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| 1 | Immediate Effects of Hegu Needling on Adhesive Scapulohumeral Periarthritis显示文摘Objective:To observe the immediate effects of Hegu needling at Ashi points in patients with adhesive scapulohumeral periarthritis (SP). Methods:A total of 60 SP cases were randomized into a treatment group and a control group, 30 in each group. Cases in the treatment group were treated with Hegu needling at Ashi points and normal needling at other local points. Cases in the control group were treated with normal needling at local points alone. The therapeutic efficacy was then evaluated and analyzed using short-form of McGill pain questionnaire (SF-MPQ) and Japanese Orthopaedic Association (JOA) shoulder scoring system. Results:Hegu needling at Ashi points can substantially alleviate pain in patients with adhesive SP, showing a statistically significant difference when compared with the control group (P<0.01 or P<0.05). In addition, cases in the treatment group obtained better effects in abductor muscle strength, endurance, arm raising, internal rotation, external rotation, activities of daily living (ADL) and joint stability than those in the control group (P<0.01 or P<0.05). Conclusion:Hegu needling at Ashi points is effective for adhesive SP. | Fan Xiao-peng Cheng Bo Huang Yin Gu Kan Zong Lei Han Chou-ping | 2013 | Journal of Acupuncture and Tuina Science2013,11,4: | 17 |
| 2 | Large-field high-resolution two-photon digital scanned light-sheet microscopy显示文摘 | Weijian Zong Jia Zhao Xuanyang Chen Yuan Lin Huixia Ren Yunfeng Zhang Ming Fan Zhuan Zhou Heping Cheng Yujie Sun Liangyi Chen | 2015 | Cell Research2015,25,2: | 12 |
| 3 | Identification and Fine Mapping of a Gene Related to Pale Green Leaf Phenotype near the Centromere Region in Rice(Oryza sativa)显示文摘A thermo-insensitive pale green leaf mutant (pgl2) was isolated from T-DNA inserted transgenic lines of rice (Oryza sativa L. subsp. japonica cv. Nipponbare). Genetic analysis indicated that the phenotype was caused by a recessive mutation in a single nuclear-encoded gene. To map the PGL2 gene, an F2 population was constructed by crossing the mutant with Longtefu (Oryza sativa L. subsp. indica). The PGL2 locus was roughly linked to SSR marker RM331 on chromosome 8. To finely map the gene, 14 new InDel markers were developed around the marker, and PGL2 was further mapped to a 2.37 Mb centromeric region. Analysis on chlorophyll contents of leaves showed that there was no obvious difference between the mutant and the wild type in total chlorophyll (Chl) content, while the ratio of Chl a / Chl b in the mutant was only about 1, which was distinctly lower than that in the wild type, suggesting that the PGL2 gene was related to the conversion between Chl a and Chl b. Moreover, the method of primer design around the centromeric region was discussed, which would provide insight into fine mapping of the functional genes in plant centromeres. | ZHU Li LiuWenzhen WU Chao LUAN Wei jiang Fu Ya ping Hu Guo cheng SI Hua min SUN Zong xiu | 2007 | Rice science2007,14,3: | 11 |
| 4 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021,10,2: | 11 |
| 5 | Green Production Technology of the Monomer of Nylon-6: Caprolactam显示文摘 | Baoning Zong Bin Sun Shibiao Cheng Xuhong Mu Keyong Yang Junqi Zhao Xiaoxin Zhang Wei Wu | 2017 | Engineering2017,3,3: | 9 |
| 6 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013,,5: | 9 |
| 7 | Evaluation of Vaporized Hydrogen Peroxide Fumigation as a Method for the Bio-decontamination of the High Efficiency Particulate Air Filter Unit显示文摘Objective To evaluate the performance of vaporized hydrogen peroxide (VHP) for the bio-decontamination of the high efficiency particulate air (HEPA) filter unit. Methods Self-made or commercially available bioindicators were placed at designated locations in the HEPA filter unit under VHP fumigation. The spores on coupons were then extracted by 0.5 h submergence in eluent followed by 200-time violent knocks. Results Due to the presence of HEPA filter in the box, spore recovery from coupons placed at the bottom of the filter downstream was significantly higher than that from coupons placed at the other locations. The gap of decontamination efficiency between the top and the bottom of the filter downstream became narrower with the exposure time extended. The decontamination efficiency of the bottom of the filter downstream only improved gently with the injection rate of H2O2 increased