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| 1 | Cryogenic 3D printing of dual-delivery scaffolds for improved bone regeneration with enhanced vascularization显示文摘Three-dimensional(3D)printing has been increasingly employed to produce advanced bone tissue engineering scaffolds with biomimetic structures and matched mechanical strengths,in order to induce improved bone regeneration in defects with a critical size.Given that the successful bone regeneration requires both excellent osteogenesis and vascularization,endowing scaffolds with both strong bone forming ability and favorable angiogenic potential would be highly desirable to induce improved bone regeneration with required vascularization.In this investigation,customized bone tissue engineering scaffolds with balanced osteoconductivity/osteoinductivity were produced via cryogenic 3D printing ofβ-tricalcium phosphate and osteogenic peptide(OP)containing water/poly(lactic-co-glycolic acid)/dichloromethane emulsion inks.The fabricated scaffolds had a hierarchically porous structure and were mechanically comparable to human cancellous bone.Angiogenic peptide(AP)containing collagen I hydrogel was then coated on scaffold surface to further provide scaffolds with angiogenic capability.A sequential release with a quick AP release and a slow but sustained OP release was obtained for the scaffolds.Both rat endothelial cells(ECs)and rat bone marrow derived mesenchymal stem cells(MSCs)showed high viability on scaffolds.Improved in vitro migration and angiogenesis of ECs were obtained for scaffolds delivered with AP while enhanced osteogenic differentiation was observed in scaffolds containing OP.The in vivo results showed that,toward scaffolds containing both AP and OP,the quick release of AP induced obvious angiogenesis in vivo,while the sustained OP release significantly improved the new bone formation.This study provides a facile method to produce dual-delivery scaffolds to achieve multiple functions. | Chong Wang Jiahui Lai Kai Li Shaokui Zhu Bingheng Lu Jia Liu Yujin Tang Yen Wei | 2021 | Bioactive Materials2021，6，1： | 7 |
| 2 | The significance and variation characteristics of interlay water in smectite of hydrocarbon source rocks显示文摘To investigate variation characteristics of interlayer water bound up with organic matter in smectite, organo-clay complexes extracted from grinded source rock samples were determined using thermo-XRD, DTA and PY-GC. The d001 diffraction peak of organo-clay complexes is postponed from 250 to 550°C before reaching 1.00 nm and accompanied by exothermal peaks on DTA and organic matter with abundant C20-C30 carbon detected by PY-GC, which is different from single smectite and indicates the existence of organic matter in the interlayer of smectite. Water desorption characteristics of organo-clay complexes are in consistent with smectite at 100 and 600°C, but different from smectite at 550°C with an additional dehydration peak and a remaining d001 diffraction peak, suggesting the water removed at 550°C is interlayer adsorption water rather than constituent water of clay minerals. Comparing the dehydration order and water loss, we conclude that part of interlayer water of smectite may act as the 'bridge' that binds organic matter and smectite, which results in water-expelled lag beyond 250°C and may provide a good medium for hydrocarbon migration and oil pool formation. | CAI JinGong LU LongFei BAO YuJin FAN Fu XU JinLi | 2012 | Science China Earth Sciences2012，55，3： | 6 |
| 3 | Densification,microstructure and mechanical properties of multicomponent(TiZrHfNbTaMo)C ceramic prepared by pressureless sintering显示文摘A multicomponent(TiZrHfNbTaMo)C ceramic has been fabricated by pressureless sintering at temperatures from 2100℃to 2500℃,using an equimolar multicomponent carbide powder synthesized by carbothermal reduction as the starting material.Influence of sintering temperature on densification,microstructure and mechanical properties of the ceramics was investigated.The relative density increases with increasing sintering temperature,and a nearly fully dense sample is achieved by pressureless sintering at 2500℃.Average grain size increases from 3.7 to 15.2μm with increasing sintering temperature from 2300 to 2500℃.The(TiZrHfNbTaMo)C ceramic sintered at 2400℃exhibits a single phase fcc structure with homogeneous chemical composition,an average grain size of 7.0μm and a relative density of96.5%,while its measured hardness is 33.2 GPa at 100 mN and 23.2 GPa at 9.8 N. | Wen Zhang Lei Chen Chenguang Xu Wenyu Lu Yujin Wang Jiahu Ouyang Yu Zhou | 2021 | Journal of Materials Science & Technology2021，，13： | 4 |
