|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Case-based learning in education of Traditional Chinese Medicine: a systematic review显示文摘OBJECTIVE:To assess the effect of case-based learning(CBL)in the education of Traditional Chinese Medicine(TCM).METHODS:The studies concerning TCM courses designed with CBL were included by searching the databases of EBSCO,Pubmed,Science Citation Index,China National Knowledge Infrastructure,Chongqing VIP database.The valid data was extracted in accordance with the included criteria.The quality of the studies was assessed with Gemma Flores-Masteo.RESULTS:A total of 22 articles were retrieved that met the selection criteria:one was of high quality;two were of low quality;the rest were categorized as moderate quality.The majority of the studiesdemonstrated the better effect produced by CBL,while a few studies showed no difference,compared with the didactic format.All included studies confirmed the favorable effect on learners'attitude,skills and ability.CONCLUSION:CBL showed the desirable results in achieving the goal of learning.Compared to didactic approach,it played a more active role in promoting students'competency.Since the quality of the articles on which the study was based was not so high,the findings still need further research to become substantiated. | Ji Chen Ying Li Yong Tang Fang Zeng Xi Wu Fanrong Liang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 30 |
| 2 | The distribution rule and seepage effect of the fractures in the ultra-low permeability sandstone reservoir in east Gansu Province,Ordos Basin显示文摘To study the impact of the fractures on development in the ultra-low permeability sandstone reservoir of the Yangchang Formation of the Upper Triassic in the Ordos Basin,data on outcrops,cores,slices,well logging and experiments are utilized to analyze the cause of the formation of the fractures,their distribution rules and the control factors and discuss the seepage flow effect of the fractures. In the studied area developed chiefly high-angle tectonic fractures and horizontal bedding fractures,inter-granular fractures and grain boundary fractures as well. Grain boundary fractures and intragranular fractures serve as vital channels linking intragranular pores and intergranular solution pores in the reservoir matrix,thus providing a good connectivity between the pores in the ultra-low perme-ability sandstone reservoir. The formation of fractures and their distribution are influenced by such external and internal factors as the palaeo-tectonic stress field,the reservoir lithological character,the thickness of the rock layer and the anisotropy of a layer. The present-day stress field influences the preservative state of fractures and their seepage flow effect. Under the tec-tonic effect of both the Yanshan and Himalayan periods,in this region four sets of fractures are distributed,respectively assuming the NE-SW,NW-SE,nearly E-W and nearly S-N orientations,but,due to the effect of the rock anisotropy of the rock formation,in some part of it two groups of nearly orthogonal fractures are chiefly distributed. Under the effect of the present-day stress field,the fractures that assume the NE-SW direction have a good connectivity,big apertures,a high permeability and a minimum starting pressure,all of which are main advantages of the seepage fractures in this region. With the development of oilfields,the permeability of the fractures of dif-ferent directions will have a dynamic change. | ZENG LianBo1,GAO ChunYu2,QI JiaFu1,WANG YongKang2,LI Liang2 & QU XueFeng2 1 State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 2 Changqing Oilfield Branch,PetroChina,Xi’an 163517,China | 2008 | Science China Earth Sciences2008，51，S2： | 22 |
