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| 1 | Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy显示文摘Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy. | Minlin Jiang Keyi Jia Lei Wang Wei Li Bin Chen Yu Liu Hao Wang Sha Zhao Yayi He Caicun Zhou | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 12 |
| 2 | Global perspectives and future research directions for the phytoremediation of heavy metal-contaminated soil:A knowledge mapping analysis from 2001 to 2020显示文摘In total,9,552 documents were extracted from the Web of Science Core Collection and subjected to knowledge mapping and visualization analysis for the field of phytoremediation of HM-contaminated soil(PHMCS)with CiteSpace 5.7 R3 software.The results showed that(1)the number of publications increased linearly over the studied period.The top 10 countries/regions,institutions and authors contributing to this field were exhibited.(2)Keyword co-occurrence cluster analysis revealed a total of 8 clusters,including“Bioremediation,”“Arsenic,”“Biochar,”“Oxidative stress,”“Hyperaccumulation,”“EDTA,”“Arbuscular mycorrhizal fungi,”and“Environmental pollution”clusters(3)In total,334 keyword bursts were obtained,and the 25 strongest,longest duration,and newest keyboard bursts were analyzed in depth.The strongest keyword burst test showed that the hottest keywords could be divided into 7 groups,i.e.,“Plant bioremediation materials,”“HM types,”“Chelating amendments,”“Other improved strategies,”“Bioremediation characteristics,”“Risk assessment,”and“Other.”Almost half of the newest topics had emerged in the past 3 years,including“biochar,”“drought,”“health risk assessment,”“electrokinetic remediation,”“nanoparticle,”and“intercropping.”(4)In total,9 knowledge base clusters were obtained in this study.The studies of Ali et al.(2013),Blaylock et al.(1997),Huang et al.(1997),van der Ent et al.(2013),Salt et al.(1995),and Salt(1998),which had both high frequencies and the strongest burst scores,have had the most profound effects on PHMCS research.Finally,future research directions were proposed. | Kehui Liu Xiaojin Guan Chunming Li Keyi Zhao Xiaohua Yang Rongxin Fu Yi Li Fangming Yu | 2022 | Frontiers of Environmental Science & Engineering2022，16，6： | 4 |
| 3 | Suppression of ETI by PTI priming to balance plant growth and defense through an MPK3/MPK6-WRKYs-PP2Cs module显示文摘Pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)are required for host defense against pathogens.Although PTI and ETI are intimately connected,the underlying molecular mechanisms remain elusive.In this study,we demonstrate that flg22 priming attenuates Pseudomonas syringae pv.tomato DC3000(Pst)AvrRpt2-induced hypersensitive cell death,resistance,and biomass reduction in Arabidopsis.Mitogen-activated protein kinases(MAPKs)are key signaling regulators of PTI and ETI.The absence of MPK3 and MPK6 significantly reduces pre-PTI-mediated ETI suppression(PES).We found that MPK3/MPK6 interact with and phosphorylate the downstream transcription factor WRKY18,which regulates the expression of AP2C1 and PP2C5,two genes encoding protein phosphatases.Furthermore,we observed that the PTI-suppressed ETI-triggered cell death,MAPK activation,and growth retardation are significantly attenuated in wrky18/40/60 and ap2c1 pp2c5 mutants.Taken together,our results suggest that the MPK3/MPK6-WRKYs-PP2Cs module underlies PES and is essential for the maintenance of plant fitness during ETI. | Dacheng Wang Lirong Wei Ting Liu Jinbiao Ma Keyi Huang Huimin Guo Yufen Huang Lei Zhang Jing Zhao Kenichi Tsuda Yiming Wang | 2023 | Molecular Plant2023，16，5： | 1 |
| 4 | Influence of driving current' s wave on accelerative per- formance of induction coil launcher显示文摘 | ZHAO KEYI CHENG SHUKANG ZHANG RUIPING | 2008 | IEEE Transactions on Magnetics2008，44，1： | 1 |
| 5 | Inductance computation consideration of induction coil launcher显示文摘 | Zhao Keyi Lei Bin Li Zhiyuan | 2009 | IEEE Transactions on Magnetics2009，45，1： | 1 |
| 6 | Bio-resolution of glycidyl (o, m, p)-methylphenyl ethers by Bacillus megaterium显示文摘 | Zhengfang Zhang Yanming Sheng Keyi Jiang Zhao Wang Yuguo Zheng Qing Zhu | 2010 | Biotechnology Letters2010，，4： | 1 |
| 7 | Mid-infrared broadband optical frequency comb generated in MgF_2 resonators显示文摘Microresonator-based optical frequency combs are broadband light sources consisting of equally spaced and coherent narrow lines,which are extremely promising for applications in molecular spectroscopy and sensing in the mid-infrared(MIR)spectral region.There are still great challenges in exploring how to improve materials for microresonator fabrication,extend spectral bandwidth of parametric combs,and realize fully stabilized soliton MIR frequency combs.Here,we present an effective scheme for broadband MIR optical frequency comb generation in a MgF_(2) crystalline microresonator pumped by the quantum cascade laser.The spectral evolution dynamics of the MIR Kerr frequency comb is numerically investigated,revealing the formation mechanism of the microresonator soliton comb via scanning the pump-resonance detuning.We also experimentally implement the modulation instability state MIR frequency comb generation in MgF_(2) resonators covering from 3380 nm to 7760 nm.This work proceeds microresonator-based comb technology toward a miniaturization MIR spectroscopic device that provides potential opportunities in many fields such as fundamental physics and metrology. | WEI WU QIBING SUN YI WANG YU YANG XIANSHUN MING LEI SHI KEYI WANG WEI ZHAO LEIRAN WANG | 2022 | Photonics Research2022，10，8： | 0 |
| 8 | An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy显示文摘Two red-emissive luminogens(TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types I and II pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy. | Hailing Zhao Nan Li Caixia Ma Zhengwei Wei Qiya Zeng Keyi Zhang Na Zhao Ben Zhong Tang | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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