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| 1 | Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy显示文摘The phosphatidylinositol 3-kinase(PI3K) pathway is frequently activated in human cancers.Class I PI3 Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate(PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate(PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin(m TOR) to play key roles in carcinogenesis. Therefore, PI3 K has become an important anticancer drug target, and currently there is very high interest in the pharmaceutical development of PI3 K inhibitors. Idelalisib has been approved in USA and Europe as the first-in-class PI3 K inhibitor for cancer therapy. Dozens of other PI3 K inhibitors including BKM120 and ZSTK474 are being evaluated in clinical trials. Multifaceted studies on these PI3 K inhibitors are being performed, such as single and combinational efficacy, resistance, biomarkers,etc. This review provides an introduction to PI3 K and summarizes key advances in the development of PI3 K inhibitors. | Wennan Zhao Yuling Qiu Dexin Kong | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 19 |
| 2 | Spatial correlation analysis of sea-bottom backscattering显示文摘The principle of the spatial correlation characteristics of sea-bottom backscattering was expounded.The Kirchhoff model is introduced to simulate sea-bottom backscattering and the spatial correlation is calculated.Some sediment characteristic parameters,such as the ratio of sediment mass density to water mass density,the ratio of sediment sound speed to water sound speed,the attenuation coefficient of sound waves,the strength and exponent of seabottom interface roughness spectrum,are considered while simulating and their influences on spatial correlation are analyzed.By establishing the expressions of the sediment characteristic parameters with the logarithmic sediment grain size,the variation tendency of the spatial correlation versus the logarithmic sediment grain size is obtained.The width of the major lobe of the spatial correlation function narrows as the logarithmic sediment grain size increases.The comparisons between simulated data and in-situ data collected in October 2007 have proven that their spatial correlation function waveforms agree well under the same sediment characteristics. | KUAI Duojie WANG Changhong FENG Lei WANG Yuling QIU Wei YI Huiqin CHEN Long | 2012 | Chinese Journal of Acoustics2012，31，3： | 9 |
| 3 | Preparation and characterization of paclitaxel-loaded poly lactic acid-co-glycolic acid coating tracheal stent显示文摘 | Kong Yingying Zhang Jie Wang Ting Qiu Xiaojian Wang Yuling | 2014 | Chinese Medical Journal2014，，12： | 4 |
| 4 | Chalcocite(bio)hydrometallurgy-current state,mechanism,and future directions:A review显示文摘There has been a strong interest in technologies suited for mining and processing of low-grade ores because of the rapid depletion of mineral resources in the world.In most cases,the extraction of copper from such raw materials is achieved by applying the leaching procedures.However,its low extraction efficiency and the long extraction period limit its large-scale commercial applications in copper recovery,even though bioleaching has been widely employed commercially for heap and dump bioleaching of secondary copper sulfide ores.Overcoming the technical challenges requires a better understanding of leaching kinetics and on-site microbial activities.Herein,this paper reviews the current status of main commercial biomining operations around the world,identifies factors that affect chalcocite dissolution both in chemical leaching and bioleaching,summarizes the related kinetic research,and concludes with a discussion of two on-site chalcocite heap leaching practices.Further,the challenges and innovations for the future development of chalcocite hydrometallurgy are presented in the end. | Shichao Yu Rui Liao Baojun Yang Chaojun Fang Zhentang Wang Yuling Liu Baiqiang Wu Jun Wang Guanzhou Qiu | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 5 | Improving the accuracy of genomic prediction for meat quality traits using whole genome sequence data in pigs显示文摘Background Pork quality can directly affect customer purchase tendency and meat quality traits have become valu-able in modern pork production.However,genetic improvement has been slow due to high phenotyping costs.In this study,whole genome sequence(WGS)data was used to evaluate the prediction accuracy of genomic best linear unbiased prediction(GBLUP)for meat quality in large-scale crossbred commercial pigs.Results We produced WGS data(18,695,907 SNPs and 2,106,902 INDELs exceed quality control)from 1,469 sequenced Duroc×(Landrace×Yorkshire)pigs and developed a reference panel for meat quality including meat color score,marbling score,L*(lightness),a*(redness),and b*(yellowness)of genomic prediction.The prediction accuracy was defined as the Pearson correlation coefficient between adjusted phenotypes and genomic estimated breeding values in the validation population.Using different marker density panels derived from WGS data,accuracy differed substantially among meat quality traits,varied from 0.08 to 0.47.Results showed that MultiBLUP outperform GBLUP and yielded accuracy increases ranging from 17.39%to 75%.We optimized the marker density and found medium-and high-density marker panels are beneficial for the estimation of heritability for meat quality.Moreover,we conducted genotype imputation from 50K chip to WGS level in the same population and found average concord-ance rate to exceed 95%and r^(2)=0.81.Conclusions Overall,estimation of heritability for meat quality traits can benefit from the use of WGS data.This study showed the superiority of using WGS data to genetically improve pork quality in genomic prediction. | Zhanwei Zhuang Jie Wu Yibin Qiu Donglin Ruan Rongrong Ding Cineng Xu Shenping Zhou Yuling Zhang Yiyi Liu Fucai Ma Jifei Yang Ying Sun Enqin Zheng Ming Yang Gengyuan Cai Jie Yang Zhenfang Wu | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 1 |
