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| 1 | Research on Formation Mechanisms of Hot Dry Rock Resources in China显示文摘As an important geothermal resource, hot dry rock(HDR) reserves have been studied in many countries. HDR resources in China have huge capacity and have become one of the most important resources for the potential replacement of fossil fuels. However, HDR resources are difficult to develop and utilise. Technologies for use with HDR, such as high–temperature drilling, reservoir characterisation, reservoir fracturing, microseismic monitoring and high–temperature power stations, originate from the field of oil and drilling. Addressing how to take advantage of these developed technologies is a key factor in the development of HDR reserves. Based on the thermal crustal structure in China, HDR resources can be divided into four types: high radioactive heat production, sedimentary basin, modern volcano and the inner–plate active tectonic belt. The prospective regions of HDR resources are located in South Tibet, West Yunnan, the southeast coast of China, Bohai Rim, Songliao Basin and Guanzhong Basin. The related essential technologies are relatively mature, and the prospect of HDR power generation is promising. Therefore, analysing the formation mechanisms of HDR resources and promoting the transformation of technological achievements, large–scale development and the utilisation of HDR resources can be achieved in China. | WANG Guiling LIN Wenjing ZHANG Wei LU Chuan MA Feng GAN Haonan | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 14 |
| 2 | Clinical study of paclitaxel plus cisplatin in the treatment of recurrent cervical cancer显示文摘Objective: To observe the efficacy and toxicities of paclitaxel plus cisplatin in the treatment of recurrent cervical cancer. Methods: Twenty-three patients with a diagnosis of recurrent cervical cancer were eligible. Three-weekly chemo- therapy regimen consisted of paclitaxel 135–150 mg/m2 infusion for 3 h on day 1, cisplatin 25 mg/m2 infusion on day 1 to 3. All patients received at least two cycles treatment. Results: The response rates was 47.8%, including CR 2 cases (8.7%), PR 9 cases (39.1%). The major toxicity included neutropenia, nausea vomiting, arthralgia, myalgia and alopecia. Conclusion: Paclitaxel combined with cisplatin is an effective therapy with acceptable adverse reactions for recurrent cervical cancer. | Yingqiu Song Guiling Li Fang Zhu Fangzheng Zhou Sheng Zhang Jing Wang Zhongyuan Ying | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 9 |
| 3 | Isolation of Tyl-copia-like Retrotransposon Sequences from the Apple Genome by Chromosome Walking Based on Modified SiteFinding-polymerase Chain Reaction显示文摘长终端重复(LTR ) retrotransposons 是为学习基因生物多样性,染色体进化,基因变化,克隆的基因和基因表达的强大的工具。缺乏 ofretrotransposon 顺序信息限制在在场的更高的 plants.Inthe 的研究学习的这些的发展, Ty1-copia-like retrotransposons 的 31 逆[转]录酶( RT )基因被放大编码区域使用的 RT 从苹果染色体识别 degenerateprimers.Nineteen RT 基因以碎片尺寸显示出极端异质,基础对作文和开的读框架完全。从一 266 bp 发源克隆 RT 基因, 1966 bpTy1-copia-like retrotransposon (命名 Tcrm1 )包括 RT-ribonuclease H-LTR 领域序列,被染色体在基因结构和 Tcrml 是包括在揭示的 applegenome.Dot 污点分析的一个 LTR 领域的第一 Ty1-copia-like retrotransposon 的顺序相同 hows 基于在 Tcrml 和另外的 LTR retrotransposons 之间的修改SiteFinding聚合酶链 reaction.Thecomparison 走完成在苹果的那个 Tcrm1 拷贝数字每 haploid 是近似 1x10 ~ 3copies 染色体。 | Guiling ZHAO Zhihong ZHANG Haiyue SUN He LI Hongyan DAI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 8 |
| 4 | Uniformly grown PtCo-modified C03O4 nanosheets as a highly efficient catalyst for sodium borohydride electrooxidation显示文摘 | Congying Song Dongming Zhang Bin Wang Zhuang Cai Peng Yan Yang Sun Ke Ye Dianxue Cao Kui Cheng Guiling Wang | 2016 | Nano Research2016，9，11： | 5 |
