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| 1 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 2 | Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor显示文摘 | Anne Brunet Azad Bonni Michael J Zigmond Michael Z Lin Peter Juo Linda S Hu Michael J Anderson Karen C Arden John Blenis Michael E Greenberg | 1999 | Cell1999，，6： | 2 |
| 3 | Sliding mode control for uncertain nonlinear systems with multiple inputs containing sector nonlinearities and deadzones 显示文摘 | Hsu K C Wang W Y Lin P Z | 2004 | IEEE Trans on Systems Man and Cybernetics-Part B: Cybernetics2004，34，1： | 1 |
| 4 | Adaptive multiple fault detection and alarm processing for loop system with probabilistic network显示文摘 | Lin W M Lin C H Sun Z C | 2004 | IEEE Transactions on Power Delivery2004，19，1： | 1 |
| 5 | Evaluation of early-stage Parkinson's disease with ^99mTc-TRODAT-1 imaging显示文摘 | Huang W S Lin S Z Lin J C | 2001 | Journal of Nuclear Medicine2001，42，9： | 1 |
| 6 | Liquefaction of CCA-treated wood and elimination of metals from the solvent by precipitation显示文摘 | LIN L Z HSE C Y | 2005 | Holzforschung2005，59，3： | 1 |
| 7 | Isolation and characterization of polymorphic microsatellites from red coral grouper(Plectropomus maculatus)显示文摘 | Zhu Z Y Lo L C Lin G | 2005 | Molecular Ecology Notes2005，5，3： | 1 |
| 8 | Mechanistic studies of electrodeposition for bioceramic coatings of calcium phosphates by an in situ pH-microsensor technique显示文摘 | Zhang J M Lin C J Feng Z D | 1998 | Journal of Electroanalytical Chemistry1998，452，2： | 1 |
| 9 | Application of a neural network machine learning model in the selection system of sheet metal bending tooling显示文摘 | Lin Z C Chang D Y | 1996 | Artificial Intelligence in Engineering1996，，1： | 1 |
| 10 | Mathematical model for a universal face bobbing hypoid gear generator显示文摘 | Shih Y P Fong Z H Lin G C Y | 2007 | ASME Journal of Mechanical Design2007，129，1： | 1 |
| 11 | Isolation, characterization and expression analysis of a leaf-specific phosphoenolpyruvate carboxylase gene in Oryza sativa 显示文摘 | LIN C F WEI C JIANG L Z | 2004 | DNASeq2004，15，26： | 1 |
| 12 | Novel Ferroelectric Poly- mermatrix Composites with a High Dielectric Constant at the Percolation Threshold显示文摘 | Dang Z M Lin Y H Nan C W | 2003 | Advanced Materials2003，15，19： | 1 |
| 13 | Hedged predictions for traditional chinese chronic gastritis diagnosis with con- fidence machine显示文摘 | Wang H Z Lin C D Yang F | 2009 | Computers in Biology and Medicine2009，39，5： | 1 |
| 14 | Simultaneous control of acid gases and P AHs using a spray dryer combined with a fabric filter using different additives 显示文摘 | LIU Z S WEI MY LIN C L | 2002 | Journal of Hazardous Materials2002，91，13： | 1 |
| 15 | Operator controlled device-to-device communications in LTE-advanced networks显示文摘 | LEI L ZHONG Z D LIN C | 2012 | IEEE Wireless Communications2012，19，3： | 1 |
| 16 | Image encryption scheme by using iterative random phase encoding in gyra- tor transform domains 显示文摘 | Liu Z Xu L Lin C | 2011 | Optics and Lasers in Engineering2011，49，4： | 1 |
| 17 | Customer-driven product configu- ration optimization for assemble-to-order manufacturing en- terprises显示文摘 | ZHOU C LIN Z LIU C | 2008 | The International Journal of Advanced Manu- facturing Technology2008，38，12： | 1 |
| 18 | Heterotrimeric G proteins regulate nitrogen-use efficiency in rice 显示文摘 | Sun H Y Qian Q Wu K Luo J J Wang S S Zhang C W Ma Y F Liu Q Huang X Z Yuan Q B Han R X Zhao M Dong G J Guo L B Zhu X D Gou Z H Wang W Wu Y J Lin H X Fu X D | 2014 | Nature Genetics2014，46，4： | 1 |
| 19 | Effect of pokeweed antiviral protein (PAP) on the infection of plant virus 显示文摘 | Chen Z C White R F Antoniw J F and Lin Q | 1991 | Plant Pathology1991，40，： | 1 |
| 20 | Effects of flue gas desulphurization sludge on the pozzolanic reaction of reject-fly-ash- blended cement pastes显示文摘 | Poon C S Qiao X C Lin Z S | 2004 | Cement and Concrete Research2004，34，10： | 1 |
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