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| 1 | 激光剥蚀信号在线平滑和去汞装置:原位微区铅同位素准确分析利器显示文摘激光原位微区分析可在微观尺度上完成样品的元素定量分析或同位素组成测定,为研究成岩、成矿物质来源和追踪地壳与地幔演化历史提供了独特的观察视野。但是,激光剥蚀等离子体质谱的一些缺陷阻碍了地质样品的高精度、高空间分辨率分析,比如:剥蚀池的位置效应、低剥蚀速率下信号波动影响、激光剥蚀脉动式信号导致的光谱螺纹效应、高频激光剥蚀造成的元素分馏效应等。为此,一些学者设计了不同规格和样式的激光剥蚀信号平滑装置来克服这些问题。但是,这些信号平滑装置普遍还存在气体吹扫时间过长和降低激光剥蚀信号灵敏度等问题。因此,研制新型的信号平滑装置对改善LA—ICP—MS的数据质量具有重要的意义。 | Hu Z Zhang W Liu Y Gao S Li M Zong K Chen H Hu S 刘勇胜 | 2015 | 矿物岩石地球化学通报2015，34，4： | 114 |
| 2 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 3 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 4 | Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo显示文摘 | Lin Y Luo E Chen X Liu L Qiao J Yan Z Li Z Tang W Zheng X Tian W | 2006 | 中国生物学文摘2006，20，5： | 31 |
| 5 | 血管周围脂肪组织中的Bmal1通过血管紧张素原转录调控管理静息期血压显示文摘血管周围脂肪组织(perivascular adipose tissue,PVAT)围绕血管,构成了在生理条件下保持血管张力所需的脉管系统的独特的功能整体层。然而,关于PVAT与血压调节之间的关系的资料很少,包括其对昼夜血压变化的潜在作用。 | Chang L Xiong W Zhao X Fan Y Guo Y Garcia-Barrio M Zhang J Jiang Z Lin JD Chen YE 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 23 |
| 6 | Multilineage differentiation of adipose-derived stromal cells from GFP transgenic mice显示文摘 | Lin Y Chen X Yan Z Liu L Tang W Zheng X Li Z Qiao J Li S Tian W | 2006 | 中国生物学文摘2006，20，5： | 16 |
| 7 | 电网电压跌落下双馈风力发电机组暂态性能的比较分析显示文摘为了较全面地研究不同运行工况下并网双馈风力发电机组的暂态运行性能,该文基于双馈发电机电磁暂态模型,采用等效集中质量法,建立了考虑风力机和发电机之间传动轴扭转柔性的风力机两个质量块等效模型。在此基础上,基于定子电压定向的矢量控制策略,对风电机组在不同风力机输出转矩、不同电网电压跌落和不同故障持续时间下分别进行了暂态运行性能的仿真,并对风力机不同质量块等效模型的结果进行比较。结果表明,双馈风力发电机组暂态性能与风力机传动链柔性、电压跌落程度和故障持续时间等密切相关。 | 李辉 叶仁杰 韩力 王荷生 Chen Z | 2010 | 太阳能学报2010，31，6： | 14 |
| 8 | Antifungal activities and action mechanisms of compounds from Tribulus terrestris L.显示文摘 | Zhang JD Xu Z Cao YB Chen HS Yan L An MM Gao PH Wang Y Jia XM Jiang YY | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 9 | 风电场不同等值模型的仿真研究显示文摘以含笼型异步发电机组的并网风电场为例,在分析单机异步风力发电机动态模型的基础上,研究了风电场容量加权单机等值、降阶变尺度多机等值、参数变换单机等值以及改进加权单机等值模型和方法。针对风电场机组参数完全相同和不同的两种算例,利用Matlab/Simulink平台建立了风电场不同等值模型,对风速扰动和风电场出口处发生三相短路故障下的风电场动、暂态运行特性进行了比较分析,研究结果验证了等值模型的正确性和适用性。 | 李辉 王荷生 赵斌 胡姚刚 Chen Z | 2011 | 太阳能学报2011，32，7： | 14 |
| 10 | Economic burden of Parkinson's disease in a developing country: A retrospective cost analysis in Shanghai, China显示文摘 | Wang G Cheng Q Zheng R Tan YY Sun XK Zhou HY Ye XL Wang Y Wang Z Sun BM Chen SD | 2006 | 中国生物学文摘2006，20，8： | 10 |