| 5 | Heat Aggregation Mechanisms of Hot Dry Rocks Resources in the Gonghe Basin, Northeastern Tibetan Plateau显示文摘Hot dry rock(HDR) is an important geothermal resource and clean energy source that may play an increasingly important role in future energy management. High-temperature HDR resources were recently detected in deep regions of the Gonghe Basin on the northeastern edge of the Tibetan Plateau, which led to a significant breakthrough in HDR resource exploration in China. This research analyzes the deep temperature distribution, radiogenic heat production, heat flow, and crustal thermal structure in the Qiaboqia Valley, Guide Plain, and Zhacanggou area of the Gonghe Basin based on geothermal exploration borehole logging data, rock thermophysical properties, and regional geophysical exploration data. The results are applied to discuss the heat accumulation mechanism of the HDR resources in the Gonghe Basin. The findings suggest that a low-velocity layer in the thickened crust of the Tibetan Plateau provides the most important source of constant intracrustal heat for the formation of HDR resources in the Gonghe Basin, whereas crustal thickening redistributes the concentrated layer of radioactive elements, which compensates for the relatively low heat production of the basal granite and serves as an important supplement to the heat of the HDR resources. The negative effect is that the downward curvature of the lithospheric upper mantle caused by crustal thickening leads to a small mantle heat flow component. As a result, the heat flows in the Qiaboqia Valley and Guide Plain of the Gonghe Basin are 106.2 and 77.6 m W/m2, respectively, in which the crust-mantle heat flow ratio of the former is 3.12:1, indicating a notably anomalous intracrustal thermal structure. In contrast, the crust-mantle heat flow ratio in the Guide Plain is 1.84:1, which reflects a typical hot crust-cold mantle thermal structure. The Guide Plain and Zhacanggou area show the same increasing temperature trend with depth, which reflects that their geothermal backgrounds and deep high-temperature environments are similar. These results provide important insight on the heat source mechanism of HDR resource formation in the Tibetan Plateau and useful guidance for future HDR resource exploration projects and target sites selection in similar areas. | LIN Wenjing WANG Guiling ZHANG Shengsheng ZHAO Zhen XING Linxiao GAN Haonan TAN Xianfeng | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 5 |
| 6 | Quantifying the Preferential Flow by Dye Tracer in the North China Plain显示文摘The preferential flow plays a vital role on the infiltration of irrigation or rainfall. The objective of this study was to quantify preferential flow in the processing of irrigation infiltration in the field scale. Tests of different initial soil water contents and irrigation intensities were conducted using Brilliant Blue FCF(C.I.42090) dye tracer in Luancheng County of the North China Plain. The results showed that the percentages of infiltration by the preferential flow for irrigation depth of 25, 50, and 75 mm were 16.67%, 43.67%, and 34.17%, with 19.72%, 61.42%, 66.64% of dyed areas in the soil profile, respectively, which indicated that preferential flow was enhanced with increasing irrigation intensity, but reduced when the irrigation intensity was over 50 mm. The percentages of preferential flow for 75 and 180 mm previous irrigation producing different initial soil water contents were 23.26% and 18.97%, with 53.23% and 39.94% of dyed areas in the soil profile, respectively. Compared with the 75 mm without previous irrigation, the results indicated that higher initial soil water contents restrained the preferential flow in the field. Therefore, intermittent irrigation and low irrigation intensity patterns, and larger depth of plowing would be suggested to reduce the preferential flow which would increase the soil water utilization efficiency and reduce pollution risk of pesticide and fertilizer to groundwater. | Qinghua Wu Chunlei Liu Wenjing Lin Meng Zhang Guiling Wang Fawang Zhang | 2015 | Journal of Earth Science2015，26，3： | 4 |
