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| 1 | Solidification microstructures of Al-Zn-Mg-Cu alloys prepared by spraydeposition and conventional casting methods显示文摘高力量 Al-Zn-Mg-Cu 合金被水花免职准备并且扔技术。Al-Zn-Mg-Cu 合金的微观结构用扫描电子显微镜学,传播电子显微镜学,和 X 光检查衍射被学习。在水花免职和常规演员组准备的合金的微观结构的第二等的阶段被检验。结果显示在常规扔条件下面,合金的微观结构揭示了粗糙的 Al/Mg ( ZnCu )的存在扔的 2 个最容易溶解的阶段,和水花处理原因在尺寸的明显的修正,形态学,并且在分离的微观结构以及减小的第二等的阶段的分发。扔水花的 Al-Zn-Mg-Cu 合金的优异微观结构被归因于高冷却率,并且与快速的团结过程联系了。 | HE Xiaoqing XIONG Baiqing SUN Zeming ZHANG Yongan WANG Feng ZHU Baohong | 2008 | Rare Metals2008，27，2： | 3 |
| 2 | Structures and Electrochemical Performances of As-spun RE-Mg-Ni-Mn-based Alloys Applied to Ni-MH Battery显示文摘The La-Mg-Ni-Mn-based AB_2-type La_(1-x)Ce_xMgNi_(3.5)Mn_(0.5)(x = 0, 0.1, 0.2, 0.3, and 0.4) alloys were fabricated by melt spinning technology. The effects of Ce content on the structures and electrochemical hydrogen storage performances of the alloys were studied systematically. The XRD and SEM analyses proved that the experimental alloys consist of a major phase LaMgNi_4 and a secondary phase LaNi_5. The variation of Ce content causes an obvious change in the phase abundance of the alloys without changing the phase composition. Namely, with the increase of Ce content, the LaMgNi_4 phase augments and the LaNi_5 phase declines. The lattice constants and cell volumes of the alloys clearly shrink with increasing Ce content. Moreover, the Ce substitution for La results in the grains of the alloys clearly refined. The electrochemical tests showed that the substitution of Ce for La obviously improves the cycle stability of the as-spun alloys. The analyses on the capacity degradation mechanism demonstrate that the improvement can be attributed to the ameliorated anti-corrosion and antioxidation ability originating from substituting partial La with Ce. The as-spun alloys exhibit excellent activation capability, reaching the maximum discharge capacities just at the first cycling without any activation treatment. The substitution of Ce for La evidently improves the discharge potential characteristics of the as-spun alloys. The discharge capacity of the alloys first increases and then decreases with growing Ce content. Furthermore, a similar trend also exists in the electrochemical kinetics of the alloys, including the high rate discharge ability(HRD), hydrogen diffusion coefficient(D), limiting current density(IL) and charge transfer rate. | 张羊换 SHANG Hongwei LI Yaqin YUAN Zeming HU Feng QI Yan ZHAO Dongliang | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，4： | 2 |
| 3 | Electrochemical Hydrogen Storage Performance of the Nanocrystalline and Amorphous Pr-Mg-Ni-based Alloys Synthesized by Mechanical Milling显示文摘The PrMg12-type composite alloy of PrMg_(11)Ni + x wt% Ni (x=100,200) with an amorphous and nanocrystalline microstructure were synthesized through the mechanical milling.Effects of milling duration and Ni content on the microstructures and electrochemical hydrogen storage performances of the ball-milled alloys were methodically studied.The ball-milled alloys obtain the optimum discharge capacities at the first cycle.Increasing Ni content dramatically enhances the electrochemical property of alloys.Milling time varying may obviously impact the electrochemical performance of these alloys.The discharge capacities show a significant upward trend with milling duration prolonging,but milling for a longer time more than 40 h induces a slight decrease in the discharge capacity of the x=200 alloy.As milling duration increases,the cycle stability clearly lowers,while it first declines and then augments under the same condition for the x=200 alloy.The high-rate discharge abilities of the ball-milled alloys show the optimum values with milling time varying. | 侯忠辉 YUAN Zeming FENG Dianchen SUN Hao 张羊换 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，1： | 2 |
| 4 | Hyperthermia differentially affects specific human stem cells and their differentiated derivatives显示文摘Dear Editor,The human body operates optimally at a core temperature of 37 degrees Celsius.Homeostasis at this temperature is essential for cellular and physiological functions(Cheshire,2016).However,infectious diseases,inflammation,injury,neoplasia,and elevated climate temperature can cause a regulated rise in body core temperature,i.e.,fever(Pasi-khova et al,2017).Indeed,an acute or chronic increase in temperature leads to detrimental effects on vasculature by altering a number of indices of vascular structure and function(DuBose et al.,1998). | Si Wang Fang Cheng Qianzhao Ji Moshi Song Zeming Wu Yiyuan Zhang Zhejun Ji Huyi Feng Juan Carlos Izpisua Belmonte Qi Zhou Jing Qu Wei Li Guang-Hui Liu Weiqi Zhang | 2022 | Protein & Cell2022，13，8： | 0 |
