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| 1 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 2 | Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。 | 刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB | 2018 | 中华高血压杂志2018，26，8： | 20 |
| 3 | Salvianolic acid b ameliorates lipopolysaccharide-induced albumin leakage from rat mesenteric venules through src-regulated transcelluar pathway and paracellular pathway显示文摘 | Pan CS Liu YH Liu YY | 2015 | PLo S One2015，10，01： | 1 |
| 4 | PeMADS6,a GLOBOSA/ PISTILLATA - like gene in Phalaenopsis equestris involved in petaloid formation, and correlated with flower longevity and ovary development 显示文摘 | Tsai WC Lee PF Chen HI Hsiao YY Wei WJ Pan ZJ Chuang MH Kuoh CS Chen WH Chen HH | 2005 | Plant Cell Physiol2005，46，07： | 1 |
| 5 | Association of IL - 10 - 1082promoter polymorphism with susceptibility to gastric cancer: evi-dence from 22 case - control studies 显示文摘 | Pan F Tian J Pan YY | 2012 | Mol Biol Rep2012，39，6： | 1 |
| 6 | Sorafenib combined with gemcitabine in EG- FR- TKI -resistant human lung cancer cells 显示文摘 | Li J Pan YY Zhang Y | 2013 | Oneol Lett2013，5，1： | 1 |
| 7 | Creating Content Modules for Chinese Ehr Doeuments and Their Trial Implementation in Wnwei City显示文摘 | Yang P Pan F Xu YY | 2012 | JOurnal of Medical Systems2012，36，6： | 1 |
| 8 | Antioxidant activity of phosphorylated exopolysaccharide produced by Lactococcus lactis subsp, lactis显示文摘 | Guo YX Pan DD Sun YY | 2013 | Carbohydrate Polymers2013，97，2： | 1 |
| 9 | Neuroprotective effects of PACAP27 in mice model of Parkinson's disease involved in the modulation of K (ATP) subunits and D2 receptors in the striatum 显示文摘 | Wang G Pan J Tan YY | 2008 | Neuropeptides2008，42，3： | 1 |
| 10 | Impaired neutrophil activity and increased susceptibility tobacterial infection in mice lacking glucose-6-phosphatase-beta显示文摘 | Cheung YY Kim SY Yiu WH Pan CJ Jun HS Ruef RA etal | 2007 | J Clin Invest2007，117，3： | 1 |
| 11 | Combined gefitinib and pemetrexed overcome the acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer显示文摘 | Wu M Yuan Y Pan YY Zhang Y | 2014 | Mol Med Rep2014，10，2： | 1 |
| 12 | A novel WRKY-like protein invoh, ed in transcriptional activation of cyst wall protein genes in Giardia lamblia显示文摘 | Pan YJ Cho CC Kao YY | 2009 | J Biol Chem2009，284，17： | 1 |
| 13 | Persistent pain maintains morphine-seeking behavior after morphine withdrawal through reduced Me CP2 repression of Glu A1 in rat central amygdala显示文摘 | Hou YY Cai YQ Pan ZZ | 2015 | J Neurosci2015，35，8： | 1 |
| 14 | Dihydroar- temisinin (DHA) induces caspase-3-dependent apoptosis in hu- man lung adenocarcinoma ASTC-a-1 cells 显示文摘 | Lu YY Chen TS Qu JL Pan WL Sun L Wei XB | 2009 | J Biomed Sci2009，16，： | 1 |
| 15 | Characterization of phosphatidylinositol-specific phospholipase C (PI-PLC) from Lilium daviddi pollen显示文摘 | Pan YY Wang X Ma LG | 2005 | Plant Cell Physiol2005，46，： | 1 |
| 16 | Influence of inorganic microele- ments on the production of camptothecin with suspension cutures of Camptotheca acuminate显示文摘 | Pan XW Shi YY Liu X Gao X Lu YT | 2004 | Plant Growth Regulation2004，44，： | 1 |
| 17 | Homeobox genes and their functions on development and neoplasm in gastrointestinal tract显示文摘 | Yu YY Pan YS Zhu ZG | 2007 | Eur J Surg Oncol2007，33，： | 1 |
| 18 | Prevalence of HIV, Syphilis,HCV and Their High Risk Behaviors among Migrant Workers inEastern China显示文摘 | Pan XH Zhu YY Wang Q | 2013 | PLoS One2013，8，57： | 1 |
| 19 | The lower peripheral blood lymphocyte/monocyte ratio assessed during routine follow-up after standard first-line chemotherapy is a risk factor for predicting relapse in patients with diffuse large B-cell lymphoma显示文摘 | Li YL Gu KS Pan YY | 2014 | Leuk Res2014，38，3： | 1 |
| 20 | Combination of cyclooxygenase-2 inhibitor and doxorubicin increases the growth inhibition and apoptosis in human hepatocellular carcinoma cells显示文摘 | Pan YY Xu SP Jia XY | 2007 | Exp Oncol2007，29，1： | 1 |
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