| 4 | Aerodynamic performance enhancement of co-flow jet airfoil with simple high-lift device显示文摘The present study performed a numerical investigation to explore the performance enhancement of a co-flow jet(CFJ)airfoil with simple high-lift device configuration,with a specific goal to examine the feasibility and capability of the proposed configuration for low-speed take-off and landing.Computations have been accomplished by an in-house-programmed Reynoldsaveraged Navier-Stokes solver enclosed by k-ωshear stress transport turbulence model.Three crucial geometric parameters,viz.,injection slot location,suction slot location and its angle were selected for the sake of revealing their effects on aerodynamic lift,drag,power consumption and equivalent lift-to-drag ratio.Results show that using simple high-lift devices on CFJ airfoil can significantly augment the aerodynamic associated lift and efficiency which evidences the feasibility of CFJ for short take-off and landing with small angle of attack.The injection and suction slot locations are more influential with respect to the aerodynamic performance of CFJ airfoil compared with the suction slot angle.The injection location is preferable to be located in the downstream of the pressure suction peak on leading edge to reduce the power expenditure of the pumping system for a relative higher equivalent lift-to-drag ratio.Another concluded criterion is that the suction slot should be oriented on the trailing edge flap for achieving more aerodynamic gain,meanwhile,carefully selecting this location is crucial in determining the aerodynamic enhancement of CFJ airfoil with deflected flaps. | Haolin ZHI Zhenhao ZHU Yujin LU Shuanghou DENG Tianhang XIAO | 2021 | Chinese Journal of Aeronautics2021，34，9： | 3 |
| 5 | Auxin response factor 6A regulates photosynthesis,sugar accumulation,and fruit development in tomato显示文摘Auxin response factors(ARFs)are involved in auxin-mediated transcriptional regulation in plants.In this study,we performed functional characterization of SlARF6A in tomato.SlARF6A is located in the nucleus and exhibits transcriptional activator activity.Overexpression of SlARF6A increased chlorophyll contents in the fruits and leaves of tomato plants,whereas downregulation of SlARF6A decreased chlorophyll contents compared with those of wild-type(WT)plants.Analysis of chloroplasts using transmission electron microscopy indicated increased sizes of chloroplasts in SlARF6A-overexpressing plants and decreased numbers of chloroplasts in SlARF6A-downregulated plants.Overexpression of SlARF6A increased the photosynthesis rate and accumulation of starch and soluble sugars,whereas knockdown of SlARF6A resulted in opposite phenotypes in tomato leaves and fruits.RNA-sequence analysis showed that regulation of SlARF6A expression altered the expression of genes involved in chlorophyll metabolism,photosynthesis and sugar metabolism.SlARF6A directly bound to the promoters of SlGLK1,CAB,and RbcS genes and positively regulated the expression of these genes.Overexpression of SlARF6A also inhibited fruit ripening and ethylene production,whereas downregulation of SlARF6A increased fruit ripening and ethylene production.SlARF6A directly bound to the SAMS1 promoter and negatively regulated SAMS1 expression.Taken together,these results expand our understanding of ARFs with regard to photosynthesis,sugar accumulation and fruit development and provide a potential target for genetic engineering to improve fruit nutrition in horticulture crops. | Yujin Yuan Xin Xu Zehao Gong Yuwei Tang Mengbo Wu Fang Yan Xiaolan Zhang Qian Zhang Fengqing Yang Xiaowei Hu Qichen Yang Yingqing Luo Lihua Mei Wenfa Zhang Cai-Zhong Jiang Wangjin Lu Zhengguo Li Wei Deng | 2019 | Horticulture Research2019，6，1： | 3 |
