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| 1 | Effect of Jinhua Qinggan granules on novel coronavirus pneumonia in patients显示文摘OBJECTIVE: To evaluate the effectiveness and safety of Jinhua Qinggan granules in the treatment of patients with novel coronavirus pneumonia(COVID-19).METHODS: Eighty cases of COVID-19 diagnosed from January 24 to February 17, 2020 in Beijing YouAn Hospital Affiliated to Capital Medical University were retrospectively analyzed. All 80 patients received symptomatic and supportive treatment.Among them, 44 patients took Jinhua Qinggan granules(treatment group) within 24 h of admission, and the remaining 36 patients either did not take Jinhua Qinggan granules or took the granules for less than 2 d(control group). In this study, we compared the duration of viral nucleic acid detection and of pneumonia absorption improvement between the two groups.RESULTS: Among the 80 cases, 37 were male(46%)and 43 were female(54%) with age ranging from15 to 86 years, with an average age of 51.19 years.The average duration of viral nucleic acid detection was(7 ± 4) d in the Jinhua Qinggan administration group and(10 ± 4) d for the control group(P =0.010), following which, nucleic acid tests were negative. Of the two groups, 56.82% in the Jinhua Qinggan treatment group and 27.78% in the control group demonstrated negative nucleic acid tests within 7 d or less. The 7-day viral clearance rate was significantly higher in the Jinhua Qinggan group compared with the control group(P = 0.009). Furthermore, the pneumonia recovery time indicated by chest CT was(8 ± 4) d in the Jinhua Qinggan group, which was significantly shorter than the control group, at(10 ± 5) d(P = 0.021). No adverse reactions were found in the treatment group after taking this medicine.CONCLUSION: In patients with COVID-19, Jinhua Qinggan granules can effectively shorten the duration of nucleic acid detection and promote the absorption of pneumonia inflammatory exudate without obvious adverse reactions. | Liu Zengli Li Xiuhui Gou Chunyan Li Li Luo Xiaolan Zhang Chun Zhang Yin Zhang Jiaying Jin Aihua Li Hongyan Zeng Yuan Li Tongzeng Wang Xiaojun | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 11 |
| 2 | STAT1 Antisense Oligonucleotides Attenuate the Proinflammatory Cytokine Release of Alveolar Macrophages in Bleomycin-Induced Fibrosis显示文摘To investigate the effect of signal transducers and activators of transcription 1 (STAT1) antisense oligonucleotides (ASON) on concentrations of TNF-α, IL-8, NO secreted by alveolar macrophages (AMs) in bleomycin-induced rat pulmonary fibrosis, five adult female Wistar rats were intratracheally instilled with bleomycin. After 7 days, the rats were killed by right ventricle of heart exsanguinations under ketamine anaesthesia and bronchoalveolar lavage (BAL) was performed to obtain AMs. AMs were divided into four groups, treated with STAT1 ASON, STAT1 sense oligonucleotides (SON), dexamethasone (DEX) and medium alone (control), respectively. AMs and media were collected after culture for 36 h. The mRNA and protein expressions of STAT1 and ICAM-1 in AMs were detected by RT-PCR and ELISA, respectively. The concentrations of TNF-α, IL-8, NO in cultured medium were detected.The STAT1 mRNA expression by AMs in the STAT1 ASON group was lower than those of AMs in the STAT1 SON group, the DEX group and the control group (p < 0.05). Moreover, the STAT1 mRNA expression by AMs in the DEX group was also lower than those of AMs in the STAT1 SON group and the control group (p < 0.05), but the STAT1 mRNA expression by AMs in the STAT1 SON group was not different from that of the control group (p >0.05). The protein expressions of STAT1 and ICAM-1 and the mRNA expression of ICAM-1 showed similar changes to the STAT1 mRNA expression by AMs. The concentrations of TNF-α, IL-8, NO in cultured medium from STAT1 ASON group were lower than those from STAT1 SON, DEX and the control groups (p < 0.05). Moreover,the concentrations of TNF-α, IL-8, NO in cultured medium from DEX group were also lower than those from the control and STAT1 SON group (p < 0.05), but no difference between STAT1 SON group and the control (p > 0.05).The results suggest that STAT1 ASON could inhibit the secretion of TNF-α, IL-8, NO in AMs, and STAT1 could become a target of treating pulmonary fibrosis. | Xianming Fan~(1,3) Zengli Wang~2 ~1Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China ~2Department of Respiratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China ~3Corresponding to:Dr.Xianming Fan,Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 8 |
