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| 1 | Geochronology of Baogutu porphyry copper deposit in Western Junggar area, Xinjiang of China显示文摘Baogutu copper deposit in Western Junggar area is a mesoscopic porphyry deposit found in recent years. Study on its geochronology will help further understand ore genesis and regional ore-forming pattern. A series of small quartz-diorite and granodiorite stocks outcrop at Baogutu area, numbered I―X according to their size. A detailed exploration on Number V stock confirmed it as a mesoscopic scale copper deposit, and various exploration work has been carried out on other stocks with ore-forming evidence. This paper studies geochronology of Number V stock using zircon SHRIMP U-Pb and single mineral K-Ar method. Twenty-five SHRIMP ages yield two 206Pb/238U weighed mean ages of 335.6 ± 7.8 Ma and 311.4 ± 3.3 Ma respectively. The older date is considered to be inherited zircon from either surrounding rock tuff or deep granitoid batholith, whereas the younger date is the formation age of ore-bearing intrusion. K-Ar ages of ore-forming biotites, 296.0 ± 3.7 Ma and 297.3 ± 3.8 Ma, in combination with Re-Os age of molybdenite, 310 Ma, confirm the ore-forming age of 310-296 Ma. Granophyre and dioritic porphyrite dikes cut Number V stock and their K-Ar ages range from 278 to 240 Ma, which confine the lower boundary of the mineralization. The framework of Baogutu ore-forming geochrono-logy can be established based on these data. | LIU YuLin GUO LiShuang LIU YuDe SONG HuiXia SONG Biao ZHANG Rui XU FaJun ZHANG YunXiao | 2009 | Science China Earth Sciences2009，52，10： | 33 |
| 2 | Accumulation of soil organic carbon during natural restoration of desertified grassland in China's Horqin Sandy Land显示文摘China's Horqin Sandy Land,a formerly lush grassland,has experienced extensive desertification that caused considerable carbon(C) losses from the plant-soil system.Natural restoration through grazing exclusion is a widely suggested option to sequester C and to restore degraded land.In a desertified grassland,we investigated the C accumulation in the total and light fractions of the soil organic matter from 2005 to 2013 during natural restoration.To a depth of 20 cm,the light fraction organic carbon(LFOC) storage increased by 221 g C/m2(84%) and the total soil organic carbon(SOC) storage increased by 435 g C/m2(55%).The light fraction dry matter content represented a small proportion of the total soil mass(ranging from 0.74% in 2005 to 1.39% in 2013),but the proportion of total SOC storage accounted for by LFOC was remarkable(ranging from 33% to 40%).The C sequestration averaged 28 g C/(m2·a) for LFOC and 54 g C/(m2·a) for total SOC.The total SOC was strongly and significantly positively linearly related to the light fraction dry matter content and the proportions of fine sand and silt+clay.The light fraction organic matter played a major role in total SOC sequestration.Our results suggest that grazing exclusion can restore desertified grassland and has a high potential for sequestering SOC in the semiarid Horqin Sandy Land. | YuQiang LI XueYong ZHAO FengXia ZHANG Tala AWADA ShaoKun WANG HaLin ZHAO TongHui ZHANG YuLin LI | 2015 | Journal of Arid Land2015，7，3： | 21 |
| 3 | Dynamic compression characteristics of layered rock mass of significant strength changes in adjacent layers显示文摘Layered rock mass of significant strength changes for adjacent layers is frequently observed in underground excavation,and dynamic loading is a prevalent scenario generated during excavation.In order to improve the driving efficiency and reduce engineering accidents,dynamic compression characteristics of this kind of rock mass should be understood.The dynamic properties of a layered composite rock mass are investigated through a series of rock tests and numerical simulations.The rock mass is artificially made of various proportions of sand,cement and water to control the distinct strength variations at various composite layers separated by parallel bedding planes.All rock specimens are prefabricated in a specially designed mould and then cut into 50 mm in diameter and 50 mm in height for split Hopkinson pressure bar(SHPB)dynamic compression testing.The test results reveal that increasing strain