| 6 | Dynamics of structural systems with various frequency-dependent damping models显示文摘这份报纸的目的是介绍包含的系统的动态分析各种各样的抑制模型。力量取决于的抑制的假定频率依赖者经由在某抑制的核上的卷绕旋转积分的运动的过去的历史工作。由选合适的抑制为抑制模型的频率依赖者的核功能,它可以从熟悉的粘弹性的材料被导出。可得到的抑制的选择上的文学的简短评论建模的 A 被介绍。模式重叠方法和 Fourier 变换方法被开发因为与各种各样的抑制计算结构的系统的动态反应当模特儿。在与各种各样的抑制模型一起的非缺乏的系统的情况中,有重复特征值的形式的分析很类似于在未受潮或粘滞地抑制的系统使用的传统的形式的分析,这被显示出。基于伪力量途径,另外,我们与进有零个起始的条件并且因此的相等的起始的条件介绍的非零转变运动的原来的方程为有各种各样的抑制的结构的系统的动力学的一个 Fourier 变换方法当模特儿。最后,一些案例研究被用来显示出导出的公式的应用程序和有效性。 | Li LI Yujin Hu Weiming DENG Lei LU Zhe DING | 2015 | Frontiers of Mechanical Engineering2015，10，1： | 2 |
| 7 | Perovskite-based color camera inspired by human visual cells显示文摘There are two primary types of photoreceptor cells in the human eye:cone cells and rod cells that enable color vision and night vision,respectively.Herein,inspired by the function of human visual cells,we develop a high-resolution perovskite-based color camera using a set of narrowband red,green,blue,and broadband white perovskite photodetectors as imaging sensors.The narrowband red,green,and blue perovskite photodetectors with color perceptions mimic long-,medium-,and short-wavelength cones cells to achieve color imaging ability.Also,the broadband white perovskite photodetector with better detectivity mimics rod cells to improve weak-light imaging ability.Our perovskite-based camera,combined with predesigned pattern illumination and image reconstruction technology,is demonstrated with high-resolution color images(up to 256 x 256 pixels)in diffuse mode.This is far beyond previously reported advanced perovskite array image sensors that only work in monochrome transmission mode.This work shows a new approach to bio-inspired cameras and their great potential to strongly mimic the ability of the natural eve. | Yujin Lu Zhong Ji Guobiao Cen Hengchao Sun Haibao Wang Chuanxi Zhao Zhong Lin Wang Wenjie Mai | 2023 | Light(Science & Applications)2023，12，2： | 2 |
| 8 | Petrogenesis of Early Permian Intrusive Rocks from Southeastern Inner Mongolia, China: Constraints on the Tectonic Framework of the Southeastern Central Asian Orogenic Belt显示文摘The late Paleozoic tectonic framework of the southeastern Central Asian Orogenic Belt is key to restricting the accretion orogeny between the Siberia Craton and the North China Craton. To clarify the framework, petrogenesis of early Permian intrusive rocks from southeastern Inner Mongolia was studied. Zircon U-Pb dating for bojite and syenogranite from Ar-Horqin indicate that they were emplaced at 288–285 Ma. Geochemical data reveal that the bojite is highly magnesian and low-K to middle-K calc-alkaline, with E-MORB-type REE and IAB-like trace element patterns. The syenogranite is a middle-K calc-alkaline fractionated A-type granite and shows oceanic-arc-like trace element patterns, with depleted Sr-Nd-Hf isotopes,(~(87)Sr/~(86)Sr)I = 0.7032–0.7042, ε_(Nd)(t) = +4.0 to +6.6 and zircon ε_(Hf)(t) = +11.14 to +14.99. This suggests that the bojite was derived from lithospheric mantle metasomatized by subducted slab melt, while the syenogranite originated from very juvenile arc-related lower crust. Usng data from coeval magmatic rocks from Linxi-Ar-Horqin, the Ar-Horqin intra-oceanic arc was reconstructed, i.e., initial transition in 290–280 Ma and mature after 278 Ma. Combined with regional geological and geophysical materials in southeastern Inner Mongolia, an early Permian tectonic framework as ‘one narrow ocean basin of the PAO', ‘two continental marginal arcs on its northern and southern' and ‘one intra-oceanic arc in its southern' is proposed. | QIAN Cheng LU Lu SHI Lu DU Jiyu WANG Yan YANG Xiaoping ZHANG Yujin | 2022 | Acta Geologica Sinica(English Edition)2022，96，5： | 1 |
| 9 | Use of fNIRS to assess resting state functional connectivity显示文摘 | Lu Chunming Zhang Yujin Biswal BB | 2010 | Journal of Neuroscience Mthods2010，186，2： | 1 |
