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| 1 | Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages显示文摘 | Xianfa Yang Boqiang Hu Yu Hou Yunbo Qiao Ran Wang Yingying Chen Yun Qian Su Feng Jun Chen Chang Liu Guangdun Peng Fuchou Tang Naihe Jing | 2018 | Cell Research2018，28，5： | 5 |
| 2 | Phase-response synchronization in neuronal population显示文摘In this study,we have formulated the phase description of the neuronal oscillator with non-instantaneous synaptic inputs and external periodic stimulus by using the phase sensitivity function.By numerical simulation,we have found that the phase of a neuronal oscillator undergoes periodic evolution or locked state,which is determined by the synaptic time constant.The synaptic time constant is also an important condition under which the global network is synchronized.When the synaptic time constant is relatively small,perfectly synchronized behavior quickly occurs in the neuronal population.As the synaptic time constant becomes slightly larger,periodic synchronization emerges in the neuronal population.However,synchronized activity in the neuronal population is lost for larger synaptic time constant.The external periodic stimulus can change the synchronization patterns in the neuronal population.With a weak low-frequency stimulus,the neuronal populations quick synchronized bursting;whereas a high-frequency stimulus can produce synchronized overlapping bursting.We have also found that neuronal oscillators with type-II phase response curves are more susceptible to synchronization than those with type-I phase response curves. | JIAO XianFa ZHU DanFeng | 2014 | Science China(Technological Sciences)2014，57，5： | 5 |
| 3 | Optimized design and performance evaluation of an electric cup-chain potato metering device显示文摘The cup-chain metering device is commonly used in potato planters despite its problems of missing-seeding,double-seeding and ground wheel sliding.A mechanical-electrical design was developed for planters to resolve these problems.A regression experiment was conducted with three factors(chain speed,chain tightening distance and cup tilting)and two indicators(missing-seeding rate and double-seeding rate).Based on the results of regression experiment,a numerical regression model was built and a multi-objective optimization method was used to get an optimal solution.Subsequently,the optimized device was tested in the field.The device design presents a tilting seed cup with a guard plate and an electric control system.The laboratory test showed that the missing-seeding rate increased with the chain speed.It initially decreases and then increases with the chain tightening distance and cup tilting angle.The double-seeding rate declines with chain speed.It increases initially and declines afterward with the chain tightening distance.The optimization resulted in a missing-seeding rate of 4.39%and a double-seeding rate of 8.78%under the parameters of 0.32 m/s seeding speed,0.94×10-3 m tightening distance,and 12.5°cup tilting angle.The field test demonstrated that electric control instead of ground wheel-driven chain enables fast seeding and precise intra-row seeding distance. | Niu Kang Fang Xianfa Liu Yangchun Lü Chengxu Yuan Yanwei | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 5 |
| 4 | Mitochondrial replacement in macaque monkey offspring by first polar body transfer显示文摘Dear Editor,Mitochondrial DNA(mtDNA)mutations are materally inherited to the offspring and mitochondrial replacement therapy(MRT)provides.a promising approach for preventing mtDNA-related 1,2 diseases.First polar body transfer(PB1T)has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.However,generation of primate offspring using PB1T has not been reported.Here,we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey(Macaca fascicularis),a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT. | Zhanyang Wang Yuzhuo Li Xianfa Yang Yan Wang Yanhong Nie Yuting Xu Xiaotong Zhang Yong Lu Tikui Zhang Qiming Liu Naihe Jing Zhen Liu Qiang Sun | 2021 | Cell Research2021，31，2： | 4 |
