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| 1 | Clinical research linking Traditional Chinese Medicine constitution types with diseases:a literature review of 1639 observational studies显示文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship. | Liang Xue Wang Qi Jiang Zeqiang Li Zhuqing Zhang Mengxing Yang Peiying Wang Xin Wang Yanqiu Qin Yuehua Li Tianxing Zhang Tianyi Wang Yi Sun Jianxiang Li Yusi Luo Hui Li Lingru | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 29 |
| 2 | Effect of Panax notoginseng saponins on the expression of beta-amyloid protein in the cortex of the parietal lobe and hippocampus, and spatial learning and memory in a mouse model of senile dementia显示文摘BACKGROUND: The pharmacological actions of Panax notoginseng saponins (PNS) lie in removing free radicals, anti-inflammation and anti-oxygenation. It can also improve memory and behavior in rat models of Alzheimer’s disease. OBJECTIVE: Using the Morris water maze, immunohistochemistry, real-time PCR and RT-PCR, this study aimed to measure improvement in spatial learning, memory, expression of amyloid precursor protein (App) and β-amyloid (Aβ), to investigate the mechanism of action of PNS in the treatment of AD in the senescence accelerated mouse-prone 8 (SAMP8) and compare the effects with huperzine A. DESIGN, TIME AND SETTING: A completely randomized grouping design, controlled animal experiment was performed in the Center for Research & Development of New Drugs, Guangxi Traditional Chinese Medical University from July 2005 to April 2007. MATERIALS: Sixty male SAMP8 mice, aged 3 months, purchased from Tianjin Chinese Traditional Medical University of China, were divided into four groups: PNS high-dosage group, PNS low-dosage group, huperzine A group and control group. PNS was provided by Weihe Pharmaceutical Co., Ltd. (batch No.: Z53021485, Yuxi, Yunan Province, China). Huperzine A was provided by Zhenyuan Pharmaceutical Co., Ltd. (batch No.: 20040801, Zhejiang, China). METHODS: The high-dosage group and low-dosage group were treated with 93.50 and 23.38 mg/kg PNS respectively per day and the huperzine A group was treated with 0.038 6 mg/kg huperzine A per day, all by intragastric administration, for 8 consecutive weeks. The same volume of double distilled water was given to the control group. MAIN OUTCOME MEASURES: After drug administration, learning and memory abilities were assessed by place navigation and spatial probe tests. The recording indices consisted of escape latency (time-to-platform), and the percentage of swimming time spent in each quadrant. The number of Aβ1-40, Aβ1-42 and App immunopositive neurons in the brains of SAMP8 mice was analyzed by immunohistochemistry. The mRNA content of App, tau, acetylcholinesterase, and synaptophysin (Syp) was tested by real time PCR and RT-PCR. RESULTS: The PCR results show that PNS can downregulate the expression of the App gene and upregulate the expression of the Syp gene in the parietal cortex and hippocampus of SAMP8 mice. The therapeutic effects of the PNS high-dosage group were greater than those of the PNS low-dosage group and the huperzine A group (P < 0.05). The results of the Morris water maze and immunohistochemistry indicated that PNS can improve the capacity for spatial learning and memory in SAMP8 mice, and reduce the content of Aβ1-40, Aβ1-42 and expression of App in the brains of SAMP8 mice. The therapeutic effects of the PNS high-dosage group were greater than that of the PNS low-dosage group and the huperzine A group (P < 0.05). CONCLUSION: These results support the hypothesis that PNS plays a therapeutic and protective role on the pathological lesions and learning dysfunction of Alzheimer’s disease. The therapeutic effects of PNS for Alzheimer’s disease are possibly achieved through downregulating the expression of the App gene and upregulating the expression of the Syp gene. The therapeutic effects of PNS are dose-dependent and are greater than the effect of huperzine A. | Zhenguo Zhong Dengpan Wu Liang Lu Jinsheng Wang Wenyan Zhang Zeqiang Qu | 2008 | Neural Regeneration Research2008，3，12： | 9 |
| 3 | Triglycerides and ratio of triglycerides to high-density lipoprotein cholesterol are better than liver enzymes to identify insulin resistance in urban middle-aged and older non-obese Chinese without diabetes显示文摘 | Sun Yu Li Wenjuan Hou Xinguo Wang Chuan Li Chengqiao Zhang Xiuping Yang Weifang Ma Zeqiang Wang Weiqing Ning Guang Zheng Huizhen Ma Aixia Song Jun Lin Peng Liang Kai Liu Fuqiang Gong Lei Wang Meijian Xiao Juan Yan Fei Yang Junpeng Wang Lingshu Tian Meng Liu Jidong Zhao Ruxing Zhu Ping Chen Li | 2014 | Chinese Medical Journal2014，，10： | 7 |