| 10 | Detecting restingstate functional connectivity in the language system using functional near-infrared spectroscopy显示文摘 | Zhang Yujin Lu Chunming Biswal BB | | Journal of Biomedical Optics0，15，4： | 1 |
| 11 | Quantitative prediction of oil saturation of unconsolidated sandstone reservoir based on time-lapse seismic “relative difference method”: Taking Zeta oil field in West Africa as an example显示文摘In view of the disadvantage that the absolute difference of time-lapse seismic(the difference between monitoring data and base data) is not only related to the change of oil saturation, but also closely related to the thickness of reservoir, a time-lapse seismic 'relative difference method'(the ratio of monitoring data to base data) not affected by the thickness of reservoir but only related to the change of fluid saturation, is proposed through seismic forward modeling after fluid displacement simulation. Given the same change of fluid saturation, the absolute difference of time-lapse seismic conforms to the law of 'tuning effect' and seismic reflection of 'thin bed', and the remaining oil prediction method based on absolute difference of time-lapse seismic is only applicable to the reservoirs with uniform thickness smaller than the tuning thickness or with thickness greater than the tuning thickness. The relative difference of time-lapse seismic is not affected by reservoir thickness, but only related to the change of fluid saturation. It is applicable to all the deep-sea unconsolidated sandstone reservoirs which can exclude the effect of pressure, temperature, pore type and porosity on seismic. Therefore, the relation between the relative difference of time-lapse seismic and the change of fluid saturation, which is obtained from seismic forward modeling after Gassmann fluid displacement simulation, can be used to quantitatively predict the change of reservoir water saturation and then the distribution of the remaining oil. The application of this method in deep sea Zeta oil field in west Africa shows that it is reasonable and effective. | LU Hongmei XU Hai WO Yujin GU Ning | 2019 | Petroleum Exploration and Development2019，46，2： | 0 |
| 12 | Correlation between per-well average dynamic reserves and initial absolute open flow potential(AOFP) for large gas fields in China and its application显示文摘Based on performance data of over 600 wells in 32 large gas fields of different types in China, the correlation is established between per-well average dynamic reserves( G) and average initial absolute open flow potential(IAOFq) of each field, and its connotation and applicability are further discussed through theoretical deduction. In log-log plot, G vs. IAOFq exhibit highly dependent linear trend, which implicates the compatibility between G and IAOFq attained through development optimization to reach the balance among annual flow capacity, maximum profits and certain production plateau, that is to match productivity with rate maintenance capacity. The correlation can be used as analogue in new gas field development planning to evaluate the minimum dynamic reserves which meet the requirement of stable and profitable production, and facilitate well pattern arrangement. It can also serve as criteria to appraise the effectiveness and infill drilling potential of well patterns for developed gas fields. | LI Xizhe LIU Xiaohua SU Yunhe WU Guoming LIU Huaxun LU Linlin WAN Yujin GUO Zhenhua SHI Shi | 2018 | Petroleum Exploration and Development2018，45，6： | 0 |
| 13 | Preparation and evaluation of controllable drug delivery system:A light responsive nanosphere based on β-cyclodextrin/mesoporous silica显示文摘A novel light responsive nanosphere was constructed,and it was used as a drug carrier to investigate the loading and release properties of the Quercetin(QU).In this paper,mesoporous silica nanoparticles(MSN)were used as a substrate,and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce—NH_(2),and the azobenzene-4,4’-dicarboxylic acid(AZO)was used as light responsive agent to introduce the group of—N=N—,and thenβ-cyclodextrin(β-CD)was combined with AZO through host-guest interaction to