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| 1 | Influence of microwave treatment under a hydrogen or methane atmosphere on the flotability of the macerals in Shenfu coals显示文摘The modification of Shenfu coals by a microwave treatment carried out under a hydrogen or a methane atmosphere, and the subsequent maceral separation by flotation, are described in this paper. The surface contact angle and the Zeta potential of the coal macerals were measured both with and without the treat- ment. The results show that the surface wettability of SFF (Shenfu Fusain) and SFV (Shenfu Vitrain) can be changed by the microwave treatment. An increase in the difference in surface wettability of SFF and SFV causes in a subsequent increase in the enrichment of inertinite and vitrinite. The results of the Zeta potential measurements show that the surface potentials of SFF and SFV are also changed by the treatment. | Zhao Wei Yang Fusheng Li Yuangang Qu Jianlin Zhou Anning | 2011 | Mining Science and Technology2011，21，6： | 15 |
| 2 | Development of Fully-Distributed Fiber Sensors Based on Brillouin Scattering显示文摘Brillouin scattering based optical fiber sensors(BOFS)have the unique advantages over other sensors such as long distance,fully distributed,and multi-parameter sensing.The progresses on the development of BOFS technology in Nanjing University are reviewed.The key technologies to make BOFS with ultra-long distance,high spatial resolution,and fast measuring speed are discussed and realized. | Xuping ZHANG Yuangang LU Feng WANG Hao LIANG Yixin ZHANG | 2011 | Photonic Sensors2011，1，1： | 7 |
| 3 | ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression显示文摘Mutations in LR RK2(Leucine rich repeat kinase 2)are a major cause of Parkinson’s disease(PD).We and others reported recently that expression of the pathogenic gain-of-function mutant form of LRRK2,LRRK2 G2019S,induc-es mitochondrial fi ssion in neurons through DLP1.Here we provide evidence that expression of LRRK2 G2019S stimulates mitochondria loss or mitophagy.We have char-acterized several LRRK2 interacting proteins and found that LRRK2 interacts with ULK1 which plays an essential role in autophagy.Knockdown of either ULK1 or DLP1 expression with shRNAs suppresses LRRK2 G2019S expression-induced mitochondrial clearance,suggesting that LRRK2 G2019S expression induces mitochondrial fi ssion through DLP1 followed by mitophagy via an ULK1 dependent pathway.In addition to ULK1,we found that LRRK2 interacts with the endogenous MKK4/7,JIP3 and coordinates with them in the activation of JNK signaling.Interestingly,LRRK2 G2019S-induced loss of mitochon-dria can also be suppressed by 3 different JNK inhibitors,implying the involvement of the JNK pathway in the path-ogenic mechanism of mutated LRRK2.Thus our fi ndings may provide an insight into the complicated pathogenesis of PD as well as some clues to the development of novel therapeutic strategies. | Yuangang Zhu Chunyan Wang Mei Yu Jie Cui Liang Liu Zhiheng Xu | 2013 | Protein & Cell2013，4，9： | 6 |
| 4 | Towards a universal organogelator:A general mixing approach to fabricate various organic compounds into organogels显示文摘Low-molecular-weight organogels(LMOG) have been attracting a surge interest in fabricating soft materials.Although the finding of the gelator molecules has been developed from serendipity to objective design,the achievement of the gelator molecules still needs good design and tedious organic synthesis.In this paper,we proposed a simple and general mixing approach to get the organogel for nearly all the organic compounds and even soluble nanoparticles without any modification.We have