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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | A multicenter retrospective cohort study of ketogenic diet therapy in 481 children with infantile spasms显示文摘Background:Ketogenic diet(KD)therapy is one of the main treatments for drug-resistant epilepsy.However,the KD therapy has been applied in only a small number of infantile spasm cases.In this large multicenter study,we investigated the efficacy of KD therapy in the treatment of infantile spasms.Methods:In this retrospective,multicenter cohort study,clinical data from main epilepsy centers were analyzed.Patients were classified into different groups according to age,type of drug and whether glucocorticoid was used before initiation of KD.Results:From October 2014 to March 2020,481 patients(308 males and 173 females)with infantile spasms were treated with the KD therapy.The age of the patients ranged from 2 months to 20 years,with a mean age of 1 year and 10 months.The number of anti-seizure medications(ASMs)used before KD initiation ranged 0-6,with a median of 3.In different time from initiation(1,3,6,and 12 months),the rates of seizure freedom after KD were 6.9,11.6;16.0 and 16.8%,respectively(x^(2)=27.1772,P<0.0001).There was a significant difference in the rate of seizure freedom between 3 months and 1 month(x^(2)=6.5498,P=0.0105)groups,and 6 months and 3 months(x^(2)=3.8478,P=0.0498)groups,but not between 12 months and 6 months(x^(2)=0.1212,P=0.7278)groups.The rates of effectiveness were 44.7;62.8,49.1 and 32.0%(x^(2)=93.2674,P<0.0001),respectively.The retention rates were 94.0,82.5,55.7 and 33.1%(x^(2)=483.7551,P<0.0001),correspondingly.The rate of effectiveness and the retention rate of KD were significantly different among the 1,3,6 and 12 months.KD treatment was the first choice in 25 patients(5.2%),55 patients(11.4%)started KD after the failure of the first ASM,158 patients(32.8%)started KD after the failure of the second ASM,157 patients(32.6%)started KD after the failure of the third drug,and 86 patients(17.9%)started KD after the failure of the fourth and more.The KD effect was not related to the number of ASMs used before KD startup(P>0.05).Two hundred and eighteen patients(45.3%)failed to respond to corticotropin or glucocorticoid before initiation.There was no significant difference in the effectiveness rate at different time points between the group of KD therapy after glucocorticoid failure and the group after non-hormone failure (x^(2)=0.8613,P=0.8348).The rate of adverse events of KD in 1,3,6,and 12 months after KD initiation were 22.3,21.7,16.8 and 6.9%,respectively.The adverse events mainly occurred during the first 3 months of KD,and the main adverse events were gastrointestinal disturbance and constipation.Conclusions:The efficacy of the KD treatment for infantile spasms was not affected by age,medication,and glucocorticoid use before initiation.KD is one of the effective treatments for infantile spasms. | Yuanzhen Ye Dan Sun Hua Li Jianmin Zhong Rong Luo Baomin Li Dengna Zhu Dan Li Shaoping Huang Yuwu Jiang Nong Xiao Yucai Chen Yuqin Zhang Mei Yu Xiaoyun Shen Li Gao Guo Zheng Congmin Zhao Baoqiang Yuan Jianxiang Liao Jiong Qin CAAE KD group | 2022 | Acta Epileptologica2022，5，1： | 2 |
| 3 | JASMIN: a parallel software infrastructure for scientific computing显示文摘 | Zeyao Mo Aiqing Zhang Xiaolin Cao Qingkai Liu Xiaowen Xu Hengbin An Wenbing Pei Shaoping Zhu | 2010 | Frontiers of Computer Science in China2010，，4： | 2 |
| 4 | Genetic and physical localization of an anthracnose resistance gene in Medicago truncatula显示文摘 | Shengming Yang Muqiang Gao Shweta Deshpande Shaoping Lin Bruce A. Roe Hongyan Zhu | 2007 | Theoretical and Applied Genetics2007，，1： | 1 |
| 5 | Formation of collagen-glycosaminoglycan blended nanofibrous scaffolds and their biological properties显示文摘 | Zhong Shaoping Teo WE Zhu Xiao | 2005 | Biomacromolecules2005，6，： | 1 |