| 7 | Cycling of phosphorus in the Jiaozhou Bay显示文摘Dissolved inorganic phosphorus (DIP ),dissolved organic phosphorus (DOP ),particulate inorganic phosphorus (P IP ) and particulate organic phosphorus (P OP ) in the Jiaozhou Bay (JZB) and its adjacent major rivers were analyzed during 2001–2003.DIP was the major form of dissolved phosphorus in JZB,representing 62%–83% of the total dissolved phosphorus (T DP ),and the P IP concentration generally exceeded the P OP concentration.The concentrations of phosphorus were higher in the north than in the south of the bay,which were related to the fluvial input and water exchange rate.The dissolved phosphorus concentrations were higher in the autumn and spring than in the summer,while the seasonal variation of particulate phosphorus showed opposite pattern.The distribution of phosphorus is mainly affected by the growth of phytoplankton,desorption/adsorption of DIP from and to particulates,and anthropogenic activities.A preliminary phosphorus budget was established.In JZB,riverine input and water exchange flow between JZB and the Huanghai (Yellow) Sea are the major sources of phosphorus,followed by industrial and domestic waste transport,and then atmospheric deposition.Phosphorus burial efficiency is estimated to be 91%.About 52.2 × 10 6 mol/a of phosphorus were assimilated by phytoplankton,of which about 68% was recycled in the water column and sediment. | Q1 Xiaohong LIU Sumei ZHANG Jing REN Jingling ZHANG Guiling | 2011 | Acta Oceanologica Sinica2011，30，2： | 4 |
| 8 | Genome-wide identification of agronomically important genes in outcrossing crops using OutcrossSeq显示文摘Many important crops(e.g.,tuber,root,and tree crops)are cross-pollinating.For these crops,no inbred lines are available for genetic study and breeding because they are self-incompatible,clonally propagated,or have a long generation time,making the identification of agronomically important genes difficult,particularly in crops with a complex autopolyploid genome.In this study,we developed a method,OutcrossSeq,for mapping agronomically important loci in outcrossing crops based on whole-genome low-coverage resequencing of a large genetic population,and designed three computation algorithms in OutcrossSeq for different types of outcrossing populations.We applied OutcrossSeq to a tuberous root crop(sweet potato,autopolyploid),a tree crop(walnut tree,highly heterozygous diploid),and hybrid crops(double-cross populations)to generate high-density genotype maps for the outcrossing populations,which enable precise identification of genomic loci underlying important agronomic traits.Candidate causative genes at these loci were detected based on functional clues.Taken together,our results indicate that OutcrossSeq is a robust and powerful method for identifying agronomically important genes in heterozygous species,including polyploids,in a cost-efficient way.The OutcrossSeq software and its instruction manual are available for downloading at www.xhhuanglab.cn/tool/OutcrossSeq.html. | Mengjiao Chen Weijuan Fan Feiyang Ji Hua Hua Jie Liu Mengxiao Yan Qingguo Ma Jiongjiong Fan Qin Wang Shufeng Zhang Guiling Liu Zhe Sun Changgeng Tian Fengling Zhao Jianli Zheng Qi Zhang Jiaxin Chen Jie Qiu Xin Wei Ziru Chen Peng Zhang Dong Pei Jun Yang Xuehui Huang | 2021 | Molecular Plant2021，14，4： | 4 |
| 9 | Exercise promotes angiogenesis by enhancing endothelial cell fatty acid utilization via liver-derived extracellular vesicle miR-122-5p显示文摘Background:Angiogenesis constitutes a major mechanism responsible for exercise-induced beneficial effects.Our previous study identified a cluster of differentially expressed extracellular vesicle microRNAs(miRNAs)after exercise and found that some of them act as exerkines.However,whether these extracellular vesicle miRNAs mediate the exercise-induced angiogenesis remains unknown.Methods:A 9-day treadmill training was used as an exercise model in C57BL/6 mice.Liver-specific adeno-associated virus 8 was used to knock down microRNA-122-5p(miR-122-5p).Human umbilical vein endothelial cells were used in vitro.Results:Among these differentially expressed extracellular vesicle miRNAs,miR-122-5p was identified as a potent pro-angiogenic factor that activated vascular endothelial growth factor signaling and promoted angiogenesis both in vivo and in vitro.Exercise increased circulating levels of miR-122-5p,which was produced mainly by the liver and shuttled by extracellular vesicles in mice.Inhibition of circulating