rate causes the increases of peak strength,σ_p,and the corresponding failure strain,ε_p,while the dynamic elastic modulus,E_d,remains almost unchanged.Interestingly,under the same strain rates,Ed of the composite rock specimen is found to decline first and then increase as the dip angle of bedding plane increases.The obtained rock failure patterns due to various dip angles lead to failure modes that could be classified into four categories from our dynamic tests.Also,a series of counterpart numerical simulations has been undertaken,showing that dynamic responses are in good agreement with those obtained from the SHPB tests.The numerical analysis enables us to Iook into the dynamic characteristics of the composite rock mass subjected to a broader range of strain rates and dip angles than these being tested. | Sen Wen Chunshun Zhang Yulin Chang Ping Hu | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，2： | 13 |
| 4 | Effects of Friction Heat on the Tribological Properties of the Woven Self-lubricating Liner显示文摘In the dry-sliding process of the woven self-lubricating liner which is used in the self-lubricating spherical plain bearing, the friction heat plays an important role in the tribological performances of the liner. It has important value to study on the relationship between tribological performances of the liner and the friction heat. Unfortunately, up to now, published work on this relationship is quite scarce. Therefore, the effect of friction heat on the tribological performances of the liner was investigated in the present work. The tribological behaviors of the liner were evaluated by using the high temperature end surface wear tester. Scanning electron microscopy (SEM) was utilized to examine the morphologies of worn surfaces of the liner and study the failure modes. Differential scanning calorimetry (DSC) measurement and X-ray diffraction (XRD) analysis were performed to study the behaviors of the wear debris. The temperature rise on the worn surface was calculated according to classical models. SEM observation shows that the dominating wear mechanism for the liner is mainly affected by friction shear force, contact pressure and friction heat. Higher fusion heat for the wear debris than that for the pure polytetrafluroethylene (PTFE) indicates that the PTFE is the main portion of the wear debris, and, the PTFE in the wear debris shows a higher crystallisation degree owing to the effects of friction shear force and the friction heat. Combining the calculated temperature rise results with the wear rate of the liner, it can be concluded that the effects of temperature rise on the tribological performances of the liner become more obvious when the temperature rise exceeds the glass transition temperature (Tg) of the PTFE. The wear resistance of the liner deteriorates dramatically when the temperature rise approaches to the melting point (Ton) of the PTFE. The tribological performances of the liner can be improved when the temperature rise exceeds Tg but is far lower than Ton. The present study on the relationship between the temperature rise and the tribological performances of the liner may provide the basis for further understanding of the wear mechanisms of the liner as well as the relationship between the formation of the PTFE transfer film and the friction heat during the dry-sliding of the liner. | YANG Yulin ZU Dalei ZHANG Ruijun QI Xiaowen | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 12 |
| 5 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 6 | Electron Beam Melted Beta-type Ti–24Nb–4Zr–8Sn Porous Structures With High Strength-to-Modulus Ratio显示文摘Electron beam melting(EBM)has been used to manufactureβ-type Ti–24Nb–4Zr–8Sn porous components with 70%porosity.EBM-produced components have favorable structural features(i.e.smooth strut surfaces,fewer defects)and an(α+β)-type microstructure,similar to that subjected to aging treatment.EBM-produced components exhibit more than twice the strength-to-modulus ratio of porous Ti–6Al–4V components having the same porosity.The processing–microstructure–property relationship and deformation behavior of EBM-produced components are discussed in detail.Such porous titanium components composed of non-toxic elements and having high strength-to-modulus ratio are highly attractive for biomedical applications. | Yujing Liu Shujun Li Wentao Hou Shaogang Wang Yulin Hao Rui Yang Timothy B.Sercombe Lai-Chang Zhang | 2016 | Journal of Materials Science & Technology2016，32，6： | 9 |