| 6 | 高阶谱与二阶循环谱在信道盲辨识与盲均衡中的性能比较(英文)显示文摘重点研究了高阶谱和二阶循环谱及其在信道盲辨识与盲均衡中的应用 ,对基于最小二乘和快速傅立叶变换的算法进行了比较 ,得出了一些重要结论 :高阶谱算法具有较强的抗高斯噪声性能 ,但其收敛速度慢 ;二阶循环谱算法具有收敛速度快和所需数据量小的优点 ,但其收敛残余误差大。 | 陈少平 朱翠涛 Chen Shaoping Zhu Cuitao | 2003 | 中南民族大学学报(自然科学版)2003，22，1： | 1 |
| 7 | Combating Web spam through trustdistrust propagation with confidence显示文摘 | Liu Xinyue Wang You Zhu Shaoping | 2013 | Pattern Recognition Letters2013，34，13： | 1 |
| 8 | Analysis of electromagnetic pulses generation from laser coupling with polymer targets: Effect of metal content in target显示文摘Powerful lasers interacting with solid targets can generate intense electromagnetic pulses(EMPs).In this study,EMPs produced by a pulsed laser(1 ps,100 J)shooting at CH targets doped with different titanium(Ti)contents at the XG-III laser facility are measured and analyzed.The results demonstrate that the intensity of EMPs first increases with Ti doping content from 1%to 7%and then decreases.The electron spectra show that EMP emission is closely related to the hot electrons ejected from the target surface,which is confirmed by an analysis based on the target–holder–ground equivalent antenna model.The conclusions of this study provide a new approach to achieve tunable EMP radiation by adjusting the metal content of solid targets,and will also help in understanding the mechanism ofEMPgeneration and ejection of hot electrons during laser coupling with targets. | Yadong Xia Feng Zhang Hongbo Cai Weimin Zhou Chao Tian Bo Zhang Dongxiao Liu Tao Yi Yilin Xu Feng Wang Tingshuai Li Shaoping Zhu | 2020 | Matter and Radiation at Extremes2020，5，1： | 1 |
| 9 | Effects of mode coupling between low-mode radiation flux asymmetry and intermediate-mode ablator roughness on ignition capsule implosions显示文摘The low-mode shell asymmetry and high-mode hot spot mixing appear to be the main reasons for the performance degradation of the National Ignition Facility(NIF)implosion experiments.The effects of the mode coupling between low-mode P2 radiation flux asymmetry and intermediate-mode L=24 capsule roughness on the implosion performance of ignition capsule are investigated by two-dimensional radiation hydrodynamic simulations.It is shown that the amplitudes of new modes generated by the mode coupling are in good agreement with the second-order mode coupling equation during the acceleration phase.The later flow field not only shows large areal density P2 asymmetry in the main fuel,but also generates large-amplitude spikes and bubbles.In the deceleration phase,the increasing mode coupling generates more new modes,and the perturbation spectrum on the hot spot boundary is mainly from the strong mode interactions rather than the initial perturbation conditions.The combination of the low-mode and high-mode perturbations breaks up the capsule shell,resulting in a significant reduction of the hot spot temperature and implosion performance. | Jianfa Gu Zhensheng Dai Shiyang Zou Wenhua Ye Wudi Zheng Peijun Gu Shaoping Zhu | 2017 | Matter and Radiation at Extremes2017，2，1： | 1 |
| 10 | Formation of Collagen Glycosaminoglyean Blended Nanofibrous Scaffolds and Their Biological Properties显示文摘 | Shaoping Zhong Wee Eong Teo Xiao Zhu | 2005 | Biomacromotecules2005，6，： | 1 |
| 11 | Generation of reac-tive species in cyanobacteria and green algae induced by al-lelochemicals of submerged macrophytes显示文摘 | Jing Wang Junying Zhu Shaoping Liu | 2011 | Chemosphere2011，8，85： | 1 |
| 12 | Steam gasification of biomass for hydrogen-rich gas in a free-fall reactor显示文摘 | Ligang Wei Shaoping Xu Li Zhang Changhou Liu Hui Zhu Shuqin Liu | 2006 | International Journal of Hydrogen Energy2006，，1： | 1 |
| 13 | JASMIN: a parallel software infrastructure for scientific computing显示文摘 | Zeyao Mo Aiqing Zhang Xiaolin Cao Qingkai Liu Xiaowen Xu Hengbin An Wenbing Pei Shaoping Zhu | 2010 | Frontiers of Computer Science in China2010，，4： | 1 |
