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| 1 | Single-cell transcriptomic atlas of primate cardiopulmonary aging显示文摘Aging is a major risk factor for many diseases,especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019(COVID-19).Resolving cellular and molecular mechanisms associated with aging in higher mammals is therefore urgently needed.Here,we created young and old non-human primate single-nucleus/cell transcriptomic atlases of lung,heart and artery,the top tissues targeted by SARS-CoV-2.Analysis of cell type-specific aging-associated transcriptional changes revealed increased systemic inflammation and compromised virus defense as a hallmark of cardiopulmonary aging.With age,expression of the SARS-CoV-2 receptor angiotensin-converting enzyme 2(ACE2)was increased in the pulmonary alveolar epithelial barrier,cardiomyocytes,and vascular endothelial cells.We found that interleukin 7(IL7)accumulated in aged cardiopulmonary tissues and induced ACE2 expression in human vascular endothelial cells in an NF-κB-dependent manner.Furthermore,treatment with vitamin C blocked IL7-induced ACE2 expression.Altogether,our findings depict the first transcriptomic atlas of the aged primate cardiopulmonary system and provide vital insights into age-linked susceptibility to SARS-CoV-2,suggesting that geroprotective strategies may reduce COVID-19 severity in the elderly. | Shuai Ma Shuhui Sun Jiaming Li Yanling Fan Jing Qu Liang Sun Si Wang Yiyuan Zhang Shanshan Yang Zunpeng Liu Zeming Wu Sheng Zhang Qiaoran Wang Aihua Zheng Shuguang Duo Yang Yu Juan Carlos Izpisua Belmonte Piu Chan Qi Zhou Moshi Song Weiqi Zhang Guang-Hui Liu | 2021 | Cell Research2021，31，4： | 10 |
| 2 | Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration显示文摘Accumulating evidence indicates an association between the circadian clock and the aging process.However,it remains elusive whether the deregulation of circadian clock proteins underlies stem cell aging and whether they are targetable for the alleviation of aging-associated syndromes.Here,we identified a transcription factor-independent role of CLOCK,a core component of the molecular circadian clock machinery,in counteracting human mesenchymal stem cell(hMSC)decay.CLOCK expression was decreased during hMSC aging.In addition,CLOCK deficiency accelerated hMSC senescence,whereas the overexpression of CLOCK,even as a transcriptionally inactive form,rejuvenated physiologically and pathologically aged hMSCs.Mechanistic studies revealed that CLOCK formed complexes with nuclear lamina proteins and KAP1,thus maintaining heterochromatin architecture and stabilizing repetitive genomic sequences.Finally,gene therapy with lentiviral vectors encoding CLOCK promoted cartilage regeneration and attenuated age-related articular degeneration in mice.These findings demonstrate a noncanonical role of CLOCK in stabilizing heterochromatin,promoting tissue regeneration,and mitigating aging-associated chronic diseases. | Chuqian Liang Zunpeng Liu Moshi Song Wei Li Zeming Wu Zehua Wang Qiaoran Wang Si Wang Kaowen Yan Liang Sun Tomoaki Hishida Yanning Cai Juan Carlos lzpisua Belmonte Pedro Guillen Piu Chan Qi Zhou Weiqi Zhang Jing Qu Guang-Hui Liu | 2021 | Cell Research2021，31，2： | 8 |
| 3 | Single atom accelerates ammonia photosynthesis显示文摘Atomically dispersed metal has gained much attention because of the new opportunities they offer in catalysis. However, it is still crucial to understand the mechanism of single-atom catalysis at molecular level for expanding them to other more difficult catalytic reactions, such as ammonia synthesis from nitrogen. In fact, developing ammonia synthesis under ambient conditions to overcome the high energy consumption in well-established Haber-Bosch process has fascinated scientists for many years.Herein, we demonstrate that single Cu atom yields facile