| 3 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 4 | Evaluation of multi-cycle performance of chemical looping dry reforming using CO_2 as an oxidant with Fe–Ni bimetallic oxides显示文摘Chemical looping dry reforming(CLDR) is an innovative technology for CO_2 utilization using the chemical looping principle.The CLDR process consists of three stages,i.e.CH4 reduction,CO_2 reforming,and air oxidation.Spinel nickel ferrite(NiFe_2O_4) was prepared and its multi-cycle performance as an oxygen carrier for CLDR was experimentally investigated.X-ray diffraction(XRD) and Laser Raman spectroscopy showed that a pure spinel crystalline phase(NiFe_2O_4) was obtained by a parallel flow co-precipitating method.NiFe_2O_4was reduced into Fe-Ni alloy and wustite(Fe_xO) during the CH_4 reduction process.Subsequent oxidation of the reduced oxygen carrier was performed with CO_2 as an oxidant to form an intermediate state:a mixture of spinel Ni_(1-x)Fe_(2+x)O_4,Fe_(2+y)O_4 and metallic Ni.And CO was generated in parallel during this stage.Approximate 185 mL of CO was generated for 1 g spinel NiFe_2O_4 in a single cycle.The intermediate oxygen carrier was fully oxidized in the air oxidation stage to form a mixture of Ni_(1+x)Fe_(2-x)O_4 and Fe_2O_3.Although the original state of oxygen carrier(NiFe_2O_4) was not fully regenerated and agglomeration was observed,a good recyclability was shown in 10 successive redox cycles. | Zhen Huang Huanqi Jiang Fang He Dezhen Chen Guoqiang Wei Kun Zhao Anqing Zheng Yipeng Feng Zengli Zhao Haibin Li | 2016 | Journal of Energy Chemistry2016，25，1： | 4 |
| 5 | Different oxidation routes for lattice oxygen recovery of double-perovskite type oxides LaSrFeCoO6 as oxygen carriers for chemical looping steam methane reforming显示文摘Double-perovskite type oxide LaSrFeCoO_6(LSFCO) was used as oxygen carrier for chemical looping steam methane reforming(CL-SMR) due to its unique structure and reactivity. Two different oxidation routes,steam-oxidation and steam-air-stepwise-oxidation, were applied to investigate the recovery behaviors of the lattice oxygen in the oxygen carrier. The characterizations of the oxide were determined by X-ray diffraction(XRD), X-ray photoelectron spectroscopy(XPS), hydrogen temperature-programmed reduction(H_2-TPR) and scanning electron microscopy(SEM). The fresh sample LSFCO exhibits a monocrystalline perovskite structure with cubic symmetry and high crystallinity, except for a little impurity phase due to the antisite defect of Fe/Co disorder. The deconvolution distribution of XPS patterns indicated that Co,and Fe are predominantly in an oxidized state(Fe^(3+) and Fe^(2+)) and(Co^(2+) and Co^(3+)), while O 1s exists at three species of lattice oxygen, chemisorbed oxygen and physical adsorbed oxygen. The double perovskite structure and chemical composition recover to the original state after the steam and air oxidation, while the Co ion cannot incorporate into the double perovskite structure and thus form the CoO just via individual steam oxidation. In comparison to the two different oxidation routes, the sample obtained by steam-oxidation exhibits even higher CH_4 conversion, CO and H_2 selectivity and stronger hydrogen generation capacity. | Kun Zhao Yang Shen Zhen Huang Fang He Guoqiang Wei Anqing Zheng Haibin Li Zengli Zhao | 2017 | Journal of Energy Chemistry2017，26，3： | 3 |
| 6 | PreparationofV2O5-WO3/TiO2-SiO2catalystforselectivecatalyticreductionofNObyNH3[J]显示文摘 | HuangHaifeng(黄海凤),ZengLi(曾立),LuHanfeng(卢晗锋),ZhouChunhe(周春何),ChenYinfei(陈银飞) | | 高等学校化学工程学报0，，： | 1 |
| 7 | Studies on Preparation and Properties of CuaN Thin Films 显示文摘 | Cui ZengLi Huang Zhixin Guo Jihua | 2009 | Nanoscience & Nanotechnology2009，6，2： | 1 |
| 8 | All-trans retinoic acidinhibited chondrogenesis of mouse embryonic palate mesenehymal cells by down-regulation of TGF-β/Smad signaling 显示文摘 | Zengli Yu and Ying Xing | 2006 | Biochem Biophys Res Commun2006，340，3： | 1 |
| 9 | Proportionate affine projection sign algorithms for network echo cancellation显示文摘 | Yang Zengli Zheng Y R Grant S L | 2011 | IEEE Trans on Audio Speech and Language Processing2011，19，8： | 1 |