miR-122-5p or liver-specific knockdown of miR-122-5p significantly abolished the exercise-induced pro-angiogenic effect in skeletal muscles,and exerciseimproved muscle performance in mice.Mechanistically,miR-122-5p promoted angiogenesis through shifting substrate preference to fatty acids in endothelial cells,and miR-122-5p upregulated endothelial cell fatty-acid utilization by targeting 1-acyl-sn-glycerol-3-phosphate acyltransferase(AGPAT1).In addition,miR-122-5p increased capillary density in perilesional skin tissues and accelerated wound healing in mice.Conclusion:These findings demonstrated that exercise promotes angiogenesis through upregulation of liver-derived extracellular vesicle miR-122-5p,which enhances fatty acid utilization by targeting AGPAT1 in endothelial cells,highlighting the therapeutic potential of miR-122-5p in tissue repair. | Jing Lou Jie Wu Mengya Feng Xue Dang Guiling Wu Hongyan Yang Yan Wang Jia Li Yong Zhao Changhong Shi Jiankang Liu Lin Zhao Xing Zhang Feng Gao | 2022 | Journal of Sport and Health Science2022，11，4： | 4 |
| 10 | Sources and distributions of terrigenous organic matter in a mangrove fringed small tropical estuary in South China显示文摘The sources and distributions of terrigenous organic matter (OM) were investigated in a small tropical estuary in the Hainan Island, South China. Plants, suspended particulate matter (SPM), and surface sediments samples in the estuary and coast were collected. Bulk properties [organic carbon (OC%), total nitrogen (TN%), stable carbon isotope (δ13C) and grain size] and lignin phenol concentrations were measured. OC% of mangrove plants was (43.4 ± 2.1)%, which is similar to the values reported for mangrove plants in other regions. OC% of sediment samples ranged from 0.07% to 1.42%, and they were related to the sediment texture. Lignin phenols in the sediment ranged from 5.16 mg/100 mg OC in the uppermost station to 0.51mg/100mg OC in the coast. The molar ratio of organic carbon to total nitrogen (C/N) (~7) and δ 13 C (~-31.1×10-3 ) of riverine SPM revealed that the major OM sources of riverine SPM were aquatic OM (phytoplankton and/or bacteria). Moreover, the lower lignin concentration (Λ8) and higher (Ad/Al)v of lignin phenols suggest that terrestrial OM in riverine SPM were mainly from soil. Furthermore, C/N ratio, δ13C and lignin phenols reveal that mangrove plants were the predominant OM sources of mangrove surface sediment. Based on the δ13C and lignin phenols, it can be concluded that the major OM sources in estuarine and coastal surface sediments were marine phytoplankton, riverine SPM and mangrove surface sediment. In addition, the higher (Ad/Al)v of lignin phenols in those coastal sediments indicate that seagrass might be a potential OM source in coastal sediments, however, the lower (Ad/Al)v in the estuarine sediments in turn suggests that seagrass could not be transported to the mangrove fringed region. A three-end-member model which is based on lignin concentrations and δ13C was applied to evaluate the contribution of mangroves to the organic matter preserved in the surface sediments. Around the mangrove fringed region, mangrove could contribute more than 50% to the sedimentary OM, and this value is much higher than riverine OM. Nevertheless, mangrove OM could not be efficiently transported to the coastal region. Our study suggests that mangrove forest is an important OM source in this small estuary. | BAO Hongyan WU Ying TIAN Lixin ZHANG Jing ZHANG Guiling | 2013 | Acta Oceanologica Sinica2013，32，4： | 3 |