| 7 | Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration显示文摘The capacity of 3D organoids to mimic physiological tissue organization and functionality has provided an invaluable tool to model development and disease in vitro.However,conventional organoid cultures primarily represent the homeostasis of self-organizing stem cells and their derivatives.Here,we established a novel intestinal organoid culture system composed of 8 components,mainly including VPA,EPZ6438,LDN193189,and R-Spondin 1 conditioned medium,which mimics the gut epithelium regeneration that produces hyperplastic crypts following injury;therefore,these organoids were designated hyperplastic intestinal organoids(Hyper-organoids).Single-cell RNA sequencing identified different regenerative stem cell populations in our Hyper-organoids that shared molecular features with in vivo injury-responsive Lgr5+stem cells or Clu+revival stem cells.Further analysis revealed that VPA and EPZ6438 were indispensable for epigenome reprogramming and regeneration in Hyper-organoids,which functioned through epigenetically regulating YAP signaling.Furthermore,VPA and EPZ6438 synergistically promoted regenerative response in gut upon damage in vivo.In summary,our results demonstrated a new in vitro organoid model to study epithelial regeneration,highlighting the importance of epigenetic reprogramming that pioneers tissue repair. | Molong Qu Liang Xiong Yulin Lyu Xiannian Zhang Jie Shen Jingyang Guan Peiyuan Chai Zhongqing Lin Boyao Nie Cheng Li Jun Xu Hongkui Deng | 2021 | Cell Research2021，31，3： | 9 |
| 8 | Impending HRT wave precursors to the Wenchuan M_s8.0 earthquake and methods of earthquake impending prediction by using HRT wave显示文摘We deployed four geo-electric monitoring stations in Sichuan and Yunnan provinces from 2004, using the new generation of equipment (PS-100) and technologies to capture the HRT wave earthquake precursor. Before the Wenchuan Ms8.0 earthquake, we recorded the HRT wave precursor at the only operating station in Hongge (HG, Δ=465 km) and found that significant impending signal had been recorded at the station in the early morning ( 0―5 am) of 12th of May, 2008. The precursor for this earthquake is consistent with precursors recorded for other strong earthquakes. The measured physical properties (geo-resistivity and telluric-current) show tidal wave period oscillations from several days to several months before the earthquakes and the amplitude of such HT oscillation increases significantly towards the occurrence of an earthquake. These HT and RT waves from the epicenter have a causal relationship with the earthquakes that happened several days later. The arrival time of two RT waves is proportional to the distance from the station to the epicenter. The estimated natural decay of the amplitude is correlated with the natural period (T0) of the earthquake fault, which is proportional to the fault length. From this relationship, we can predict the earthquake magnitude. For magnitude 6―9 earthquakes, the natural period is about 1―6 hours. Such oscillation comes from the epicenter area and they can propagate several thousand kilometers in the Earth's crust. Before a strong earthquake in the shallow crust, the conductive pore fluid will experience major changes before the fault rapture. Such fluid change will emit an oscillation in the pore fluid pressure. This is the mechanism for the HRT wave generation. Since the China Earthquake Administration funded the HRT wave short-term earth-quake prediction project in 2003, the first record of HRT precursor wave has been recorded from the 2004-12-26 Sumatra Mw9.0 earthquake with the largest epicentre distance Δ=2900 km. Thereafter, we have captured HRT waves from more than twenty strong earthquakes, which are well-matched and show repeatability, consistency and regularity. All our observation with the HRT waves demonstrate that HRT wave precursors to earthquakes indeed exist. Strong earthquakes can be predicted and short-term and impending earthquake prediction is achievable in the very near future. From all the observations, including the ones at HG station from Wenchuan Ms8.0 earthquake, we conclude that using HRT wave to predict earthquakes is feasible. | QIAN FuYe ZHAO BiRu QIAN Wei ZHAO Jian HE ShiGen ZHANG HongKui LI ShiYu LI ShaoKun YAN GuLiang WANG ChengMin SUN ZhenKai ZHANG DongNing LU Jun ZHANG Ping YANG GuoJun SUN JiaLin GUO ChunSheng TANG YuXiong XU JianMing XIA KunTao JU Hang YIN BangHong LI Ming YANG DongSheng QI WeiLuo HE TaiMing GUAN HuaPing ZHAO YuLin | 2009 | Science China Earth Sciences2009，52，10： | 8 |
