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| 1 | Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial显示文摘Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in 2010.However,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with mCRC.This observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC patients.Methods:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across China.Eligible patients received different chemotherapeutic regimens combined with bevacizumab.The efficacy and safety data in the intention-to-treat study population were analyzed.Results:A total of 611 patients were included in the efficacy analysis.The median overall survival and median progression-free survival was 18.00 and 10.05 months,respectively.The objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety assessments.And 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher AEs.The incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and safety.Bevacizumab in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acceptable and manageable safety profile. | Fenghua Wang Guanghai Dai Yanhong Deng Yong Tang Wei Wang Zuoxing Niu Feng Bi Liangjun Zhu Zengqing Guo Jin Yan Bing Hu Min Tao Shujun Yang Suzhan Zhang Lu Wen Ruihua Xu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 2 | Immobilization of simulated radio- nuclide 133Cs(+) by fly ash-based genpolymer显示文摘 | Li Oin Sun Zengqing Tao Dejing | 2013 | Journal of h~ardous materials2013，262，： | 1 |
| 3 | ApolynomialtimedecompositionsalgorithmforPetrinetsbasedonindexesoftransitions显示文摘 | ZENGQingtian | 2011 | JournalofInformationTechnology2011，10，4： | 1 |
| 4 | 显示文摘 | Xiong Y Fang J ZengQ H | 2008 | Journal of Membrane Science2008，311，12： | 1 |
| 5 | One way of surface alloying treatment on iron surface based on surface mechanical attrition treatment and heat treatment显示文摘 | Huayun Du Yinghui Wei Wanming Lin Lifeng Hou Zengqing Liu Yanli An Wenfu Yang | 2009 | Applied Surface Science2009，，20： | 1 |
| 6 | A multicentre randomised trial comparing weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>S-1 with weekly paclitaxel<ce:hsp sp='0.25'/>+<ce:hsp sp='0.25'/>5-fluorouracil for patients with advanced gastric cancer显示文摘 | Dingzhi Huang Yi Ba Jianping Xiong Nong Xu Zhao Yan Zhixiang Zhuang Zhuang Yu Huiping Wan Yang Zhang Ting Deng Rongsheng Zheng Zengqing Guo Chunhong Hu Meiling Wang Zhonghe Yu Yang Yao Jichang Meng | 2013 | European Journal of Cancer2013，，： | 1 |
| 7 | Optimal cut-off values of BMI, waist circumference and waist:height ratio for defining obesity in Chinese adults显示文摘 | ZengQ HeY DongS | 2014 | Br J Nutr2014，112，10： | 1 |
| 8 | Coating of SWNTs with nickel by electroless plating method显示文摘 | ZENGQ BAYAZITOGLU Y ZHU J et a1 | 2005 | Mater Sci Forum2005，，： | 1 |
| 9 | Finite-time-convergent differentiator based on singular perturbation technique显示文摘 | Xinhua Wang Zengqing Chen Geng Yang | 2007 | IEEE Transactions on Automatic Control2007，52，9： | 1 |
| 10 | PRL-3 and PRL-1 promote cell migration, invasion, and metastasis显示文摘 | ZENGQ DONG M GUO K | 2003 | Cancer Res2003，63，11： | 1 |
| 11 | Photolumines-cenceandRamanspectroscopystudiesofEu(OH)3rodsathighpressures显示文摘 | ZengQ - DingZJ ZhangZ M etal | 2010 | JPhysChem C2010，114，11： | 1 |
| 12 | An ANN-based classification approach using decomposed input space for transient stability assessment 显示文摘 | TSOSK GUXP ZENGQ Y etal | 1998 | Electric Power System Research1998，46，3： | 1 |
| 13 | MeasurementsofGlacierVariationinthe Tibetan Plateau Using Landsat Data显示文摘 | LiZ Sun W ZengQ | 1998 | RemoteSensingofEnvironment1998，63，3： | 1 |
| 14 | Regulation of cellgrowth by estrogen signaling and potential targets in thy-roid cancer显示文摘 | Chen G G VlantisA C ZengQ | 2008 | Curr Cancer Drug Targets2008，8，5： | 1 |