designed a universal gelator molecule,which forms organogels with more than 40 kinds of organic solvents from aploar to polar solvents.More interestingly,when other organic compounds or even nanomaterials,which are soluble in certain organic solvents,are mixed with this gelator molecule,they can form organogels no matter whether the individual compounds could form organogel or not.This method is applicable to nearly all kinds of soluble organic compounds and opens an efficient and universal way to fabricate gel materials. | DUAN PengFei LI YuanGang JIANG Jian WANG TianYu LIU MingHua | 2011 | Science China Chemistry2011，54，7： | 5 |
| 5 | Virtual reality-based rehabilitation in patients following total knee arthroplasty:a systematic review and meta-analysis of randomized controlled trials显示文摘Background:Physical therapy is regarded as an essential aspect in achieving optimal outcomes following total knee arthroplasty(TKA).The coronavirus disease 2019(COVID-19)pandemic has made face-to-face rehabilitation inaccessible.Virtual reality(VR)is increasingly regarded as a potentially effective option for offering health care interventions.This systematic review and meta-analysis investigate VR-based rehabilitation's effectiveness on outcomes following TKA.Methods:From inception to May 22,2021,PubMed/Medline,Embase,Web of Science,the Cochrane Central Register of Controlled Trials,Scopus,PsycINFO,Physiotherapy Evidence Database,China National Knowledge Infrastructure,and Wanfang were comprehensively searched to identify randomized controlled trials(RCTs)evaluating the effect of VR-based rehabilitation on patients following TKA according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the Cochrane Handbook for Systematic Reviews of Interventions.Results:Eight studies were included in the systematic review,and seven studies were included in the meta-analysis.VR-based rehabilitation significantly improved visual analog scale(VAS)scores within 1 month(standardized mean difference[SMD]:−0.44;95%confidence interval[CI]:−0.79 to−0.08,P=0.02),the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)within 1 month(SMD:−0.71;95%CI:−1.03 to−0.40,P<0.01),and the Hospital for Special Surgery Knee Score(HSS)within 1 month and between 2 months and 3 months(MD:7.62;95%CI:5.77 to 9.47,P<0.01;MD:10.15;95%CI:8.03 to 12.27,P<0.01;respectively)following TKA compared to conventional rehabilitation.No significant difference was found in terms of the Timed Up and Go(TUG)test.Conclusions:VR-based rehabilitation improved pain and function but not postural control following TKA compared to conventional rehabilitation.More high-quality RCTs are needed to prove the advantage of VR-based rehabilitation.As the COVID-19 pandemic continues,it is necessary to promote this rehabilitation model. | Linbo Peng Yi Zeng Yuangang Wu Haibo Si Bin Shen | 2022 | Chinese Medical Journal2022，，2： | 5 |
| 6 | Developing conservation strategies for Pinus koraiensis and Eleutherococcus senticosus by using model-based geographic distributions显示文摘We described potential changes in the geographic distribution and occurrence probability of Pinus koraiensis Sieb. et Zucc. and Eleutherococcus senticosus(Rupr. et Maxim.) Maxim. in the counties of northeast China. This information was used to identify priority areas for protection and provide protection and management recommendations within each studied county. The two species were mapped in 2884 study plots throughout this region over a 4-year period(38 400N–53 300 N, 115 050E–135 020E). We used the species distribution models(Maxent), systematic conservation planning models(Marxan), and Geographic Information