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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | Heavy metal pollution of soils and vegetables in the midstream and downstream of the Xiangjiang River, Hunan Province显示文摘219 农业土壤和 48 件蔬菜样品的一个总数在湖南省 Xiangjiang 河(Hengyang 长沙节) 从中流并且下游地被收集。累积特征。 | WANG Lixia GUO Zhaohui XIAO Xiyuan CHEN Tongbin LIAO Xiaoyong SONG Jie WU Bin | 2008 | Journal of Geographical Sciences2008，18，3： | 56 |
| 3 | Cancer statistics, 2014显示文摘 | Rebecca Siegel Jiemin Ma Zhaohui Zou Ahmedin Jemal | 2014 | CA A Cancer Journal for Clinicians2014，，1： | 48 |
| 4 | Phytoplankton community structure and environmental parameters in aquaculture areas of Daya Bay,South China Sea显示文摘Environmental characteristics and phytoplankton community structure were investigated in two aquaculture areas in Dapeng Cove of Daya Bay,South China Sea,between April 2005 and June 2006.Phytoplankton abundance ranged between 5.0 and 8877.5 cells/mL,with an average of 751.8 cells/mL.The seasonal cycle of phytoplankton were demonstrated by frequent oscillations,with recurrent high abundances from late spring to autumn and a peak stage in late winter.Diatoms were the predominant phytoplankton group,accounting for 93.21%of the total abundance.The next most abundant group was the dinoflagellates,which made up only 1.24%of total abundance. High concentrations of Alexandrium tamarense(Lebour) Balech with a maximum of 603.0 cells/mL were firstly recorded in this area known for high rates of paralytic shellfish poisoning(PSP) contamination.Temperatures and salinities were within the suitable values for the growth of phytoplankton,and were important in phytoplankton seasonal fluctuations.The operation of the Daya Bay Nuclear Power Station(DNPS) exerts influences on the phytoplankton community and resulted in the high abundances of toxic dinoflagellate species during the winter months.Dissolved inorganic nitrogen(DIN) and dissolved silicate(DSi) were suffcient,and rarely limited for the growth of phytoplankton.Dissolved inorganic phosphorus(DIP) was the most necessary element for phytoplankton growth. The enriched environments accelerated the growth of small diatoms,and made for the shift in predominant species from large diatom Rhizosolenia spp.to chain-forming diatoms such as Skeletonema costatum,Pseudo-nitzschia spp.and Thalassiosira subtilis. | WANG Zhaohui ZHAO Jiangang ZHANG Yujuan CAO Yu | 2009 | Journal of Environmental Sciences2009，21，9： | 44 |
| 5 | Prediction of urban human mobility using large-scale taxi traces and its applications显示文摘这篇论文在一个城市的出租车交通系统调查人的活动性模式。这个工作集中于预言 humanmobility fromdiscovering 模式在从城市的热点的旅客提取数量(PUQ ) 的数字。这份报纸建议改进 ARIMA 基于预言方法在一个热点预报旅客的空间时间的变化。有 4 000 出租车 GPS 的一个大规模 realworld 数据集合的评估跟踪超过一年表演一个预言错误仅仅 5.8% 。我们也探索预言途径的申请帮助司机发现他们的下位旅客。用历史的真实世界的数据的模拟结果证明与我们的指导,驱动程序能减少花的时间,距离旅行,到发现他们的下位旅客在 37.1% 和 6.4% ,分别地。 | Xiaolong LI Gang PAN Zhaohui WU Guande QI Shijian LI Daqing ZHANG Wangsheng ZHANG Zonghui WANG | 2012 | Frontiers of Computer Science2012，6，1： | 45 |
| 6 | The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage显示文摘在应力之上,肿瘤 suppressor p53 的水平显著地被提高,是众所周知的。然而尽管有广泛的研究,包含的内在的机制重要为导致压力的 p53 规定内部播放器仍然不充分被理解。我们人的 lincRNA-RoR (RoR ) 是 p53 的一个强壮的否定管理者的现在的证据。不同于通过 ubiquitin-proteasome 小径引起 p53 降级的 MDM2, RoR 通过和异构的原子 ribonucleoprotein 的直接相互作用压制 p53 翻译我(hnRNP 我) 。重要地,带 hnRNP 的一个 28 底 RoR 序列我有约束力的主题为 p53 压抑必要、足够。我们进一步证明 RoR 禁止调停 p53 的房间周期拘捕和 apoptosis。最后,我们表明 p53 transcriptionally 导致 RoR 表示的一个 RoR-p53 自动调整的反馈环。一起,这些结果建议 RoR-hnRNP I-p53 轴可以组成一个另外的监视网络让房间更好对各种各样的压力作出回应。 | Ali Zhang Nanjiang Zhou Jianguo Huang Qian Liu Koji Fukuda Ding Ma Zhaohui Lu Cunxue Bai Kounosuke Watabe Yin-Yuan Mo | 2013 | Cell Research2013，23，3： | 47 |
| 7 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 8 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 9 | Progress and recent trend in MILD combustion显示文摘Moderate or intense low oxygen dilution(MILD)combustion plays a significant role in the mitigation of combustion-generated pollutants and greenhouse gases whilst meeting thermal efficiency needs.However,due to the lack of the fundamental knowledge on this combustion,there is a misconception that MILD combustion should be established by high preheating of the air,which has limited its application.Our research and development on this combustion has been performed for several years. We have