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| 1 | Grey-matter volume as a potential feature for the classification of Alzheimer's disease and mild cognitive impairment: an exploratory study显示文摘Specific patterns of brain atrophy may be helpful in the diagnosis of Alzheimer's disease(AD). In the present study, we set out to evaluate the utility of grey-matter volume in the classification of AD and amnestic mild cognitive impairment(aMCI) compared to normal control(NC) individuals. Voxel-based morphometric analyses were performed on structural MRIs from 35 AD patients, 27 aMCI patients, and 27 NC participants. A two-sample two-tailed t-test was computed between the NC and AD groups to create a map of abnormal grey matter in AD. The brain areas with significant differences were extracted as regions of interest(ROIs), and the grey-matter volumes in the ROIs of the aMCI patients were included to evaluate the patterns of change across different disease severities. Next, correlation analyses between the grey-matter volumes in the ROIs and all clinical variables were performed in aMCI and AD patients to determine whether they varied with disease progression. The results revealed significantly decreased grey matter in the bilateral hippocampus/parahippocampus, the bilateral superior/middle temporal gyri, and the right precuneus in AD patients.The grey-matter volumes were positively correlated with clinical variables. Finally, we performed exploratory linear discriminative analyses to assess the classifying capacity of grey-matter volumes in the bilateral hippocampus and parahippocampus among AD, aMCI, and NC. Leave-one-out crossvalidation analyses demonstrated that grey-matter volumes in hippocampus and parahippocampus accurately distinguished AD from NC. These findings indicate that grey-matter volumes are useful in the classification of AD. | Yane Guo Zengqiang Zhang Bo Zhou Pan Wang Hongxiang Yao Minshao Yuan Ningyu An Haitao Dai Luning Wang Xi Zhang Yong Liu | 2014 | Neuroscience Bulletin2014，30，3： | 7 |
| 2 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 3 | Optimized design and experiment of the three-arm transplanting mechanism for rice potted seedlings显示文摘The transplanting arm of two-arm transplanting mechanism is easy to cause seedlings injury and missing due to its faster speed relative to the seedlings.In order to solve the existed problems,a three-arm transplanting mechanism for rice potted seedlings was developed in this study.The developed three-arm transplanting mechanism for rice potted seedling can make the transplanting arm realize special trajectory and attitude through the unequal planetary gear transmission.The kinematic model of three-arm transplanting mechanism for rice potted seedling was established,and the optimal design software was developed.Based on the heuristic optimization algorithm named“parameter guide”,a set of satisfied mechanism parameters required by the rice potted seedling transplanting were obtained.The trajectory and attitude of three-arm transplanting mechanism used for the rice potted seedling were analyzed.Besides,the virtual simulation results were basically consistent with the optimization software results,and the correctness of theoretical analysis and virtual simulation were also verified by each other.When the developed transplanting mechanism picked up the seedling,the velocity of transplanting arm relative to the seedling was reduced by about 30%.The results showed that the injury rate of rice potted seedling transplanting mechanism was 0.04%,the missing rate of seedling was 1.4%,the integrity rate of seedling pot matrix was 96%,and the success rate of picking seedling was 99.92%. | Jianjun Yin Zeliang Wang Maile Zhou Luning Wu Yan Zhang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，5： | 3 |
| 4 | Angular distribution of terahertz emission from laser interactions with solid targets显示文摘Intense femtosecond laser-plasma interactions can produce high power terahertz radiations.In our experiment,the polished copper target was irradiated by a p-polarized laser with intensity of more than 1018 W/cm2 at an incident angle of 67.5 from the target normal.The THz energy from three dierent detection angles is measured.The maximum emission is found in the direction at an angle of 45 to the laser backward direction,which is more than one order of magnitude higher than in the other two directions.A simple theoretical model has been established to explain the measurements. | DU Fei LI Chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi GE XuLei LI YuTong MA JingLong LIU XiaoLong ZHANG Lu SHENG ZhengMing CHEN LiMing LU Xin DONG QuanLi WANG ZhaoHua WEI ZhiYi ZHANG Jie | 2012 | Science China(Information Sciences)2012，55，1： | 2 |
| 5 | Use of angiotensin-converting enzyme inhibitors and angiotensin Ⅱ receptor blockers in context of COVID-19 outbreak:a retrospective analysis显示文摘The possible effects of angiotensin-converting enzyme inhibitors(ACEIs)or angiotensin Ⅱ receptor blockers(ARBs)on COVID-19 disease severity have generated considerable debate.We performed a single-center,retrospective analysis of hospitalized adult COVID-19 patients in Wuhan,China,who had definite clinical outcome(dead or discharged)by February 15,2020.Patients on anti-hypertensive treatment with or without ACEI/ARB were compared on their clinical characteristics and outcomes.The medical records from 702 patients were screened.Among the 101 patients with a history of hypertension and taking at least one anti-hypertensive medication,40 patients were receiving ACEI/ARB as part of their regimen,and 61 patients were on antihypertensive