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| 1 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | Total parathyroidectomy combined with partial autotransplantation for the treatment of secondary hyperparathyroidism显示文摘为长期的肾的失败引起的第二等的甲状腺机能过盛的背景药治疗可能在疾病的早阶段是可得到的,但是它不是为严肃的病人同样有效的。学习的目的是评估通过 2006 年 9 月, parathroidectomy 和自体移植从 1999 年 9 月与第二等的 hyperparathyroidism.Methods 在尿毒症的病人与前臂自体移植相结合的全部的 parathyroidectomy 的效果在 20 个病人被执行。在外科手术前的甲状旁腺的 ultrasonography 和外科的探索的结果之间的连贯被比较。intraoperatively,浆液钙集中和未经触动的甲状旁腺的荷尔蒙(iPTH ) 外科手术前地被监视, 71 增生的甲状旁腺的腺全部的 postoperatively.Results A 是在 20 个病人的 resected。在 B-ultrasonography 和 intraoperative 探索之间的甲状旁腺的本地化的一致率是 94.4% 。平均 iPTH 价值是(110.90 捩瑡潩獮漠捣牵敲 ? 湩㈠瀠瑡敩瑮 ????? 湡 ? 桴牥 ? 慷 ? 潮瀠牥潩数慲楴敶搠慥桴 ? 湯汣獵潩 ? 慌慰潲 ' 盏妻鏂邽惮嫆啼蠹缿?畣敲瑴条 ? 湡 ? 獡楰慲楴湯椠 ? 晥楦楣湥 ? 湡 ? 慳敦映牯氠癩牥爠獥 ' 虡 N 湯 .????? | ZOU Qiang WANG Hong-ying ZHOU Jian LAO Zheng-yin XUE Jun LI Ming-xin LI Hai-ming JIN Yi-ting GU Yong ZHANG Yan-ling | 2007 | Chinese Medical Journal2007，，20： | 22 |
| 4 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial显示文摘 | Ann-Lii Cheng Yoon-Koo Kang Zhendong Chen Chao-Jung Tsao Shukui Qin Jun Suk Kim Rongcheng Luo Jifeng Feng Shenglong Ye Tsai-Sheng Yang Jianming Xu Yan Sun Houjie Liang Jiwei Liu Jiejun Wang Won Young Tak Hongming Pan Karin Burock Jessie Zou Dimitris Volio | 2009 | Lancet Oncology2009，，1： | 23 |
| 5 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 6 | Effect of Rare Earth on Microstructures and Properties of High Speed Steel With High Carbon Content显示文摘The effects of rare earth (RE) on the microstructures and properties of high carbon high speed steel (HCHSS) were investigated. The results show that when suitable RE is added to the HCHSS, the effect of RE on the austenite and eutectic carbides is obvious. The austenite grain and coarse eutectic structure are refined, and flake carbides in the eutectic structures become short and fine. After heat treatment, most of the eutectic carbides are spheroidized and distributed in a uniform manner. The hardness and red hardness of modified HCHSS are slightly increased; impact toughness is greatly increased by 37.81% and reaches 10.17 J/cm^2. The mechanism by which RE improves the structures and properties of HCHSS is also analyzed. | YANG Jun ZOU De-ning LI Xiao-ming DU Zhong-ze | 2007 | Journal of Iron and Steel Research(International)2007，14，1： | 20 |
| 7 | Decline of serum CA724 as a probable predictive factor for tumor response during chemotherapy of advanced gastric carcinoma显示文摘Objective: To evaluate the predictive value of decline in the serum level of carbohydrate antigen 724(CA724) on tumor response during the chemotherapy in patients with advanced gastric carcinoma(GC). Methods: The serum CA724 level was determined by electrochemiluminescence immunoassay, while the objective response rate(ORR) was assessed according to response evaluation criteria in solid tumors(RECIST). The association of the changes of serum concentration of CA724 with ORR was analyzed. Results: The ORR in CA724(pretreatment serum level) high and low groups was 32.3%(20/62) and 52.8%(19/36), respectively(P=0.045). The relationship between the reduction of CA724 and the ORR was statistically significant(P=0.044). Receiver operating characteristic(ROC) curve established the best cutoff value of the decrease ratio of CA724 as 20.5%. Conclusions: CA724 decline seems to indicate chemotherapy efficacy in patients with advanced GC, and an average drop of 20.5% in serum CA724 appears to predict the sensitivity to chemotherapy. | Li Zou Jun Qian | 2014 | Chinese Journal of Cancer Research2014，26，4： | 20 |
