and experimental methods is highlighted.The reliability of this diffusivity database is validated by comparing the calculated and measured concentration profiles,diffusion paths,and Kirkendall shifts in various binary,ternary and quaternary diffusion couples.Next,the established diffusivity databases along with thermodynamic and other thermo-physical properties are utilized to simulate the microstructural evolution for Al alloys during solidification,interdiffusion and precipitation.A special discussion is presented on the phase-field simulation of interdiffusion microstructures in a series of Ni-Al diffusion couples composed of γ,γ',and β phases under the effects of both coherent strain and external compressive force.Future orientations in the establishment of next generation of diffusivity database are finally addressed. | DU Yong ZHANG LiJun CUI SenLin ZHAO DongDong LIU DanDan ZHANG WeiBin SUN WeiHua JIE WanQi | 2012 | Science China(Technological Sciences)2012，55，2： | 6 |
| 14 | Different quasispecies with great mutations hide in the same subgroup J field strain of avian leukosis virus显示文摘Blood samples were collected from a local strain of chickens associated with serious tumor cases in Shandong Province.The samples were inoculated into chicken embryo fibroblast and DF-1 cells for virus isolation and identification,respectively.The inoculated cells were screened for three common chicken tumor viruses.Nine strains of avian leukosis virus subgroup J(ALV-J) were identified,and were designated LY1201‐LY1209.The env gene from the LY1201 strain was amplified and cloned.All nine resultant env clones(clones 01-09) were sequenced,and the gp85 and gp37 amino acid regions were subjected to homology analysis.Clones 01 and 03 had 10 amino acid deletions in the gp85 region compared to the other seven clones,suggesting that at least two quasispecies with obvious mutations coexist in the same field strain.Among these nine clones,three had identical gp85 and gp37 sequences,and were recognized as the dominant LY1201 quasispecies.The amino acid sequence homology of gp37 and gp85 among the nine clones was 98.5%-100.0% and 96.6%-100.0% respectively,suggesting that the gp85 region of the env gene can better display the quasispecies diversity of ALV-J than gp37. | MAO YaQing LI WeiHua DONG Xuan LIU JinHua ZHAO Peng | 2013 | Science China(Life Sciences)2013，56，5： | 6 |
| 15 | Electrochemical properties of spinel LiMn_2O_4 and LiAl_(0.1)Mn_(1.9)O_(3.9)F_(0.1) synthesized by solid-state reaction显示文摘Two types of spinel cathode powders, LiMn2O4 and LiAl0.1Mn1.9O3.9F0.1, were synthesized by solid-state reaction. X-ray diffraction (XRD) patterns of the prepared samples were identified as the spinel structure with a space group of Fd 3 m. The cubic lattice parameter was determined from least-squares fitting of the XRD data. The LiAl0.1Mn1.9O3.9F0.1 sample showed a little lower initial capacity, but better cycling performance than the LiMn2O4 sample at both room temperature and an elevated temperature. The Vanderbilt method was used to test the electrochemical conductivity of the LiMn2O4 samples. The electrochemical impedance spec-troscopy (EIS) method was employed to investigate the electrochemical properties of these spinel LiMn2O4 samples. | Tao Li Weihua Qiu Hailei Zhao Jingjing Liu | 2008 | Journal of University of Science and Technology Beijing2008，15，2： | 6 |
| 16 | Macroinvertebrates in the bed sediment of the Yellow River显示文摘Extensive agricultural,industrial and urban development in the Yellow River,China,have modified the sediment-water balance,flow and inundation regimes,longitudinal connectivity,integrity of riparian vegetation,and water quality.Macroinvertebrate assemblages in the bed sediment of main channel and major reservoirs of the Yellow River are described in detail for the first time.A total of 74 taxa comprising 17 taxa of oligochaetes,48 taxa of aquatic insects,5 taxa of molluscs,and 4 taxa of other animals were recorded.A range of feeding guilds were represented,including, collector-gatherers(32 taxa),predators(17 taxa),scrapers(16 taxa),shredders(6 taxa)and collector-filterers(2 taxa).Both the mean density and biomass of macroinvertebrates were significantly higher in sites located in the artificial reservoirs compared with the main river channel. Assemblages varied spatially;Oligochaetes dominated assemblages in upper reaches,insects dominated in middle reaches and other animals(e.g.Crustacea)dominated in lower reaches. Collector-gatherers were dominant throughout the entire river.Classification analysis identified five site-groups on the basis of macroinvertebrate presence/absence:downstream of reservoirs;vegetated sites;reservoir sites;polluted sites,and;lower-reach sites.Lower macroinvertebrate richness,density and biomass,compared with other similar large rivers,were attributed to modification of the sediment-water balance and associated disturbance of benthic habitats.Pollution,stability of sediment and sediment concentration combined to influence the distribution of macroinvertebrates.This knowledge will substantially benefit the recent focus on the health and environmental water requirements of the Yellow River. | ZHAO Weihua WANG Haijun WANG Hongzhu Paul G CLOSE | 2011 | International Journal of Sediment Research2011，26，3： | 6 |
| 17 | Giant enhancement of magnetocaloric effect in metallic glass matrix composite显示文摘The magnetocaloric effect (MCE) has made great success in very low temperature refrigeration, which is highly desirable for application to the extended higher tem-perature range. Here we report the giant enhancement of MCE in the metallic glass composite. The large magnetic refrigerant capacity (RC) up to 103 J·kg-1 is more than double the RC of the well-known crystalline magnetic refrigerant compound Gd5Si2Ge1.9Fe0.1 (357 J·kg-1) and MnFeP0.45As0.55 (390 J·kg-1)(containing either ex-orbitant-cost Ge or poisonous As). The full width at half maximum of the magnetic entropy change (ΔSm) peak almost spreads over the whole low-temperature range (from 303 to 30 K), which is five times wider than that of the Gd5Si2Ge1.9Fe0.1 and pure Gd. The maximum ΔSm approaches a nearly constant value in a wide tem-perature span over 100 K, and however, such a broad table-like region near room temperature has seldom been found in alloys and compounds. In combination with the intrinsic amorphous nature, the metallic glass composite may be potential for the ideal Ericsson-cycle magnetic refrigeration over a broad temperature range near room temperature. | WANG YongTian BAI HaiYang PAN MingXiang ZHAO DeQian WANG WeiHua | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，4： | 5 |
| 18 | Novel insights into the molecular mechanisms of a-fetoprotein expression and malignant phenotypes of hepatocellular carcinoma显示文摘MicroRNA122(miR-122)is highly liver-specific and constitutes more than 70%of microRNAs(miRNAs)in the normal adult liver.a-fetoprotein(AFP)is the most conventional tumor marker used for detecting and surveying hepatocellular carcinoma(HCC),one of the more common and lethal cancers worldwide.In a recent issue of Nature Communications,Kojima et al.have revealed a strong association between the two biomarkers,1 providing novel insights into the roles of miR-122 in AFP expression and malignant phenotypes of HCC. | Zhiqing Hu Weihua Zhao | 2012 | Cellular & Molecular Immunology2012，9，1： | 5 |
| 19 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 20 | Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression显示文摘Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic regimens.The aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA patients.However,the underpinning mechanism remains poorly understood.Deubiquitinase(DUB)is regarded as a main orchestrator in maintaining protein homeostasis.Here,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent manner.The depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in vivo.Further analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient samples.Collectively,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients. | Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin Wu Chenxi Zhao Jiao Wang Jiabin Lu Bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong Bo Yang Hong Zhu Qiaojun He | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 5 |
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