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| 1 | Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death显示文摘Mitochondrial 钙 uniporter (MCU ) 是在在真核细胞的房间的 mitochondrial 的保存 Ca 2+ transporter。然而,在氧化导致压力的房间死亡的 MCU 蛋白质的角色仍然保持不清楚。这里,我们证明宫外地表示的 MCU 是在局部性的 mitochondrial HeLa 和主要小脑的小粒神经原(CGN ) 。内长的 MCU 减少 mitochondrial Ca 2+ 举起追随者组织安刺激击倒并且稀释氧化应力在 HeLa 房间和 CGN 导致的房间死亡。我们也发现 MCU 与 VDAC1 交往并且调停在 CGN 的 VDAC1 导致 overexpression 的房间死亡。这发现证明那 MCU-VDAC1 建筑群调整 mitochondrial Ca 2+ 举起和氧化导致压力的 apoptosis,它可能表示为氧化应力的治疗学的目标联系了疾病。 | Yajin Liao Yumin Hao Hong Chen Qing He Zengqiang Yuan Jinbo Cheng | 2015 | Protein & Cell2015，6，6： | 12 |
| 2 | Enabling practical electrocatalyst-assisted photoelectro- chemical water splitting with earth abundant materials显示文摘 | Xiaogang Yang Rui Liu Yumin He James Thorne Zhi Zheng Dunwei Wang | 2015 | Nano Research2015，8，1： | 11 |
| 3 | Overview and countermeasures of cancer burden in China显示文摘Cancer is one of the leading causes of human death worldwide.Treatment of cancer exhausts significant medical resources,and the morbidity and mortality caused by cancer is a huge social burden.Cancer has therefore become a serious economic and social problem shared globally.As an increasingly prevalent disease in China,cancer is a huge challenge for the country’s healthcare system.Based on recent data published in the Journal of the National Cancer Center on cancer incidence and mortality in China in 2016,we analyzed the current trends in cancer incidence and changes in cancer mortality and survival rate in China.And also,we examined several key risk factors for cancer pathogenesis and discussed potential countermeasures for cancer prevention and treatment in China. | Yian Wang Qijia Yan Chunmei Fan Yongzhen Mo Yumin Wang Xiayu Li Qianjin Liao Can Guo Guiyuan Li Zhaoyang Zeng Wei Xiong He Huang | 2023 | Science China(Life Sciences)2023，66，11： | 5 |
| 4 | Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA显示文摘Nasopharyngeal carcinoma(NPC)is a malignant tumor that usually occurs in people from Southeast Asia and Southern China.NPC is prone to migration and invasion,leading to poor prognosis.A large number of circular RNAs(circ RNAs)exacerbate the process of metastasis in NPC;however,their underlying mechanisms remain unclear.We found that the circular RNA circ CCNB1,encoded by the oncogene CCNB1,was downregulated in NPC biopsies and cell lines.In vitro assays show that circ CCNB1 inhibits NPC cell migration and invasion.Moreover,circ CCNB1 induces a protein,nuclear factor 90(NF90),to bind and prolong the half-life of tight junction protein 1(TJP1)m RNA.Upregulation of TJP1 enhances tight junctions between cancer cells and inhibits NPC cell migration and invasion.This study reveals a novel biological function of circ CCNB1 in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and TJP1 m RNA,and may provide a potential therapeutic target for NPC. | Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou Chunmei Fan Le Tang Yongzhen Mo Yumin Wang Qijia Yan Zhaojian Gong Zheng Li Qianjin Liao Can Guo He Huang Xi Zeng Guiyuan Li Zhaoyang Zeng Wei Xiong Fuyan Wang | 2022 | Science China(Life Sciences)2022，65，11： | 4 |
| 5 | Review of source identification methodologies for heavy metals in solid waste显示文摘Source characterization of heavy metals is prerequisite to assessing their potential contamination pathways and environmental risks,based on which pollution control and environmental remediation measures can be properly targeted.In the present study,recent progress in methodologies of source identification of heavy metals in solid waste are summarized.The key scientific concerns related to these methodologies based on the total contents,chemical speciation,isotopic composition,and single-particle signature are also discussed.Finally,prospective research with regard to source identification of heavy metals in solid waste is discussed according to current research conditions and progress. | ZHANG Hua YAO QiSheng ZHU YuMin FAN ShiSuo HE PinJing | 2013 | Chinese Science Bulletin2013，58，2： | 3 |