| 8 | Synthetic hexaploid wheat and its utilization for wheat genetic improvement in China显示文摘Synthetic hexaploid wheat (Triticum turgidum × Aegilops tauschii) was created to explore for novel genes from T. turgidum and Ae. tauschii that can be used for common wheat improvement. In the present paper, research advances on the utilization of synthetic hexaploid wheat for wheat genetic improvement in China are reviewed. Over 200 synthetic hexaploid wheat (SHW) accessions from the International Maize and Wheat Improvement Centre (CIMMYT) were introduced into China since 1995. Four cultivars derived from these, Chuanmai 38, Chuanmai 42, Chuanmai 43 and Chuanmai 47, have been released in China. Of these, Chuanmai 42, with large kernels and resistance to stripe rust, had the highest average yield (> 6 t/ha) among all cultivars over two years in Sichuan provincial yield trials, outyielding the commercial check cultivar Chuanmai 107 by 22.7%. Meanwhile, by either artificial chromosome doubling via colchicine treatment or spontaneous chromosome doubling via a union of unreduced gametes (2n) from T. turgidum-Ae. tauschii hybrids, new SHW lines were produced in China. Mitotic-like meiosis might be the cytological mechanism of spontaneous chromosome doubling. SHW lines with genes for spontaneous chromosome doubling may be useful for producing new SHW-alien amphidiploids and double haploid in wheat genetic improvement. | Wuyun Yang Dengcai Liu Jun Li Lianquan Zhang Huiting Wei Xiaorong Hu Youliang Zheng Zhouhu He Yuchun Zou | 2009 | Journal of Genetics and Genomics2009，36，9： | 18 |
| 9 | Investigation of quality of life in patients with lung cancer by the EORTC QLQ-C30(V3.0) Chinese version显示文摘Objective To explore quality of life(QOL) and its influencing factors in patients with lung cancer.Methods A QOL questionnaire(European Organization for Research and Treatment of Cancer [EORTC] Quality of Life Questionnaire-Core 30 [QLQ-C30] Chinese version) was used with 138 patients with lung cancer participating in the study. A statistical description of the general characteristics of the patients with lung cancer was performed. The patients' QLQ-C30 scores were compared with the reference value for each dimension. To analyze the influence of QOL in different genders, age groups, and cancer stages, ttests and rank sum tests were used to compare the differences in QOL using a 5% significance level. Results The QLQ-C30 function scores in PF(physical functioning), EF(emotional functioning), SF(social functioning), and GH(global functioning), and symptom scales in NV(nausea and vomiting), DY(dyspnea), SL(insomnia), and FI(financial difficulties) were significantly different(P < 0.05) in comparison to the reference values. Female patients were worse than males(P < 0.05) in EF, NV, and DI(diarrhea). The later the stage of lung cancer, the worse the quality of life became; the functional scales in RF(role functioning), EF, CF, SF, and GH, and symptom scales in PA(pain), AP(appetite), and SL differences were statistically significant(P < 0.05). Conclusion This study aids understanding of the status of the quality of life of Chinese patients with cancer and might be useful for clinical work, theory research, and health policymakers. | Jun Li Xiaoguang Xiao Yao Wei Yang Li Man Zou Shiying Yu Yuan Chen Qian Chu | 2015 | Oncology and Translational Medicine2015，1，3： | 18 |
| 10 | Deep-seated structure and metallogenic dynamics of the Ailaoshan polymetallic mineralization concentration area, Yunnan Province, China显示文摘The Ailaoshan poly-metallic mineralization concentrated area (MCA) consists of the well known Ailaoshan metallogenic belt and adjacent mineral districts and/or deposits. Located in an area of several complex and intersecting tectonic units, the Ailaoshan poly-metallic MCA is controlled by deep crustal and mantle tectonism. Through interpretation of remote sensing images, we identified a large ring structure system that surrounds