and the decontamination efficiency decreased instead when the injection rate exceeded 2.5 g/min. The commercially available bioindicators were competent to indicate the disinfection efficiency of VHP for the HEPA filter unit. Conclusion The HEPA filter unit is more difficult than common enclosure to decontaminate using VHP fumigation. Complete decontamination can be achieved by extending fumigation time. VHP fumigation can be applied for in-situ biodecontamination of the HEPA filter unit as an alternative method to formaldehyde fumigation. | JIA Hai Quan LI Yan Ju SUN Bei ZHAO Si Qing YI Ying ZHAO Ming ZHANG Zong Xing PAN Xin QI Jian Cheng | 2013 | Biomedical and Environmental Sciences2013,26,2: | 8 |
| 8 | Oscillation analysis of a DFIG-based wind farm interfaced with LCC-HVDC显示文摘With the increasing capacity of wind farm, HVDC technology has become a promising transmission scheme for long distance transportation of large-scale wind power. However oscillation caused by this system will have a great influence on the security and stability of power system operation. In this paper, the oscillation of a doubly-fed induction generator(DFIG)-based wind farm interfaced with line commutated converter(LCC) based HVDC is discussed. Low-frequency oscillation and subsynchronous oscillation(SSO) are studied since these two oscillations are the particularly concerned oscillations in the stability study of power system in recent years. The model of a DFIG-based wind farm interconnected with LCC-HVDC is developed. The impact of drive train model's structure and parameters on the oscillation characteristics is analyzed. Eigenvalue and participation factor analysis are used to identify the three main modes, which include controller mode, electromechanical mode, and shaft mode. The effects of DFIG controller's parameters, wind speed and operating conditions of HVDC on those modes are studied. Electromagnetic transient simulations are performed to verify the results of the eigenvalue analysis. | YANG Lin XIAO Xiang Ning PANG Cheng Zong | 2014 | Science China(Technological Sciences)2014,57,12: | 7 |
| 9 | H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak显示文摘AIM To investigate the protective efficacy ofH2 strain attenuated live hepatitis A vaccines(H2-strain vaccines)in hepatitis A(HA)outbreaks.METHODS With the permission of theirparents,5551 pre-school and grade 1-3 primaryschool children were inoculated with 1 dose(106.5TCID50)of H2-strain vaccines in anonrandomized,controlled trial conducted inFucheng County,Hebei Province in May 1997.Another 6485 children in the same grades andcompatible in gender and age were enrolled ascontrols.Epidemiological and serological surveywas conducted to evaluate the protectiveefficacy of the vaccines.ELISA was used todetect serum IgM anti-HAV.RESULTS HA outbreak started in early May1998,peaked in the middle of the same month,and lasted about 80 days.Overall 302 HA caseswere found,192(53.58%)were 5-9 years old.One vaccinee and 25 control cases were found tohave hepatitis A,which account for 0.28%(1/356)and 5.92%(25/422)of all vaccinees andcontrols in the 14 villages,respectively.The protective efficacy of vaccines was 95.27%(95% Cl:85.83%-104.72%).In subjects testedfor anti-HAV IgM from 13 villages,1(0.40%)overt and 11(4.06%)asymptomatic HAV caseswere found in 271 vaccinees,but 21(6.69%)ofovert and asymptomatic ones were found in 314controls.CONCLUSION H2 strain vaccines were excellent in preventing overt hepatitis A, but not so effective in preventing asymptomatic hepatitis A virus infection. A booster dose might be needed to get permanent reliable immunity. | Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu | 2000 | World Journal of Gastroenterology2000,6,6: | 7 |
| 10 | An-Luo-Hua-Xian Pill Improves the Regression of Liver Fibrosis in Chronic Hepatitis B Patients Treated with Entecavir显示文摘Background and Aims:Chronic hepatitis B(CHB)can cause liver fibrosis and lead to cirrhosis and cancer.As the effectiveness of antiviral therapy to reverse liver fibrosis is limited,We aimed to evaluate the effect of An-Luo-Hua-Xian pill(ALHX)on fibrosis regression in CHB patients treated with entecavir(ETV).Methods:Treatment-naïve patients with CHB were randomly treated with ETV alone or combined with ALHX(ETV+ALHX)between October 1,2013 and December 31,2020.Demographic,laboratory,and liver histology data before and after 78 weeks of treatment were collected.The Ishak fibrosis score(F)was used and fibrosis regression required a decrease in F of≥1 after treatment.Results:A total of 780 patients were enrolled,and 394 with a second liver biopsy after treatment were included in the per-protocol population,132 in ETV group and 262 in ETV+ALHX group.After 78 weeks of treatment,the fibrosis regression rate in the ETV+ALHX group was significantly higher than that of the ETV group at baseline F≥3 patients:124/211(58.8%)vs.45/98(45.9%),p=0.035.The percentage of patients with a decreased liver stiffness measurement(LSM)was higher in the ETV+ALHX group:156/211(73.9%)vs.62/98(63.