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| 1 | Antioxidant properties of glutamine and its role in VEGF-Akt pathways in portal hypertension gastropathy显示文摘AIM: To investigate the effects of glutamine on oxidative/nitrosative stress and the vascular endothelial growth factor (VEGF)-Akt-endothelial nitric oxide synthase (eNOS) signaling pathway in an experimental model of portal hypertension induced by partial portal vein ligation (PPVL). METHODS: Portal hypertension was induced by PPVL. The PPVL model consists of a partial obstruction of the portal vein, performed using a 20 G blunt needle as a guide, which is gently removed after the procedure. PPVL model was performed for 14 d beginning treatment with glutamine on the seventh day. On the fifteenth day, the mesenteric vein pressure was checked and the stomach was removed to test immunoreactivity and oxidative stress markers. We evaluated the expression and the immunoreactivity of proteins involved in the VEGF-Akt-eNOS pathway by Western blotting and immunohistochemical analysis. Oxidative stress was measured by quantification of the cytosolic concentration of thiobarbituric acid reactive substances (TBARS) as well as the levels of total glutathione (GSH), superoxide dismutase (SOD) activity, nitric oxide (NO) production and nitrotyrosine immunoreactivity. RESULTS: All data are presented as the mean ± SE. The production of TBARS and NO was significantly increased in PPVL animals. A reduction of SOD activity was detected in PPVL + G group. In the immunohistochemical analyses of nitrotyrosine, Akt and eNOS, the PPVL group exhibited significant increases, whereas decreases were observed in the PPVL + G group, but no difference in VEGF was detected between these groups. Western blotting analysis detected increased expression of phosphatidylinositol-3-kinase (PI3K), P-Akt and eNOS in the PPVL group compared with the PPVL + G group, which was not observed for the expression of VEGF when comparing these groups. Glutamine administration markedly alleviated oxidative/nitrosative stress, normalized SOD activity, increased levels of total GSH and blocked NO overproduction as well as the formation of peroxynitrite. CONCLUSION: Glutamine treatment demonstrated to reduce oxidative damage but does not reduce angiogenesis induced by PH in gastric tissue, demonstrating a beneficial role for the PI3K-Akt-eNOS pathway. | Camila Marques Francielli Licks Ingrid Zattoni Beatriz Borges Luiz Eduardo Rizzo de Souza Claudio Augusto Marroni Norma Possa Marroni | 2013 | World Journal of Gastroenterology2013，19，28： | 9 |
| 2 | Personalized surgical management of colorectal cancer in elderly population显示文摘Colorectal cancer(CRC)in the elderly is extremely common but only a few clinicians are familiar with the complexity of issues which present in the geriatric population.In this phase of the life cycle,treatment is frequently suboptimal.Despite the fact that,nowadays,older people tend to be healthier than in previous generations,surgical undertreatment is frequently encountered.On the other hand,surgical overtreatment in the vulnerable or frail patient can lead to unacceptable postoperative outcomes with high mortality or persistent disability.Unfortunately,due to the geriatric patient being traditionally excluded from randomized controlled trials for a variety of factors(heterogeneity,frailty,etc.),there is a dearth of evidence-based clinical guidelines for the management of these patients.The objective of this review was to summarize the most relevant clinical studies available in order to assist clinicians in the management of CRC in the elderly.More than in any other patient group,both surgical and non-surgical management strategies should be carefully individualized in the elderly population affected by CRC.Although cure and sphincter preservation are the primary goals,many other variables need to be taken into account,such as maintenance of cognitive status,independence,life expectancy and quality of life. | Giampaolo Ugolini Federico Ghignone Davide Zattoni Giacomo Veronese Isacco Montroni | 2014 | World Journal of Gastroenterology2014，20，14： | 5 |
| 3 | How to select elderly colorectal cancer patients for surgery: a pilot study in an Italian academic medical center显示文摘Objective: Cancer is one of the most common diagnoses in elderly patients. Of all types of abdominal cancer, colorectal cancer(CRC) is undoubtedly the most frequent. Median age at diagnosis is approximately 70 years old worldwide. Due to the multiple comorbidities affecting elderly people, frailty evaluation is very important in order to avoid over- or undertreatment. This pilot study was designed to investigate the variables capable of predicting the long-term risk of mortality and living situation after surgery for CRC.Methods: Patients with 70 years old and older undergoing elective surgery for CRC were prospectively enrolled in the study. The patients were preoperatively