found that the requirements for establishing the MILD combustion are more relaxed than previously.It is also revealed that this combustion of different type,i.e.,non-premixed,partially premixed and fully premixed,can be achieved by firing various fuels(i.e.,gaseous,liquid and solid fuels).It is suggested that the application of the MILD combustion can be expanded significantly.The present review summarizes the progress and recent trend made in the R&D of this combustion and recommends further fundamental studies for improving our knowledge and widening its applications. | LI PengFei MI JianChun DALLY B B WANG FeiFei WANG Lin LIU ZhaoHui CHEN Sheng ZHENG ChuGuang | 2011 | Science China(Technological Sciences)2011，54，2： | 31 |
| 10 | Abrasion characteristic analyses of solid-liquid two-phase centrifugal pump显示文摘Based on the solid-liquid two-phase mixture transportation test, the renormalization group (RNG) k-e turbulent model was utilized to simulate the solid-liquid two-phase turbulent flow in a centrifugal pump. By comparing the simulated and experimental results, inner flow features were revealed to improve the abrasion characteristic of the solid-liquid two-phase centrifugal pump. The influence of the solid phase on centrifugal pump abrasive performance is small when the particle volume fraction is less than 2.5%. The aggregation degree of the solid particles is enhanced as the particle diameter increases from 0.1 to 1 mm; however, the mixture density on the pressure side is reduced when the particle diameter increases to 1 mm for the impact of inertia. The wear on the hub is most severe for the shear stress on this position; it is also the largest. The wear characteristic is affected greatly by the parameters of the solid phase. The wear chracteristic can be optimized by decreasing the blade outlet angle. In the modified design, the blade angle is different, whereas the other geometric dimensions remain the same. The improved pump is simulated to contrast with the original pump. The results show that the values of mixture density and shear stress both decrease. The wear condition of the blade is improved to a certain extent. | LI Yi ZHU Zuchao HE Zhaohui HE Weiqiang | 2011 | Journal of Thermal Science2011，20，3： | 23 |
| 11 | Stability of roof structure and its control in steeply inclined coal seams显示文摘To improve the effectiveness of control of surrounding rock and the stability of supports on longwall topcoal caving faces in steeply inclined coal seams, the stability of the roof structure and hydraulic supports was studied with physical simulation and theoretical analysis. The results show that roof strata in the vicinity of the tail gate subside extensively with small cutting height, while roof subsidence near the main gate is relatively assuasive. With increase of the mining space, the caving angle of the roof strata above the main gate increases. The characteristics of the vertical and horizontal displacement of the roof strata demonstrate that caved blocks rotate around the lower hinged point of the roof structure, which may lead to sliding instability. Large dip angle of the coal seam makes sliding instability of the roof structure easier.A three-hinged arch can be easily formed above both the tail and main gates in steeply inclined coal seams. With the growth in the dip angle, subsidence of the arch foot formed above the main gate decreases significantly, which reduces the probability of the roof structure becoming unstable as a result of large deformation, while the potential of the roof structure's sliding instability above the tail gate increases dramatically. | Li Xiaomeng Wang Zhaohui Zhang Jinwang | 2017 | International Journal of Mining Science and Technology2017，27，2： | 21 |