| 9 | Coupled modeling and analysis of radiometer effect and residual gas damping on proof mass in purely gravitational orbit显示文摘Spacecrafts free of all but gravitational forces are important in precision navigation,gravity field measurement and basic scientific research.The Inner-formation Flying System,one kind of spacecrafts free of all but gravitational forces,is used for gravitational field measurement with high precision.Restraining the interfering factors on the inner-satellite is one of the keys to gravitational field measurement.Radiometer effect and residual gas damping are both interfering forces on the inner-satellite caused by gas molecules.By analyzing the mechanism of the two forces,a coupled model for radiometer effect and residual gas damping was established,which contained the coupling term and reflected the actual force of gas molecules on the inner-satellite.The simulation results showed the coupling property of radiometer effect and residual gas damping:The actual force of gas molecules is directly proportional to the average pressure in the cavity and the largest cross-sectional area of the inner-satellite,but is inversely proportional to the square root of the average temperature in the cavity. | LIU HongWei WANG ZhaoKui ZHANG YuLin | 2011 | Science China(Technological Sciences)2011，54，4： | 8 |
| 10 | Ultrasonic vibrations and coal permeability: Laboratory experimental investigations and numerical simulations显示文摘Ultrasonic vibrations in coal lead to cavitation bubble oscillation, growth, shrinkage, and collapse, and the strong vibration of cavitation bubbles not only makes coal pores break and cracks propagate, but plays an important role in enhancing the permeability of coal. In this paper, the influence of ultrasonic cavitation on coal and the effects of the sonic waves on crack generation, propagation, connection, as well as the effect of cracks on the coal permeability, are studied. The experimental results show that cracks in coal are generated even connected rapidly after ultrasonic cavitation. Under the effect of ultrasonic cavitation,the permeability increases between 30% and 60%, and the number of cracks in coal also significantly increased. Numerical experiments show that the effective sound pressure is beneficial to fracture propagation and connection, and it is closely related to the permeability. Moreover, the numerical simulations and physical experiments provide a guide for the coal permeability improvement. | Zhang Junwen Li Yulin | 2017 | International Journal of Mining Science and Technology2017，27，2： | 7 |
| 11 | A framework for equipment systems-of-systems effectiveness evaluation using parallel experiments approach显示文摘Equipment systems-of-systems(So S) effectiveness evaluation can provide important reference for construction and optimization of the equipment So S. After discussing the basic theory and methods of parallel experiments, we depict an So S effectiveness analysis and evaluation method using parallel experiments theory in detail. A case study is carried out which takes the missile defense system as an example. An artificial system of the missile defense system is constructed with the multi-agent modeling method. Then, single factor, multiple factors and defense position deployment computational experiments are carried out and evaluated with the statistical analysis method. Experiment results show that the altitude of the secondary interception missile is not the key factor which affects So S effectiveness and putting the defense position ahead will increase defense effectiveness. The case study demonstrates the feasibility of the proposed method. | Zilong Cheng Li Fan Yulin Zhang | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 7 |
