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| 1 | Spatial-temporal Pattern and Differences of Land Use Changes in the Three Gorges Reservoir Area of China during 1975-2005显示文摘Regional land use changes are an important part of global changes.The research on land use changes in the Three Gorges Reservoir Area of China attracts a lot of attention owing to the Three Gorges Dam building.The Three Gorges Reservoir Area becomes one of the important research areas.This study analyzed the transforming processes and traits of each land use type and the regional differences of land use changes during the past 30 years,summarized the distribution of different land use types in different buffer zones and regresses the equation areas and different buffer distances based on buffer analyses and regression analyses,and then analyzed the transforming rules in different buffer distances,got the optimal influence distances.The research results indicate that,(1) cultivated land lies at the northwest of the reservoir and was decreasing,however,the construction land was increasing,especially the urban construction land,a large number of land was flooded because of the reservoir water level rise;(2) urban area was sprawling quickly in developed and neighboring areas,and a great deal of cultivated land and a considerable amount of grassland were occupied;in the earlier time,rural settlements occupied lots of cultivated land and a sum of forestry land in the later time;(3) the optimum influenced distances for cultivated land and forestry land were 10-35 km,and for urban and rural settlements were in 5-20 km.Overall,this research can reflect the spatial-temporal characteristics of land use changes during the 30 years,and it is helpful for urban planning and land use planning in the reservoir area. | CAO Yingui ZHOU Weit WANG Jing YUAN Chun | 2011 | Journal of Mountain Science2011，8，4： | 9 |
| 2 | Coupled GIMP and CPDI material point method in modelling blast-induced three-dimensional rock fracture显示文摘Three-dimensional rock fracture induced by blasting is a highly complex problem and has received considerable attention in geotechnical engineering.The material point method is firstly applied to treat this challenging task.Some inherent weaknesses can be overcome by coupling the generalized interpolation material point(GIMP)and the convected particle domain interpolation technique(CPDI).For the media in the borehole,unchanged GIMP-type particles are used to guarantee a homogenous blast pressure.CPDITetrahedron type particles are employed to avoid the fake numerical fracture near the borehole for the rock material.A blasting experiment using three-dimensional single-borehole rock was simulated to examine the applicability of the coupled model under realistic loading and boundary conditions.A good agreement was achieved between the simulation and experimental results.Moreover,the mechanism of three-dimensional rock fracture was analyzed.It was concluded that rock particle size and material parameters play an important role in rock damage.The reflected tensile waves cause severe damage in the lower part of the model.Rayleigh waves occur on the top face of the rock model to induce a hoop failure band. | Duanying Wan Meng Wang Zheming Zhu Fei Wang Lei Zhou Ruifeng Liu Weiting Gao Yun Shu Hu Xiao | 2022 | International Journal of Mining Science and Technology2022，32，5： | 2 |
| 3 | An innovative model for the transient response of a spherical thin-shell transducer and an experimental confirmation显示文摘 | Lin Fa Xin Zhou YuXiao Fa YanDong Zhang JinPeng Mou Meng Liang MaoMao Wang Qi Zhang PengFei Ding WeiTing Feng Hong Yang MeiShan Zhao | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 1 |
| 4 | Thermal effects on fracture toughness of cracked straight-through Brazilian disk green sandstone and granite显示文摘Cracked straight-through Brazilian disc(CSTBD) samples prepared using two rock materials were used for thermal treatment from room temperature to 700℃. Uniaxial splitting experiments were performed using an automatic electro-hydraulic servo press to study the evolution laws of physical and fracture properties of different deep rock materials under high-temperature geological conditions. The fracture characteristics were measured using an industrial camera and digital image correlation technology to analyze the effect of high temperature on fracture properties and failure modes of the CSTBD samples after different thermal treatments. The micro-damage properties of green sandstone and granite materials were obtained using a scanning electron microscope(SEM). The following conclusions were drawn from the test results:(1) With the increasing temperature, the fracture characteristics of green sandstone and granite change from brittle fracture to plasticity fracture, the longitudinal wave velocity of granite decreases sharply at 600℃, and the damage factor reaches 0.8748 at 700℃.(2) The fracture toughness of green sandstone and granite decreases with increasing temperature;however, the decreasing range of granite is larger than that of green sandstone.(3) As the temperature increases, the fracture morphologies of green sandstone and granite materials become rougher, whereas thermal damage cracks of granite and intergranular fractures inside sandstone as well as pores of sandstone increase.(4) The crack tip opening displacement and peak strain corresponding to peak load increase with the temperature. | Lei Zhou Weiting Gao Liyuan Yu Zheming Zhu Jianxing Chen Xingkai Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 1 |
| 5 | ReLFA:Resist Link Flooding Attacks via Renyi Entropy and Deep Reinforcement Learning in SDN-IoT显示文摘Link flooding attack(LFA)is a fresh distributed denial of service attack(DDoS).Attackers can cut off the critical links,making the services in the target area unavailable.LFA manipulates legal lowspeed flow to flood critical links,so traditional technologies are difficult to resist such attack.Meanwhile,LFA is also one of the most important threats to Internet of things(IoT)devices.The introduction of software defined network(SDN)effectively solves the security problem of the IoT.Aiming at the LFA in the software defined Internet of things(SDN-IoT),this paper proposes a new LFA mitigation scheme ReLFA.Renyi entropy is to locate the congested link in the data plane in our scheme,and determines the target links according to the alarm threshold.When LFA is detected on the target links,the control plane uses the method based on deep reinforcement learning(DRL)to carry out traffic engineering.Simulation results show that ReLFA can effectively alleviate the impact of LFA in SDN IoT.In addition,the rerouting time of ReLFA is superior to other latest schemes. | Jiushuang Wang Ying Liu Weiting Zhang Xincheng Yan Na Zhou Zhihong Jiang | 2022 | China Communications2022，19，7： | 1 |
| 6 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
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