| 15 | Residue substitution enhances the immunogenicity of neoepitopes from gastric cancers显示文摘Objective:Neoantigens arising from gene mutations in tumors can induce specific immune responses,and neoantigen-based immunotherapies have been tested in clinical trials.Here,we characterized the efficacy of altered neoepitopes in improving immunogenicity against gastric cancer.Methods:Raw data of whole-exome sequencing derived from a patient with gastric cancer were analyzed using bioinformatics methods to identify neoepitopes.Neoepitopes were modified by P1Y(the first amino acid was replaced by tyrosine)and P2L(the second amino acid was replaced by leucine).T2 binding and stability assays were used to detect the affinities between the neoepitopes and the HLA molecules,as well as the stabilities of complexes.Dendritic cells(DCs)presented with neoepitopes stimulated naïve CD8+T cells to induce specific cytotoxic T lymphocytes.ELISA and carboxyfluorescein succinimidyl ester were used to detect IFN-γand TNF-αlevels,and T cell proliferation.Perforin was detected by flow cytometry.The cytotoxicity of T cells was determined using the lactate dehydrogenase assay.Results:Bioinformatics analysis,T2 binding,and stability assays indicated that residue substitution increased the affinity between neoepitopes and HLA molecules,as well as the stabilities of complexes.DCs presented with altered neoepitopes stimulated CD8+T cells to release more IFN-γand had a greater effect on promoting proliferation than wild-type neoepitopes.CD8+T cells stimulated with altered neoepitopes killed more wild-type neoepitope-pulsed T2 cells than those stimulated with wild-type neoepitopes,by secreting more IFN-γ,TNF-α,and perforin.Conclusions:Altered neoepitopes exhibited greater immunogenicity than wild-type neoepitopes.Residue substitution could be used as a new strategy for immunotherapy to target neoantigens. | Huahui Yu Jieyu Li Yuan Yuan Yu Chen Jingwen Hong Chunmei Ye Wansong Lin Huijing Chen Zengqing Guo Bo Li Yunbin Ye | 2021 | Cancer Biology & Medicine2021，18，4： | 0 |
| 16 | Production and Market of China's Architectural Pottery显示文摘Architectural pottery mainly includes various ceramic wall and floor tile products, and is an important decorative material for both interior and exterior walls and floors. Compared with other decorative materials, ceramic wall and floor tiles have such unique advantages as being fire-proof, ageing-proof, humidity-proof, heat resistant, easy cleaning, corrosion-resistant against acid and alkali, and toxic gas free. Therefore, in the fierce competition among so many wall and floor decorative materials, they have maintained a leading position for years. | Wu Zengqing Zhonglun Ceramic General Company,State Administration of Building Materials | 1997 | China's Foreign Trade1997，，1： | 0 |
| 17 | Recent Progress of the Active Materials with Various Micro‑structures for Flexible Textile‑Based Supercapacitors显示文摘Flexible textile-based supercapacitors have exhibited great potential for use in e-textile systems due to their high flexibility,light weight and ease of integration into the textile materials.The capacitance and energy density of current textile-based supercapacitors,however,are insufficient to meet the high demands of wearable electronics and smart textiles.This review summarizes the recent progress of enhancement methods regarding textile-based supercapacitors,including the multidimen-sional nanostructure of active materials,the structural designs of textile substrates and the wearable softness.Furthermore,the remaining challenges and future prospects of constructing high-performance flexible textile-based supercapacitors for smart textiles and wearable electronics are also proposed. | Ming Li Zengqing Li Lijun Qu Fuxing Chen Mingwei Tian | 2022 | Advanced Fiber Materials2022，4，5： | 0 |
| 18 | Ensemble learning system to identify nutritional risk and malnutrition in cancer patients without weight loss information显示文摘Dear Editor,Malnutrition is a prevalent disease in oncology practice(Arends et al.,2017).With its cancer-specific prevalence ranging from 21%–72%,malnutrition is responsible for 10%–20% cancer deaths(Yin et al.,2021b).However,malnutrition is often underestimated,misclassified,or left untreated in cancer care(Hébuterne et al.,2014). | Liangyu Yin Jie Liu Ming Liu Jin Zheng Aiguo Xu Quanjun Lyu Yongdong Feng Zengqing Guo Hu Ma Jipeng Li Zhikang Chen Hui Wang Zengning Li Chunling Zhou Xi Gao Min Weng Qinghua Yao Wei Li Tao Li Hanping Shi Hongxia Xu | 2023 | Science China(Life Sciences)2023，66，5： | 0 |
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