| 3 | Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-γ显示文摘AIM: To examine the role of Fibrinogen-like protein 2 (fgl2)/fibroleukin in tumor development. Fgl2 has been reported to play a vital role in the pathogenesis in MHV-3 (mouse hepatitis virus) induced fulminant and severe hepatitis,spontaneous abortion,allo-and xeno-graft rejection by mediating 'immune coagulation'. METHODS: Tumor tissues from 133 patients with six types of distinct cancers and the animal tumor tissues from human hepatocellular carcinoma (HCC) model on nude mice (established from high metastasis HCC cell line MHCC97LM6) were obtained. RESULTS: Hfgl2 was detected in tumor tissues from 127 out of 133 patients as well as tumor tissues collected from human HCC nude mice. Hfgl2 was highly expressed both in cancer cells and interstitial inflammatory cells including macrophages,NK cells,and CD8+ T lymphocytes and vascular endothelial cells. Hfgl2 mRNA was localized in cells that expressed hfgl2 protein. Fibrin (nogen) co-localization with hfgl2 expression was determined by dual immunohistochemical staining. In vitro,IL-2 and IFN-γ increased hfgl2 mRNA by 10-100 folds and protein expression in both THP-1 and HUVEC cell lines. One-stage clotting assays demonstrated that THP-1 and HUVEC cells expressing hfgl2 had increased procoagulant activity following cytokines stimulation. CONCLUSION: The hfg12 contributes to the hypercoagulability in cancer and may induce tumor angiogenesis and metastasis via cytokine induction. | Kai Su Fang Chen Wei-Ming Yan Qi-Li Zeng Li Xu Dong Xi Bin Pi Xiao-Ping Luo Qin Ning | 2008 | World Journal of Gastroenterology2008，14，39： | 20 |
| 4 | Climate change, water resources and sustainable development in the arid and semi-arid lands of Central Asia in the past 30 years显示文摘The countries of Central Asia are collectively known as the five '-stans': Uzbekistan, Kyrgyzstan, Turkmenistan, Tajikistan and Kazakhstan. In recent times, the Central Asian region has been affected by the shrinkage of the Aral Sea, widespread desertification, soil salinization, biodiversity loss, frequent sand storms, and many other ecological disasters. This paper is a review article based upon the collection, identification and collation of previous studies of environmental changes and regional developments in Central Asia in the past 30 years. Most recent studies have reached a consensus that the temperature rise in Central Asia is occurring faster than the global average. This warming trend will not only result in a higher evaporation in the basin oases, but also to a significant retreat of glaciers in the mountainous areas. Water is the key to sustainable development in the arid and semi-arid regions in Central Asia. The uneven distribution, over consumption, and pollution of water resources in Central Asia have caused severe water supply problems, which have been affecting regional harmony and development for the past 30 years. The widespread and significant land use changes in the 1990 s could be used to improve our understanding of natural variability and human interaction in the region. There has been a positive trend of trans-border cooperation among the Central Asian countries in recent years. International attention has grown and research projects have been initiated to provide water and ecosystem protection in Central Asia. However, the agreements that have been reached might not be able to deliver practical action in time to prevent severe ecological disasters. Water management should be based on hydrographic borders and ministries should be able to make timely decisions without political intervention. Fully integrated management of water resources, land use and industrial development is essential in Central Asia. The ecological crisis should provide sufficient motivation to reach a consensus on unified water management throughout the region. | YU Yang PI Yuanyue YU Xiang TA Zhijie SUN Lingxiao Markus DISSE ZENG Fanjiang LI Yaoming CHEN Xi YU Ruide | 2019 | Journal of Arid Land2019，11，1： | 20 |
| 5 | Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients显示文摘BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening test.However, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still unknown.AIM To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC patients.METHODS A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-Meier univariate analysis.RESULTSIn Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.CONCLUSION MSEPT9 analysis may add valuable information to current tumor staging. Serum m SEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. | Xue Yang Zhi-Jie Xu Xi Chen Shuang-Shuang Zeng Long Qian Jie Wei Mei Peng Xiang Wang Wan-Li Liu Hong-Ying Ma Zhi-Cheng Gong Yuan-Liang Yan | 2019 | World Journal of Gastroenterology2019，25，17： | 16 |