| 4 | A capability matching and ontology reasoning method for high precision OGC web service discovery显示文摘Finding the right spatially aware web service in a heterogeneous distributed environment using criteria such as service type,version,time,space,and scale has become a challenge in the integration of geospatial information services.A new method for retrieving Open Geospatial Consortium(OGC)Web Service(OWS)that deals with this challenge using page crawling,link detection,service capability matching,and ontology reasoning,is described in this paper.Its major components are distributed OWS,the OWS search engine,the OWS ontology generator,the ontology-based OWS catalog service,and the ontology-based multi-protocol OWS client.Experimental results show that the execution time of this proposed method equals only 0.26 of that of Nutch’s method.In addition,the precision is much higher.Moreover,this proposed method can carry out complex OWS reasoning-based queries.It is being used successfully for the Antarctica multi-protocol OWS portal of the Geo-Information Web Service Portal of the Polar. | Nengcheng Chen Zeqiang Chen Chuli Hu Liping Di | 2011 | International Journal of Digital Earth2011，4，6： | 6 |
| 5 | Effects of Panax notoginseng saponins in a rat model of Alzheimer's disease显示文摘BACKGROUND: Modern pharmacological studies have demonstrated that Panax notoginseng saponins (PNS) can ameliorate and protect from neuropathological impairment. Whether PNS can improve the abnormality in memory and behavior of rats with Alzheimer's disease (AD) remains unclear. OBJECTIVE: Based on a Morris water maze test, this study aimed to measure improvements of spatial learning and memory by PNS in a rat model of AD, and to compare effects with huperzine A. DESIGN: A completely randomized grouping design, controlled animal experiment. SETTING: Center of Research & Development of New Drugs, Guangxi Traditional Chinese Medical University. MATERIALS: Ninety healthy Wistar rats of both genders, 15-month-old (n =75) and 3-month-old rats as young controls (n =15), were used for this study. The study was performed in accordance with animal ethics guidelines for the use and care of animals. PNS was provided by Weihe Pharmaceutical Co., Ltd (permission No. Z53021485, Yuxi, Yunan Province, China). Morris water maze equipment was provided by the Institute of Physiology, Chinese Academy of Science. METHODS: This study was performed at the Center of Research & Development of New Drugs, Guangxi Traditional Chinese Medical University from June 2003 to April 2005. Of the included rats, 15 healthy aged rats were randomly chosen as aged controls, and the remaining 60 aged rats were randomly divided into 4 groups with 15 rats in each: model group, PNS high- and low-dose groups, and an huperzine A group. Rats in the model group and the 3 treated groups were treated with intraperitoneal infusion of 9.6 g/L D-galactose (5 mL/kg) every day for 6 weeks successively to induce a subacute aging model. During week 7, animals received 1 μL ibotenic acid (5 g/L) bilaterally into the nucleus basalis of Meynert to create a rat model of AD. The young and old rat controls received, in parallel, a corresponding volume of saline. Two weeks later, rats in the PNS high- and low-dose groups were gavaged with 200 and 100 mg/kg PNS suspension, respectively. Huperzine A suspension (0.3 mg/kg) was used in the huperzine A group. Rats in the other 3 groups were gavaged with a corresponding volume of normal saline. In each group, administration was carried out once per day for 4 consecutive weeks. MAIN OUTCOME MEASURES: After administration, learning and memory abilities were measured by place navigation and spatial probe tests. Recording indices consisted of escape latency (time-to-platform), number of times to find the platform within 2 minutes, number of times the animal crosses the original platform location, and the percent of swimming time in each quadrant. RESULTS: Several rats died due to inflammatory reactions following brain lesion or intragastric administration; therefore, 61 rats were included in the final analysis. Results of spatial navigation test: Escape latency of rats in the model group was significantly prolonged, and number