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| 1 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 2 | 5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer显示文摘Non-small-cell lung cancer(NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine(5 hmC) signatures in circulating cell-free DNA(cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here,we employed a sensitive and reliable method to map genome-wide 5 hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5 hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers from 66 patients and 67 healthy controls(mean decrease accuracy>3.2, P < 3.68E-19) using machine-learning-based tumor classifiers with high accuracy. Thus,the unique signature of 5 hmC in tumor patient's cfDNA identified in our study may provide valuable information in facilitating the development of new diagnostic and therapeutic modalities for NSCLC. | Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu Yueqin Wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 7 |
| 3 | An experimental study on metal precipitation driven by fluid mixing: implications for genesis of carbonate-hosted lead–zinc ore deposits显示文摘A type of carbonate-hosted lead–zinc(Pb–Zn)ore deposits, known as Mississippi Valley Type(MVT)deposits, constitutes an important category of lead–zinc ore deposits. Previous studies proposed a fluid-mixing model to account for metal precipitation mechanism of the MVT ore deposits, in which fluids with metal-chloride complexes happen to mix with fluids with reduced sulfur, producing metal sulfide deposition. In this hypothesis, however, the detailed chemical kinetic process of mixing reactions, and especially the controlling factors on the metal precipitation are not yet clearly stated. In this paper, a series of mixing experiments under ambient temperature and pressure conditions were conducted to simulate the fluid mixing process, by titrating the metal-chloride solutions, doping withor without dolomite, and using NaHS solution. Experimental results, combined with the thermodynamic calculations, suggest that H_2S, rather than HS^-or S^(2-),dominated the reactions of Pb and/or Zn precipitation during the fluid mixing process, in which metal precipitation was influenced by the stability of metal complexes and the pH. Given the constant concentrations of metal and total S in fluids, the pH was a primary factor controlling the Pb and/or Zn metal precipitation. This is because neutralizing or neutralized processes for the ore-forming fluids can cause instabilities of Pb and/or Zn chloride complexes and re-distribution of sulfur species, and thus can facilitate the hydrolysis of Pb and Zn ions and precipitation of sulfides. Therefore, a weakly acidic to neutral fluid environment is most favorable for the precipitation of Pb and Zn sulfides associated with the carbonate-hosted Pb–Zn deposits. | Yan Zhang Runsheng Han Xing Ding Junjie He Yurong Wang | 2019 | Acta Geochimica2019，38，2： | 4 |
| 4 | Study on Forced Convective Heat Transfer of Non-Newtonian Nanofluids显示文摘This paper is concerned with the forced convective heat transfer of dilute liquid suspensions of nanoparticles(nanofluids) flowing through a straight pipe under laminar conditions. Stable nanofluids are formulated by usingthe high shear mixing and ultrasonication methods. They are then characterised for their size, surface charge,thermal and theological properties and tested for their convective heat transfer behaviour. Mathematical modellingis performed to simulate the convective heat transfer of nanofluids using a single phase flow model and consideringnanofluids as both Newtonian and non-Newtonian fluid. Both experiments and mathematical modellingshow that nanofluids can substantially enhance the convective heat transfer. Analyses of the results suggest thatthe non-Newtonian character of nanofluids influences the overall enhancement, especially for nanofluids with anobvious non-Newtonian character. | Yurong He Yubin Men Xing Liu Huilin Lu Haisheng Chen Yulong Ding | 2009 | Journal of Thermal Science2009，18，1： | 4 |
| 5 | The effects of ultrasonic irradiation on the crystalline显示文摘 | CAO Yurong XING Ming LI Huilin | 2002 | Journal of Applied Polymer Science2002，84，： | 1 |
| 6 | Insights into simultaneous adsorption and oxidation of antimonite[Sb(III)]by crawfish shell-derived biochar:spectroscopic investigation and theoretical calculations显示文摘Removal of antimonite[Sb(Ⅲ)]from the aquatic environment and reducing its biotoxicity is urgently needed to safeguard environmental and human health.Herein,crawfish shell-derived biochars(CSB),pyrolyzed at 350,500,and 650℃,were used to remediate Sb(Ⅲ)in aqueous solutions.The adsorption data best fitted to the pseudo-second-order kinetic and Langmuir isotherm models.Biochar produced at 350℃(CSB350)showed the highest adsorption capacity(27.7 mg g^(−1)),and the maximum 78%oxidative conversion of Sb(Ⅲ)to Sb(V).The adsorption results complemented with infrared(FTIR),X-ray photoelectron(XPS),and near-edge X-ray absorption fine structure(NEXAFS)spectroscopy analyses indicated that the adsorption of Sb(Ⅲ)on CSB involved electrostatic interaction,surface complexation with oxygen-containing functional groups(C=O,O=C-O),π-πcoordination with aromatic C=C and C-H groups,and H-bonding with-OH group.Density functional theory calculations verified that surface complexation was the most dominant adsorption mechanism,whilstπ-πcoordination and H-bonding played a secondary role.Furthermore,electron spin resonance(ESR)and mediated electrochemical reduction/oxidation(MER/MEO)analyses confirmed that Sb(Ⅲ)oxidation at the biochar surface was governed by persistent free radicals(PFRs)(•O_(2)^(−)and•OH)and the electron donating/accepting capacity(EDC/EAC)of biochar.The abundance of preferable surface functional groups,high concentration of PFRs,and high EDC conferred CSB350 the property of an optimal adsorbent/oxidant for Sb(Ⅲ)removal from water.The encouraging results of this study call for future trials to apply suitable biochar for removing Sb(Ⅲ)from wastewater at pilot scale and optimize the process. | Hanbo Chen Yurong Gao Jianhong Li Chenghua Sun Binoy Sarkar Amit Bhatnagar Nanthi Bolan Xing Yang Jun Meng Zhongzhen Liu Hong Hou Jonathan WCWong Deyi Hou Wenfu Chen Hailong Wang | 2022 | Biochar2022，4，1： | 0 |
| 7 | Chiral carbon dots from glucose by room temperature alkaliassisted synthesis for electrocatalytic oxidation of tryptophan enantiomers显示文摘Chiral catalysis is one of the most direct and effective approach to obtain pure optical enantiomers.Chiral carbon dots(CDs)as carbon-based chiral catalysts show great potential in chiral catalysis.Herein,we report a facile one step base-catalyzed aldol condensation to fabricate the chiral CDs from glucose at ambient temperature and pressure.The formation of chiral CDs involves the processes of isomerization and aldol condensation.These chiral CDs have been demonstrated that they have selective capacity for electrocatalytic oxidization of tryptophan enantiomers.L type of CDs(LCDs)is more likely to catalyze L-tryptophan(Trp)than D-Trp with the selective factor(I_(L)/I_(D))of 1.60,whereas the D type of CDs(DCDs)tends to catalyze D-Trp(I_(L)/I_(D):0.63).Theoretical calculations combined with various contrast experiments(temperature and pH)demonstrate that the selectively electrocatalytic capacity of chiral CDs toward Trp isomers is due to the different hydrogen-bond interactions between chiral CDs and Trp. | Mengling Zhang Xing Fan Xin Du Yurong Ma Xiting Wang Hui Huang Yang Liu Youyong Li Zhenhui Kang | 2023 | Nano Research2023，16，7： | 0 |
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