valence-electron isolation from the conjugated π electron cloud of p-CN. Electron spin resonance measurements reveal that these isolated valence electrons can be easily excited to generate free electrons under photo-illumination, thus inducing high efficient photo-induced ammonia synthesis under ambient conditions.The NH_3 producing rate of copper modified carbon nitride(Cu-CN) reached 186 μmol g^(-1) h^(-1) under visible light irradiation with the quantum efficiency achieved 1.01% at 420 nm monochromatic light. This finding surely offers a model to open up a new vista for the ammonia synthesis at gentle conditions. The introduction of single atom to isolate the valence electron also represents a new paradigm for many other photocatalytic reactions, since the most photoinduced processes have been successfully exploited sharing the same origin. | Pengcheng Huang Wei Liu Zhihai He Chong Xiao Tao Yao Youming Zou Chengming Wang Zeming Qi Wei Tong Bicai Pan Shiqiang Wei Yi Xie | 2018 | Science China Chemistry2018，61，9： | 8 |
| 4 | Phase transformation,thermodynamics and kinetics property of Mg90Ce5RE5(RE=La,Ce,Nd)hydrogen storage alloys显示文摘The Mg90Ce5 RE5(RE=La,Ce,Nd)alloys were prepared by a vacuum induction furnace and their micro structure,phase transformation,thermodynamics and kinetics property were systematically studied by XRD,SEM,TEM,and PCT characterization methods.The result shows that the activated alloys are composed of Mg/MgH2 and corresponding REH2+x with nanoscale.The REH2+x grain with Ce and La or Nd functional group have lower nucleation potential barriers than CeH2+x grains as the nucleation location,thus improve the hydrogen absorption kinetics of these alloys among which the Mg90Ce5Nd5 alloy can absorb 90%of the hydrogen within 2 min at 320℃.In addition,the Mg90Ce10 alloy has the lowest activation energy with 103.2 kJ mol-1 and the fastest desorption kinetics,which can release 5 wt%of the hydrogen within 20 min at 320℃.This is a correlation with grain size and the in-suit formed CeH2.73/CeO2 interface.Moreover,the co-doping Ce and La or Nd can effectively disorganize the thermodynamic stability of Mg-based hydrogen storage alloys to a certain degree,but the dehydrogenation kinetics of that still is restricted by the recombination energy of hydrogen ions on the surface. | Hui Yong Shihai Guo Zeming Yuan Yan Qi Dongliang Zhao Yanghuan Zhang | 2020 | Journal of Materials Science & Technology2020，47，16： | 5 |
| 5 | Phase evolution,hydrogen storage thermodynamics and kinetics of ternary Mg90Ce5Sm5 alloy显示文摘Greatly stable thermodynamics and sluggish kinetics impede the practical application of Mg-based hydrogen storage alloys.The modifications of composition and structure are important strategies in turning these hydrogen storage properties.In this study,Mg-based Mg90Ce5 Sm5 ternary alloy fabricated by vacuum induction melting was investigated to explore the performance and the reaction mechanism as hydrogen storage material by X-ray diffraction(XRD),scanning electron microscope(SEM),transmission electron microscopy(TEM) and pressure-composition isotherms(PCI) measurements.The results indicate that the Mg-based Mg90Ce5 Sm5 ternary alloy consists of two solid solution phases,including the major phases(Ce,Sm)5 Mg41 and the minor phases(Ce,Sm)Mg12.After hydrogen absorption,these phases transform into the MgH2 and(Ce,Sm)H2.73 phase,while after hydrogen desorption,the MgH2 transforms into the Mg phase,but the(Ce,Sm)H2.73 phases are not changed.The alloy has a reversible hydrogen capacity of about 5.5 wt% H2 and exhibits well isothermal hydrogen absorption kinetics.Activation energy of 106 kJ/mol was obtained from the hydrogen desorption data between 573 and 633 K,which also exhibits the enhanced kinetics compared with the pure MgH2 sample,as a result of bimetallic synergy catalysis function of(Ce,Sm)H2.73 phases.The rate of hydrogen desorption is controlled by the release and recombination of H2 from the Mg surface.Furthermore,the changes of enthalpy and entropy of hydrogen absorption/desorption were calculated to be-80.0 kJ/mol H2,-137.5 J/K/mol H2 and 81.2 kJ/mol H2,139.2 J/K/mol H2,respectively. | Hui Yong Shihai Guo Zeming Yuan Wei Zhang Yan Qi Dongliang Zhao Yanghuan Zhang | 2020 | Journal of Rare Earths2020，38，6： | 3 |