of times to find the platform within 2 minutes were significantly reduced compared with other groups (both P < 0.05). No significant differences in these two indices were measured among the administration groups (all P > 0.05). Results of spatial probe test: Times for crossing the original platform location and percent of time spent in the quadrant of original platform location were significantly less in the model group than in the other groups (P < 0.05). There were no significant differences in these two indices among the administration groups (P > 0.05). CONCLUSION: PNS can remarkably improve spatial learning and memory abilities of rats with AD. The therapeutic effect of PNS is not dose-dependent and is equivalent to the effect of huperzine A. | Zhenguo Zhong Zeqiang Qu Yunping Bao Naiping Wang Fengfen Zhang Wenyan Zhang | 2008 | Neural Regeneration Research2008，3，1： | 5 |
| 6 | Design and implementation of automatic shading device for diffuse radiation measurement显示文摘Considering the problem of too large area the shading disc covered,complex shadow band coefficients and too big diffuse radiation measurement bias,an automatic shading device for diffuse radiometer is designed and realized. Set a shading ball on the automatic sun tracker,drive linkage parallelogram structure with the declination axis arm,the shading ball can rotate synchronously with the motion of the sun and shade beam radiation measured with pyranometer,thus shading beam radiation and measuring diffuse radiation can be realized automatically. The comparison test results show that the automatic shading device can realize diffuse radiation measurement automatically,the accuracy of diffuse radiation readings can get a 18. 7% improvement compared with traditional measure system,greatly improves the reliability and accuracy of the diffuse radiation measurement. | LYU Wenhua BIAN Zeqiang CHONG Wei | 2015 | Instrumentation2015，2，3： | 4 |
| 7 | Synthesis and characterization of Li_(1.3)Al_(0.3)Ti_(1.7)(PO_4)_3-coated LiMn_2O_4 by wet chemical route显示文摘Li1.3Al0.3Ti1.7(PO4)3-coated LiMn2O4 was prepared by wet chemical route. The phase,surface morphology,and electrochemical properties of the prepared powders were characterized by X-ray diffraction,scanning electron micrograph,and galvanostatic charge-discharge experiments. Li1.3Al0.3Ti1.7(PO4)3-coated LiMn2O4 has similar X-ray diffraction patterns as LiMn2O4. The corner and border of Li1.3Al0.3Ti1.7(PO4)3-coated LiMn2O4 particles are not as clear as the uncoated one. The two powders show similar values of lithiumion diffusion coefficient. When cycled at room temperature and 55°C for 40 times at the charge-discharge rate of 0.2C,Li1.3Al0.3Ti1.7(PO4)3-coated LiMn2O4 shows the capacity retentions of 98.2% and 93.9%,respectively,which are considerably higher than the values of 85.4% and 79.1% for the uncoated one. Both the capacity retention differences between Li1.3Al0.3Ti1.7(PO4)3-coated LiMn2O4 and LiMn2O4 cycling at room temperature and 55°C become larger with the increase of charge-discharge rate. When the charge-discharge rate reaches 2C,the capacity retention of LATP-coated LiMn2O4 becomes 8.4% higher than the uncoated LiMn2O4 for room temperature cycling,and it becomes 11.1% higher than the latter when cycled at 55°C. | Wu Xianming Li Runxiu Chen Shang He Zeqiang | 2009 | Rare Metals2009，28，2： | 4 |
| 8 | Development of Solar Spectroradiometer for Meteorological Observation显示文摘A newgeneration of solar spectroradiometer has been developed by CUST/JRSI to improve solarirradiance observation data under hyperspectral resolution. It is based on the grating spectroradiometer with a back-thinned CCD linear image sensor and is operated in a hermetically sealed enclosure. The solar spectroradiometer is designed to measure the solar spectral irradiance from300 nm to 1100 nm wavelength range with the spectral resolution of 2 nm( the full width at half maximum). The optical bench is optimized to minimize stray light. The Peltier device is used to stabilize the temperature of CCD sensor to 25℃,while the change of temperature of CCD sensor is controlled to ±1℃ by the dedicated Peltier driver and control circuit. | Liu Liying Zheng Feng Zhang Guoyu Xu Yigang Yang Liyan Lyu Wenhua Bian Zeqiang Chong Wei Li Ye | 2017 | Instrumentation2017，4，1： | 3 |