| 6 | Data mining-based study on sub-mentally healthy state among residents in eight provinces and cities in China显示文摘OBJECTIVE: To apply data mining methods to research on the state of sub-mental health among residents in eight provinces and cities in China and to mine latent knowledge about many conditions through data mining and analysis of data on 3970 sub-mentally healthy individuals selected from 13385 relevant question naires.METHODS: The strategic tree algorithm was used to identify the main mani festations of the state of sub-mental health. The backpropogation artificial neural network was used to analyze the main mani festations of sub-healthy mental states of three different degrees. A sub-mental health evaluation model was then established to achieve predictive evaluationresults.RESULTS: Using classifications from the Scale of Chinese Sub-healthy State, the main manifestations of sub-mental health selected using the strate gictree were F1101(Do you lack peace of mind?),F1102(Are you easily nervous when something comes up?), and F1002(Do you often sigh?). The relative intensity of manifestations of sub-mental health was highest for F1101, followed by F1102,and then F1002. Through study of the neural network, better differentiation could be made between moderate and severe and between mild and severe states of sub-mental health. The differentiation between mild and moderate sub-mental health states was less apparent. Additionally, the sub-mental health state evaluation model, which could be used to predict states of sub-mental health of different individuals, was established using F1101, F1102, F1002, and the mental self-assessment totals core.CONCLUSION: The main manifestations of the state of sub-mental health can be discovered using data mining methods to research and analyze the latent laws and knowledge hidden in research evidence on the state of sub-mental health. The state of sub-mental health of different individuals can be rapidly predicted using the model established here.This can provide a basis for assessment and intervention for sub-mental health. It can also replace the relatively outdated approaches to research on sub-health in the technical era of information and digitization by combining the study of states of sub-mental health with information techniques and by further quantifying the relevant information. | Hongmei Ni Xuming Yang Chengquan Fang Yingying Guo Mingyue Xu Yumin He | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 3 |
| 7 | Engineering of dendritic dopant-free hole transport molecules:enabling ultrahigh fill factor in perovskite solar cells with optimized dendron construction显示文摘Developing dopant-free hole-transporting materials(HTMs)for high-performance perovskite solar cells(PVSCs)has been a very active research topic in recent years since HTMs play a critical role in optimizing interfacial charge carrier kinetics and in turn determining device performance.Here,a novel dendritic engineering strategy is first utilized to design HTMs with a D-A type molecular framework,and diphenylamine and/or carbazole is selected as the building block for constructing dendrons.All HTMs show good thermal stability and excellent film morphology,and the key optoelectronic properties could be fine-tuned by varying the dendron structure.Among them,MPA-Cz-BTI and MCz-Cz-BTI exhibit an improved interfacial contact with the perovskite active layer,and non-radiative recombination loss and charge transport loss can be effectively suppressed.Consequently,high power conversion efficiencies(PCEs)of 20.8%and 21.35%are achieved for MPA-Cz-BTI and MCz-Cz-BTI based devices,respectively,accompanied by excellent long-term storage stability.More encouragingly,ultrahigh fill factors of 85.2%and 83.5%are recorded for both devices,which are among the highest values reported to date.This work demonstrates the great potential of dendritic materials as a new type of dopant-free HTMs for high-performance PVSCs with excellent FF. | Wei Chen Yang Wang Bin Liu Yajun Gao Ziang Wu Yongqiang Shi Yumin Tang Kun Yang Yujie Zhang Weipeng Sun Xiyuan Feng Frédéric Laquai Han Young Woo Aleksandra B.Djurisic Xugang Guo Zhubing He | 2021 | Science China Chemistry2021，64，1： | 2 |
| 8 | Bulk growth and separation of single-walled carbon nanotubes from rhenium catalyst显示文摘Bulk synthesis of single-walled carbon nanotubes(SWNTs)using solid catalyst has been challenging,despite of recent breakthrough in the chirality-specific growth on the flat substrate surface.In this work,we propose a porous magnesia support rhenium catalyst for bulk synthesis of SWNTs.It is found that the well-dispersed catalyst with a high melting point and the optimal chemical vapor deposition reaction conditions account for the growth of SWNTs.Detailed characterizations reveal the produced SWNTs are dominant in(n,n−1)and(n,n−2)species.Furthermore,by using a multicolumn chromatography post-growth separation method,SWNTs with three defined diameter ranges were obtained.This work guides the design of porous oxide supported catalyst for bulk synthesis and diameter-dependent sorting of SWNTs,which will ultimately help harness the extraordinary properties of SWNTs. | Chen Ma Yumin Liu Lili Zhang Liu Qian Yiming Zhao Ying Tian Qianru Wu Dong Li Nan Zhao Xueting Zhang Liantao Xin Huaping Liu Pengxiang Hou Chang Liu Maoshuai He Jin Zhang | 2022 | Nano Research2022，15，7： | 2 |