| 6 | Structures and Electrochemical Performances of As-spun RE-Mg-Ni-Mn-based Alloys Applied to Ni-MH Battery显示文摘The La-Mg-Ni-Mn-based AB_2-type La_(1-x)Ce_xMgNi_(3.5)Mn_(0.5)(x = 0, 0.1, 0.2, 0.3, and 0.4) alloys were fabricated by melt spinning technology. The effects of Ce content on the structures and electrochemical hydrogen storage performances of the alloys were studied systematically. The XRD and SEM analyses proved that the experimental alloys consist of a major phase LaMgNi_4 and a secondary phase LaNi_5. The variation of Ce content causes an obvious change in the phase abundance of the alloys without changing the phase composition. Namely, with the increase of Ce content, the LaMgNi_4 phase augments and the LaNi_5 phase declines. The lattice constants and cell volumes of the alloys clearly shrink with increasing Ce content. Moreover, the Ce substitution for La results in the grains of the alloys clearly refined. The electrochemical tests showed that the substitution of Ce for La obviously improves the cycle stability of the as-spun alloys. The analyses on the capacity degradation mechanism demonstrate that the improvement can be attributed to the ameliorated anti-corrosion and antioxidation ability originating from substituting partial La with Ce. The as-spun alloys exhibit excellent activation capability, reaching the maximum discharge capacities just at the first cycling without any activation treatment. The substitution of Ce for La evidently improves the discharge potential characteristics of the as-spun alloys. The discharge capacity of the alloys first increases and then decreases with growing Ce content. Furthermore, a similar trend also exists in the electrochemical kinetics of the alloys, including the high rate discharge ability(HRD), hydrogen diffusion coefficient(D), limiting current density(IL) and charge transfer rate. | 张羊换 SHANG Hongwei LI Yaqin YUAN Zeming HU Feng QI Yan ZHAO Dongliang | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，4： | 2 |
| 7 | Working-in-tandem mechanism of multi-dopants in enhancing electrocatalytic nitrogen reduction reaction performance of carbon- based materials显示文摘Developing carbon-based electrocatalysts with excellent N2 adsorption and activation capability holds the key to achieve highly efficient nitrogen reduction reaction(NRR)for reaching its practical application.Here,we report a highly active electrocatalyst--metal-free pyrrolic-N dominated N,S co-doped carbon(pyrr-NSC)for NRR.Based on theoretical and experimental results,it is confirmed that the N and S-dopants practice a working-in-tandem mechanism on pyrr-NSC,where the N-dopants are utilized to create electropositive C sites for enhancing N2 adsorption and the S-dopants are employed to induce electron backdonation for facilitating N2 activation.The synergistic effect of the pyrrolic-N and S-dopants can also suppress the irritating hydrogen evolution reaction,further boosting the NRR performance.This work gives an indication that the combination of two different dopants on electrocatalyst can enhance NRR performance by working in the two tandem steps-the adsorption and activation of N2 molecules,providing a new strategy for NRR electrocatalyst design. | Wenqing Zhang Keke Mao Jingxiang Low Hengjie Liu Yanan Bo Jun Ma Qiaoxi Liu Yawen Jiang Jiuzhong Yang Yang Pan Zeming Qi Ran Long Li Song Yujie Xiong | 2021 | Nano Research2021，14，9： | 2 |