Systems(Arc GIS10.0). The distributions of two species were correlated in the study area, enabling unique and economically viable joint conservation measures to be implemented. Three models were combined to identify feasible priority conservation sites. We used local spatial statistics to assess all identified conservation areas in relation to potential climate change based shifts in the geographic distribution of the two species. Model-based conservation strategies were used to identify effective measures to protect and utilize these two tree species in the study region. This study presents a novel technique for assessing wild plant distributions, in addition to serving as a model for the conservation of other species within the framework of general forest management, ecological construction, and geographical surveying. | Jizhong Wan Chunjing Wang Jinghua Yu Siming Nie Shijie Han Juzhao Liu Yuangang Zu Qinggui Wang | 2016 | Journal of Forestry Research2016，27，2： | 4 |
| 7 | Exosomes rewire the cartilage microenvironment in osteoarthritis:from intercellular communication to therapeutic strategies显示文摘Osteoarthritis(OA)is a prevalent degenerative joint disease characterized by cartilage loss and accounts for a major source of pain and disability worldwide.However,effective strategies for cartilage repair are lacking,and patients with advanced OA usually need joint replacement.Better comprehending OA pathogenesis may lead to transformative therapeutics.Recently studies have reported that exosomes act as a new means of cell-to-cell communication by delivering multiple bioactive molecules to create a particular microenvironment that tunes cartilage behavior.Specifically,exosome cargos,such as noncoding RNAs(ncRNAs)and proteins,play a crucial role in OA progression by regulating the proliferation,apoptosis,autophagy,and inflammatory response of joint cells,rendering them promising candidates for OA monitoring and treatment.This review systematically summarizes the current insight regarding the biogenesis and function of exosomes and their potential as therapeutic tools targeting cell-to-cell communication in OA,suggesting new realms to improve OA management. | Yuangang Wu Jiao Li Yi Zeng Wenchen Pu Xiaoyu Mu Kaibo Sun Yong Peng Bin Shen | 2022 | International Journal of Oral Science2022，14，3： | 4 |
| 8 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 9 | Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats显示文摘包含神经蛋白质 -synuclein 的包括身体(-syn) 在几 neurodegenerative 疾病被观察,包括 Parkinson 的疾病(PD ) 。而且,在老鼠大脑的 -syn 的在表示上部分由在 substantia nigra (SN ) 触发 dopaminergic 神经原的退化模仿 neuropathological 和 PD 的行为的特征。Mitochondrial 机能障碍对 PD 致病也中央,并且 -syn 在线粒体被发现。然而, -syn-induced neurotoxicity 的精确机制留下逃犯。检验 -syn-induced neurodegeneration 的潜在的机制,我们在用 recombinant 的老鼠的 SN 的过去表示的 -syn 联系 adeno 的病毒的向量(rAAV-syn ) 。把结果标记的 Immunohistochemical 和 immunogold 显示 -syn 在向量注射以后在 SN 和 striatum 是成功地过去表示的。酷氨酸的数字 hydroxylase 积极(dopaminergic ) 神经原显著地在当时,与 rAAV-syn 注射的老鼠被减少与控制老鼠相比。与控制老鼠相比, -syn-conjugated 金牌粒子的密度在轴突是更大的,细胞质,原子核,并且尤其是另外在在 rAAV-syn-injected 老鼠的 SN 神经原的线粒体。另外,有 rAAV-syn 的 SN 神经原 transfected 与不连续的外部膜和内部像液泡的结构展出了肿的线粒体,强烈建议 -syn-induced mitochondrial 机能障碍。在 rAAV-syn-injected 老鼠的线粒体也在 autophagosomes 被观察。有电压依赖者阴离子隧道 1 的 -Syn co-immunoprecipitated (VDAC1 ) ,导致 mitochondrial 解开的 mitochondrial 渗透转变毛孔(mPTP ) 的一个部件和 apoptosis。-syn 的在表示上可以通过和 mitochondrial VDAC1 的一个相互作用引起 dopaminergic 神经原的退化,它导致 mPTP 激活,解开的 mitochondrial,和房间死亡。 | Lingling Lu Chunyan Zhang Qing Cai Qiang Lu Chunli Duan Yuangang Zhu Hui Yang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 3 |
