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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | A clinical and long-term follow-up study of perioperative sequential triple therapy for gastric cancer显示文摘INTRODUCTIONAlthough the long-term postoperative survival rateof gastric cancer(GC) patients has been improvedsignificantly since the local dissection of lymph nodewas widely used in China,yet the low curativeresection rate and the high recurrence rate fromperitoneal and hepatic metastases hinder it fromfurther improvement.To alter the currentunsatisfactory status of GC treatment,a | Zou SC Qiu HS Zhang CW Tao HQ | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 3 | Proline accumulation in rice seedlings exposed to hydroxyl radical stress in relation to antioxidation显示文摘PROLINE(Pro)is an essential amino acid for proteins and free Pro extensively exists in plants.Pro accumulates in plant cells in response to water stress,salinity,low temperature,air pollu-tants,etc.and has been mainly studied for its role in the osmotic adjustment of plants subject-ed to drought and salinity.In addition to acting as a cytoplasmic osmoticum,Pro | Jiang, MY Guo, SC Zhang, XM | 1997 | Chinese Science Bulletin1997，42，10： | 14 |
| 4 | Discovery of virus pathogen from soft-shelled turtle Trionyx sinesis显示文摘THE soft-shelled turtle Trionyx sinesis, because of its nutritional and medicinal values, | Zhang, QY Li, ZQ Jiang, YL Liang, SC Gui, JF | 1997 | Chinese Science Bulletin1997，42，6： | 3 |
| 5 | Adaptive immunity in the liver显示文摘 | Zongwen Shuai Miranda WY Leung Xiaosong He Weici Zhang Guoxiang Yang Patrick SC Leung M Eric Gershwin | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 6 | Experimental study of gold distribution in the algae-organic matter-fluid system显示文摘THE previous simulating experiments show that many algae can greatly accumulate goldfrom solution under some conditions. Some other experiments further indicate that organ-ic matter and crude oil can also play an important role in gold geochemistry processes such asleaching, migration, reduction and precipitation. However, these biometallogeneses are | Xie, SC Yin, HF Wang, HM Zhou, XG Fu, JM Sheng, GY Zhang, HZ Lu, JL | 1997 | Chinese Science Bulletin1997，42，19： | 3 |
| 7 | Proteomic analysis reveals distinctive protein profiles involved in CD8^(+) T cell-mediated murine autoimmune cholangitis显示文摘Autoimmune cholangitis arises from abnormal innate and adaptive immune responses in the liver,and T cells are critical drivers in this process.However,little is known about the regulation of their functional behavior during disease development.We previously reported that mice with T cell-restricted expression of a dominant negative form of transforming growth factor beta receptor type Ⅱ(dnTGFβ RII)spontaneously develop an autoimmune cholangitis that resembles human primary biliary cholangitis(PBC).Adoptive transfer of CD8^(+) but not CD4^(+) T cells into Rag1^(−/−)mice reproduced the disease,demonstrating a critical role for CD8^(+) T cells in PBC pathogenesis.Herein,we used SOMAscan technology to perform proteomic analysis of serum samples from dnTGFβRII and B6 control mice at different ages.In addition,we analyzed CD8 protein profiles after adoptive transfer of splenic CD8^(+) cells into Rag1^(−/−)recipients.The use of the unique SOMAscan aptamer technology revealed critical and distinct profiles of CD8 cells,which are key to biliary mediation.In total,254 proteins were significantly increased while 216 proteins were significantly decreased in recipient hepatic CD8^(+) cells compared to donor splenic CD8^(+) cells.In contrast to donor splenic CD8^(+) cells,recipient hepatic CD8^(+) cells expressed distinct profiles for proteins involved in chemokine signaling,focal adhesion,T cell receptor and natural killer cell-mediated cytotoxicity pathways. | Weici Zhang Ren Zhang Jun Zhang Ying Sun Patrick SC Leung Guo-Xiang Yang Zongwen Shuai William M Ridgway M Eric Gershwin | 2018 | Cellular & Molecular Immunology2018，15，8： | 3 |
| 8 | Expression of stem cell factor and C-kit receptor in neural cells after brain injury显示文摘 | Zhang SC Fedoroff S | 1999 | Acta Neuropathol (Berl)1999，97，： | 1 |
| 9 | Rho-kinase: regulation, (dys)function, and inhibition显示文摘 | Amin E Dubey BN Zhang SC | 2013 | Bioi Chern2013，394，11： | 1 |
| 10 | Association between IgE anti- body against soluble egg antigen and resistance to reinfection with Schistosoma japonicum 显示文摘 | Zhang ZS Wu HW Chen SC | 1997 | Tran R Soc Trop Med Hyg1997，91，5： | 1 |
| 11 | Differentiation of spinal motor neurons from pluripotent human stem cells显示文摘 | Hu BY Zhang SC | 2009 | Nat Protoc2009，4，9： | 1 |
| 12 | Engineered measlesvirus Edmonston strain used as a novel oncolytic viral sys-tem against human hepatoblastoma 显示文摘 | Zhang SC Wang WL Cai WS | 2012 | BMC Cancer2012，12，： | 1 |
| 13 | Regulatory CD4 +/CD8 + double neg- ative T cells 显示文摘 | Kim EY Juvet SC Zhang L | 2011 | Methods Mol Biol2011，677，3： | 1 |
| 14 | Histone deacetylases(HDAC)-induced histone modifications in the amygdala:a role in rapid tolerance to the anxiolytic effects of ethanol显示文摘 | Sakharkar AJ Zhang H Tang L Shi G Pandey SC | 2012 | Alcohol Clin Exp Res2012，36，1： | 1 |
| 15 | Time-dependent inhibition(TDI)of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction显示文摘 | Fang ZZ Zhang YY Ge GB Huo H Liang SC Yang L | 2010 | Br J Clin Pharmacol2010，69，2： | 1 |
| 16 | Neurotransplantation of Magnetically-Labeled Oligodendrocyte Progenitors:Magnetic Resonance Tracking of Cell Migration and Myelination显示文摘 | BULTE JWM ZHANG SC VAN GELDEREN P | 1999 | Proc Natl Acad Sci USA(S0027-8424)1999，96，15： | 1 |
| 17 | Dietary patterns and breast Cancer risk among Chinese women 显示文摘 | Zhang Caixia Ho SC Fu Jianhua | 2011 | Cancer Causes Con- trol2011，22，1： | 1 |
| 18 | 显示文摘 | Liu L Zhang T Li SC | 2009 | Mater Lett2009，63，23： | 1 |
| 19 | Inhibitoryeffects of4-hydroxy-2,5-dimethyl-3 (2H) -furanone (HDMF) on acyl-homoserine lactone-mediated virulence factor production andbiofilm formation in Pseudomonas aeruginosa PAOl 显示文摘 | Choi SC Zhang C Moon S | 2014 | JMicrobiol2014，52，9： | 1 |
| 20 | Differentiation of spinal motor neurons from pluripotent human stem cells显示文摘 | Hu BY Zhang SC | 2009 | Nat Protoc2009，4，9： | 1 |
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