| 6 | Cross-Layer Adaptive Resource Allocation Algorithm with Diverse QoS Requirements for Single-Cell OFDMA Systems显示文摘The orthogonal frequency division multiple access( OFDMA) based communication system has been considered as the main trend of next-Generation communication system. But the existing resource allocation algorithm designed for such system is always with high complexity thus hard to be realized. To solve such problem with the constraints of spectrum efficiency and buffer state,a novel cross-layer resource allocation algorithm( RAA) is proposed in this paper. The goal of our RAA is to maximize the system throughput while satisfying several practical constraints,such as fairness among services,head of line( Ho L) delay and diverse quality of service( Qo S) requirements. Due to these constraints,finding the optimal solution becomes a NPhard problem. Therefore in this paper a novel method to solve such problem with acceptable complexity is proposed within following steps: firstly,based on the link state we formulate the ideal subchannel allocation strategy as a convex optimization problem,which can be efficiently solved by our proposed lagrange multiplier technique subchannel allocation( LMTSA) algorithm; secondly,according to the obtained channel allocation matrix,a power allocation algorithm based on the water-filling power allocation( WPA) idea is deployed to get the optimal power allocation matrix combining with adaptive modulation and coding( AMC); finally,through a greedy algorithm,the ultimate subchannel and power allocation matrix can be obtained based on iterative method. The simulation results illustrate that we can achieve the higher throughput and better Qo S performance than the widely-used maximum throughput( MT) algorithm and round robin( RR) algorithm. | Li Zeng Xi Li Hong Ji Ke Wang | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，1： | 14 |
| 7 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 8 | De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome显示文摘 | Yongyi Yuan Jianguo Zhang Qing Chang Jin Zeng Feng Xin Jianjun Wang Qingyan Zhu Jing Wu Jingqiao Lu Weiwei Guo Xukun Yan Hui Jiang Binfei Zhou Qi Li Xue Gao Huijun Yuan Shiming Yang Dongyi Han Zixu Mao Ping Chen Xi Lin Pu Dai | 2014 | Cell Research2014，24，11： | 13 |
| 9 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 10 | Combining sap flow measurement-based canopy stomatal conductance and ^(13)C discrimination to estimate forest carbon assimilation显示文摘The available methods for studying C uptake of forest and their problems in practices are reviewed, and a new approach to combining sap flow and 13C techniques is proposed in this paper. This approach, obtained through strict mathematic derivation, combines sap flow measure-ment-based canopy stomatal conductance and 13C discrimi-nation to estimate instantaneous carbon assimilation rate of a forest. Namely the mean canopy stomatal conductance (gc) acquired from accurate measurement of sap flux density is integrated with the relationship between 13C discrimination (?) and Ci/Ca (intercellular/ambient CO2 concentrations) and with that between Anet (net photosynthetic rate) and gCO2 (stomatal conductance for CO2) so that a new relation be-tween forest C uptake and ? as well as gc is established. It is a new method of such kind for studying the C exchange be-tween forest and atmosphere based on experimental ecology. | ZHAO Ping LU Ping MA Ling SUN Guchou RAO Xingquan CAI Xi'an ZENG Xiaoping | 2005 | Chinese Science Bulletin2005，50，18： | 9 |
