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| 1 | Development of a Haploid-Inducer Mediated Genome Editing System for Accelerating Maize Breeding显示文摘Crop breeding aims to generate pure in bred lines with multiple desired traits. Doubled haploid (DH) and genome editing using CRISPR/Cas9 are two powerful game-changing technologies in crop breeding. However, both of them still fall short for rapid generation of pure elite lines with integrated favorable traits. Here, we report the development of a Haploid-Inducer Mediated Genome Editing (IMGE) approach, which utilizes a maize haploid inducer line carrying a CRISPR/Cas9 cassette targeting for a desired agronomic trait to pollinate an elite maize in bred line and to generate genome-edited haploids in the elite maize background. Homozygous pure DH lines with the desired trait improvement could be generated within two generations, thus bypassing the lengthy procedure of repeated crossing and backcrossing used in conventional breeding for integrating a desirable trait into elite commercial backgrounds. | Baobao Wang Lei Zhu Binbin Zhao Yongping Zhao Yurong Xie Zhigang Zheng Yaoyao Li Juan Sun Haiyang Wang | 2019 | Molecular Plant2019，12，4： | 32 |
| 2 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 3 | 5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer显示文摘Non-small-cell lung cancer(NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine(5 hmC) signatures in circulating cell-free DNA(cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here,we employed a sensitive and reliable method to map genome-wide 5 hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5 hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers from 66 patients and 67 healthy controls(mean decrease accuracy>3.2, P < 3.68E-19) using machine-learning-based tumor classifiers with high accuracy. Thus,the unique signature of 5 hmC in tumor patient's cfDNA identified in our study may provide valuable information in facilitating the development of new diagnostic and therapeutic modalities for NSCLC. | Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu Yueqin Wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 7 |
| 4 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 5 | Fabrication and characterization of novel meso-porous carbon/n-octadecane as form-stable phase change materials for enhancement of phase-change behavior显示文摘In this study, series of novel composite phase change materials(PCMs) were prepared through vacuum impregnation by using meso-porous carbon as a supporting matrix and n-octadcane as PCMs.The meso-porous carbon material was prepared through one-pot co-assembly method, using resorcinol and formaldehyde as carbon precursor, tetraethoxysilane as silica sources and triblock copolymer F127 as a template. And the phase behaviors of n-octadcane confined in the nano-porous structure of the meso-porous carbon were further investigated. Fourier transform-infrared spectroscopy spectra show that n-octadecane was effectively encapsulated in the porous structure of mesoporous carbon and the composite PCMs were successfully prepared. Differential scanning calorimetry results confirm that the composite PCMs possess a good phase change behavior, fast thermal-response rate and excellent thermal cycling stability. In addition, the composite PCMs possess expected heat storage and heat release properties. All these results demonstrate that the composite PCMs possess good comprehensive property so that they can be used widely in energy storage systems. | Yurong Liu Yongpeng Xia Kang An Chaowei Huang Weiwei Cui Sheng Wei Rong Ji Fen Xu Huanzhi Zhang Lixian Sun | 2019 | Journal of Materials Science & Technology2019，35，5： | 4 |
| 6 | All-climate aqueous supercapacitor enabled by a deep eutectic solvent electrolyte based on salt hydrate显示文摘Aqueous supercapacitors(SCs)have received considerable attention owing to the utilization of low-cost,non-flammable,and low-toxicity aqueous electrolytes thus could eliminate the safety and cost concerns,but their wide temperature range applications have generally suffered from frozen of electrolyte and insufficient ionic conductivity at low temperatures.Herein,we demonstrate the feasibility of using an unconventional Deep Eutectic Solvent(DES)based on H2O-Mg(ClO4)2·6 H2O binary system as electrolyte to construct all-climate aqueous carbon-based SC.This unconventional class DES completely base on inorganic substances and achieving simply mix inexpensive salts and water together at the right proportions.Attributed to the attractive feature of extremely low freeze temperature of-69℃,this electrolyte can enable the 1.8 V carbon-based SC to fully work at-40℃with outstanding cycling stability.This DES electrolyte comprising of a single salt and a single solvent without any additive will open up an avenue for developing simple and green electrolytes to construct all-climate SC. | Xudong Bu Yurong Zhang Yinglun Sun Lijun Su Jianing Meng Xionggang Lu Xingbin Yan | 2020 | Journal of Energy Chemistry2020，29，10： | 2 |
| 7 | Reduced mucosal injury of SPF chickens by mast cell stabilization after infection with very virulent infectious bursal disease virus显示文摘 | Decheng Wang Yufeng Liu Ruiping She Jingjing Xu Liqiang Liu Jinmao Xiong Yurong Yang Quan Sun Kaisong Peng | 2009 | Veterinary Immunology and Immunopathology2009，，3： | 1 |
| 8 | Numerical study of particle cluster flow in risers with cluster - based approach 显示文摘 | Lu Huilin Sun Qiaoqun He Yurong | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 9 | Spacebome SAR simulation of natural ground scene RCS 显示文摘 | JlN Yurong SUN Zaoyu LIANG Diannong | 2007 | ModemElectronics Technology2007，，7： | 1 |