%),p=0.056.Logistic regression analysis showed that ETV combined with ALHX was associated with fibrosis regression[odds ratio(OR)=1.94,p=0.018],and a family history of hepatocellular carcinoma was on the contrary.(OR=0.41,p=0.031).Conclusions:ETV combined with ALHX increased liver fibrosis regression in CHB patients. | Yi-Qi Liu Chi Zhang Jia-Wen Li Li-Hua Cao Zhan-Qing Zhang Wei-Feng Zhao Qing-Hua Shang Da-Zhi Zhang An-Lin Ma Qing Xie Hong-Lian Gui Guo Zhang Ying-Xia Liu Jia Shang Shi-Bin Xie Jun Li Xu-Qing Zhang Zhi-Qiang Zou Yu-Ping Chen Zong Zhang Ming-Xiang Zhang Jun Cheng Fu-Chun Zhang Li-Hua Huang Jia-Bin Li Qing-Hua Meng Hai-Bin Yu Yu-Qiang Mi Yan-Zhong Peng Zhi-Jin Wang Li-Ming Chen Fan-Ping Meng Wan-Hua Ren Lang Bai Yi-Lan Zeng Rong Fan Xian-Zhi Lou Wei-Feng Liang Hui Liu Hui Zhuang Hong Zhao Gui-Qiang Wang | 2023 | Journal of Clinical and Translational Hepatology2023,11,2: | 7 |
| 11 | Design,Synthesis and in vitro Evaluation of a New Class of Novel Cyclooxygenase-2 Inhibitors:3,4-diaryl-3-pyrrolin-2-ones显示文摘design, synthesis and in vivo evaluation of a new class of COX-2 inhibitors 3, 4-diaryl-3-pyrrolin-2-ones are reported. | Ai Ping BAI, Zong Ru GUO*, Wen Hui HU, Fang SHEN, Gui Fang CHENG Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050 | 2001 | Chinese Chemical Letters2001,12,9: | 7 |
| 12 | GC/MS Analysis of Organic Compounds in Hot Water-Extractable Fraction from Shenfu Coal显示文摘Shenfu Coal was extracted with hot pure water and slurry was isolated. The concentrated benzene-soluble fraction (CBSF) was analyzed with GC/MS and four types of organic compounds (OCs) were detected: HACOCs,DTEs,DMDT and LCAs. The amount of benzyl benzoate which is the most abundant OC was calculated by an inter-nal standard method with an indicated amount of BP. The broken hydrogen bonds and ether bonds were responsible for the extraction of OCs from the coal .DTEs,DMDT and LCAs are essentially insoluble in water,whereas they are soluble,probably owing to intermolecular interaction of OCs with HACOCs. | LI Bao-min YUAN Cheng ZONG Zhi-min CAO Jing-pei LIU Guang-feng WEI Xian-yong | 2007 | Journal of China University of Mining and Technology2007,17,3: | 7 |
| 13 | Blockade of HCN2 Channels Provides Neuroprotection Against Ischemic Injury via Accelerating Autophagic Degradation in Hippocampal Neurons显示文摘In the central nervous system,hyperpolarizationactivated cyclic nucleotide-gated(HCN)channels are essential to maintain normal neuronal function.Recent studies have shown that HCN channels may be involved in the pathological process of ischemic brain injury,but the mechanisms remain unclear.Autophagy is activated in cerebral ischemia,but its role in cell death/survival remains controversial.In this study,our results showed that the HCN channel blocker ZD7288 remarkably decreased the percentage of apoptotic neurons and corrected the excessive autophagy induced by oxygen-glucose deprivation followed by reperfusion(OGD/R)in hippocampal HT22 neurons.Furthermore,in the OGD/R group,p-mTOR,p-ULK1(Ser757),and p62 were significantly decreased,while p-ULK1(Ser317),atg5,and beclin1 were remarkably increased.ZD7288 did not change the expression of p-ULK1(Ser757),ULK1(Ser317),p62,Beclin1,and atg5,which are involved in regulating autophagosome formation.Besides,we found that OGD/R induced a significant increase in Cathepsin D expression,but not LAMP-1.Treatment with ZD7288 at 10μmol/L in the OGD/R group did not change the expression of cathepsin D and LAMP-1.However,chloroquine(CQ),which decreases autophagosome-lysosome fusion,eliminated the correction of excessive autophagy and neuroprotection by ZD7288.Besides,shRNA knockdown of HCN2 channels significantly reduced the accumulation of LC3-Ⅱand increased neuron survival in the OGD/R and transient global cerebral ischemia(TGCI)models,and CQ also eliminated the effects of HCN2-shRNA.Furthermore,we found that the percentage of LC3-positive