| 14 | ICI and ISI analysis and mitigation for OFDM systems with insufficient cyclic prefix in time-varying channels显示文摘 | Chen Shaoping Zhu Cuitao | 2004 | IEEE Transactions on Consumer Electronics2004，50，1： | 1 |
| 15 | Generation of reactive oxygen species in cyanobacteria and green algae induced by al- lelochemicals of submerged maerophytes显示文摘 | Jiang Wang Junying Zhu Shaoping Liu | 2011 | Chemospere2011，85，6： | 1 |
| 16 | Diverse foraging strategies of breeding Swinhoe's Storm-petrel in the productive marginal sea of the Northwest Pacific显示文摘Understanding the foraging behavior is essential for investigating seabird ecology and conservation,as well as monitoring the well-being of the marine environment.Breeding seabirds adopt diverse foraging strategies to maximize energy gains and cope with the intensified challenges of parenting and self-maintenance.Such tradeoff may stem from the heterogeneity of food resources and the constraints of central place foraging.Nevertheless,abundant marine productivity could alleviate the energy limitation for seabirds,resulting in a consistent foraging approach.Here,we investigated the foraging strategy during the breeding season of a cryptic small-sized seabird,Swinhoe’s Storm-petrel(Hydrobates monorhis),in the Yellow Sea,a productive marginal sea of the Northwest Pacific.Using GPS tracking,we evaluated habitat preference,quantified the foraging strategy,and tested if environmental conditions and individual traits influence foraging trips.We found that Swinhoe’s Storm-petrels preferred nearshore areas with shallow water and engaged in primarily short foraging trips.Distinctive southeastward and southwestward strategies emerged when combining trip metrics,including foraging direction,duration,and maximum distance.The bathymetry,proximity to the coastline,and sea surface temperature differed in two foraging strategies.Foraging strategies exhibited flexibility between individuals,potentially explained by wing morphology,in which longer-winged birds are more likely to embark on longer-distance foraging trips.These findings highlight the impact of environmental factors and individual traits on seabirds’foraging decisions in productive marginal sea ecosystems.Our study also provides valuable insights into the foraging ecology of this Asian endemic storm-petrel. | Yachang Cheng Lei Zhu Lin Xue Shisheng Ma Nan Jia Shaoping Zang Zhihai Cao Jing Yuan Yang Liu | 2024 | Avian Research2024，15，1： | 0 |
| 17 | Current-Induced Magnetic Switching in an L1_(0) FePt Single Layer with Large Perpendicular Anisotropy Through Spin–Orbit Torque显示文摘In this study,current-induced partial magnetization-based switching was realized through the spin–orbit torque(SOT)in single-layer L1_(0) FePt with a perpendicular anisotropy(K_(u⊥))of 1.19×10^(7) erg·cm^(-3)(1 erg·cm^(-3)=0.1 J·m^(-3)),and its corresponding SOT efficiency(βDL)was 8×10^(-6) Oe·(A·cm^(-2))^(-1)(1 Oe=79.57747 A·m^(-1)),which is several times higher than that of the traditional Ta/CoFeB/MgO structure reported in past work.The SOT in the FePt films originated from the structural inversion asymmetry in the FePt films since the dislocations and defects were inhomogeneously distributed within the samples.Furthermore,the FePt grown on MgO with a granular structure had a larger effective SOT field and effi-ciency than that grown on SrTiO_(3)(STO)with a continuous structure.The SOT efficiency was found to be considerably dependent on not only the sputtering temperature-induced chemical ordering but also the lattice mismatch-induced evolution of the microstructure.Our findings can provide a useful means of efficiently electrically controlling a magnetic bit that is highly thermally stable via SOT. | Kaifeng Dong Chao Sun Laizhe Zhu Yiyi Jiao Ying Tao Xin Hu Ruofan Li Shuai Zhang Zhe Guo Shijiang Luo Xiaofei Yang Shaoping Li Long You | 2022 | Engineering2022，8，5： | 0 |