construct light responsive nanoparticles(MSN@β-CD).The structure and properties of the carrier were analyzed by FTIR,BET,XPS,TGA,XRD,SEM and TEM.In vitro drug release studies showed the release rate of QU@MSN@β-CD(dark)was 12.19%within 72 h,but the release rate of QU@MSN@β-CD(light 10 min)was 26.09%,exhibiting a light-responsive property.The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU.Therefore,the controllable light-responsive drug delivery system has great application prospects. | Yi Wu Hongzhou Shang Shisheng Lai Yali Di Xiaoran Sun Ning Qiao Lihua Han Zheng Zhao Yujin Lu | 2023 | Chinese Journal of Chemical Engineering2023，62，10： | 0 |
| 14 | Insight into the role of ethylene glycol on thermodynamics and nucleation kinetics of dimethyl terephthalate in mixed solvent system显示文摘Dissolution and nucleation are two essential processes for industrial crystallization.This paper in-vestigates the effect of ethylene glycol addition on the crystallization behavior of dimethyl terephthalate(DMT)in solution.The DMT solubility in mixed solvent system(methanol-ethylene glycol)was deter-mined by isothermal satiation approach,and the solubility was associated using seven models.The model fitting results were consistent with the experimental values.Based on the results,the metastable zone width(MSZW)of DMT was detected by the polythermal approach;the modified Sangwal's theory was used to investigate the nucleation behavior,which can provide a new way of thought for better analysis of the crystallization behavior.The results demonstrated that MSZW was associated with various elements,such as cooling rate,saturation temperature and mass fraction of ethylene glycol.The addition of ethylene glycol slowed down the nucleation rate as shown by the broadening of MSZW.We derive the solid-liquid interface energy,the nucleation driving force,the critical nucleation size and the critical Gibbs free energy according to the classical nucleation theory.It is demonstrated that the nucleation driving force and the solid-liquid interface energy are dependent and jointly influence the MSZW. | Yujin Zhang Chunyan Shi Jing Tang Li Liu Dongxia Yan Qing Zhou Xingmei Lu Songyan Jia | 2024 | Particuology2024，85，2： | 0 |
| 15 | 广东省放疗医师对乳腺癌改良根治术后放射治疗认识现状调查分析(英文)显示文摘Objective:The aim of our study was to comprehensively access current status of radiotherapy physicians' opinions in post-mastectomy radiotherapy(PMRT) for breast cancer in Guangdong province.Methods:From June 2007 to June 2008,questionnaires on the clinical value,sequencing with chemotherapy and endocrine therapy,indications and irradiated targets for PMRT were sent to physicians of all radiotherapy departments registering at Radiotherapy Professional Committee of Guangdong Anti-cancer Association.Results:There were 126 physicians joining this investigation.Proportions of physicians who accepted the views that PMRT could merely improve local control or can improve both local control and overall survival were 100% and 25.2%.The most common sequences of PMRT and chemotherapy or endocrine therapy were 'sandwich' and sequential modes,performed 46.9% and 59.5% respectively.The median interval of surgery and PMRT was 8 weeks.Proportions of physicians who accepted T3-4 diseases,or four or more axillary lymph nodes metastasis,or T1-2 with 1-3 positive lymph nodes,or T1-2N0 with primary tumor located in the center or inner quadrant as the indications of PMRT were 97.6%,100%,46.8%,13.5%,respectively.Proportions of physicians who accepted chest wall,supraclavicular region,internal mammary chain or axilla as irradiated targets were 86.5%,100%,49.2% and 38.9% respectively.Conclusion:For Radiotherapy physicians of Guangdong Province,there is still lacking of consensus in the opinions of whether PMRT can improve survival,and optimal sequencing with chemotherapy or endocrine therapy,and how to make decision for patients with T1-2 with 1-3 positive lymph nodes,and rational irradiated targets,which requires advanced professional training for physicians and further prospective clinical trial evidences to guide clinical practice. | Xiaobo Huang Ge Wen Nianji Cui Yujin Zhang Taixiang Lu Xunxing Guan Mengzhong Liu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，4： | 0 |