| 6 | Synthesis, crystal structures and fluorescence properties of 3-(2-pyridyl)coumarin derivatives显示文摘 | Tianzhi Yu Sidan Yang Yuling Zhao Hui Zhang Xiaoqian Han Duowang Fan Yongqing Qiu Lili Chen | 2010 | Journal of Photochemistry & Photobiology A: Chemistry2010，，1： | 1 |
| 7 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
| 8 | Novel design and synthesis of 1D bamboo-like CNTs@Sn_(4)P_(3)@C coaxial nanotubes for long-term sodium ion storage显示文摘In this work,a novel bamboo-like carbon nanotubes@Sn4P3@carbon(BLCNTs@Sn_(4)P_(3)@C)coaxial nanotubes are designed and prepared using a newly developed hydrothermal method followed by a phophidation process.The prepared Sn_(4)P_(3) nanoparticles are uniformly coated and wrapped on the one-dimensional(1D)bamboo-like CNTs,which is covered by a uniform carbon layer to form a sandwich-like structure with Sn_(4)P_(3) in between.The inner CNT and outer carbon can effectively maintain the structural stability and serve as the good electron conductors.Additionally,the outer carbon coating layer can effectively keep BLCNTs@Sn_(4)P_(3)@C nanotubes separate each other,preventing aggregation of Sn_(4)P_(3) during charge/discharge when this material is used as anode for sodium ion batteries.The anode of BLCNTs@Sn_(4)P_(3)@C shows excellent reversible capacity and a long cycling of over 2000 cycles.The unique design of coaxial nanotubes is greatly beneficial to the electrochemical performance of Sn_(4)P_(3) for sodium ion storage. | Qianyu Zhang Yuling Xu Lifeng Qiu Axue Liu Rui Wang Longhai Zhang Chaofeng Zhang Yan-Jie Wang Jiujun Zhang | 2022 | Green Energy & Environment2022，7，6： | 0 |
| 9 | Theory and signal processing of acoustic correlation techniques for current velocity measurement显示文摘到估计水流速度的声学的关联大小的一个理论模型和信号处理被讨论。在 Fraunhofer 地区以内的音量回响的声纳时空关联功能被导出。功能,在指数的表格,是声学的关联大小的理论模型。在当前的速度的大多数信息被包含的地方,在关联函数的振幅的最大值附近的关联值的特征首先被分析。局部性的最不吝啬的广场(LLMS ) 标准为速度评价被提出。顺序的二次的编程(SQP ) 方法作为优化方法被采用。因此为当前的速度测量的声学的关联技术的系统的信号处理方法被建立。一个原型声学的关联水流剖析程序(ACCP ) 经历了几海试用,理论模型近似与试验性的结果与一致的结果表演。包括从 ACCP 的速度和方向的当前的侧面与从声学的 Doppler 当前的剖析程序(ADCP ) 的那些相比。由两台仪器的当前的侧面相当同意很好。另外,由 ACCP 的速度测量的标准差统计上被计算,它比预言的价值大一些。 | ZHU Weiqing FENG Lei WANG Changhong WANG Yuling QIU Wei | 2008 | Chinese Journal of Acoustics2008，27，1： | 0 |
| 10 | Comparative study on the obsolescence of domestichumanities and social sciences显示文摘Based on 2,217,047 references of 280,280 source articles in CSSCI 2006-2008,we compared the aging law of seven disciplines of humanities and social sciences by means of synchronous citation analysis and discovered the overall aging phenomenon of humanities and social sciences.The results showed that the aging of History did not strictly follow the negative exponential function;the aging speed of humanities is slower than social sciences;the dependence of History and Philosophy on archival literature is the strongest;each discipline of the humanities and social sciences has a basic function:half life(H)*Price Index(P)=constant C,C is 2.6 or so;the maximum citation age of humanities and social sciences at this stage is 3 years. | QIU Junping SONG Yanhui YANG Siluo Zhang Yuling | 2012 | Journal of Library Science in China2012，，1： | 0 |
| 11 | Nonylphenol photodegradation by novel ternary MIL-100(Fe)/ZnFe_(2)O_(4)/PCN composite under visible light irradiation via double charge transfer process显示文摘Nonylphenol(NP)residues,as a typical endocrine disrupting chemical(EDC),frequently exist in sewage,surface water,groundwater and even drinking water,which poses a serious threat to human health due to its bioaccumulation.In order to remove NP,a series of MIL-100(Fe)/Zn Fe_(2)O_(4)/flake-like porous carbon nitride(MIL/ZC)was synthesized through in-situ synthesis at room temperature.High performance of ternary MIL/ZC is used to degrade NP under visible light irradiation.The results show that 30MIL/ZC2(20 wt.%Zn Fe_(2)O_(4))ternary composite had the best photocatalytic activity(99.84%)when the dosage was 30 mg.Further mechanism analysis shows that the excellent photocatalytic activity of 30MIL/ZC2could be ascribed to the double charge transfer process between flake-like porous carbon nitride(PCN)and other catalysts in the ternary heterojunction,and the separation of photogenerated electron-hole pairs was more effective.In addition,the 30MIL/ZC2 also showed high stability after five cycles of the photodegradation reaction.Furthermore,the active substance(·O_(2)^(-))was considered to be the main active substance in the NP degradation process.Based on the research results,the possible photocatalytic reaction mechanism of 30MIL/ZC2ternary composite was proposed and discussed in detail. | Kailin Xu Li Jiao Chuqiao Wang Yiming Bu Yuling Tang Liwei Qiu Qiuya Zhang Liping Wang | 2022 | Journal of Environmental Sciences2022，34，1： | 0 |
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