| 9 | Spatio-temporal enabled urban decision-making process modeling and visualization under the cyber-physical environment显示文摘Urban management is increasingly dependent on the construction of cyber-physical systems, which have been widely deployed in multiple fields, including agriculture, transportation, and health care. Cyberphysical systems provide a large volume of big sensory data. Thus, the application of big data for urban emergency decision-making has become a challenge. Traditional decision-making models are unable to overcome several technical problems, including spatio-temporal information support and access to real-time service for disaster management and emergency response. In this paper, we propose a spatio-temporal enabled urban decision-making process modeling method in the cyber-physical environment and discuss the development off our basic metadata components, the definition of eleven-tuple information description structure. A prototype system is designed for modeling registering, management, visualization, and other functions. Decision-making processes are implemented as composite process chains through three phases, i.e., decision-making process modeling,instantiation of the decision-making process chain and execution of the decision-making process chain. For application to gas leak events, the decision-making process is executed to confirm the feasibility of the proposed decision-making process modeling method and the flexibility of the eleven-tuple information structure. | WANG Wei HU ChuanBo CHEN NengCheng XIAO ChangJiang WANG Chao CHEN ZeQiang | 2015 | Science China(Information Sciences)2015，58，10： | 3 |
| 10 | Sol-gel preparation and characterization of Li_(1.3)Al_(0.3)Ti_(1.7)(PO_4)_3 sintered with flux of LiBO_2显示文摘Li1.3Al0.3Ti1.7(PO4)3 pellets sintered with different mole fractions of LiBO2 were prepared by sol-gel method.The structural identification,surface morphology,ionic conductivity,and activation energy of the pellets were studied by X-ray diffraction,scanning electron microscopy,and electrochemical impedance spectroscopy.The results show that all the Li1.3Al0.3Ti1.7(PO4)3 pellets sintered with different mole fractions of LiBO2 have similar X-ray diffraction patterns.The sintered pellet becomes denser and the boundary and corner of the particles become illegible with the increase of LiBO2.Among the Li1.3Al0.3Ti1.7(PO3)4 pellets sintered with different mole fractions of LiBO2,the one sintered with 1 mol% LiBO2 shows the highest ionic conductivity of 3.95×10-4 S.cm-1 and the lowest activation energy of 0.2469 eV. | WU Xianming,LI Runxiu,CHEN Shang,HE Zeqiang,and MA Mingyou College of Chemistry and Chemical Engineering,Jishou University,Jishou 416000,China | 2010 | Rare Metals2010，29，5： | 3 |
| 11 | Landscape Pattern Optimization of Chengdu Based on Modern Garden City显示文摘TOptimization of regional landscape pattern is significant for improving function and value of ecosystem,and restraining the expansion of urban layout.Taking Chengdu City for example,this paper applied RS and GIS techniques,landscape indexes and ecological service function evaluation to further analyze the temporal and spatial characteristics of landscape pattern and spatial differences of regional ecological functions,and on this basis,identified the spatial distribution of ecological source lands.Based on the long-term objective of building Chengdu into a modem garden city,this paper applied the accumulative cost distance model and introduced garden city theory to construct regional ecological corridors and ecological nodes,and explored the approaches of optimizing landscape pattern of modem garden city.The results showed that a great deal of arable land has been transferred to construction land in the urbanization;intensity of regional ecological functions showed obvious spatial differences;ecological source lands were mainly distributed in the Longmen Mountain,the Qionglai Mountain,the Changqiu Mountain and the Longquan Mountain;according to actual conditions of the study area,the road ecological corridors,river corridors and agricultural corridors in the layout of 'four rings and six radial corridors' were constructed;ecological nodes dominated by intersection,wetland and forest park were formed.This research method and results are significant references for building Chengdu into a modem garden | LIUXu LI Yonghong WANG Kaijun FU Zeqiang | 2016 | Journal of Landscape Research2016，8，4： | 2 |