| 12 | Residents’ perspectives and responses to environmental degradation in the upper Dadu River, eastern Tibetan Plateau显示文摘Environmental degeneration in the Tibetan Plateau attracts worldwide attention, whereas case studies on how the residents understand and respond to environmental degeneration are scarce. Using a Participatory Rural Appraisal method, this paper investigates how the people in different regions in the upper Dadu River understand and respond to environmental degeneration, based on comparative field surveys in three villages, in which Danzamu village is chosen from villages in the valley region, Kerma village from mountainside region, Rico village from the mountain and plateau region. The results show that: (1) although awakened to environmental degeneration, the residents in different regions have different responses. As agricultural labors have been transferred to the secondary and tertiary industries, population pressure in Danzamu and Kerma villages is mitigated. Residents in Danzamu village actively respond to natural disasters and forest degradation, as their livelihoods never rely on forests and rangelands again. Whereas the residents in Kerma village negatively respond to natural disasters, forest and meadow degradation and the ruin of wildlife resources, as their livelihoods still rely on stockbreeding. Labors in Rico village are hard to transfer to the secondary and tertiary industries, so they have to raise more livestock to make a living. Active measures are just taken to avoid livestock loss, not to avoid forest and meadow degradation and the ruin of wildlife resources. So the most fragile region is the mountain and plateau region and mountainside region, not the valley region. (2) Livelihood strategy is the key factor affecting the residents to respond to population pressure and environmental degeneration. So the framework of sustainable livelihood strategy should be used to explain and intervene in issues of population pressure and environmental degradation in ecotones. (3) Transferring agricultural labors to the secondary and tertiary industries were favorable to improving people’s livelihood. It is necessary to reduce the education fees to speed up the pace of labors transferring in the mountainside region. In the mountain and plateau region, preferable ways also include the development of towns, highways, education equipment and other establishments. | YAN Jianzhong ZHANG Yili LIU Linshan BAI Wanqi ZHU Huiyi SHI Yulin ZHENG Du | 2006 | Journal of Geographical Sciences2006，16，3： | 7 |
| 13 | Changes in T lymphocyte subsets after severe traumatic brain injury显示文摘BACKGROUND: Besides local changes of cranial parenchymal cells, hemorrhage, etc., severe traumatic brain injuries also cause the changes of total body fluid and various functions, and the changes of lymphocytes and T lymphocyte subsets should be paid more attention to. OBJECTIVE: To reveal the changing laws of T lymphocyte subsets after severe traumatic brain injury, and compare with mild to moderate brain injury. DESIGN: A comparative observation. SETTINGS: Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City; Central Laboratory of Shenzhen Hospital of Prevention and Cure for Chronic Disease. PARTICIPANTS: All the subjects were selected from the Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City from August 2002 to August 2005. Thirty patients with severe brain injury, whose Glasgow coma score (GCS) was ≤ 8 points, were taken as the experimental group, including 21 males and 9 females, aging 16–62 years. Meanwhile, 30 patients with mild traumatic brain injury were taken as the control group (GCS ranged 14–15 points), including 18 males and 12 females, aging 15–58 years. All the subjects were in admission at 6 hours after injury, without disease of major organs before injury. Informed consents were obtained from all the patients or their relatives. METHODS: ① The T lymphocytes and the subsets in peripheral blood were detected with immunofluorescent tricolor flow cytometry at 1, 3, 7 and 14 days after injury in both groups. ② The conditions of pulmonary infections were observed at 4 days after injury. The differences of