| 12 | Chronic idiopathic thrombocytopenic purpura in adult Chinese patients: a retrospective single centered analysis of 1791 cases显示文摘Background Adult chronic idiopathic thrombocytopenic purpura (ITP) is a common hematologic disease characterized by persistent thrombocytopenia. So far, there were only a few reports on adult Chinese patients with chronic ITP. This study aimed at defining the treatment outcome and prognostic factors for chronic ITP based on a large cohort of Chinese patients followed up for over 25 years at a single center Methods The medical records of 1791 patients aged 14 years or older who were diagnosed as having chronic ITP at our hospital from 1974 to 1999 were retrospectively analyzed Results The female to male ratio was 2∶1, with a median age of 34 years (ranging from 14 to 80 years), median platelet count of 38×10 9/L [range (1-99)×10 9/L], and median follow up of 36 months (range 1-220 months) Steroids were used in 689 patients, among them 209 (30.3%) achieved complete remission (CR) A splenectomy was performed in 124 patients, and response to steriod pre splenectomy was not available in 14 patients The CR rate after a splenectomy was lower in steroid nonresponders (29 of 90, 32.2%) than in those who relapsed after successful steroid treatment (12 of 20, 60.0%) ( P <0 05) In comparison with patients negative for antinuclear antibody (ANA), those who were ANA positive had similar responses to steroids, but a significantly shorter remission period after a splenectomy ( P <0 01) Conclusions Adult Chinese chronic ITP patients can have long term remission after steroid therapy and splenectomies Primary steroid refractoriness is a prognostic factor predicting poor subsequent response to a | LIHong-qiang ZHANGLei ZHAOHui JILin-xiang YANGRen-chi | 2005 | Chinese Medical Journal2005，，1： | 20 |
| 13 | A Review of Seasonal Climate Prediction Research in China显示文摘The ultimate goal of climate research is to produce climate predictions on various time scales. In China, efforts to predict the climate started in the 1930 s. Experimental operational climate forecasts have been performed since the late 1950 s,based on historical analog circulation patterns. However, due to the inherent complexity of climate variability, the forecasts produced at that time were fairly inaccurate. Only from the late 1980 s has seasonal climate prediction experienced substantial progress, when the Tropical Ocean and Global Atmosphere project of the World Climate Research program(WCRP) was launched. This paper, following a brief description of the history of seasonal climate prediction research, provides an overview of these studies in China. Processes and factors associated with the climate variability and predictability are discussed based on the literature published by Chinese scientists. These studies in China mirror aspects of the climate research effort made in other parts of the world over the past several decades, and are particularly associated with monsoon research in East Asia. As the climate warms, climate extremes, their frequency, and intensity are projected to change, with a large possibility that they will increase. Thus, seasonal climate prediction is even more important for China in order to effectively mitigate disasters produced by climate extremes, such as frequent floods, droughts, and the heavy frozen rain events of South China. | WANG Huijun FAN Ke SUN Jianqi LI Shuanglin LIN Zhaohui ZHOU Guangqing CHEN Lijuan LANG Xianmei LI Fang ZHU Yali CHEN Hong ZHENG Fei | 2015 | Advances in Atmospheric Sciences2015，32，2： | 20 |
| 14 | Robust Transcriptional Activation in Plants Using Multiplexed CRISPR-Act2.0 and mTALE-Act Systems显示文摘为内长的基因的柔韧的 transcriptional 激活的用户友好的工具高度在植物被要求。我们以前显示出那由撤销联系 CRISPR 的蛋白质组成的一个 dCas9-VP64 系统(dCas9 ) 9 与四辆双人脚踏车熔化了使活跃之物 VP16 (VP64 ) 能被用于的 transcriptional 的重复在植物的内长的基因的 transcriptional 激活。在这研究,我们在植物为提高的 transcriptional 激活开发了向量系统的第二代。我们为基于 dCas9 的 transcriptional 激活测试了多重策略,并且由 dCas9 和产出的修改指南 RNA 支架 gRNA2.0 (指明的 CRISPR-Act2.0 ) 发现那 VP64 的同时的招募更强壮的 transcriptional 激活比 dCas9-VP64 系统。而且,我们开发了复合抄写为在植物的多达四基因的同时的激活的像使活跃之物的受动器激活(mTALE 行为) 系统。我们的结果建议 mTALE 行为是比在测试的大多数情况中的 CRISPR-Act2.0 甚至更有效的。另外,我们用积极反馈环探索了织物特定的基因激活。有趣地,我们的学习比当由激活探针使不安时,其它可以引起目标基因 silencing 到 transcriptional 激活,和紧调整的基因的表明某些内长的基因是更顺从的。因此,这些新工具能被用来调查基因规章的网络和他们的控制机制。复合 CRISPR-Act2.0 和 mTALE 行为系统的汇编是两个基于优化并且克隆策略的 PCR 独立的金门和网关,它将在 dicots 和 monocots 便于 transcriptional 激活应用程序。 | Levi G. Lowder Jianping Zhou Yingxiao Zhang Aimee Malzahn Zhaohui Zhong Tzung-Fu Hsieh Daniel F. Voytas Yong Zhang Yiping Qi | 2018 | Molecular Plant2018，11，2： | 19 |