| 11 | The epigenetic landscape of exercise in cardiac health and disease显示文摘With the rising incidence of cardiovascular diseases,the concomitant mortality and morbidity impose huge burdens on quality of life and societal costs.It is generally accepted that physical inactivity is one of the major risk factors for cardiac disease and that exercise benefits the heart in both physiological and pathologic conditions.However,the molecular mechanisms governing the cardioprotective effects exerted by exercise remain incompletely understood.Most recently,an increasing number of studies indicate the involvement of epigenetic modifications in the promotion of cardiac health and prevention of cardiac disease.Exercise and other lifestyle factors extensively induce epigenetic modifications,including DNA/RNA methylation,histone post-translational modifications,and non-coding RNAs in multiple tissues,which may contribute to their positive effects in human health and diseases.In addition,several studies have shown that maternal or paternal exercise prevents age-associated or high-fat dietinduced metabolic dysfunction in the offspring,reinforcing the importance of epigenetics in mediating the beneficial effects of exercise.It has been shown that exercise can directly modify cardiac epigenetics to promote cardiac health and protect the heart against various pathological processes,or it can modify epigenetics in other tissues,which reduces the risk of cardiac disease and affords cardioprotection through exerkines.An in-depth understanding of the epigenetic landscape of cardioprotective response to exercise will provide new therapeutic targets for cardiac diseases.This review,therefore,aimed to acquaint the cardiac community with the rapidly advancing and evolving field of exercise and epigenetics. | Guiling Wu Xing Zhang Feng Gao | 2021 | Journal of Sport and Health Science2021，10，6： | 3 |
| 12 | Hydrothermal Systems Characterized by Crustal Thermally-dominated Structures of Southeastern China显示文摘Southeastern China(SE China)is located in the Pacific tectonic domain and has experienced a series of tectono-magmatic events induced by the subduction of the Paleo-Pacific Plate since the late Mesozoic.The subduction formed a series of NE-NNE oriented faults under a NW-SE regional stress field,along which a number of thermal springs occur.Previous studies have focused on the genesis mechanism of specific geothermal fields in SE China,but the general characteristics of hydrothermal systems in SE China remains unclear.In this study,we investigate the correlation between geothermal activity,hydrochemical type and regional faults by studying the distribution of hydrothermal activity and geochemical properties of typical hydrothermal systems in SE China.The hydrothermal systems in SE China have a crustal thermally-dominated structural origin unique to the specific geological and tectonic conditions of the Eurasian Plate margin.The upwelling of the asthenosphere and the widespread granitoids with high radiogenic heat production in SE China provide major heat sources for regional geothermal anomalies.The NE-oriented crustal thermally-dominated faults are critical for the formation of geothermal anomalies and NW-oriented extensional faults have created favorable conditions for meteoric water infiltration,transportation and the formation of thermal springs. | WANG Guiling GAN Haonan LIN Wenjing YUE Gaofan YAN Xiaoxue LI Tingxin ZHANG Wei MA Feng | 2023 | Acta Geologica Sinica(English Edition)2023，97，4： | 2 |
| 13 | Genesis of Geothermal Fluid in Typical Geothermal Fields in Western Sichuan,China显示文摘The hydrogeochemical characteristics of geothermal fluids can reveal the genesis of geothermal systems and act as important references for developing and using geothermal resources.This study presents hydrogeochemical processes and thermal cycle mechanisms of typical geothermal fields in Western Sichuan.Based on the geological conditions in Western Sichuan,29 hot springs in three geothermal fields in the Batang and Litang areas were selected for hydrochemical and isotopic(δD andδ18O)analyses.Furthermore,the temperature of the thermal reservoir was calculated and the upflow cooling process of the hot springs was analyzed.Most of the subterranean hot waters in Batang and Litang are of the HCO3-Na hydrochemical type.The ion variation in Batang is primarily affected by water-rock interactions.There is a strong positive correlation between Na+,B?,and Cl?in Litang,suggesting that they have the same material source.The Na+and metaboric acid content is relatively high,which indicates that the groundwater runoff in both areas is relatively long-lasting,with