medication other than ACEI/ARB.We observed no statistically significant differences in percentages of in-hospital mortality(28%vs.34%,P=0.46),ICU admission(20%vs.28%,P=0.37)or invasive mechanical ventilation(18%vs.26%,P=0.31)between patients with or without ACEI/ARB treatment.Further multivariable adjustment of age and gender did not provide evidence for a significant association between ACEI/ARB treatment and severe COVID-19 outcomes.Our findings confirm the lack of an association between chronic receipt of reninangiotensin system antagonists and severe outcomes of COVID-19.Patients should continue previous antihypertensive therapy until further evidence is available. | Jiuyang Xu Chaolin Huang Guohui Fan Zhibo Liu Lianhan Shang Fei Zhou Yeming Wang Jiapei Yu Luning Yang Ke Xie Zhisheng Huang Lixue Huang Xiaoying Gu Hui Li Yi Zhang Yimin Wang Frederick G.Hayden Peter W.Horby Bin Cao Chen Wang | 2020 | Frontiers of Medicine2020，14，5： | 2 |
| 6 | Impaired Functional Connectivity of the Thalamus in Alzheimer’ s Disease and Mild Cognitive Impairment: A Resting-State fMRI Study显示文摘 | Bo Zhou Yong Liu Zengqiang Zhang Ningyu An Hongxiang Yao Pan Wang Luning Wang Xi Zhang Tianzi Jiang | 2013 | Current Alzheimer Research2013，，7： | 1 |
| 7 | Polarization of terahertz emission out of incident plane from laser interactions with solid targets显示文摘A powerful terahertz(THz) pulse was produced by a p-polarized,70 fs,800 nm laser interacting with solid targets at an incident angle of 45°.The polarization of the THz emission was measured out of the laser incident plane.The results showed that it was linearly polarized.We established a surface current model to explain this phenomenon,assuming that the transient current moving along the plasma surface was responsible for the generation of the THz emission.The model expectation and the experimental result were in good agreement. | DU Fei LI Chun ZHOU MuLin WANG WeiMin SU LuNing ZHENG Yi LI YuTong MA JingLong SHENG ZhengMing CHEN LiMing LU Xin WANG ZhaoHua WEI ZhiYi ZHANG Jie | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 1 |
| 8 | New Antibacterial Dihydropyrones Induced by Co-Culture of Penicillium crustosum PRB-2 and Penicillium citrinum HDN11-186显示文摘Two new dihydropyrones,rhytismatones C(1)and D(2),and a known compound,penicillenol A1(3),were isolated from the co-culture broth of the deep-sea-derived fungus Penicillium crustosum PRB-2 and Suaeda salsa-derived endophytic fungus Peni-cillium citrinum HDN11-186.Their structures were elucidated through comprehensive analysis of nuclear magnetic resonance(NMR)spectra and mass spectra.The absolute configurations of new compounds were determined by calculating the electronic circular di-chroism(ECD)spectrum.UPLC-MS data showed that compounds 1–3 could only be detected in the media of co-culture,suggesting new biosynthetic pathways were activated in the co-cultured fungi.Compound 1 showed obvious antibacterial activities against Pro-teus sp.MMBC-1002 and Bacillus subtilis MMBC-1004 with minimum inhibitory concentration(MIC)both at 25μmolL^(-1). | YU Guihong ZHOU Luning WU Guangwei LI Dehai | 2024 | Journal of Ocean University of China2024，23，1： | 0 |
| 9 | Measures of bioavailable serum sex hormone levels in aging Chinese by protein chip显示文摘The purpose of this study was to develop a protein chip technique based on receptor binding assays to measure bioavailable serum sex hormone levels (BSSHL). 224 aging healthy Chinese were investigated to get the referenced values of BSSHL for the first time. In the assays recombined sex hormone receptor proteins were jointed to polysaccharide coated slides to make protein chip, and the dose-dependence curves of sex hormone on chip were prepared. The data showed that this method had good precision (CV<16%) and accuracy (Bias<10%), and the sensitivity could reach 1 pmol/L. From the results, BSSHL of men and women declined with aging, but no significant differences were observed. The BSSHL of aging men were higher than those of women. The bioavailable serum androgen level of men was 52―112 pmol/L, women's was 3―70 pmol/L and the whole group was 41.9―81.4 pmol/L. The bioavailable serum estrogen level of men was 0.8―3.0 pmol/L, women's was 1.2―2.5 pmol/L and the whole group was 0.6―2.64 pmol/L. Based on the assays, BSSHL measurement by protein chip can meet the needs of epidemiological studies in terms of speed, accuracy and sample volume required, and was helpful in quantitative assessment of aging people's health. | ZHOU Yong, CHANG Shuying, MENG Xiaoluo, YU Huafeng, WANG Luning, HE Jinggui, ZHANG Baohe, ZHANG Juntian, GENG Meiyu & DU Guanhua Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, China Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China General Hospital of Air Force, PLA, Beijing 100036, China 304 Hospital of PLA, Beijing 100037, China Beijing Tongren Hospital, Beijing 100730, China General Hospital of PLA, Beijing 100853, China | 2006 | Science China(Life Sciences)2006，49，3： | 0 |
| 10 | Synthesis of Metal-Organic Frameworks Derived Composite Nanomaterials and their Properties显示文摘Metal-organic frameworks(MOFs)are a new class of crystalline porous materials with periodic network structures,which are formed by self-assembly between metal ions and bridging organic linkers.Due to high surface areas,large pore volumes,and tunable surface properties,MOFs present promising application in gas storage and separation,drug delivery,heterogeneous catalysis,etc.Recently,MOFs are found to | Qin Kuang Yinyun Lv Wenwen Zhan Yiting Wang Luning Chen Qi Zhou | 2016 | 功能材料信息2016，13，2： | 0 |
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