| 8 | Gaseous hydrogen storage properties of Mg-Y-Ni-Cu alloys prepared by melt spinning显示文摘For purpose of promoting the hydrogen absorption and desorption thermodynamics and kinetics properties of Mg-Ni-based alloys, partially substituting Y and Cu for Mg and Ni respectively and melt spinning technique were applied for getting Mg25-xYxNi9 Cu(χ = 0-7) alloys. Their microstructures and phases were characterized with the help of X-ray diffraction and transmission electron microscopy. Their hydrogen absorbing and desorbing properties were tested by a Sievert apparatus, DSC, and TGA, which were connected with a H2 detector. In order to estimate the dehydrogenation activation energy of alloy hydride, both Arrhenius and Kissinger methods were applied for calculation. It is found that their hydriding kinetics notably declines, however, their hydrogen desorption kinetics conspicuously improves, with spinning rate and Y content increasing. Their hydrogen desorption activation energy markedly decreases under the same constraint, and it is found that melt spinning and Y substituting Mg improve the real driving force for dehydrogenation. As for the tendency of hydrogen absorption capacity,it presents an elevation firstly and soon after a decline with the rising of spinning rate, however, it always lowers with Y content growing. With Y content and spinning rate increasing, their thermodynamic parameters(△H and △S absolute values) visibly decrease, and the starting hydrogen desorption temperatures of alloy hydrides obviously lower. | Yanghuan Zhang Yaqin Li Wei Zhang Zeming Yuan Zhonghui Hou Yan Qi Shihai Guo | 2019 | Journal of Rare Earths2019，37，7： | 2 |
| 9 | The AILESinfrared beamline on the third generation synchrotronradiation facility SOLEIL显示文摘 | Pascale R Mathieu R QI Zeming | 2006 | Infrared Phys Technol2006，49，12： | 1 |
| 10 | The green emission and local structure of the scintillator PbWO4显示文摘 | QI Zeming SHI Chaoshu ZHOU Dongfang | 2001 | Physica B2001，307，： | 1 |
| 11 | Photocatalytic degradation of gaseous toluene on Fe-TiO 2 under visible light irradiation: A study on the structure, activity and deactivation mechanism显示文摘 | Song Sun Jianjun Ding Jun Bao Chen Gao Zeming Qi Xiaoyan Yang Bo He Chengxiang Li | 2012 | Applied Surface Science2012，，12： | 1 |
| 12 | Comparison study of the luminescent properties of the white-light long afterglow phosphors: Ca x MgSi 2 O 5+ x :Dy 3+ ( x =1, 2, 3)显示文摘 | Yonghu Chen Xuerui Cheng Miao Liu Zeming Qi Chaoshu Shi | 2008 | Journal of Luminescence2008，，5： | 1 |
| 13 | Structure and hydrogen storage characteristics of as-spun Mg-Y-Ni-Cu alloys显示文摘Experimental alloys with compositions of Mg(25-x)YxNi9Cu(x=0,1,3,5,7)have been successfully prepared through melt spinning method.The phase compositions and microstructures were measured by X-Ray diffraction(XRD)and high-resolution transmission electron microscopy(HRTEM).The de-/hydrogenation properties were measured by utilizing Sievert apparatus,differential scanning calorimetry(DSC)and thermal gravimetric analyzer(TGA)connected with a H2 detector.The Arrhenius and Kissinger methods were adopted to calculate their dehydrogenation activation energies.The results show that hydrogen absorption kinetics of the alloys notably decline while their hydrogen desorption kinetics conspicuously improve with spinning rate increasing.The dehydrogenation activation energy markedly decreases with spinning rate increasing,which makes the hydrogen desorption kinetics improve.The thermodynamic parameters(H and S absolute values)clearly decrease with spinning rate increasing.The hydrogen absorption capacity exhibits different trends with spinning rate rising.Specifically,hydrogen absorption capacity increases at the beginning and declines later for Y1 alloy,but that of Y7 alloy always decreases with spinning rate growing. | Yanghuan Zhang Pengpeng Wang Zhonghui Hou Zeming Yuan Yan Qi Shihai Guo | 2019 | Journal of Materials Science & Technology2019，35，8： | 1 |