| 5 | Synthesis and Photocatalytic Activity of Ti-pillared Bentonite显示文摘支柱 Ti 的火山灰成胶状黏土成功地用那能导致 TiO_2 支柱的转变从的一个修改方法被准备了对在低温度(150 deg C ) 的锐钛矿阶段非结晶。=1.94 nm 由支柱 Ti 的火山灰成胶状黏土获得了的 d_(001 ) 的价值比相应未加工的泥土(1.56 nm ) 的大。由于形成的大量 Ti 支柱,支柱 theTi 的火山灰成胶状黏土在吸附玫瑰精 B (RB ) 显示出一个优秀能力。photocatalyticactivity 和运动方程被在紫外照耀下面分解 RB 答案调查。支柱 Ti 的火山灰成胶状黏土显示出超级相片,这被发现为 RB 答案的降级的催化活动与未经治疗的火山灰成胶状黏土和纯 TiO_2 相比,并且 RB 答案的降级的运动方程是一个 1.5 颂诗方程。 | TANG Jianwen WU Pingxiao ZHENG Shaoyan LIU Yun WANG Feifei XIE Xianfa | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 3 |
| 6 | Relative manifold based semi-supervised dimensionality reduction显示文摘 | Xianfa CAI Guihua WEN Jia WEI Zhiwen YU | 2014 | Frontiers of Computer Science2014，8，6： | 3 |
| 7 | TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs显示文摘pluripotent 干细胞(PSC ) 的临床的治疗基于移植被 teratomas 或肿瘤的经常的开发在动物模型和临床的病人妨碍了。因此,在干细胞治疗澄清 carcinogenesis 的机制为减少 tumorigenicity 的风险是很重要的。这里,我们区分 Oct4-GFP 老鼠胚胎的干细胞(mESCs ) 进神经祖先房间(NPC ) 并且发现少数 Oct4+ 房间连续地以 Oct4+ 状态被支撑。这些房间能在标准转换字符媒介被充实并且增殖。有趣地,这些充实的房间的区别潜力紧与许多更高的 tumorigenic 活动被限制,它是因此定义的同样区别抵抗的转换字符(医生转换字符) 。Transcriptomic 和 epigenomic 分析证明医生转换字符被初发的细菌描绘像房间的基因签名(Dazl, Rec8, Stra8, Blimp1,等等) 并且从 mESCs 不同的特定的 epigenetic 模式。而且,医生转换字符拥有细菌房间潜力产生 Sycp3+ haploid 房间并且能居住在 busulfan 导致的没有精子的输精管。最后,我们发现 TGF 发信号是在 TGF 发信号的医生转换字符,和抑制的 overactivated 由导致医生转换字符的完整的区别消除导出 mESC 的 NPC 的 tumorigenicity。这些数据表明那像房间的医生转换字符是的这些 TGF-hyperactivated 细菌为导出转换字符的目标房间治疗的 tumorigenicity 和在导出转换字符的 NPC 移植发信号的 TGF 的那抑制的主要贡献者能急速地减少肿瘤开发的风险。 | Xianfa Yang Ran Wang Xiongjun Wang Guoqing Cai Yun Qian Su Feng Fangzhi Tan Kun Chen Ke Tang Xingxu Huang Naihe Jing Yunbo Qiao | 2018 | Journal of Molecular Cell Biology2018，10，3： | 2 |
| 8 | 查看详情显示文摘 | Yu Zijia Zhang Xianfa Yang Guiling | | 0，，24： | 1 |
| 9 | Preparation of α-calcium sulfate hemihydrate from FGD gypsum in K, Mg-containing concentrated CaCl 2 solution under mild conditions显示文摘 | Baohong Guan Liuchun Yang Zhongbiao Wu Zhuoxian Shen Xianfa Ma Qingqing Ye | 2009 | Fuel2009，，7： | 1 |
| 10 | Crystallization routes and metastability of α-calcium sulfate hemihydrate in potassium chloride solutions under atmospheric pressure显示文摘 | Baohong Guan Xianfa Ma Zhongbiao Wu | 2009 | J Chem Eng Data2009，54，3： | 1 |
| 11 | Design and optimization of an automatic hydraulic steer-by-wire system for an agricultural chassis显示文摘To meet the requirements of fast steering at low vehicle speed and slow steering at high vehicle speed,the automatic steering of agricultural chassis must control both the wheel steering angle and the steering angle’s angular speed.This study applied hydraulic steer-by-wire technology to the automatic steering control of agricultural chassis.First,the transmission mechanism of the designed steering system was optimized.According to the rule of least squares,aiming at the minimum sum of squares of errors between 10 ideal outer wheel angles and real outer wheel angles,the optimal solution of hole spacing on both sides of the steering hydraulic cylinder piston rod was 925 mm.The outer wheel angle error of the optimized steering mechanism throughout the steering stroke was less than 0.15°.Additionally,a hydraulic steer-by-wire system was developed,and the parameters of its critical components were calculated.Then,the compound control strategy of the steering cylinder piston rod displacement and moving speed was formulated for this automatic steering system.The entire control system included a valve control signal calculation model,an initial velocity calculation model,a correction velocity calculation model,and an attenuation velocity calculation model,and the formulae of each model were deduced.Based on the optimized parameters and the developed control strategy,a simulation model was built in AMESim,and simulation results showed that the proposed control strategy could achieve simultaneous controls of piston rod displacement and speed at different vehicle speeds and loads.The horizontal and vertical displacements of the right wheel center were plotted for typical vehicle speeds and steering commands.The results of this study provided a new idea for the application of hydraulic steer-by-wire technology in the automatic steering of agricultural chassis. | Yinhao Jin Yanwei Yuan Licheng Zhu Decheng Wang Bo Zhao Xianfa Fang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，1： | 1 |