reduced flow velocity;moreover,the metasilicic acid content is relatively high,which supports this conclusion.Both hydrogen and oxygen isotopes plot near the atmospheric precipitation line,indicating that groundwater recharge is functionally obtained from precipitation.The calculated thermal storage temperatures in Batang and Litang were 88–199℃ and 96–154℃,respectively.The proportion of cold water mixing in Batang was 64%–67%,while that in Litang was 60%–68%.According to the calculated results,the initial thermal cycle depth of the Batang area(4540–4780 m)was greater than that of the Litang area(3150–3960 m).The enthalpy of the deep parental geothermal fluid in Batang was 1550 J/g with a Cl^(-)concentration of 37 mg/L,while that in Litang was 2100 J/g with a Cl^(-)concentration of 48 mg/L. | ZHAO Jiayi WANG Guiling ZHANG Cuiyun XING Linxiao LI Man ZHANG Wei | 2021 | Acta Geologica Sinica(English Edition)2021，95，3： | 2 |
| 14 | MXene-Derived Defect-Rich TiO2@rGO as High-Rate Anodes for Full Na Ion Batteries and Capacitors显示文摘Sodium ion batteries and capacitors have demonstrated their potential applications for next-generation low-cost energy storage devices.These devices’s rate ability is determined by the fast sodium ion storage behavior in electrode materials.Herein,a defective TiO2@reduced graphene oxide(M-TiO2@rGO)self-supporting foam electrode is constructed via a facile MXene decomposition and graphene oxide self-assembling process.The employment of the MXene parent phase exhibits distinctive advantages,enabling defect engineering,nanoengineering,and fluorine-doped metal oxides.As a result,the M-TiO2@rGO electrode shows a pseudocapacitance-dominated hybrid sodium storage mechanism.The pseudocapacitance-dominated process leads to high capacity,remarkable rate ability,and superior cycling performance.Significantly,an M-TiO2@rGO//Na3 V2(PO4)3 sodium full cell and an M-TiO2@rGO//HPAC sodium ion capacitor are fabricated to demonstrate the promising application of M-TiO2@rGO.The sodium ion battery presents a capacity of 177.1 mAh g-1 at 500 mA g-1 and capacity retention of 74%after 200 cycles.The sodium ion capacitor delivers a maximum energy density of 101.2 Wh kg-1 and a maximum power density of 10,103.7 W kg-1.At 1.0 A g-1,it displays an energy retention of 84.7%after 10,000 cycles. | Yongzheng Fang Yingying Zhang Chenxu Miao Kai Zhu Yong Chen Fei Du Jinling Yin Ke Ye Kui Cheng Jun Yan Guiling Wang Dianxue Cao | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 15 | Oncogenic MORC2 in cancer development and beyond显示文摘Microrchidia CW-type zinc finger 2(MORC2)is a member of the MORC superfamily of nuclear proteins.Growing evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor suppressors.The present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target genes.This systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future. | Shan Zhang Ayao Guo Huan Wang Jia Liu Chenshuang Dong Junyi Ren Guiling Wang | 2024 | Genes & Diseases2024，11，2： | 1 |
| 16 | Synthesis and optical properites of high-purity CoO nanowires prepared by an environmentally friendly molten salt route显示文摘 | Wang Wenzhong Zhang Guiling | 2009 | Jour nal of Crystal Growth2009，311，： | 1 |
| 17 | Isolation and characterization of genomic retrotransposon sequences from octoploid strawberry (Fragaria?×?ananassa Duch.)显示文摘 | Yue Ma Haiyue Sun Guiling Zhao Hongyan Dai Xiuyan Gao He Li Zhihong Zhang | 2008 | Plant Cell Reports2008，，3： | 1 |
| 18 | Identification of Genes Involved in Immune Response, Microsatellite, and SNP Markers from Expressed Sequence Tags Generated from Hemocytes of Freshwater Pearl Mussel (Hyriopsis cumingii)显示文摘 | Zhiyi Bai Yuxin Yin Songnian Hu Guiling Wang Xiaowei Zhang Jiale Li | 2009 | Marine Biotechnology2009，，4： | 1 |
| 19 | 查看详情显示文摘 | Yu Zijia Zhang Xianfa Yang Guiling | | 0，，24： | 1 |
| 20 | Distributions and sea-to-air fluxes of methane and nitrous oxide in the North East China Sea in summer显示文摘 | Guiling Zhang Jing Zhang Jingling Ren Jianbing Li Sumei Liu | 2008 | Marine Chemistry2008，，1： | 1 |
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