| 16 | Low thermal conductivity of dense(TiZrHfVNbTa)C_(x) high-entropy carbides by tailoring carbon stoichiometry显示文摘Transition metal carbides are promising candidates for thermal protection materials due to their high melting points and excellent mechanical properties.However,the relatively high thermal conductivity is still a major obstacle to its application in an ultra-high-temperature insulation system.In this work,the low thermal conductivity of dense(TiZrHfVNbTa)Cx(x=0.6-1)high-entropy carbides has been realized by adjusting the carbon stoichiometry.The thermal conductivity gradually decreases from 10.6 W·m^(−1)·K^(−1) at room temperature to 6.4 W·m^(−1)·K^(−1) with carbon vacancies increasing.Due to enhanced scattering of phonons and electrons by the carbon vacancies,nearly full-dense(97.9%)(TiZrHfVNbTa)C_(0.6) possesses low thermal conductivity of 6.4 W·m^(−1)·K^(−1),thermal diffusivity of 2.3 mm^(2)·s^(−1),as well as electrical resistivity of 165.5μΩ·cm.The thermal conductivity of(TiZrHfVNbTa)C_(0.6) is lower than that of other quaternary and quinary high-entropy carbide ceramics,even if taking the difference of porosity into account in some cases,which is mainly attributed to compositional complexity and carbon vacancies.This provides a promising route to reduce the thermal conductivity of high-entropy carbides by increasing the number of metallic elements and carbon vacancies. | Lei CHEN Wen ZHANG Wenyu LU Boxin WEI Sijia HUO Yujin WANG Yu ZHOU | 2023 | Journal of Advanced Ceramics2023，12，1： | 0 |
| 17 | Highly crystalline and water-wettable benzobisthiazole-based covalent organic frameworks for enhanced photocatalytic hydrogen production显示文摘Two-dimensional covalent organic frameworks are promising for photocatalysis by virtue of their structural and functional diversity,but generally suffer from low activities relative to their inorganic competitors.To fulfill their full potential re quires a rational tailoring of their structures at different scales as well as their surface properties.Herein,we demonstrate benzobisthiazole-based covalent organic frameworks as a superior photocatalyst for hydrogen production.The product features high crystallinity with ordered 2.5-nm-wide cylindrical mesopores and great water wettability.These structural advantages afford our polymeric photo catalyst with fast charge carrier dynamics as evidenced by a range of spectroscopic characterizations and excellent catalytic performances when suspended in solution or supported on melamine foams.Under visible-light irradiation,it enables efficient and stable hydrogen evolution with a production rate of 487μmol h^(-1)(or a mass-specific rate of 48.7 mmol g^(-1)h^(-1))—far superior to the previous state of the art.We also demonstrate that hydrogen production can be stoichiometrically coupled with the oxidation conversion of biomass as exemplified by the conversion of furfuryl alcohol to 2-furaldehyde. | Wei Huang Yongpan Hu Zhengyuan Qin Yujin Ji Xuan Zhao Yunling Wu Qing He Youyong Li Chunfeng Zhang Jun Lu Yanguang Li | 2023 | National Science Review2023，10，1： | 0 |
| 18 | Computer vision-aided bioprinting for bone research显示文摘Bioprinting is an emerging additive manufacturing technology that has enormous potential in bone implantation and repair. The insufficient accuracy of the shape of bioprinted parts is a primary clinical barrier that prevents widespread utilization of bioprinting,especially for bone design with high-resolution requirements. During the last five years, the use of computer vision for process control has been widely practiced in the manufacturing field. Computer vision can improve the performance of bioprinting for bone research with respect to various aspects, including accuracy, resolution, and cell survival rate. Hence, computer vision plays a substantial role in addressing the current defect problem in bioprinting for bone research. In this review, recent advances in the application of computer