| 12 | In situ preparation of K2CO3 supported kraft lignin activated carbon as solid bal catalyst tbr biodiesel production显示文摘 | Li Xianfa Zuo Yong Zilang Ying et tzl | 2013 | Fuel2013，113，： | 1 |
| 13 | Blow-up analysis for a nonlinear diffusion equation with nonlinear boundary conditions显示文摘 | Jiang Zhaoxin Zheng Sining Song Xianfa | 2004 | Applied Mathematics Letters2004，17，： | 1 |
| 14 | Blow-up and blow up rate for a reacton-diffusion model with multiple nonlinearities显示文摘 | Song Xianfa Zheng Sining | 2003 | Nonlinear Analysis2003，54，： | 1 |
| 15 | Existence of best simultaneous approximations in L_p(S, Σ, X) without the RNP assumption显示文摘Let(S, Σ, μ) be a complete positive σ-finite measure space and let X be a Banach space. We consider the simultaneous proximinality problem in Lp(S, Σ, X) for 1 p < +∞. We establish some N-simultaneous proximinality results of Lp(S, Σ0, Y) in Lp(S, Σ, X) without the Radon-Nikody′m property(RNP) assumptions on the space span Y and its dual span Y*, where Σ0is a sub-σ-algebra of Σ and Y a nonempty locally weakly compact closed convex subset of X. In particular, we completely solve one open problem and partially solve another one in Luo et al.(2011). | LUO XianFa LI Chong | 2015 | Science China Mathematics2015，58，4： | 1 |
| 16 | Blow-up analysis for a nonlinear diffusion equation with nonlinear boundary conditions显示文摘 | Zhaoxin Jiang Sining Zheng Xianfa Song | 2004 | Applied Mathematics Letters2004，，2： | 1 |
| 17 | Stochastic Model and Neural Coding of Large-scale Neuronal Population with Variable Coupling Strength显示文摘 | Xianfa J Rubin W | 2005 | Neurocomputing2005，，： | 1 |
| 18 | Synthesis of LiFePO4/C polyacenes using iron oxyhydroxide as an iron source显示文摘 | Yang Gulling Zhang Xianfa Liu Jing | 2010 | J Power Sources2010，195，60： | 1 |
| 19 | Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development显示文摘Primary germ layers have the potential to form all tissues in the mature organism,and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements.Previous studies indicated that spatial and temporal patterns of gene expression in the gastrula predispose individual regions to distinct cell fates.However,the underlying epigenetic mechanisms remain largely unexplored.Here,we profile the spatiotemporal landscape of the epigenome and transcriptome of the mouse gastrula.We reveal the asynchronous dynamics of proximal chromatin states during germ layer formation as well as unique gastrula-specific epigenomic features of regulatory elements,which have strong usage turnover dynamics and clear germ layerspecific signatures.Importantly,we also find that enhancers around organogenetic genes,which are weakly expressed at the gastrulation stage,are frequently pre-marked by histone H3 lysine 27 acetylation(H3K27ac)in the gastrula.By using the transgenic mice and genome editing system,we demonstrate that a pre-marked enhancer,which is located in the intron of a brain-specific gene 25W009E07Rik,exhibits specific enhancer activity in the ectoderm and future brain tissue,and also executes important function during mouse neural differentiation.Taken together,our study provides the comprehensive epigenetic information for embryonic patterning during mouse gastrulation,demonstrates the importance of gastrula pre-marked enhancers in regulating the correct development of the mouse embryo,and thus broadens the current understanding of mammalian embryonic development and related diseases. | Xianfa Yang Boqiang Hu Jiaoyang Liao Yunbo Qiao Yingying Chen Yun Qian Su Feng Fang Yu Ji Dong Yu Hou He Xu Ran Wang Guangdun Peng Jinsong Li Fucnou Tang Naihe Jing | 2019 | Cell Research2019，29，11： | 1 |
| 20 | In Situ Preparation of K 2 CO 3 Supported Kraft Lignin Activated Carbon as Solid Base Catalyst for Biodiesel Production显示文摘 | Li Xianfa Zuo Yong Zhang Ying | 2013 | Fuel2013，113，： | 1 |
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