the MCA. This ring structure encloses regional deep-crustal faults, ductile shear zones, geothermal anomalies, magmatic rocks, and the major mineral deposits, all of which are the reflections of deep tectonic geodynamics that have been long active in this area. Geophysical data indicate that the crust is comprised of relatively stable two or three layers, with some irregular lower-velocity belts. The Moho in the ring sutures occurs as an area of local uplift. There exists an obvious transitional zone between the crust and mantle boundaries. Asthenopheric mantle shows multi-layer upwelling, which indicates multiple events during different geological epochs. It is believed that these mantle events or pulses were responsible for the formation of the regional shear zones, magmatic rocks, and polymetallic orebodies. Furthermore, an integrated metallogenic dynamics model related to the asthenopheric upwelling pulses in the MCA is established, defining events as old as Late Paleozoic. | GE LiangSheng DENG Jun GUO XiaoDong ZOU YiLin LIU YinChun | 2009 | Science China Earth Sciences2009，52，10： | 16 |
| 11 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 12 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 13 | Enhanced TLR-induced NF-KB signaling and type I interferon responses in NLRC5 deficient mice显示文摘 | Yanzheng Tong Jun Cui Qingtian Li Jia Zou Helen Y Wang Rong-Fu Wang | 2012 | Cell Research2012，22，5： | 14 |
| 14 | The Interactions among DWARF10,Auxin and Cytokinin Underlie Lateral Bud Outgrowth in Rice显示文摘Previous studies have shown that DWARF10(D10) is a rice ortholog of MAX4/RMS1/DAD1,encoding a carotenoid cleavage dioxygenase and functioning in strigolactones/strigolactone-derivatives(SL) biosynthesis.Here we use D10-RNA interference(RNAi) transgenic plants similar to d10 mutant in phenotypes to investigate the interactions among D10,auxin and cytokinin in regulating rice shoot branching.Auxin levels in node 1 of both decapitated D10-RNAi and wild type plants decreased significantly,showing that decapitation does reduce endogenous auxin concentration,but decapitation has no clear effects on auxin levels in node 2 of the same plants.This implies that node 1 may be the location where a possible interaction between auxin and D10 gene would be detected.D10 expression in node 1 is inhibited by decapitation,and this inhibition can be restored by exogenous auxin application,indicating that D10 may play an important role in auxin regulation of SL.The decreased expression of most OsPINs in shoot nodes of D10-RNAi plants may cause a reduced auxin transport capacity.Furthermore,effects of auxin treatment of decapitated plants on the expression of cytokinin biosynthetic genes suggest that D10 promotes cytokinin biosynthesis by reducing auxin levels.Besides,in D10-RNAi plants,decreased storage cytokinin levels in the shoot node may partly account for the increased active cytokinin contents,resulting in more tillering phenotypes. | Shuying Zhang Gang Li Jun Fang Weiqi Chen Haipai Jiang Junhuang Zou Xue Liu Xianfeng Zhao Xiaobing Li Chengcai Chu Qi Xie Xiangning Jiang Lihuang Zhu | 2010 | Journal of Integrative Plant Biology2010，52，7： | 14 |
| 15 | Metformin induces apoptosis of pancreatic cancer cells显示文摘AIM:To assess the role and mechanism of metformin in inducing apoptosis of pancreatic cancer cells.METHODS:The human pancreatic cancer cell lines ASPC-1,BxPc-3,PANC-1 and SW1990 were exposed to metformin.The inhibition of cell proliferation and colony formation via apoptosis induction and S phase arrest in pancreatic cancer cell lines of metformin was tested.RESULTS:In each pancreatic cancer cell line tested,metformin inhibited cell proliferation in a dose dependent manner in MTS(3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assays).Flow