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| 1 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 2 | EFFECT OF LASER SCANNING SPEED ON PHASE CONSTITUTION AND WEAR RESISTANCE OF LASER CLADDING HARD FACING ALLOY STELLITE 12显示文摘Effect of laser scanning speed on phase constitution,microstructure,microhardness and wearresistance of laser-cladding hard facing alloy Stellite 12 has been investigated by means of across-flow-type CO2 laser of 1.5 kW.The laser-cladding layer on the alloy consists of ma-trix phase of suppersaturated solid solution γ(Co,Cr)and complex hexagonal carbideM7C3.Under certain condition,at higher laser scanning speed,the suppersaturated solubilityof elements increases in γ(Co,Cr),and the precipitation of the complex carbtde M7C3 de-creases,so the microhardness increases and the wear resistance decreases.But at slower laserscanning speed,more complex carbide M7C3 may precipitate,and the wear resistance may beimproved.Therefore,it is believed that the principal factor in improving wear resistance is theprecipitation of carbide M7C3,while increment of microhardness is the suppersaturated solu-bility of elements in matrix phase γ(Co,Cr). | XU Yourong ZHANG Henghua CHEN Darning XIE Fuchun XU Mingyu Shanghai University of Science and Technology,Shanghai,ChinaCHEN Lanying SU Baorong QIAN Hongbin Shanghai Optics and Fine Mechinery Research Institute,Academia Sinica,Shanghai,China XU Yourong,professor,Department of Materials Science and Engineering,Shanghai University of Science and Technology,Shanghai 201800,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，5： | 3 |
| 3 | Theoretical analysis of the electrical and magnetic field distributions in a toroidal eore with circular cross section 显示文摘 | Darning Zhang Chek Fok Foo | 1999 | IEEE Transactions on Magnetics1999，35，3： | 1 |
| 4 | Investigation of nitrogen doped TiO, photocatalytic films prepared by reactive magnetron sputtering 显示文摘 | CHEN Songzhe ZHANG Pengyi ZHUANG Darning | 2004 | Catal Cornmun2004，5，： | 1 |
| 5 | Effect of the substrate state on the mierostructure and tribologieal properties of sulphide layer on 1045 steel 显示文摘 | Zhang Ning Zhuang Darning Lin Jia Jun | 2000 | Applied Surface Science2000，161，12： | 1 |
| 6 | A surface functional monomer directing strategy for highly dense imprinting of TNT at surface of silica nanoparticles显示文摘 | GAO Darning ZHANG Zhongping WU Minghong | 2007 | J Am Chem Soc2007，129，25： | 1 |
| 7 | Substrate Temperature Dependence of the Properties of ZAO Thin Films Deposited by Magnetron Sputtering显示文摘 | Fu Engang Zhuang Darning Zhang Gong | 2003 | Applied Surface Science2003，217，1： | 1 |
| 8 | Feasibility of integrated seed making and directional solidification of TiA1 alloy using cold crucible显示文摘 | Zhang Chengjun Fu Hengzhi Xu Darning | 2009 | Trans Nonferrous Metals Soc China2009，19，： | 1 |
| 9 | Electrospinning of threedimensional nanofibrous tubes with controllable architectures显示文摘 | Zhang Darning Chang Jiang | 2008 | Nano Lett2008，8，10： | 1 |
| 10 | Physical mapping of ribosomal RNA genes in peonies (Paeonia, Paeoniaceae) by fluorescent in situ hybridization: implications for phylogeny and concerted evolution显示文摘 | Darning Zhang Tao Sang | 1999 | American Journal of Botany1999，86，5： | 1 |
| 11 | Airtight negative pressure dust-control technology and application of transpcrsite in the coal conveyer belt system 显示文摘 | Ma Yundong Jia Huiyan Zhang Darning | 2008 | Journal of coal science & engineering2008，，14： | 1 |
| 12 | Airtight negative pressure dust-control technology and application of transpersite in the coal conveyer belt system显示文摘 | Ma Yundong Jia Huiyan Zhang Darning | 2008 | Joumal of Coal Science & Engineering2008，，14： | 1 |
| 13 | Ecology Habits of Equus Hemionus and Gazella Subgutturosa in Kalamaili Ungulate Reserve in Autumn 显示文摘 | HU Defu ZHANG Darning LAN Chunmei | 1998 | Journal of Forestry Resereh1998，9，2： | 1 |
| 14 | Genetic studies of A2M and BACEI genes in Chinese Han Alzheimer's disease patients显示文摘 | Lei Cai Guomei Tang Lishan Chen Bosheng Zhang Sanduo Jiang Darning Ren | 2005 | 中国生物学文摘2005，19，11： | 1 |
| 15 | Nonlinear analysis of truss structures using force method and genetic algorithm显示文摘 | Sun Fangjin Y'm Zhixiang Zhang Darning | 2009 | Joumal of Liaoning Technical University Natural Science2009，28，3： | 1 |
| 16 | Remote Detection of Hydrocarbon Microseepage in a Loess Covered Area显示文摘Hydrocarbon microseepage can result in related near-surface mineral alterations.In this study,we evaluated the potential of detecting these alterations with field measured and satellite acquired hyperspectral data.Fourteen soil samples and reflectance spectra were collected in the Xifeng Oilfield,a loess covered area.Soil samples were analyzed in the laboratory for calcite,dolomite,kaolinite,illite,and mixedlayer illite/smectite content,and we processed reflectance spectra for continuum removal to derive clay and carbonate mineral absorption depth(H).High correlation between absorption depth and mineral content was shown for clay and mineral carbonate with field measured spectra.Based on the result for the field spectra,we proposed and tested a fast index based on the absorption depth of clay and carbonate minerals with a hyperspectral image of the area.The detected hydrocarbon microseepage anomalies matched well with those shown in the geological map. | Liang Zhao Darning Wang Shengbo Chen Lin Li Tianyu Zhang | 2020 | Journal of Earth Science2020，31，1： | 0 |
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