| 10 | Pentazole anion cyclo-N_5^-: a rising star in nitrogen chemistry and energetic materials显示文摘Nitrogen and carbon are common elements in nature. The development of nitrogen chemistry, however, is obviously left behind by that of carbon chemistry. Prof. Christ [1] attributed this reason to the stability difference between nitrogen-nitrogen bond and carbon-carbon bond. From N≡N,N=N to N–N bond, the bond dissociation energy increases significantly and the stability becomes worse rapidly, which is in contrast with stable C–C bond and unstable C≡C bond in carbon chemistry. Thus, lots of stable 'polycarbon' | Pengcheng Wang Qiuhan Lin Yuangang Xu Ming Lu | 2018 | Science China Chemistry2018，61，11： | 3 |
| 11 | Low does cyclophosphanide rescues myocardial function from ischemia-reperfusion in rats 显示文摘 | Jiahua Zhu Yuangang Qiu Qigi Wang | 2008 | Eur J Cadithorac Surg2008，34，： | 1 |
| 12 | Synthesis and cytotoxicity of water soluble quaternary salt derivatives of camptothecin显示文摘 | Zu Yuangang Li Qingyong Fu Yujie | 2004 | Bioorg Med Chem Lett2004，14，15： | 1 |
| 13 | Preparation and characterization of chitosan-polyvinyl alcohol blend hydrogels for the controlled release of nano-insulin显示文摘 | ZU Yuangang ZHANG Ying ZHAO Xiuhua | 2012 | International Journal of Biological Macromolecules2012，50，： | 1 |
| 14 | Source-field-plated Ga_2O_3 MOSFET with a breakdown voltage of 550 V显示文摘Ga_2O_3 metal–oxide–semiconductor field-effect transistors(MOSFETs) with high-breakdown characteristics were fabricated on a homoepitaxial n-typed β-Ga_2O_3 film, which was grown by metal organic chemical vapor deposition(MOCVD) on an Fedoped semi-insulating(010) Ga_2O_3 substrate. The structure consisted of a 400 nm unintentionally doped(UID) Ga_2O_3 buffer layer and an 80 nm Si-doped channel layer. A high k HfO_2 gate dielectric film formed by atomic layer deposition was employed to reduce the gate leakage. Moreover, a source-connected field plate was introduced to enhance the breakdown characteristics. The drain saturation current density of the fabricated device reached 101 mA/mm at V_(gs) of 3 V. The off-state current was as low as 7.1 ×10^(-11) A/mm, and the drain current I_(ON)/I_(OFF) ratio reached 10~9. The transistors exhibited three-terminal off-state breakdown voltages of 450 and 550 V, corresponding to gate-to-drain spacing of 4 and 8 μm, respectively. | Yuanjie Lü Xubo Song Zezhao He Yuangang Wang Xin Tan Shixiong Liang Cui Wei Xingye Zhou Zhihong Feng | 2019 | Journal of Semiconductors2019，40，1： | 1 |
| 15 | Oxidative stability of sunflower oil supplemented with carnosic acid compared with synthetic antioxidants during accelerated storage显示文摘 | YING Z LEI Y YUANGANG Z | 2010 | Food Chemistry2010，118，： | 1 |
| 16 | Ultrasound- assisted extraction of flaxseed oil using immobilized enzymes显示文摘 | Long Jingjing Fu Yujie Zu Yuangang | 2011 | Bioresource Technology2011，102，21： | 1 |
| 17 | Optimisation of microwave- assisted enzymatic extraction of corilagin and geraniin from Geranium sibiricum Linne and evaluation of antioxidant activity显示文摘 | YANG Yuchun LI Ji ZU Yuangang | 2010 | Food Chemistry2010，122，1： | 1 |
| 18 | Breaking the spores of the fungus Ganoderma lucidum by supercritical CO2 显示文摘 | FU Yujie LIU Wei ZU Yuangang | 2009 | Food Chem2009，112，1： | 1 |
| 19 | Elimination of p-chlorophenol in biofilm reactors-a comparative study of continuous flowand sequenced batch operation显示文摘 | Kaballo Hans-Peter Zhao Yuangang Wilderer Peter A | | 0，，01： | 1 |
| 20 | Novel low-k dielectric buried layer high voltage LDMOS on partial SOI显示文摘 | Luo Xiaorong Wang Yuangang Deng Hao | 2010 | IEEE Transactions on Electron Devices2010，57，2： | 1 |
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