| 12 | LiMn_2O_4 thin films derived by rapid thermal annealing and their performance as cathode materials for Li ion battery显示文摘The LiMn2O4 thin film as a cathode material was prepared through solution deposition followed by rapid thermal annealing (RTA). The phase identification and the study of surface morphology were carried out by X-ray diffraction and scanning electron microscopy. Electrochemical properties were examined by cyclic voltammetry, galvanostatic charge-discharge experiments, and electrochemical impedance spectroscopy. The results show that the film prepared by this method is homogeneous, dense, and crack-free. The thin film has a capacity of 38 μAh/(cm2?μm) with the capacity loss of 0.037% per cycle after being cycled for 100 times. The average diffusion coefficient for lithium ions in the RTA-derived LiMn2O4 thin film is 1 × 10?10 cm2?s?1. | WU Xianming HE Zeqiang MA Mingyou XIAO Zhuobing XU Mingfei | 2006 | Rare Metals2006，25，6： | 2 |
| 13 | Use of Service Middleware Based on ECHO with CSW for Discovery and Registry of MODIS Data显示文摘现在, NASA 正在生产几 terabytes 中等分辨率成像分光辐射函数(MODIS ) 数据每天;怎么与标准发现数据,例如用一个国际标准的特定的时间,地点,和规模变得越来越重要。在这份报纸,为有户外 Geospatial 协会(OGC ) 目录服务鈥擶e b 侧面(CSW ) 的集成地球观察系统票据交换所(回响) 的使用的面向服务的体系结构被提出。建筑学由三个角色组成:一个服务请求者(用户) ,一个服务供应商(回响元数据服务器) ,和一个服务经纪人(GeoNetwork CSW 和 MODIS 注册表服务中间件) 。核心部件 -- MODIS 登记服务中间件包括三个部件:元数据 fetcher,元数据变压器,和元数据收款机。元数据 fetcher 被用来从回响元数据服务者取元数据;元数据变压器为从一种形式的变换元数据负责到另外一个;元数据收款机负责登记基于 ISO19139 的元数据到 CSW。一个原型系统被使用服务中间件技术和一个标准接口和协议设计并且实现。可行性和登记的反应时间和 MODIS 数据的检索借助于现实主义的 LPDAAC_ECS 被评估 MODIS 数据中心。这个原型系统和体系结构和方法可行、有效的实验表演的实现。 | CHEN Zeqiang CHEN Nengcheng | 2010 | Geo-Spatial Information Science2010，13，3： | 2 |
| 14 | Increased cycling stability of AlPO4-coated LiMn2O4 for lithium ion batteries显示文摘 | LIU Dongqiang HE Zeqiang | 2007 | Materials Letters2007，61，25： | 1 |
| 15 | Characterization and electrochemical properties of LiMn2O4 thin films prepared by solution deposition显示文摘 | Wu Xianming Ph D He Zeqiang Xu Mingfei Li Xinhai Xiao Zhuobing | 2006 | Journal of Wuhan University of Technology - Mater Sci Ed2006，，3： | 1 |
| 16 | Synthesis and elec- trochemical properties of SnO2-CuO nanocomtposite powders 显示文摘 | Ma Mingyou He Zeqiang Xiao Zhuobing | 2006 | Trans Nonferrous Met S China2006，16，： | 1 |
| 17 | Analysis of interactions between genetic variants of BMP4 and environmental factors with nonsyndromic cleft lip with or without cleft palate susceptibility显示文摘 | Jianyan L Zeqiang G Yongjuan C | 2010 | Int J Oral Maxillofac Surg2010，39，1： | 1 |
| 18 | A flexible data and sensor planning service for virtual sensors based on web service 显示文摘 | Chen Zeqiang Chen Nengcheng Di Liping | 2011 | IEEE Sensors Journal2011，11，6： | 1 |
| 19 | Detailed sedimentary structure of the Mianning segment of the Anninghe fault zone revealed by H/V spectral ratio显示文摘The Anninghe fault is a major left-lateral strike-slip fault in southwest China and a seismic gap with a potential earthquake larger than MW 7.0 lies in the Mianning-Xichang segment according to recent observations.The shallow structure of this region can offer a glimpse into the geometry of the fault,which plays an important role in earthquake hazard mitigation.To further investigate the sedimentary structure of the Anninghe fault zone,two dense linear arrays with a station spacing of around 80 m were deployed across the fault.In this study,the H/V spectral ratio(HVSR),together with its peak frequency at each station site,was obtained by applying the Nakamura method.Our findings demonstrate that the peak frequency behaves in high correlation with lithology and is controlled by topography.HVSR in foothills or regions with magmatic intrusion shows a single peak at about 2–3 Hz.In locations with abundant Quaternary sedimentation,such as Anninghe valleys and fracture zones,another low-frequency peak around 0.4 Hz can be noticed in HVSR.By using the empirical relationship,the thickness of the sedimentary layer around the fault fracture zone is estimated to be 300–600 m.Furthermore,the sedimentary interface shows a downward dip to the east,possibly influenced by the east-west extrusion stress.Considering the resonance effect,buildings with 6–9 stories in the valley area of the Anninghe require additional attention in earthquake hazard prevention. | Zeqiang Chen Huajian Yao Xihui Shao Song Luo Hongfeng Yang | 2023 | Earthquake Research Advances2023，3，3： | 1 |
| 20 | Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides 显示文摘 | HUANG Min XIE Shengxue MA Zeqiang | 2006 | Biochem Biophys Res Commun2006，339，2： | 1 |
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