measurement data were compared with the t test. MAIN OUTCOME MEASURES: Changes of T lymphocytes subsets at 1–14 days after severe and mild or moderate traumatic injury. RESULTS: Finally, 28 and 25 patients with mild to moderate traumatic brain injury, whereas 25 and 21 patients with severe traumatic brain injury were analyzed at 7 and 14 days respectively, and the missed ones died due to the development of disease. ① Changes of T lymphocyte subsets: At 1 and 3 days after injury, CD3, CD4, CD8, CD4/CD8 began to decrease, whereas CD8 increased in the experimental group, which were very significantly different from those in the control group (t =2.77–3.26, P < 0.01), and began to recover at 7 days, which were significantly different from those in the control group (t = 2.06–2.24, P < 0.05), and generally recovered to the normal levels at 14 days (P > 0.05). ② Conditions of pulmonary infections: At 4 days after injury, the rate of pulmonary infection was significantly different between the experimental group and control group [73% (22/30), 0, χ2=37.29, P < 0.01]. CONCLUSION: Patients with severe traumatic brain injury suffer from damages of cellular immune function at early period (within 7 days), and they are easily to be accompanied by pulmonary infections. | Yulu Miao Mingxia Zhang Yulin Nie Wan Zhao Bin Huang Zhengming Jiang Shaoxiong Yu Zhibin Huang Hongjin Fu | 2007 | Neural Regeneration Research2007，2，2： | 7 |
| 14 | A Modified Direct Allocation Algorithm with Application to Redundant Actuators显示文摘控制分配考虑与多重、冗余的致动器为控制系统控制指令分发的问题。这篇论文集中于直接分配方法,与修改 pseudoinverse 再分配方法,单一的方法解决的线性编程方法,和亚坡度优化方法相比使算法的时间要求类似。到构造可到达的时刻的离线的计算致动器设置了的还原剂,当致动器的数字与传统的方法相比是不到 10 时,一条新途径基于控制有效性矩阵的空空间被建议,它是优异的。到联机的减少计算,寻找与需要的时刻被排列的方面的一个改进方法被介绍,弄短由检查仅仅在需要的时刻附近躺着的方面的搜索时间。发现如此的方面,可到达的时刻集合的顶点在离线的计算期间被使正常化并且节省。当致动器的数字是不到 10 时,模拟结果证明至少 32.22% 离线的计算时间将用空基于空间的建设被节省。在联机计算,修改方法与三个上述的方法相比卓越地表现。而且,当冗余的致动器的一个显著大数字被设置时,它可以高效地解决控制分配的问题。 | TANG Shengyong ZHANG Shijie ZHANG Yulin | 2011 | Chinese Journal of Aeronautics2011，24，3： | 6 |
| 15 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 16 | The calcium-dependent protein kinase ZmCDPK7 functions in heat-stress tolerance in maize显示文摘Global warming poses a serious threat to crops.Calcium-dependent protein kinases(CDPKs)/CPKs play vital roles in plant stress responses,but their exact roles in plant thermotolerance remains elusive.Here,we explored the roles of heat-induced ZmCDPK7 in thermotolerance in maize.ZmCDPK7-overexpressing maize plants displayed higher thermotolerance,photosynthetic rates,and antioxidant enzyme activity but lower H2 O2 and malondialdehyde(MDA)contents than wild-type plants under heat stress.ZmCDPK7-knockdown plants displayed the opposite patterns.ZmCDPK7 is attached to the plasma membrane but can translocate to the cytosol under heat stress.ZmCDPK7 interacts with the small heat shock protein sHSP17.4,phosphorylates sHSP17.4 at Ser-44 and the respiratory burst oxidase homolog RBOHB at Ser-99,and up regulates their expression.Site-directed mutagenesis of sHSP17.4 to generate a Ser-44-Ala substitution reduced ZmCDPK7’s enhancement of catalase activity but enhanced ZmCDPK7’s suppression of MDA accumulation in heat-stressed maize protoplasts.sHSP17.4,ZmCDPK7,and RBOHB were less strongly upregulated in response to heat stress in the abscisic acid-deficient mutant vp5 versus the wild type.Pretreatment with an RBOH inhibitor suppressed sHSP17.4 and ZmCDPK7 expression.Therefore,abscisic acid-induced ZmCDPK7 functions both upstream and downstream of RBOH and participates in thermotolerance in maize by mediating the phosphorylation of sHSP17.4,which might be essential for its chaperone function. | Yulong Zhao Hanwei Du Yankai Wang Huali Wang Shaoyu Yang Chaohai Li Ning Chen Hao Yang Yihao Zhang Yulin Zhu Luyao Yang Xiuli Hu | 2021 | Journal of Integrative Plant Biology2021，63，3： | 6 |