cytometric analysis showed that metformin reduced the number of cells in G1 and increased the percentage of cells in S phase as well as the apoptotic fraction.Enzymelinked immunosorbent assay(ELISA) showed that metformin induced apoptosis in all pancreatic cancer cell lines.In Western blot studies,metformin induced poly-ADP-ribose polymerase(PARP) cleavage(an indicator of caspase activation) in all pancreatic cancer cell lines.The general caspase inhibitor(VAD-fmk) completely abolished metformin-induced PARP cleavage and apoptosis in ASPC-1 BxPc-3 and PANC-1,the caspase-8 specific inhibitor(IETD-fmk) and the caspase-9 specific inhibitor(LEHD-fmk) only partially abrogated metformin-induced apoptosis and PARP cleavage in BxPc-3 and PANC-1 cells.We also observed that metformin treatment dramatically reduced epidermal growth factor receptor(EGFR) and phosphorylated mitogen activated protein kinase(P-MAPK) in both a time-and dose-dependent manner in all cell lines tested.CONCLUSION:Metformin significantly inhibits cell proliferation and apoptosis in all pancreatic cell lines.And the metformin-induced apoptosis is associated with PARP cleavage,activation of caspase-3,-8,and-9 in a time-and dose-dependent manner.Hence,both caspase-8 and-9-initiated apoptotic signaling pathways contribute to metformin-induced apoptosis in pancreatic cell lines. | Luo-Wei Wang Zhao-Shen Li Duo-Wu Zou Zhen-Dong Jin Jun Gao Guo-Ming Xu | 2008 | World Journal of Gastroenterology2008，14，47： | 13 |
| 16 | The role of Med19 in the proliferation and tumorigenesis of human hepatocellular carcinoma cells显示文摘 | Shao-wu ZOU Kai-xing AI Zhi-gang WANG Zhou YUAN Jun YAN Qi ZHENG | 2011 | Acta Pharmacologica Sinica2011，32，3： | 12 |
| 17 | Endoscopic findings and clinicopathologic characteristics of colonic schistosomiasis:A report of 46 cases显示文摘AIM:To make a retrospective analysis of endoscopy findings and clinicopathologic characteristics of colonic schistosomiasis in order to further improve our understanding of the disease and decrease its misdiagnosis. METHODS:Endoscopy findings and clinicopathologic characteristics of 46 intestinal schistosomiasis patients were retrospectively analyzed.All the patients underwent colonoscopy and all biopsy specimens stained with hematoxylin and eosin were observed under a light microscope. RESULTS:Of the 46 colonic schistosomiasis patients,1 was diagnosed as acute schistosomal colitis,16 as chronic schistosomal colitis and 29 as chronic active schistosomal colitis according to their endoscopic findings and pathology.Not all patients were suspected of or diagnosed as colonic schistosomiasis.Of the 12 misdiagnosed patients,4 were misdiagnosed as ulcerativecolitis,1 as Crohn's disease,and 7 as ischemic colitis.The segments of rectum and sigmoid colon were involved in 29 patients(63.0%) .Intact Schistosoma ova were deposited in colonic mucosa accompanying infiltration of eosinocytes,lymphocytes,and plasma cells in acute schistosomal colitis patients.Submucosal fibrosis was found in chronic schistosomal colitis patients.Among the 17 patients with a signal polyp,hyperplastic polyp,canalicular adenoma with a low-grade intraepithelial neoplastic change,tubulovillous adenoma with a highgrade intraepithelial neoplastic change were observed in 10,5,and 2 patients,respectively.Eight out of the 46 patients were diagnosed as colonic carcinoma. CONCLUSION:Endoscopy contributes to the diagnosis of colonic schistosomiasis although it is nonspecific. A correct diagnosis of colonic schistosomiasis can be established by endoscopy in combination with its clinicopathologic characteristics. | Cao, Jun Liu, Wen-Jia Xu, Xin-Yun Zou, Xiao-Ping | 2010 | World Journal of Gastroenterology2010，16，6： | 12 |