| 15 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 16 | Gain-of-function mutant p53 in cancer progression and therapy显示文摘p53 is a key tumor suppressor,and loss of p53 function is frequently a prerequisite for cancer development.The p53 gene is the most frequently mutated gene in human cancers;p53 mutations occur in>50%of all human cancers and in almost every type of human cancers.Most of p53 mutations in cancers are missense mutations,which produce the full-length mutant p53(mutp53)protein with only one amino acid difference from wild-type p53 protein.In addition to loss of the tumor-suppressive function of wild-type p53,many mutp53 proteins acquire new oncogenic activities independently of wild-type p53 to promote cancer progression,termed gain-of-function(GOF).Mutp53 protein often accumulates to very high levels in cancer cells,which is critical for its GOF.Given the high mutation frequency of the p53 gene and the GOF activities of mutp53 in cancer,therapies targeting mutp53 have attracted great interest.Further understanding the mechanisms underlying mutp53 protein accumulation and GOF will help develop effective therapies treating human cancers containing mutp53.In this review,we summarize the recent advances in the studies on mutp53 regulation and GOF as well as therapies targeting mutp53 in human cancers. | Cen Zhang Juan Liu Dandan Xu Tianliang Zhang Wenwei Hu Zhaohui Feng | 2020 | Journal of Molecular Cell Biology2020，12，9： | 18 |
| 17 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 18 | Kinetics and isotherms of Neutral Red adsorption on peanut husk显示文摘Adsorption of Neutral Red (NR) onto peanut husk in aqueous solutions was investigated at 295 K. Experiments were carried out as function of pH, adsorbent dosage, contact time, and initial concentration. The equilibrium adsorption data were analyzed by Langmuir, Freundlich, Temkin, Dubinin-Radushkevich, and Toth isotherm models. The results indicated that the Toth and Langmuir models provided the best correlation of the experimental data. The adsorption capacity of peanut husk for the removal of NR was determined with the Langmuir and found to be 37.5 mg/g at 295 K. The adsorption kinetic data were modeled using the pseudo-first order, pseudo-second order, and intra-particle diffusion kinetic equations. It was seen that the pseudo-first order and pseudo-second order kinetic equations could describe the adsorption kinetics. The intraparticle diffusion model was also used to express the adsorption process at the two-step stage. It was implied that peanut husk may be suitable as adsorbent material for adsorption of NR from aqueous solutions. | Runping HAN Mingsheng TANG | 2008 | Journal of Environmental Sciences2008，20，9： | 16 |
| 19 | Recent Significant Tornadoes in China显示文摘1.Introduction Compared with the United States,whose annual number of tornadoes can exceed 1000,the average number of tornadoes per year in China over the past half a century is estimated to be fewer than 100(Fan and Yu,2015),even though both countries are located in a similar latitudinal zone of the Northern Hemisphere.The annual average recorded number of F1(Fujita scale)or EF1(enhanced Fujita scale)intensity or higher tornadoes in China between 1961 and 2010 is | Ming XUE Kun ZHAO Mingjung WANG Zhaohui LI Yongguang ZHENG | 2016 | Advances in Atmospheric Sciences2016，33，11： | 16 |
| 20 | Intelligent control of mode-locked femtosecond pulses by time-stretch-assisted real-time spectral analysis显示文摘Mode-locked fiber lasers based on nonlinear polarization evolution can generate femtosecond pulses with different pulse widths and rich spectral distributions for versatile applications through polarization tuning.However,a precise and repeatable location of a specific pulsation regime is extremely challenging.Here,by using fast spectral analysis based on a time-stretched dispersion Fourier transform as the spectral discrimination criterion,along with an intelligent polarization search algorithm,for the first time,we achieved real-time control of the spectral width and shape of mode-locked femtosecond pulses;the spectral width can be tuned from 10 to 40 nm with a resolution of ~1.47 nm,and the spectral shape can be programmed to be hyperbolic secant or triangular.Furthermore,we reveal the complex,repeatable transition dynamics of the spectrum broadening of femtosecond pulses,including five middle phases,which provides deep insight into ultrashort pulse formation that cannot be observed with traditional mode-locked lasers. | Guoqing Pu Lilin Yi Li Zhang Chao Luo Zhaohui Li Weisheng Hu | 2020 | Light(Science & Applications)2020，9，1： | 16 |
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