| 11 | 纳米粒疗法:一种新兴的癌症治疗方法显示文摘纳米粒具有在肿瘤细胞靶向定位和促进细胞吸收的功能,可在增强疗效的同时减少副作用,纳米粒疗法作为一种新型的癌症治疗方法正逐渐应用于临床。本文主要介绍纳米粒的主要结构及其区别于其他类型抗癌药物的特性,讨论目前第1代纳米粒疗法的临床应用以及处于临床前研究的最新纳米粒治疗系统,并总结纳米粒治疗系统目前已取得的成果和今后发展的趋势及挑战。 | 梁尔光 王玉丽 高春生 Davis ME Chen Z Shin DM | 2009 | 国际药学研究杂志2009，36，1： | 7 |
| 12 | Arabidopsis thaliana histone deacetylase1(AtHD1)is localized in euchromatic regions and demonstrates histone deacetylase activity in vitro显示文摘Arabidopsis thaliana 嘘一 deacetylase 1 (AtHD1 或 AtHDA19 ) ,酵母 RPD3 的一个相当或相同的事物,是在植物的许多生理、发展的过程的一个全球管理者。尽管有为在植物基因规定和开发的 AtHD1 的一个角色的基因证据, AtHD1 的生物化学、细胞的性质糟糕被理解。这里,我们在 vivo 报导 AtHD1 的细胞的本地化模式并且嘘在 vitro 的一项 deacetylase 活动。绿荧光灯的蛋白质(GFP ) 的短暂、稳定的表示在洋葱房间标注了 AtHD1 并且分别地,在转基因的 Arabidopsis 的根,种子和叶子表明 AtHD1 在 euchromatic 区域大概在原子核是局部性的并且从核排除。AtHD1 的本地化模式与涉及核形成和 transgenes 的 silencing 并且分别地重复了 DNA 元素的 AtHD2 和 AtHDA6 的那些不同。另外,一 hist 一 deacetylase 活动试金证明在细菌生产的 recombinant AtHD1 示威了一特定嘘在 vitro 的一项 deacetylase 活动。数据建议 AtHD1 是原子蛋白质并且拥有嘘为对植物生长和开发重要的全球 transcriptional 规定负责的一项 deacetylase 活动。 | Paulus M Fong Lu Tian Z Jeffrey Chen | 2006 | Cell Research2006，16，5： | 6 |
| 13 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 14 | Purified human bone marrow multipotent mesenchymal stem cells regenerate infarcted myocardium in experimental rats显示文摘 | Zhang S Jia Z Ge J Gong L Ma Y Li T Guo J Chen P Hu Q Zhang P Liu Y Li Z Ma K Li L Zhou C | 2006 | 中国生物学文摘2006，20，5： | 5 |
| 15 | Nuclear reprogramming: the zygotic transcription program is established through an“erase-and-rebuild” strategy显示文摘卵母细胞显示母亲特定的基因表达式侧面,它被换到当染色质的一个单倍体集合被传递到发展成一个胚胎的受精卵时, zygotic 介绍。位于这抄写 reprogramming 下面的机制当前是未知的。等到当抄写在幼芽的泡卵母细胞被关掉时,一般抄写因素和 transcriptional 管理者的一个范围从染色质被分裂,这里,我们表明那。染色质因素(CF ) 的全球分离破坏在染色质和 CF 之间的物理接触并且在功能的水平导致母亲的抄写节目的檫除。与染色质论坛分开的批评抄写因素和管理者遗体延长了时期,并且立即在专业版以后与染色质成为 re-associated 原子形成。Thisis 由象 DNA 和抄写那样的原子功能的重建跟随了速度集合。我们建议母亲的抄写节目在卵子发生期间被擦掉产生相对天真的染色质, zygotic 抄写节目是在授精以后的重建的重新。这个过程作为“ erase-and-rebuild ”被称为过程,它被用来重设抄写节目,和最可能的其它原子过程也,从母亲的到胚胎的。我们进一步在伴随的纸出现(高 T,等,房间物件 2007;17:135-150 .) 一样的策略也被采用到改编 transcriptional,这在体细胞介绍原子转移和单性生殖,建议这当模特儿在早胚胎开始期间对 transcriptional reprogramming 的所有形式普遍适用。从染色质的 CF 的排水量也为抄写沉默的现象提供解释在期间对 zygotic 转变母亲。 | Feng Sun Haiyan Fang Ruizhen Li Tianlong Gao Junke Zheng Xuejin Chen Wenqin Ying Hui Z Sheng | 2007 | Cell Research2007，17，2： | 5 |