| 14 | Enhanced hydrogen storage performance of Mg-Cu-Ni system catalyzed by CeO2 additive显示文摘In this paper,the as-cast Mg85Cu5Ni10 alloy and Mg85Cu5Ni10-x wt%CeO2(x=0,4,8)alloys were prepared successfully by vacuum induction smelting and ball milling.The microstructure,hydrogen absorption/desorption kinetics and thermodynamics performances of the alloys were studied in detail.The results show that the Mg85Cu5Ni10 alloys with CeO2 additive have faster hydrogenation/dehydrogenation kinetics and better thermodynamic properties.The dehydrogenation activation energy is reduced to 81.211 kJ/mol from 119.142 by adding 8 wt%CeO2.CeO2 contributes to producing structural defects,nanocrystallines,grain boundaries,partial amorphous,lattice dislocations and cracks which are favorable to provide more hydrogen diffusion channels during hydriding/dehydriding process.Meanwhile,CeO2 additive weakens the bond energy of Mg-H.These micro structural changes caused by CeO2 additive improve the hydrogen storage performance of Mg85Cu5Ni10 markedly. | Yi Yin Bo Li Zeming Yuan Yan Qi Yanghuan Zhang | 2020 | Journal of Rare Earths2020，38，9： | 1 |
| 15 | Local structure and luminescence of nanocrystalline显示文摘 | Zeming Qi Chaoshu Shi Weiwei Zhang | 2002 | Applied Physics Letters2002，15，81： | 1 |
| 16 | White-light long-lasting phosphorescence from Tb 3+ -activated Y 2 O 2 S phosphor显示文摘 | Bo Liu Chaoshu Shi Zeming Qi | 2006 | Journal of Physics and Chemistry of Solids2006，，8： | 1 |
| 17 | The roles of Eu 2+ and Dy 3+ in the blue long-lasting phosphor Sr 2 MgSi 2 O 7 : Eu 2+ , Dy 3+显示文摘 | Chaoshu Shi Yibing Fu Bo Liu Guobin Zhang Yonghu Chen Zeming Qi Xixian Luo | 2006 | Journal of Luminescence2006，，： | 1 |
| 18 | A Unique Ru-N_(4)-P Coordinated Structure Synergistically Waking Up the Nonmetal P Active Site for Hydrogen Production显示文摘Numerous experiments have demonstrated that the metal atom is the active center of monoatomic catalysts for hydrogen evolution reaction(HER),while the active sites of nonmetal doped atoms are often neglected.By combining theoretical prediction and experimental verification,we designed a unique ternary Ru-N_(4)-P coordination structure constructed by monodispersed Ru atoms supported on N,P dual-doped graphene for highly efficient hydrogen evolution in acid solution.The density functional theory calculations indicate that the charge polarization will lead to the most charge accumulation at P atoms,which results in a distinct nonmetallic P active sites with the moderate H∗adsorption energy.Notably,these P atoms mainly supply highly efficient catalytic sites with ultrasmall absorption energy of 0.007 eV.Correspondingly,the Ru-N_(4)-P demonstrated outstanding HER performance not only in an acidic condition but also in alkaline environment.Notably,the performance of Ru-NPC catalyst at high current is even superior to the commercial Pt/C catalysts,whether in acidic or alkaline medium.Our in situ synchrotron radiation infrared spectra demonstrate that a P-H_(ads) intermediate is continually emerging on the Ru-NPC catalyst,actively proving the nonmetallic P catalytically active site in HER that is very different with previously reported metallic sites. | Chuanqiang Wu Shiqing Ding Daobin Liu Dongdong Li Shuangming Chen Huijuan Wang Zeming Qi Binghui Ge Li Song | 2020 | Research2020，，1： | 1 |
| 19 | Local structure and luminescence of nanocrystalline显示文摘 | ZEMING QI CHAOSHU SHI | 2002 | AppPhys Lett2002，81，15： | 1 |
| 20 | The Green Emission and Local Structure of the Scintillator PbWO4显示文摘 | Qi Zeming Shi Chaoshu Zhou Dongfang Tang Honggao Liu Tao Hu Taidou | 2001 | Physica B2001，307，： | 1 |
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