| 17 | Periodic Solution and Ergodic Stationary Distribution of Stochastic SIRI Epidemic Systems with Nonlinear Perturbations显示文摘This paper formulates two stochastic nonautonomous SIRI epidemic systems with nonlinear perturbations.The main aim of this study is to investigate stochastic dynamics of the two SIRI epidemic systems and obtain their thresholds.For the nonautonomous stochastic SIRI epidemic system with white noise,the authors provide analytic results regarding the stochastic boundedness,stochastic permanence and persistence in mean.Moreover,the authors prove that the system has at least one nontrivial positive T-periodic solution by using Lyapunov function and Hasminskii’s theory.For the system with Markov conversion,the authors establish sufficient conditions for positive recurrence and existence of ergodic stationary distribution.In addition,sufficient conditions for the extinction of disease are obtained.Finally,numerical simulations are introduced to illustrate the main results. | ZHANG Weiwei MENG Xinzhu DONG Yulin | 2019 | Journal of Systems Science & Complexity2019，32，4： | 6 |
| 18 | miR-27b-3p/MARCH7 regulates invasion and metastasis of endometrial cancer cells through Snail-mediated pathway显示文摘Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7(MARCH7),also known as axotrophin,was originally identified in mouse embryonic stem cells.MARCH7 is involved in T-cell proliferation,neuronal development,and the immune system.However,its role in endometrial cancer(EC)remains unclear.This study aimed to investigate the role of MARCH7 in EC.Quantitative polymerase chain reaction,immunohistochemistry,and western blot analysis were used to examine the expression of MARCH7,E-cadherin,Snail,and Vimentin in EC cell lines or clinical specimens.The role of MARCH7 in maintaining EC cell malignant phenotype was determined by transwell assay and using xenograft tumor model.Dual-luciferase reporter gene assay was performed to determine whether MARCH7 is an authentic target of miR-27b-3p.Our data showed that the expression level of MARCH7 in EC tissues was higher than that in normal endometrium tissues.The level of MARCH7 was positively associated with that of Snail and Vimentin,clinical stage,and histological grade,while negatively associated with that of E-cadherin.Knockdown of MARCH7 inhibited the invasion and metastasis of EC cells in vitro and in vivo.The opposite effect was observed after overexpressing MARCH7.MARCH7 promoted invasion and metastasis of EC cells via the Snail-mediated pathway.Furthermore,MARCH7 was demonstrated to be an authentic target of miR-27b-3p,and miR-27b-3p decreased the stimulus effect induced by MARCH7.These data indicate that MARCH7 may be an oncogenic factor and a therapeutic target for EC.miR-27b-3p/MARCH7 may also regulate EC cell invasion and metastasis via the Snail-mediated pathway. | Ling Liu Jianguo Hu Tinghe Yu Shuang You Yulin Zhang Lina Hu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 6 |
| 19 | Twin structure of the lath martensite in low carbon steel显示文摘It has been well accepted that the martensites in quenched carbon steels exhibit two typical morphologies which are closely dependent on the carbon content, i.e. lath martensite in low carbon steels and lenticular martensite in high carbon steels. Based on conventional belief, the lath martensites in low carbon steels are with high density dislocations as the substructure, in contrast to twin substructure in lenticular high carbon martensite. In the present work, an intensive transmission electron microscopy investigation was made to characterize the microstructures of the lath martensite in a low carbon steel of 0.2 wt%C. It was found that lots of lath martensites consist of twin as their substructure, rather than high density dislocations. In addition, nanoscale precipitates cohering with ferrite matrix were found at the twin interfaces. The orientation relationships between the precipitates and the ferrite matrix are in good agreement with that of primitive hexagonal ω phase in titanium alloys and other bcc metals or alloys. | Pan Zhang Yulin Chen Wenlong Xiao Dehai Ping Xinqing Zhao | 2016 | Progress in Natural Science:Materials International2016，26，2： | 6 |
| 20 | Macrophage-activating lipopeptide-2 downregulates the expression of ATP-binding cassette transporter A1 by activating the TLR2/ NF-KB/ZNF202 pathway in THP-1 macrophages显示文摘 | Liangjie Peng Zizhen Zhang Min Zhang Xiaohua Yu Feng Yao Yulin Tan Dan Liu Duo Gong Huang Chong Xiaoyan Liu Xilong Zheng Guoping Tian Chaoke Tang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，4： | 6 |
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