| 16 | Short-term Exposure to Fine Particles and Risk of Cause-Specific Mortality--China,2013-2018显示文摘What is already known about this topic?Short-term exposure to PM2.5 has been associated with population excess death.This issue is of critical concern in China given its high level of exposure to PM2.5 compared to that of the rest of the world.What is added by this report?Existing studies were conducted from 2013-2015 and have failed to capture the full effects of China’s actions towards cleaner air in recent years,such as the first Action Plan for Air Pollution Prevention and Control issued in 2013.This study uses the longest time series data to date from 2013-2018,provides the latest evidence on PM2.5 and cause-specific death nationwide,and identifies regional patterns of PM2.5-related effects as well as PM2.5-related susceptible populations.What are the implications for public health practice?This study suggests that the development of standards and the implementation of actions to clean the air and protect public health should be tailored to PM2.5-related sensitive diseases,susceptible populations,and regional patterns. | Chen Chen Tiantian Li Lijun Wang Jinlei Qi Wangying Shi Mike Z He Qinghua Sun Jiaonan Wang Huanhuan Zhu Xiaoming Shi | 2019 | China CDC weekly2019，1，1： | 5 |
| 17 | 考虑磁路饱和及集肤效应的异步风力发电机组暂态性能分析显示文摘为准确分析异步发电机不同详细模型对大型风电机组暂态性能的影响,该文结合2个质量块的风力机传动链等效模型,分别建立了笼型异步发电机考虑主磁路、定转子漏磁路饱和以及集肤效应影响的风电机组数学模型。针对大型风电机组在机械大扰动和电网电压骤降情况下,利用Matlab/Simulink平台对机组在不同数学模型描述时的暂态过程进行了仿真比较。结果表明,尤其在电网电压骤降时,电机磁路饱和对机组暂态运行性能的影响较为显著。 | 李辉 赵斌 韩力 Chen Z | 2010 | 太阳能学报2010，31，3： | 4 |
| 18 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 19 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 20 | 母乳喂养和孕产妇心血管病风险:30万中国妇女的前瞻性研究显示文摘母乳喂养给儿童健康带来了大量好处,并且也与母亲生命后期心血管病风险降低相关。然而,有关其对心血管病影响的证据仍然不一致,特别是在东亚人中,母乳喂养的频率和持续时间与西方国家的频率和持续时间显著不同。2004-2008年,中国香港嘉道理生物样本库(China Kadoorie biobank)从中国10个不同地区招募了年龄30-79岁受试者50万人,基线无心血管病的女性受试者289 573人在8年的随访中, | 刘莉 叶鹏 Peters SAE Yang L Guo Y Chen Y Bian Z Du J Yang J Li S Li L Woodward M Chen Z | 2017 | 中华高血压杂志2017，25，8： | 4 |
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