| 11 | Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats显示文摘ObjectiveTo 检验外长地管理的 intermedin 的效果( IMD , adrenomedullin-2 )在动脉的血压上,在自发地高血压的老鼠( SHR )象一样的心脏的功能和心血管的 IMD 受体系统星期旧的雄的老鼠在 Wistar 京都( WKY )组被划分调查联系 mechanisms.MethodsThirteen ( n = 12 ), SHR 组( n = 12 ), IMD 组( SHR 每小时与 IMD 1-47 灌输了 500 ng/kg , n = 12 ),并且 ADM 组(与 adrenomedullin 灌输的 SHR 500 ng/kg 每dp/dt 最大 ), 在 SHR 离开了室的收缩压力和心率。而且, IMD 也禁止了心血管的 IMD 受体,心肌的受体修改活动的蛋白质(RAMP1 和 RAMP2 ) ,大动脉的 RAMP1, RAMP2, RAMP3,和 calcitonin 的蛋白质在表示上像受体的受体(CRLR ) ;大动脉的 RAMP1, RAMP2, RAMP3 和 CRLR 基因表示的压制的起来规定;并且显著地提高了 mRNA 许多心肌的 atrial natriuretic 肽(ANP ) 和心肌的大脑 natriuretic 肽(BNP ) 。另外,在 SHR 的 IMD 1-47 管理增加了大动脉的营地集中和减少的心肌的营地 concentration.ConclusionThese 调查结果支持作为心血管的活跃的肽, IMD 在高血压期间涉及血压减小和心脏的功能改善的推测。位于这效果下面的机制可以包含形成由的受体建筑群有约束力的 IMD 斜面和 CRLR,和营地层次和另外的心血管的活跃因素的结果的规定,例如 ANP 和 BNP。 | Ying Yuan Xi Wang Qiang Zeng Hong-Mei Wu Yong-Fen Qi Chao-Shu Tang | 2012 | Journal of Geriatric Cardiology2012，9，1： | 9 |
| 12 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 13 | Underwater image quality enhancement of sea cucumbers based on improved histogram equalization and wavelet transform显示文摘Sea cucumbers usually live in an environment where lighting and visibility are generally not controllable,which cause the underwater image of sea cucumbers to be distorted,blurred,and severely attenuated.Therefore,the valuable information from such an image cannot be fully extracted for further processing.To solve the problems mentioned above and improve the quality of the underwater images of sea cucumbers,pre-processing of a sea cucumber image is attracting increasing interest.This paper presents a newmethod based on contrast limited adaptive histogram equalization and wavelet transform(CLAHE-WT)to enhance the sea cucumber image quality.CLAHE was used to process the underwater image for increasing contrast based on the Rayleigh distribution,and WTwas used for de-noising based on a soft threshold.Qualitative analysis indicated that the proposed method exhibited better performance in enhancing the quality and retaining the image details.For quantitative analysis,the test with 120 underwater images showed that for the proposed method,the mean square error(MSE),peak signal to noise ratio(PSNR),and entropy were 49.2098,13.3909,and 6.6815,respectively.The proposed method outperformed three established methods in enhancing the visual quality of sea cucumber underwater gray image. | Xi Qiao Jianhua Bao Hang Zhang Lihua Zeng Daoliang Li | 2017 | Information Processing in Agriculture2017，4，3： | 9 |
| 14 | Reaction decoupling in thermochemical fuel conversion and technical progress based on decoupling using fluidized bed显示文摘Thermochemical conversion of fuels via pyrolysis/carbonization,cracking,gasification and combustion has to involve a number of individual reactions called attribution reactions to form an intercorrelated reaction network for any conversion process.By separating one or some attribution reactions from the others to decouple their interactions existing in the reaction network,the so-called reaction decoupling enables a better understanding of the complex thermal conversion process and further the optimization of the conditions for attribution reactions as well as the entire conversion process to realize advanced performances.The dual bed conversion and two-stage conversion are the two representative types of fuel conversion technologies developed in recent years based on reaction decoupling.Many technical advantages have been proven for such decoupling fuel conversion technologies,such as poly-generation of products,low-cost production of high-grade products,elimination of undesirable products or pollutants,easy operation and control,and so on.The treated fuels with decoupling conversion technologies mainly include solid biomass and coal,as well as liquid petroleum oil.This paper is devoted to reiteration of the reaction decoupling concept and further to reviewing the research,developments and successful applications of several decoupling fuel conversion technologies of two such types by using fluidized bed as their major reactors. | Zhennan Han Sulong Geng Xi Zeng Shipei Xu a Ping An Jiguang Cheng Jun Yang Feng Li Suyi Zhang Miao Liu Guoqing Guan Guangwen Xu | 2018 | Carbon Resources Conversion2018，1，2： | 8 |