puncta that co-localized with LAMP-1-positive lysosomes decreased in Con-shRNAtransfected HT22 neurons exposed to OGD/R or CQ.In HCN2-shRNA-transfected HT22 neurons,the percentage of LC3-positive puncta that co-localized with LAMP-1-positive lysosomes increased under OGD/R;however,the percentage was significantly decreased by the addition of CQ to HCN2-shRNA-transfected HT22 neurons.The present results demonstrated that blockade of HCN2 channels provides neuroprotection against OGD/R and TGCI by accelerating autophagic degradation attributable to the promotion of autophagosome and lysosome fusion. | Cheng Chen Li Liu Ya-Qiao Shu Ping Jing Yun Lu Xiao-Xue Zhang Xian-Gang Zong Lian-Jun Guo Chang-Jun Li | 2020 | Neuroscience Bulletin2020,36,8: | 6 |
| 14 | Effect of specimen thickness on Mode Ⅱ fracture toughness of rock显示文摘Anti symmetric four point bending specimens with different thickness, without and with guiding grooves, were used to conduct Mode Ⅱ fracture test and study the effect of specimen thickness on Mode Ⅱ fracture toughness of rock. Numerical calculations show that the occurrence of Mode Ⅱ fracture in the specimens without guiding grooves (when the inner and outer loading points are moved close to the notch plane) and with guiding grooves is attributed to a favorable stress condition created for Mode Ⅱ fracture, i.e. tensile stress at the notch tip is depressed to be lower than the tensile strength or to be compressive stress, and the ratio of shear stress to tensile stress at notch tip is very high. The measured value of Mode Ⅱ fracture toughness K ⅡC decreases with the increase of the specimen thickness or the net thickness of specimen. This is because a thick specimen promotes a plane strain state and thus results in a relatively small fracture toughness. | RAO Qiu hua 1,SUN Zong qi 1,WANG Gui yao 2,XU Ji cheng 3,ZHANG Jing yi 3 (1.College of Resources, Environment and Civil Engineering, Central South University, Changsha 410083, China 2.River and Sea Department, Changsha Communications Univer | 2001 | Journal of Central South University of Technology2001,8,2: | 5 |
| 15 | Multiple-SO3H functioned ionic liquid as efficient curing agent for phthalonitrile-terminated poly(phthalazinone ether nitrile)显示文摘Combined with the advantages of low melting point,high thermal stability and strong acidity,a multipleSO_3H functioned ionic liquid(MIL) was developed successfully as a curing agent to promote the curing reaction of phthalonitrile-terminated poly(phthalazinone ether nitrile)(PPEN-Ph).The curing kinetics over differential scanning calorimetry(DSC) showed that both the initial curing temperature T_(p0') and apparent activation energy Ea'(based on Kissinger equation) were reduced significantly over MIL(207.9℃ and 101.5 kJ/mol) compared to the common curing agent ZnCl_2(268.5℃ and 201.5 kJ/mol).Moreover,under identical curing conditions,the resulting thermosetting resin over former(T_(d5%)=526.1℃) showed better thermal stability than that over latter(T_(d5%)=512.1 ℃).These results indicated that MIL should be a good candidate as a curing agent for phthalonitrile resins. | Zhi-Huan Weng Yu Qi Li-Shuai Zong Cheng Liu Jin-Yan Wang Xi-Gao Jian | 2017 | Chinese Chemical Letters2017,28,5: | 4 |
| 16 | A composite material model for investigation of micro-fracture mechanism of brittle rock subjected to uniaxial compression显示文摘A two phase model of rock was proposed in order to investigate the mechanism of brittle fracture due to uniaxial compression, in which rock was considered to be a composite material consisting of hard grains and colloids. The stress state in colloid region near grains was calculated using Finite Element Method (FEM). The influence of the tensile stresses on the crack initiation and failure process of brittle rock subjected to uniaxial compression was investigated by numerical experiments. The FE results show that tensile stresses are induced easily in the neighboring area of hard grains with the maximum value near grain boundaries. The distribution of tensile stresses depends on the relative position of hard grains. The cracks initiated just near the boundary area of hard grains, which was governed by tensile stress. These results clearly reveal the micro fracture mechanism of brittle rock loaded by uniaxial compression. It can be concluded that the failure mode of brittle rock under uniaxial compression is still tensile fracture from the point view of microstructure. However, since the wide colloid region is still under compressive stress state, further propagation of boundary cracks through this region obviously needs more external load, thus causing the uniaxial compressive strength of rock much higher than its tensile strength obtained via Brazilian (splitting) | CHEN Feng,SUN Zong qi,XU Ji cheng,ZHANG Jing yi (Key Laboratory of Nonferrous Metal Materials Science & Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001,8,4: | 4 |
