|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Insights into the chemistry of new particle formation and growth events in Pittsburgh based on aerosol mass spectrometry 显示文摘 | Zhang Q Stanier C O Canagaratna M R Jayne J T Worsnop D R Pandis S N Jimenez J L | 2004 | Environ Sci Technol2004，38，18： | 1 |
| 4 | Association analysis between pseudorabies antibody and five single-nucleotide polymorphisms in pigs显示文摘 | Zhang S J Jafer O Yuan J F | 2009 | Animal2009，3，10： | 1 |
| 5 | 显示文摘 | Zhang F S Nriagu J O Itoh H | 2005 | Water Research2005，39，23： | 1 |
| 6 | Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake 显示文摘 | Zhang J V Ren P G Avsian-Kretehmer O 2005 | 2005 | Science2005，310，： | 1 |
| 7 | Photocatalytic removal and recov- ery of mercury from water using TiO2-modified sewage sludge carbon显示文摘 | Zhang F Nriagu J O Itoh H | 2004 | Journal of Photochemistry and Photobiology A: Chemistry2004，167，2： | 1 |
| 8 | Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer 显示文摘 | Zhang J Kamdar O Le W | 2009 | Am J Respir Cell Mol Biol2009，40，： | 1 |
| 9 | Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes 显示文摘 | Riechmann J L Heard J Martin G Reuber L Jiang C Keddie J Adam L Pineda O Ratcliffe O J Samaha R R Creelman R Pilgrim M Broun P Zhang J Z Ghandehari D Sherman B K Yu G | 2000 | Science2000，290，： | 1 |
| 10 | Detection of antibody to LAV/ HTLV-Ⅲ in sera from hemophiliacs in China显示文摘 | Zeng Y Fan J Zhang O | 1986 | AIDS Res1986，2，1： | 1 |
| 11 | Membrane-bound SIV envelope trimers are immunogenic in ferrets after in- tranasal vaccination with a replication-competent canine dis- temper virus vector显示文摘 | Zhang X S Wallace O Wright K J | 2013 | Virology2013，446，12： | 1 |
| 12 | Obestatin, a peptide encoded by the ghrelin gene,opposes ghrelin's effects on food intake显示文摘 | Zhang J V Ren P G Avsian-Kretchmer O | 2005 | Science2005，310，5750： | 1 |
| 13 | Tin whisker growth: Substrate effect understanding CTE mismatch and IMC formation显示文摘 | ZHANG Y FAN C XU C KHASELEY O ABYS J | 2004 | CircuiTree2004，17，6： | 1 |
| 14 | Research and development into laying wire ropes using FE analysis显示文摘 | Sun J F Wang G L Zhang H O | 2003 | Wire Industry2003，70，7： | 1 |
| 15 | Lanthanum complexes of spheroidal carbon shells显示文摘 | Heath J R O' Brien S C Zhang Q Liu Y Curl R F Kroto H W Tittel F K Smalley R E | 1985 | J Am Chem Soc1985，107，： | 1 |
| 16 | Compound- specific chlorine isotope ratios of TCE,PCE and DCE isomers by direct injection using CF-IRMS 显示文摘 | Shouakar-Stash O Drimmie R J Zhang M | 2006 | Applied Geochemistry2006，21，5： | 1 |
| 17 | Synthesis and characterization of monodisperse ultra-thin silica-coated magnetic nanoparticles显示文摘 | Ming Zhang Brian L Cushing Charles J O'Connor | 2008 | Nanotechnology2008，19，： | 1 |
| 18 | Multi-operator image retar- geting with automatic integration of direct and indirect seam carving 显示文摘 | Luo S Q Zhang J P Zhang O | 2012 | Image and Vision Computing2012，30，9： | 1 |
| 19 | Recent advances in the echocardiographic diagnosis of mitral valve prolapse显示文摘 | CHENG T O WANG X F ZHANG J | 2010 | Int J Cardiol2010，140，： | 1 |
| 20 | IL-10 promotes resistance to apoptosis and metastatic potential in lung tumor ceil lines显示文摘 | Zeng L O'Connor C Zhang J | 2010 | Cytokine2010，49，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员