screened using 11 internationally-validated-frailty-assessment tests. The endpoints of the study were long-term mortality and living situation. The data were analyzed using univariate Cox proportional-hazard regression analysis to verify the predictive value of score indices in order to identify possible risk factors.Results: Forty-six patients were studied. The median follow-up time after surgery was 4.6 years(range, 2.9-5.7 years) and no patients were lost to follow-up. The overall mortality rate was 39%. Four of the patients who survived(4/28, 14%) lost their functional autonomy. The preoperative impaired Timed Up and Go(TUG), Eastern Cooperative Group Performance Status(ECOG PS), Instrumental Activities of Daily Living(IADLs), Vulnerable Elders Survey(VES-13) scoring systems were significantly associated with increased long term mortality risk.Conclusion: Simplified frailty-assessing tools should be routinely used in elderly cancer patients before treatment in order to stratify patient risk. The TUG, ECOG-PS, IADLs and VES-13 scoring systems are potentially able to predict long-term mortality and disability. Additional studies will be needed to confirm the preliminary data in order to improve management strategies for oncogeriatric surgical patients. | Giampaolo Ugolini Francesco Pasini Federico Ghignone Davide Zattoni Maria Letizia Bacchi Reggiani Daniele Parlanti Isacco Montroni | 2015 | Cancer Biology & Medicine2015，12，4： | 4 |
| 4 | The diffusion of equity incentive plans in italian listed companies:what is the trigger? 显示文摘 | ALESSANDRO ZATTONI ALESSANDRO MINICHILLI | 2009 | Corporate Governance: An International Review2009，，2： | 1 |
| 5 | Plasma bubble formation induced by holmium laser:an in vitro study显示文摘 | Cecchetti W Zattoni F Nigro F | 2004 | Urology2004，63，： | 1 |
| 6 | Plasma bubble formation induced by holmium laser: an in vitro study显示文摘 | W Cecchetti F Zattoni F Nigro A Tasca | 2004 | Urology2004，，3： | 1 |
| 7 | 11ae Diffusion of Equity Incentive Plans in Italian Listed Companies: What Is the Trigger 显示文摘 | Alessandro Zattoni Alessandro Minichilli | 2009 | Corporate Governance: An International Review2009，，2： | 1 |
| 8 | Plasma bubble forma-tion induced by holmium laser an in vitro study显示文摘 | Cecchetti W Zattoni F Nigro F | | 0，，03： | 1 |
| 9 | Systematic Review and Meta-analysis of Studies Reporting Oncologic Outcome After Robot-assisted Radical Prostatectomy 显示文摘 | Giacomo Novara Vincenzo Ficarra Simone Mocellin Thomas E. Ahlering Peter R. Carroll Markus Graefen Giorgio Guazzoni Mani Menon Vipul R. Patel Shahrokh F. Shariat Ashutosh K. Tewari Hendrik Van Poppel Filiberto Zattoni Francesco Montorsi Alexandre Mottrie | 2012 | European Urology2012，，： | 1 |
| 10 | Plasma bubble for- mation induced by holmium laser au in vitro study 显示文摘 | Cecchetti W Zattoni F Nigro F | 2004 | Urology2004，63，3： | 1 |
| 11 | The Diffusion of Equity Incentive Plans in Italian Listed Companies: What is the Trigger 显示文摘 | Alessandro Zattoni and Alessandro MinichJlli | 2009 | Corporate Governance: An International Review2009，，17： | 1 |
| 12 | The Challenge of Education in Colorectal Cancer Surgery: A Comparison of Early Oncological Results, Morbidity, and Mortality Between Residents and Attending Surgeons Performing an Open Right Colectomy显示文摘 | Isacco Montroni Federico Ghignone Giancarlo Rosati Davide Zattoni Alessio Manaresi Mario Taffurelli Giampaolo Ugolini | 2013 | Journal of Surgical Education2013，，： | 1 |
| 13 | Lymphatic and vascular embolizations are independent predictive variables of inguinal lymph node involvement in pa- tients with squamous cell carcinoma of the penis: Gruppo Uro-Oncologico del Nord Est (Northeast Uro-Oncological Group) Penile Cancer data base data 显示文摘 | Ficarra V Zattoni F Cunico S C | 2005 | Cancer2005，103，12： | 1 |
| 14 | Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing显示文摘 | ZATTONI M SERHAN C N | 2007 | J Exp Med2007，204，2： | 1 |
| 15 | Plasma bubble formation induced by holmium laser an in vitro study显示文摘 | Cecchetti W Zattoni F Nigro F et a1 | 2004 | Urology2004，63，3： | 1 |
| 16 | Hollow-fiber flow field-flow fractionation显示文摘 | Zattoni A Casolari S Rambaldi D C | 2007 | Current Anal Chem2007，3，4： | 1 |
| 17 | Exploring the Political Side of Board Involvement in Strategy:A Study of Mixed ownership Institutions显示文摘 | RAVASI D ZATTONI A | | 0，，8： | 1 |
| 18 | The diffusion of equity incentive plans in italian listed compa-nies:what is the trigger显示文摘 | Alessandro zattoni Alessandro minichilli | 2009 | Corporate Governance:An In-ternational Review2009，，2： | 1 |
| 19 | A contingency model of boards of directors and firm innovation: The moderating role of firm size 显示文摘 | Zona F Zattoni A Minichilli A | 2013 | British Journal of Management2013，24，3： | 1 |
| 20 | Plasma bubble formation induced by holmium laser an in vitro study 显示文摘 | Cecchetti W Zattoni F Nigro F | 2004 | Urology2004，63，3： | 1 |
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