| 5 | Study on NaK Plugging Meter显示文摘For plugging meter as Fig.1,structure and size of the plugging orifices is the key point determining measurement range and accuracy.By theoretical analysis,a design criterion is obtained as formula(1).After the cooling and heat transfer process numerically simulated,the fitted curve of temperature of the blocking hole | WANG Zeming CHAI Baohua FENG Bo LONG Yuyi | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 6 | Porous framework materials for energy&environment relevant applications:A systematic review显示文摘Carbon peaking and carbon neutralization trigger a technical revolution in energy&environment related fields.Development of new technologies for green energy production and storage,industrial energy saving and efficiency reinforcement,carbon capture,and pollutant gas treatment is in highly imperious demand.The emerging porous framework materials such as metal–organic frameworks(MOFs),covalent organic frameworks(COFs)and hydrogen-bonded organic frameworks(HOFs),owing to the permanent porosity,tremendous specific surface area,designable structure and customizable functionality,have shown great potential in major energy-consuming industrial processes,including sustainable energy gas catalytic conversion,energy-efficient industrial gas separation and storage.Herein,this manuscript presents a systematic review of porous framework materials for global and comprehensive energy&environment related applications,from a macroscopic and application perspective. | Yutao Liu Liyu Chen Lifeng Yang Tianhao Lan Hui Wang Chenghong Hu Xue Han Qixing Liu Jianfa Chen Zeming Feng Xili Cui Qianrong Fang Hailong Wang Libo Li Yingwei Li Huabin Xing Sihai Yang Dan Zhao Jinping Li | 2024 | Green Energy & Environment2024，9，2： | 0 |
| 7 | mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic,mesenchymal and neural stem cells显示文摘Dear Editor,Stem cells,including pluripotent stem cells and adult stem cells,possess the remarkable capability of being able to selfrenew while at the same time having potential to differentiate into different cell lineages and functionally distinct cell types.Human embryonic stem cells(hESCs)can differentiate into all adult stem cell types,including human mesenchymal stem cells(hMSCs)and human neural stem cells(hNSCs),but can also give rise to all terminally differentiated cell types(Wang et al.,2021a).Through the continuous replenishment of differentiated cells,stem cells support tissue homeostasis and respond to tissue injuries.Given the promising applications of stem cells in cell therapy and regenerative medicine,insights into molecular events underlying stem cell maintenance,self-renewal ability and pluripotency,continue to garner strong interest(Shan et al.,2021).Although metabolic pathways have been implicated in the reciprocal regulations of stem cell self-renewal and differentiation as well as organ homeostatic maintenance(Garcia-Prat et al.,2017),central aspects of how metabolic requirements differ and are regulated across the various types of human stem cells in our body remain enigmatic. | Qun Chu Feifei Liu Yifang He Xiaoyu Jiang Yusheng Cai Zeming Wu Kaowen Yan Lingling Geng Yichen Zhang Huyi Feng Kaixin Zhou Si Wang Weiqi Zhang Guang-Hui Liu Shuai Ma Jing Qu Moshi Song | 2022 | Protein & Cell2022，13，9： | 0 |
| 8 | Classical spin liquid state in a rhombic lattice metal-organic framework显示文摘Discovering more and new geometrically frustrated systems remains an active point of inquiry in fundamental physics for the existence of unusual states of matter.Here,we report spin-liquid-like behavior in a two-dimensional(2D)rhombic lattice Fe-metal-organic framework(Fe-MOF)with frustrated antiferromagnetism.This Fe-MOF exhibits a high frustration factor f=|θCW|/TN≥315,and its long-range magnetic order is suppressed down to 180 mK.Detailed theoretical calculations demonstrate strong antiferromagnetic coupling between adjacent Fe3+ions,indicating the potential of a classical spin-liquid-like behavior.Notably,a T-linear heat capacity parameter,γ,originating from electronic contributions and with magnetic field independence up to 8 T,can be observed in the specific heat capacity measurements at low-temperature,providing further proof for the spin-liquid-like behavior.This work highlights the potential of MOF materials in geometrically frustrated systems,and will promote the research of exotic quantum physics phenomena. | Sihua Feng Chao Wang Jiyin Zhao Xuguang Liu Chaocheng Liu Zeming Qi Lei Chen Huijuan Wang Minghui Fan Hengli Duan Wensheng Yan | 2024 | Nano Research2024，17，4： | 0 |
| 9 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
| 10 | A lysosomal polarity-specific two-photon fluorescent probe for visualization of autophagy显示文摘Autophagy plays a vital role in maintaining the balance of normal physiological state of living cells.In this paper,a polarity-specific two-phot on fluorescent probe Lyso-NA based on naphthalimide was synthesized for the purpose of monitoring autophagy during biological research.The results of photophysical properties and theoretical calculation con firmed that different polarities of solvents mainly effected fluorescent intensities of probe.Fluoresce nt intensity,quantum yield and fluorescence lifetime of probe kept a good linear relationship with polarity respectively.In addition,due to its low toxicity and selective accumulation in lysosomes,Lyso-NA is suitable for detecting changes in lysosomal polarity of living cells.Compare with the imaging results of plasmid transfection,a better performed realtime long-term fluoresce nt visualization of autophagy in living cells was achieved.Probe Lyso-NA can work as an efficient and cost effective imaging tool for visualizing autophagy in living cells. | Zixiang Yuan Jun Chen Qin Zhou Ao Liu Zeming Qiang Min Fang Man Chen Yan Feng Haizhu Yu Xiuli Yang Xiangming Meng | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
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