| 10 | Induction of apoptosis by puerarin in colon cancer HT-29 cells显示文摘 | Zengli Yu Wenjie Li | 2005 | Cancer Letters2005，，1： | 1 |
| 11 | Preliminary radioimmunoimaging and biodistribution of ^131iodine-labeled single-chain antibody fragment against progastrin-releasing peptide(31-98) in small cell lung cancer xenografts显示文摘 | Hong Zhihui Shi Yizhen Liu Zengli Zhou Xiaolin Yang Yi Tang Jun | 2014 | Chinese Medical Journal2014，，11： | 1 |
| 12 | Glycemicindexoffoodandtheeffectofdietarytreatmentfordiabetes显示文摘 | ZhangJH ZengLY | 2005 | ChineseJournalofClinicalRehabilitation2005，19，27： | 1 |
| 13 | Effect of torrefaction on structure and fast pyrolysis behavior of corncobs显示文摘 | Anqing Zheng Zengli Zhao Sheng Chang Zhen Huang Xiaobo Wang Fang He Haibin Li | 2013 | Bioresource Technology2013，，： | 1 |
| 14 | Induction of apoptosis by puerarin in colon cancer HT-29 cells显示文摘 | Yu Zengli Li Wenjie | 2006 | Cancer Letters2006，238，1： | 1 |
| 15 | Effects of high-pro- tein diets on body weight, glycaemic control, blood lipids and blood pressure in type 2 diabetes: Meta-analysls of randomised controlled trials 显示文摘 | Dong Jiayi Zhang Zengli Wang Peiyu | 2013 | BrJNutr2013，110，5： | 1 |
| 16 | TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells显示文摘 | Gengyun Wen Michael A. Partridge Bingyan Li Mei Hong Wupeng Liao Simon K. Cheng Yongliang Zhao Gloria M. Calaf Tian Liu Jun Zhou Zengli Zhang Tom K. Hei | 2011 | Cancer Letters2011，，1： | 1 |
| 17 | Anovel fault-analysis method for the power grid withinverter-interfaced distribution generators 显示文摘 | YANG Zengli ZHANG Zhe YIN Xianggen | 2015 | Journal ofElectrical Engineering and Computer Science2015，32，14： | 1 |
| 18 | The SKI proto-oncogene restrains the resident CD103^(+)CD8^(+) T cell response in viral clearance显示文摘Acute viral infection causes illness and death.In addition,an infection often results in increased susceptibility to a secondary infection,but the mechanisms behind this susceptibility are poorly understood.Since its initial identification as a marker for resident memory CD8^(+)T cells in barrier tissues,the function and regulation of CD103 integrin(encoded by ITGAE gene)have been extensively investigated.Nonetheless,the function and regulation of the resident CD103^(+)CD8^(+)T cell response to acute viral infection remain unclear.Although TGFβsignaling is essential for CD103 expression,the precise molecular mechanism behind this regulation is elusive.Here,we reveal a TGFβ–SKI–Smad4 pathway that critically and specifically directs resident CD103^(+)CD8^(+)T cell generation for protective immunity against primary and secondary viral infection.We found that resident CD103^(+)CD8^(+)T cells are abundant in both lymphoid and nonlymphoid tissues from uninfected mice.CD103 acts as a costimulation signal to produce an optimal antigenic CD8^(+)T cell response to acute viral infection.There is a reduction in resident CD103^(+)CD8^(+)T cells following primary infection that results in increased susceptibility of the host to secondary infection.Intriguingly,CD103 expression inversely and specifically correlates with SKI proto-oncogene(SKI)expression but not R-Smad2/3 activation.Ectopic expression of SKI restricts CD103 expression in CD8^(+)T cells in vitro and in vivo to hamper viral clearance.Mechanistically,SKI is recruited to the Itgae loci to directly suppress CD103 transcription by regulating histone acetylation in a Smad4-dependent manner.Our study therefore reveals that resident CD103^(+)CD8^(+)T cells dictate protective immunity during primary and secondary infection.Interfering with SKI function may amplify the resident CD103^(+)CD8^(+)T cell response to promote protective immunity. | Bing Wu Ge Zhang Zengli Guo Gang Wang Xiaojiang Xu Jian-liang Li Jason K.Whitmire Junnian Zheng Yisong Y.Wan | 2021 | Cellular & Molecular Immunology2021，18，10： | 1 |
| 19 | Experimental Investigation of Fracture Toughness of Frozen Soil 显示文摘 | Hongsheng Li Haitian Yang and Zengli Liu | 2000 | Journal of Cold Regions Engineering2000，14，1： | 1 |
| 20 | Com-parative analysis of morphological characteristics and effec-tive composition content of wild and cultivated Epimedium pubescens and Epimedium wushanense (Berberidaceae)显示文摘 | QUAN Qiumei FANG Zengli LI Yunxiang | | 0，，29： | 1 |
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