| 18 | Kinetic study of transverse electron-scale interface instability in relativistic shear flows显示文摘Interfacial magnetic field structures induced by transverse electron-scale shear instability(mushroom instability)are found to be strongly associated with electron and ion dynamics,which in turn will influence the development of the instability itself.We find that high-frequency electron oscillations are excited normal to the shear interface.Also,on a larger time scale,the bulk of the ions are gradually separated under the influence of local magnetic fields,eventually reaching an equilibrium related to the initial shear conditions.Wepresent a theoretical model of this behavior.Such separation on the scale of the electron skin depth will prevent different ions from mixing and will thereafter restrain the growth of higher-order instabilities.We also analyze the role of electron thermal motion in the generation of the magnetic field,and we find an increase in the instability growth rate with increasing plasma temperature.These results have potential for providing a more realistic description of relativistic plasma flows. | Peilin Yao Hongbo Cai Xinxin Yan Wenshuai Zhang Bao Du Jianmin Tian Enhao Zhang Xuewu Wang Shaoping Zhu | 2020 | Matter and Radiation at Extremes2020，5，5： | 0 |
| 19 | Commissioning experiment of the high-contrast SILEX-Ⅱ multi-petawatt laser facility显示文摘The results of a commissioning experiment on the SILEX-Ⅱlaser facility(formerly known as CAEP-PW)are reported.SILEX-Ⅱis a complete optical parametric chirped-pulse amplification laser facility.The peak power reached about 1 PWin a 30 fs pulse duration during the experiment.The laser contrast was better than 1010 at 20 ps ahead of the main pulse.In the basic laser foil target interaction,a set of experimental data were collected,including spatially resolved x-ray emission,the image of the coherent transition radiation,the harmonic spectra in the direction of reflection,the energy spectra and beam profile of accelerated protons,hot-electron spectra,and transmitted laser energy fraction and spatial distribution.The experimental results show that the laser intensity reached 531020 W/cm^(2) within a 5.8μm focus(FWHM).Significant laser transmission did not occur when the thickness of theCHfoil was equal to or greater than 50 nm.The maximum energy of the accelerated protons in the target normal direction was roughly unchanged when the target thickness varied between 50 nm and 15μm.The maximum proton energy via the target normal sheath field acceleration mechanism was about 21 MeV.We expect the on-target laser intensity to reach 10^(22) W/cm^(2) in the near future,after optimization of the laser focus and upgrade of the laser power to 3 PW. | Wei Hong Shukai He Jian Teng Zhigang Deng Zhimeng Zhang Feng Lu Bo Zhang Bin Zhu Zenghai Dai Bo Cui Yuchi Wu Dongxiao Liu Wei Qi Jinlong Jiao Faqiang Zhang Zuhua Yang Feng Zhang Bi Bi Xiaoming Zeng Kainan Zhou Yanlei Zuo Xiaojun Huang Na Xie Yi Guo Jingqin Su Dan Han Ying Mao Leifeng Cao Weimin Zhou Yuqiu Gu Feng Jing Baohan Zhang Hongbo Cai Minqing He Wudi Zheng Shaoping Zhu Wenjun Ma Dahui Wang Yinren Shou Xueqing Yan Bin Qiao Yi Zhang Congling Zhong Xiaohui Yuan and Wenqing Wei | 2021 | Matter and Radiation at Extremes2021，6，6： | 0 |
| 20 | Kinetic simulation study of one dimensional collisional bounded plasma显示文摘A self-consistent kinetic simulation study of one dimensional collisional bounded plasma is presented. The formation of stable sheath potential is investigated.It is found that mass ratio of electron and ion not only affects the level of sheath potential, but also affects the ion temperature of system. It is clarified that the effects of secondary emission electron on both the total potential drop and the temperature are not important. | ZHU Shaoping (Institute of Applied Physics and Computational Mathematics, Beijing 100088) | 1999 | Nuclear Science and Techniques1999，10，3： | 0 |
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