| 10 | Elastic-plastic study on high building with SRC transferring story显示文摘 | Li Yurong Qiu Tao Sun Binnan | 2006 | Journal of Zhejiang Uni- versity SCIENCE A2006，7，3： | 1 |
| 11 | Toxic effects of enrofloxacin on growth rate and catalase activity in Eisenia fetida显示文摘 | Yuhong Gao Xinsheng Sun Zhenjun Sun Na Zhao Yurong Li | 2008 | Environmental Toxicology and Pharmacology2008，，2： | 1 |
| 12 | Cormnunity surveys and risk factor analysis of human alveolar and cystic echinococcosis in Ningxia Hui Autonomous Region, China 显示文摘 | YANG Yurong SUN Tao LI Zhengzhi | 2006 | Bulletin of the World Health Organization2006，84，9： | 1 |
| 13 | Simultaneous separation and purification of total polyphenols, ehlorogenic acid and phlorizin from thinned young apples显示文摘 | Lijun Sun Yurong Guo Chengeheng Fu | 2013 | Food Chemistry2013，，136： | 1 |
| 14 | Numerical Study of Particle Cluster Flow in Risers with Cluster-Based Approach 显示文摘 | Lu Huilin Sun Qiaoqun He Yurong | 2005 | Chem Eng Sci2005，60，23： | 1 |
| 15 | Simultaneous separation and purifycation of total polyphenols,chlorogenic acid and phlorizin from thinned young apples显示文摘 | Lijun Sun Yurong Guo Chengcheng Fu | 2013 | Food Chemistry2013，136，2： | 1 |
| 16 | A novel a- daptive-feedrate interpolation method for NURBS tool path with drive constraints显示文摘 | SUN Yuwen ZHAO Yang BAO Yurong | 2014 | International Journal of Machine Tools and Manufacture2014，77，： | 1 |
| 17 | China’s Recent Progresses in Polar Climate Change and Its Interactions with the Global Climate System显示文摘During the recent four decades since 1980,a series of modern climate satellites were launched,allowing for the measurement and record-keeping of multiple climate parameters,especially over the polar regions where traditional observations are difficult to obtain.China has been actively engaging in polar expeditions.Many observations were conducted during this period,accompanied by improved Earth climate models,leading to a series of insightful understandings concerning Arctic and Antarctic climate changes.Here,we review the recent progress China has made concerning Arctic and Antarctic climate change research over the past decade.The Arctic temperature increase is much higher than the global-mean warming rate,associated with a rapid decline in sea ice,a phenomenon called the Arctic Amplification.The Antarctic climate changes showed a zonally asymmetric pattern over the past four decades,with most of the fastest changes occurring over West Antarctica and the Antarctic Peninsula.The Arctic and Antarctic climate changes were driven by anthropogenic greenhouse gas emissions and ozone loss,while tropical-polar teleconnections play important roles in driving the regional climate changes and extreme events over the polar regions.Polar climate changes may also feedback to the entire Earth climate system.The adjustment of the circulation in both the troposphere and the stratosphere contributed to the interactions between the polar climate changes and lower latitudes.Climate change has also driven rapid Arctic and Southern ocean acidification.Chinese researchers have made a series of advances in understanding these processes,as reviewed in this paper. | Xichen LI Xianyao CHEN Bingyi WU Xiao CHENG Minghu DING Ruibo LEI Di QI Qizhen SUN Xiaoyu WANG Wenli ZHONG Lei ZHENG Meijiao XIN Xiaocen SHEN Chentao SONG Yurong HOU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 1 |
| 18 | Toxic effects of enrofloxacin on growth rate and catalase activity in Eisenia fetida显示文摘 | Yuhong Gao Xinsheng Sun Zhenjun Sun Na Zhao Yurong Li | 2008 | Environmental Toxicology and Pharmacology2008，，2： | 1 |
| 19 | Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus显示文摘Previous studies have suggested that thrombospondin-1(TSP-1) regulates the transforming growth factor beta 1(TGF-b1)/phosphorylated Smad2/3(p Smad2/3) pathway. Moreover, TSP-1 is closely associated with epilepsy. However, the role of the TSP-1-regulated TGFb1/p Smad2/3 pathway in seizures remains unclear. In this study, changes in this pathway were assessed following kainic acid(KA)-induced status epilepticus(SE) in rats.The results showed that increases in the TSP-1/TGF-b1/p Smad2/3 levels spatially and temporally matched the increases in glial fibrillary acidic protein(GFAP)/chondroitin sulfate(CS56) levels following KA administration.Inhibition of TSP-1 expression by small interfering RNA or inhibition of TGF-b1 activation with a Leu-Ser-Lys-Leu peptide significantly reduced the severity of KA-induced acute seizures. These anti-seizure effects were accompanied by decreased GFAP/CS56 expression and Smad2/3 phosphorylation. Moreover, inhibiting Smad2/3 phosphorylation with ponatinib or SIS3 also significantly reduced seizure severity, alongside reducing GFAP/CS56 immunoreactivity. These results suggest that the TSP-1-regulated TGF-b1/p Smad2/3 pathway plays a key role in KA-induced SE and astrogliosis, and that inhibiting this pathway may be a potential anti-seizure strategy. | Yurong Zhang Mengdi Zhang Wei Zhu Xiaohong Pan Qiaoyun Wang Xue Gao Chaoyun Wang Xiuli Zhang Yuxia Liu Shucui Li Hongliu Sun | 2020 | Neuroscience Bulletin2020，36，3： | 1 |
| 20 | Simultaneousseparation and purification of total polyphenols,chlorogenic acidand phlorizin from thinned young apples显示文摘 | Lijun Sun Yurong Guo Chengcheng Fu | 2013 | Food Chemistry2013，136，2： | 1 |
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