| 15 | Risk Factors and Pregnancy Outcomes: Complete versus Incomplete Placenta Previa in Mid-pregnancy显示文摘 | Yun FENG Xue-yin LI Juan XIAO Wei LI Jing LIU Xue ZENG Xi CHEN Kai-yue CHEN Lei FAN Qing-ling KANG Su-hua CHEN | 2018 | Current Medical Science2018，38，4： | 8 |
| 16 | Microvesicles(MIVs)secreted from adipose-derived stem cells(ADSCs)contain multiple microRNAs and promote the migration and invasion of endothelial cells显示文摘Extracellular vesicles(EVs)such as microvesicles(MIVs)play an important role in intercellular communications.MIVs are small membrane vesicles sized 100e1000 nm in diameter that are released by many types of cells,such as mesenchymal stem cells(MSCs),tumor cells and adipose-derived stem cells(ADSC).As EVs can carry out autocrine and paracrine functions by controlling multiple cell processes,it is conceivable that EVs can be used as delivery vehicles for treating several clinical conditions,such as to improve cardiac angiogenesis after myocardial infarction(MI).Here,we seek to investigate whether ADSC-derived MIVs contain microRNAs that regulate angiogenesis and affect cell migration of endothelial cells.We first characterized the ADSC-derived MIVs and found that the MIVs had a size range of 100 e300 nm,and expressed the MIV marker protein Alix.We then analyzed the microRNAs in ADSCs and ADSC-derived MIVs and demonstrated that ADSC-derived MIVs selectively released a panel of microRNAs,several of which were related to angiogenesis,including two members of the let-7 family.Furthermore,we demonstrated that ADSC-derived MIVs promoted the cell migration and invasion of the HUVEC endothelial cells.The PKH26-labeled ADSC-derived MIVs were effectively uptaken into the cytoplasm of HUVEC cells.Collectively,our results demonstrate that the ADSC-derived MIVs can promote migration and invasion abilities of endothelial cells,suggesting pro-angiogenetic potential.Future studies should focus on investigating the roles and mechanisms through which ADSC-derived MIVs regulate angiogenesis. | Bo Huang Lin-Feng Huang Ling Zhao Zongyue Zeng Xi Wang Daigui Cao Lijuan Yang Zhenyu Ye Xian Chen Bin Liu Tong-Chuan He Xiaozhong Wang | 2020 | Genes & Diseases2020，7，2： | 8 |
| 17 | Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer显示文摘AIM:To explore the association between AT-rich interactive domain 1A(ARID1A)protein loss by immunohistochemistry and both clinicopathologic characteristics and prognosis in patients with colorectal cancer.METHODS:We retrospectively collected clinicopathologic data and archived paraffin-embedded primary colorectal cancer samples from 209 patients,including 111patients with colon cancer and 98 patients with rectal cancer.The tumor stage ranged from stageⅠto stageⅣaccording to the 7th edition of the American Joint Committee on Cancer tumor-node-metastasis(TNM)staging system.All patients underwent resection of primary colorectal tumors.The expression of ARID1A protein in primary colorectal cancer tissues was examined by immunohistochemical staining.The clinicopathologic association and survival relevance of ARID1A protein loss in colorectal cancer were analyzed.RESULTS:ARID1A loss by immunohistochemistry was not rare in primary colorectal cancer tumors(25.8%).There were 7.4%,24.1%,22.2%and 46.3%of patients with ARID1A loss staged at TNM stageⅠ,Ⅱ,ⅢandⅣ,respectively,compared with 20.0%,22.6%,27.7%and 29.7%of patients without ARID1A loss staged at TNM stageⅠ,Ⅱ,ⅢandⅣ,respectively.In patients with ARID1A loss,the distant metastasis rate was 46.3%.However,only 29.7%of patients without ARID1A loss were found to have distant metastasis.In terms of pathologic differentiation,there were 25.9%,66.7%and 7.4%with poorly,moderately and well differentiated tumors in patients with ARID1A loss,and 14.2%,72.3%and 13.5%with poorly,moderately and well differentiated tumors in patients without ARID1A loss,respectively.ARID1A loss was associated with late TNM stage(P=0.020),distant metastasis(P=0.026),and poor pathological classification(P=0.035).However,patients with positive ARID1A had worse overall survival compared to those with negative ARID1A in stageⅣcolorectal cancer(HR=2.49,95%CI:1.13-5.51).CONCLUSION:ARID1A