vision in bioprinting for bone research are summarized and categorized into three groups based on different defect types: bone scaffold process control, deep learning, and cell viability models. The collection of printing parameters,data processing, and feedback of bioprinting information, which ultimately improves printing capabilities, are further discussed. We envision that computer vision may offer opportunities to accelerate bioprinting development and provide a new perception for bone research. | Changxi Liu Liqiang Wang Weijie Lu Jia Liu Chengliang Yang Chunhai Fan Qian Li Yujin Tang | 2022 | Bone Research2022，10，2： | 0 |
| 19 | Double crosslinked biomimetic composite hydrogels containing topographical cues and WAY-316606 induce neural tissue regeneration and functional recovery after spinal cord injury显示文摘Spinal cord injury(SCI)is an overwhelming and incurable disabling condition,for which increasing forms of multifunctional biomaterials are being tested,but with limited progression.The promising material should be able to fill SCI-induced cavities and direct the growth of new neurons,with effective drug loading to improve the local micro-organism environment and promote neural tissue regeneration.In this study,a double crosslinked biomimetic composite hydrogel comprised of acellularized spinal cord matrix(ASCM)and gelatin-acrylated-β-cyclodextrin-polyethene glycol diacrylate(designated G-CD-PEGDA)hydrogel,loaded with WAY-316606 to activate canonical Wnt/β-catenin signaling,and reinforced by a bundle of three-dimensionally printed aligned polycaprolactone(PCL)microfibers,was constructed.The G-CD-PEGDA component endowed the composite hydrogel with a dynamic structure with a self-healing capability which enabled cell migration,while the ASCM component promoted neural cell affinity and proliferation.The diffusion of WAY-316606 could recruit endogenous neural stem cells and improve neuronal differentiation.The aligned PCL microfibers guided neurite elongation in the longitudinal direction.Animal behavior studies further showed that the composite hydrogel could significantly recover the motor function of rats after SCI.This study provides a proficient approach to produce a multifunctional system with desirable physiological,chemical,and topographical cues for treating patients with SCI. | Xingchang Zhao Xianzhe Lu Kai Li Shiqiang Song Zhaohui Luo Chuanchuan Zheng Chengliang Yang Xiumei Wang Liqiang Wang Yujin Tang Chong Wang Jia Liu | 2023 | Bioactive Materials2023，，6： | 0 |
| 20 | Aerodynamic characteristics of co-flow jet wing with simple high-lift devices显示文摘Numerical investigations are conducted to explore the aerodynamic characteristics of three-dimensional Co-Flow Jet(CFJ) wing with simple high-lift devices during low-speed takeoff and landing. Effects of three crucial parameters of CFJ wing, i.e., angle of attack, jet momentum and swept angle, are comprehensively examined. Additionally, the aerodynamic characteristics of two CFJ configurations, i.e., using open and discrete slots for injection, are compared. The results show that applying CFJ technique to a wing with simple high-lift device is able to generate more lift,reduce drag and enlarge stall margin with lower energy expenditure due to the super-circulation effect. Increasing the jet intensity can reduce the drag significantly, which is mainly contributed by the reaction jet force. The Oswald efficiency factor is, in some circumstances, larger than one,which indicates the potential of CFJ in reducing induced drag. Compared with clean wing configuration, using CFJ technique allows the aerodynamic force variation less sensitive to the swept angle, and such phenomenon is better observed for small swept angle region. Eventually, it is interesting to know that the discrete slotted CFJ configuration demonstrates a promising enhancement in aerodynamic performance in terms of high lift, low drag and efficiency. | Zhenhao ZHU Tianhang XIAO Haolin ZHI Shuanghou DENG Yujin LU | 2022 | Chinese Journal of Aeronautics2022，35，10： | 0 |
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