| 9 | Discussion on calculation of the local flexibility due to the crack in a pipe显示文摘 | Yumin He Junjie Ye Xuefeng Chen Zhengjia He | 2009 | Mechanical Systems and Signal Processing2009，23，： | 1 |
| 10 | Optimal channels of the Garvey-Kelson mass relations in extrapolation显示文摘Garvey-Kelson mass relations connect nuclear masses of neighboring nuclei within high accuracy, and provide us with convenient tools in predicting unknown masses by extrapolations from existent experimental data. In this paper we investigate optimal'channels' of the Garvey-Kelson relations in extrapolation to the unknown regions, and tabulate our predicted masses by using these optimized channels of the Garvey-Kelson relations. | Man Bao Zeng He YiYuan Cheng YuMin Zhao Akito Arima | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，2： | 1 |
| 11 | Adap- tive multiresolution finite element method based on sec- ond generation wavelets 显示文摘 | He Yumin Chen Xuefeng Xiang Jiawei | 2007 | Finite Elements in Analy- sis and Design2007，43，67： | 1 |
| 12 | Ceramic Green Tape Extrusion for Laminated Ob- ject Manufacturing显示文摘 | Zhang Yumin He Xiaodong Han Jiecai | 1999 | Materials Letters1999，40，6： | 1 |
| 13 | Alz 03 Ceramics Preparation by LOM(Laminated Object Manufacturing) 显示文摘 | Zhang Yumin He Xiaodong Du Shanyi | 2001 | The International Journal of Advanced Manufacturing Technology2001，17，7： | 1 |
| 14 | Preparation and evaluation of duloxetine hydrochloride enteric-coated pellets with different enteric polymers显示文摘The main purpose of the present study was to prepare duloxetine hydrochloride(DXH) entericcoated pellets using different enteric polymers. Three layers(drug-loaded layer, barrier layer,and enteric-coated layer) were applied to the inert core pellets, successively. The optimal formulation was manufactured by employing suspension layering method in fluidized bed processor(FBP) with varieties of enteric polymers like Aqoat? AS-LF, Eudragit? L30D55 and HPMCP-HP55. The prepared pellets were measured for physical characterization and the in vitro dissolution profile. Scanning electron microscopy(SEM) was conducted to observe the morphology of pellets, and different kinetic models were applied to analyze the release mechanism of Cymbalta? and home-made pellets. The coating weight gain of enteric-coated layer containing Eudragit? L30D55, Aqoat? AS-LF and HP-55 were determined to be 35%, 26% and 24%, respectively. The similarity factors(f2) of self-made capsules with above polymers and commercially available capsules(Cymbalta?) were above 50 in the dissolution medium of pH 6.8 phosphate buffer solution(PBS). SEM figures showed the smooth surfaces of selfprepared pellets using Eudragit? L30D55 and Aqoat? AS-LF, whereas rough surface was found in the HP-55 pellets at day 0, and an impurity was appearing in the condition of 40 ℃/75% relative humidity for 1 month. In conclusion, the pellets prepared by utilizing Eudragit? L30D55 and Aqoat?AS-LF were the optimal preparations based on the dissolution profile and stability. | Chen Kuang Yinghua Sun Bing Li Rui Fan Jing Zhang Yumin Yao Zhonggui He | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，3： | 1 |
| 15 | Adaptive multiresolution finite dement method based on second Generation wavelets显示文摘 | Yumin He | 2007 | Finite Elements in Analysis andDesign2007，43，6： | 1 |
| 16 | Autophagy is involved in anticancer effects of matrine on SGC-7901 humangastric cancer cells显示文摘 | Junqiang Zhang Yumin Li Xiaohui Chen Tao Liu Yingtai Chen Wenting He Quanbao Zhang Shiyuan Liu | 2011 | Oncology Reports2011，，1： | 1 |
| 17 | Discus- sion on calculation of the local flexibility due to the crack in a pipe显示文摘 | He Yumin Ye Junjie Chen Xuefeng | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 18 | Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells显示文摘 | Shiyuan Liu Yumin Li Wei Chen Pengfei Zheng Tao Liu Wenting He Junqiang Zhang Xiangting Zeng | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 19 | Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats显示文摘 | Haibo He Jia Xu Yuanqing Xu Changcheng Zhang Hongwu Wang Yumin He Ting Wang Ding Yuan | 2011 | Journal of Ethnopharmacology2011，，1： | 1 |
| 20 | Cyclooxygenase-2 ?765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population显示文摘 | Jianhong He Quanbao Zhang Zhijian Ren Yumin Li Xun Li Wence Zhou Hui Zhang Wenbo Meng Jun Yan Wenting He | 2012 | Molecular Biology Reports2012，，4： | 1 |
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