protein loss is associated with clinicopathologic characteristics in colorectal cancer patients and with survival in stageⅣpatients. | Xiao-Li Wei De-Shen Wang Shao-Yan Xi Wen-Jing Wu Dong-Liang Chen Zhao-Lei Zeng Rui-Yu Wang Ya-Xin Huang Ying Jin Feng Wang Miao-Zhen Qiu Hui-Yan Luo Dong-Sheng Zhang Rui-Hua Xu | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 18 | Forest canopy height mapping over China using GLAS and MODIS data显示文摘The Geoscience Laser Altimeter System(GLAS)accurately detects the vertical structural information of a target within its laser spot and is a promising system for the inversion of structural features and other biophysical parameters of forest ecosystems.Since the GLAS footprints are discontinuously distributed with a relativity low density,continuous vegetation height distributions cannot be mapped with a high accuracy using GLAS data alone.The MODIS BRDF product provides more forest structural information than other optical remote sensing data.This study aimed to map forest canopy heights over China from the GLAS and MODIS BRDF data.Firstly,the waveform characteristic parameters were extracted from the GLAS data by the method of wavelet analysis,and the terrain index was calculated using the ASTER GDEM data.Secondly,the model reducing the topographic influence was constructed from the waveform characteristic parameters and terrain index.Thirdly,the final canopy height estimation model was constructed from the neural network combining the canopy height estimated with the GLAS point and the MODIS BRDF data,and applied to get the continuous canopy height map over China.Finally,the map was validated by the measured data and the airborne Li DAR data,and the validation results indicated that forest canopy heights can be estimated with high accuracy from combined GLAS and MODIS data. | YANG Ting WANG Cheng LI GuiCai LUO SheZhou XI XiaoHuan GAO Shuai ZENG HongCheng | 2015 | Science China Earth Sciences2015，58，1： | 8 |
| 19 | Outcomes of adult-to-adult living donor liver transplantation: a single center experience显示文摘背景自从2002年1月, adult-to-adult 生活施主肝移植( AALDLT )响应学习介绍的 cadaveric 施主 livers.This 的缺乏在中国获得了增加的流行在 70 个病人的一个总数经历了的单个 center.Methods 的 AALDLT 的结果的详细分析在我们在2002年1月和2007年1月 .Among 之间的中心的 AALDLT 这些,没有中间的肝的静脉, 67 个病人收到了正确脑叶接枝, 3 个病人收到了双grafts. | FENG Xi YUAN Ding WEI Yong-gang LI Fu-qiang WEN Tian-fu ZENG Yong ZHAO Ji-chun WANG Wen-tao XU Ming-qing YANG Jia-yin MA Yu-kui CHEN Zhe-yu YE Hui YAN Lti-nan LI Bo | 2009 | Chinese Medical Journal2009，，7： | 8 |
| 20 | Characterization and pilot scale test of a fluidized bed two-stage gasification process for the production of clean industrial fuel gas from low-rank coal显示文摘To utilize low rank coal efficiently,a fluidized bed two-stage(FBTS)gasification process,mainly consisting of a FB pyrolyzer and a transport FB(TFB)gasifier,has been proposed for the production of clean fuel gas.To verify the feasibility and technical features of this novel gasification technology,a pilot autothermal platform,with a treating capacity of 100 kg/h for coal,was designed and built up.By adopting a kind of lignite from Inner Mongolia,the running state and fuel gas quality were compared systematically under typical operational conditions.The results show that by keeping the reaction temperatures of pyrolyzer and gasifier at around 840C and 1000C,respectively,the corresponding tar content in fuel gas at the outlets of pyrolyzer and gasifier were 1127 mg/Nm3 and 365 mg/Nm3,reaching a high tar removal efficiency.Under the stable operation state,the volume fractions of CO,H2,CH4 and CO2 in fuel gas were 14.4%,8.3%,3.4%and 11.3%,respectively,and the corresponding higher heating value of fuel gas was about 1100 kcal/Nm3.Compared with the tar from pyrolyzer,the heavy oil fraction in tar from gasifier reduced significantly,while the light oil components increased sharply simultaneously,showing significant effect of catalytic reforming by hot char bed on tar removal. | Xi Zeng Fang Wang Zhennan Han Yanlin Sun Yanbin Cui Guangwen Xu | 2018 | Carbon Resources Conversion2018，1，1： | 8 |
您所在的机构暂未开通此部分的功能，请联系管理员