| 17 | Synthesis of a New Series of Bone Affinity Compounds显示文摘A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapative (HA) affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay. | Ying WANG Hong CHEN Zong Ming WAN Mao Sheng CHENG Xue Chao WANG Guo Liang CONG Sheng JING Zi Ping YAN Bo WU | 2006 | Chinese Chemical Letters2006,17,3: | 3 |
| 18 | High performance of a unique mesoporous polystyrene-based adsorbent for blood purification显示文摘A multi-functional polystyrene based adsorbent(NKU-9)with a unique mesoporous and a high surface area was prepared by suspension polymerization for removal of therapeutic toxins in blood purification.The adsorbent produced had an almost equal amount of mesopore distribution in the range from 2 to 50 nm.The adsorption of serum toxins with different molecular weights were examined by in vitro adsorption assays and compared with some clinical currently used adsorbents such as HA-330,Cytosorb and BL-300 which are produced by China,America and Japan,respectively.Test results indicated that the adsorption rate for pentobarbital by NKU-9 was 81.24%which is nearly as high as HA-330(81.44%).The latter adsorbent is currently used for acute detoxification treatment in China.To reach adsorption equilibrium,NKU-9 was faster than HA-330,which implies short treatment time.For the removal of middle molecular toxins such as b2-microglobulin(98.88%),NKU-9 performed better adsorptive selectivity than Cytosorb(92.80%).In addition,NKU-9 showed high performance for the removal of albumin-bound toxins(e.g.,bilirubin),and its adsorption rate for total bilirubin(80.79%)in plasma was 8.4%higher than that of anion exchange resin BL-300 which is currently used to eliminate bilirubin in clinic.Therefore,our results indicate that the newly developed adsorbent with a wide distribution and almost equal amount of mesopores is a multifunctional adsorbent for high efficient removal of serum toxins with different molecular weights which might be an excellent blood purification adsorbent especially to treat diseases that conventional medical methods are low or not efficient. | Jian Chen Wenyan Han Jie Chen Wenhui Zong Weichao Wang Yue Wang Guanghui Cheng Chunran Li Lailiang Ou Yaoting Yu | 2017 | Regenerative Biomaterials2017,4,1: | 3 |
| 19 | YTHDF1 promotes NLRP3 translation to induce intestinal epithelial cell inflammatory injury during endotoxic shock显示文摘Dear editor,Endotoxic shock usually results from infection-induced physiologic, pathologic, and biologic abnormalities(Singer et al., 2016). Undeniably, it is still a profoundly damaging and life-threatening condition for many individuals(Guan et al., 2019;Ding et al., 2021). Studies have shown that it is associated with the accumulation of apoptotic markers(Kayagaki et al., 2015;Zong et al., 2019). | Xin Zong Xiao Xiao Fu Jie Yuanzhi Cheng Mingliang Jin Yulong Yin Yizhen Wang | 2021 | Science China(Life Sciences)2021,64,11: | 3 |
| 20 | Serosurvey of Avian metapneumovirus, Orithobacterium rhinotracheale, and Chlamydia psittaci and Their Potential Association with Avian Airsacculitis显示文摘Seasonal outbreaks of airsacculitis in China's poultry cause great economic losses annually.This study tried to unveil the potential role of Avian metapneumovirus(AMPV),Ornithobacterium rhinotracheale(ORT) and Chlamydia psittaci(CPS) in avian airsacculitis.A serological investigation of 673 breeder chickens and a case-controlled study of 430 birds were undertaken.Results showed that infection with AMPV,ORT,and CPS was highly associated with the disease.The correlation between AMPV and CPS were positively robust in both layers and broilers.Finally,we determined the co-infection with AMPV,ORT,and CPS was prevalent in the sampled poultry farms suffering from respiratory diseases and the outbreak of airsacculitis was closely related to simultaneous exposure to all three agents. | ZUO Zong Hui ZHANG Tian Yuan GUO Yong Xia CHU Jun QU Guang Gang MIAO Li Zhong SHEN Zhi Qiang HE Cheng | 2018 | Biomedical and Environmental Sciences2018,31,5: | 3 |