| 18 | A Novel RT-LAMP Assay for Rapid and Simple Detection of Classical Swine Fever Virus显示文摘A simple and rapid assay for the detection of Classical swine fever virus(CSFV)was established using reverse transcription loop-mediated isothermal amplification(RT-LAMP).This study describes the amplification of the genomic RNA of CSFV under isothermal conditions(63℃)within one hour,using a set of six primers(two outer primers,two inner primers and two loop primers).This RT-LAMP assay showed 100-fold higher sensitivity than the standard RT-PCR method and identified eighteen additional positive cases that were negative when tested by RT-PCR.This RT-LAMP was able to detect all the 13 strains of CSFV but not the BVDV.PRRSV.SIV. PRV-PCV,thus showed a good specificity.Products amplified by RT-LAMP can be visualized by agarose gel electrophoresis and in addition,either as a white precipitate at the bottom of the tube after a pulse spin or as a color change when dyed with SYBR Green I which are visible to the naked eye.Because RT-LAMP is low-cost and produces rapid results,it has the potential to be an excellent tool for CSFV surveillance in the field,especially in developing countries. | Lei CHEN Xue-zheng FAN Qin WANG Lu XU Qi-zu ZHAO Yuan-chen ZHOU Jun LIU Bo TANG Xing-qi ZOU | 2010 | Virologica Sinica2010，25，1： | 12 |
| 19 | Self-assemble peptide biomaterials and their biomedical applications显示文摘Inspired by self-assembling peptides found in native proteins,deliberately designed engineered peptides have shown outstanding biocompatibility,biodegradability,and extracellular matrix-mimicking microenvironments.Assembly of the peptides can be triggered by external stimuli,such as electrolytes,temperature,and pH.The formation of nanostructures and subsequent nanocomposite materials often occur under physiological conditions.The respective properties of side chains in each amino acids provide numerous sites for chemical modification and conjugation choices of the peptides,enabling various resulting supramolecular nanostructures and hydrogels with adjustable mechanical and physicochemical properties.Moreover,additional functionalities can be easily induced into the hydrogels,including shearthinning,bioactivity,self-healing,and shape memory.It further broaden the scope of application of self-assemble peptide materials.This review outlines designs of self-assembly peptide(β-sheet,α-helix,collagen-like peptides,elastin-like polypeptides,and peptide amphiphiles)with potential additional functionalities and their biomedical applications in bioprinting,tissue engineering,and drug delivery. | Jun Chen Xuenong Zou | 2019 | Bioactive Materials2019，4，1： | 12 |
| 20 | Relationship of microstructure transformation and hardening behavior of type 17-4 PH stainless steel显示文摘The relationship between the microstructure transformation of type 17-4 PH stainless steel and the aging hardening be- havior was investigated. The results showed that, when 17-4 PH stainless steel aging at 595°C, the bulk hardness of samples attains its peak value (42.5 HRC) for about 20 min, and then decreases at all time. TEM revealed the microstructure corresponding with peak hardness is that the fine spheroid-shape copper with the fcc crystal structure and the fiber-shape secondary carbide M23C6 precipitated from the lath martensite matrix. Both precipitations of copper and M23C6 are the reasons for strengthening of the alloy at this tem- perature. With the extension of holding time at this temperature, the copper and secondary carbide grow and lose the coherent rela- tionship with the matrix, so the bulk hardness of samples decreases. | Jun Wang Hong Zou Cong Li Ruling Zuo Shaoyu Qiu Baoluo Shen | 2006 | Journal of University of Science and Technology Beijing2006，13，3： | 10 |
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