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| 1 | Endoscopic removal of gastric ectopic pancreas:An initial experience with endoscopic submucosal dissection显示文摘AIM:To evaluate the therapeutic usefulness and safety of endoscopic resection in patients with gastric ectopic pancreas.METHODS:A total of eight patients with ectopic pancreas were included.All of them underwent endoscopic ultrasonography before endoscopic resection.Endo-scopic resection was performed by two methods:endo-scopic mucosal resection(EMR)by the injection-and-cut technique or endoscopic mucosal dissection(ESD).RESULTS:We planned to perform EMR in all eight cases but EMR was successful in only four cases.In the other four cases,saline spread into surrounding normal tissues and the lesions becameattened,which made it impossible to remove them by EMR.Inthose four cases,we performed ESD and removed the lesions without any complications.CONCLUSION:If conventional EMR is difficult to remove gastric ectopic pancreas,ESD is a feasible alternative method for successful removal. | Dong Yup Ryu Gwang Ha Kim Do Youn Park Bong Eun Lee Jae Hoon Cheong Dong Uk Kim Hyun Young Woo Jeong Heo Geun Am Song | 2010 | World Journal of Gastroenterology2010，16，36： | 24 |
| 2 | Risk factors for local recurrence after en bloc endoscopic submucosal dissection for early gastric cancer显示文摘AIM: To investigate factors related to recurrence following en bloc resection using endoscopic submucosal dissection(ESD) in patients with early gastric cancer(EGC). METHODS: A total of 1121 patients(1215 lesions) who had undergone ESD for gastric neoplasia between April 2003 and May 2010 were retrospectively reviewed. Data from 401 patients(415 lesions) were analyzed, following the exclusion of those who underwent piecemeal resection, with deep resection margin invasion or lateral margin infiltration, and diagnosed with benign lesions. RESULTS: Local recurrence after en bloc ESD was found in 36 cases(8.7%). Unclear resection margins, long procedure times, and narrow safety margins were identified as risk factors for recurrence. Lesions located in the upper third of the stomach showed a higher rate of recurrence than those located in the lower third of the stomach(OR = 2.9, P = 0.03). The probability of no recurrence for up to 24 mo was 79.9% in those with a safety resection margin ≤ 1 mm and 89.5% in those with a margin > 1 mm(log-rank test, P = 0.03). CONCLUSION: Even in cases in which en bloc ESD is performed for EGC, local recurrence still occurs. To reduce local recurrences, more careful assessment will be needed prior to the implementation of ESD in casesin which the tumor is located in the upper third of the stomach. In addition, clear identification of tumor boundaries as well as the securing of sufficient safety resection margins will be important. | Ju Yup Lee Kwang Bum Cho Eun Soo Kim Kyung Sik Park Yoo Jin Lee Yoon Suk Lee Byoung Kuk Jang Woo Jin Chung Jae Seok Hwang | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，7： | 8 |
| 3 | Long-term outcomes of endoscopic submucosal dissection for early gastric cancer: a single-center experience显示文摘 | Mun Ki Choi Gwang Ha Kim Do Youn Park Geun Am Song Dong Uk Kim Dong Yup Ryu Bong Eun Lee Jae Hoon Cheong Mong Cho | 2013 | Surgical Endoscopy2013，，11： | 6 |
| 4 | 在一项以社区为基础的大规模韩国人群筛选队列研究中把血清前列腺特异性抗原作为前列腺体积和下尿路症状的一个预测指标显示文摘为了评估血清前列腺特异抗原对前列腺体积及下尿路症状(由IPSS评分来表示)的预测功能,我们收集了2001年1月至2011年12月首次入选韩国前列腺健康协会筛选项目的男性患者资料。血清前列腺特异抗原水平大于10ngml。或年龄大于40岁的患者被剔除。因此,共34857人纳入了我们的研究,检测和估算所有患者的血清PSA,PV和IIPSS。使用线性和年龄修正的多因素Logistic回归分析来评估PSA与PV或IPSS之间的潜在联系。PSA对估算PV及IPSS的预测价值通过ROC曲线下面积来评估。平均PV为29.9ml,平均PSA水平为1.49ng ml^-1,平均IPSS为15.4,PSA与PV之间有显著关系,在年龄修正后IPSS评分与PSA有显著相关性。PSA预测PV〉20ml,25ml和35ml的AUC分别为0.722,0.728和0.779。PSA预测IPSS〉7,〉13,〉19的AUC分别为0.548,0.536和0.537。在一项以社区为基础的大型筛选队列研究中,血清PSA是一个很强的PV预测指标。尽管PSA与IPSS也有着重要相关性,但PSA对截止水平以上的IPSS预测价值并不理想。需要通过进一步的前瞻性对照研究来明晰PSA与LUTS之间以及PSA与PV之间的确切相互作用。这些研究也许可以建议如何应用PSA来临床预测PV和IPSS。 | Dong Soo Park Jong Jin Oh Jae Yup Hong Young Kwon Hong Don Kyung Choi In Hyuck Gong Jin HoHwang Sung Won Kwon | 2013 | Asian Journal of Andrology2013，15，2： | 5 |
| 5 | Is ineffective esophageal motility associated with gastropharyngeal reflux disease?显示文摘AIM: To evaluate the association between ineffective esophageal motility (IEM) and gastropharyngeal reflux disease (GPRD) in patients who underwent ambulatory 24-h dual-probe pH monitoring for the evaluation of supraesophageal symptoms. METHODS: A total of 632 patients who underwent endoscopy,esophageal manometry and ambulatory 24-h dual-pH monitoring due to supraesophageal symptoms (e.g. globus,hoarseness,or cough) were enrolled. Of them,we selected the patients who had normal esophageal motility and IEM. The endoscopy and ambulatory pH monitoring findings were compared between the two groups. RESULTS: A total of 264 patients with normal esophageal motility and 195 patients with the diagnosis of IEM were included in this study. There was no difference in the frequency of reflux esophagitis and hiatal hernia between the two groups. All the variables showing gastroesophageal reflux and gastropharyngeal reflux were not different between the two groups. The frequency of GERD and GPRD,as defined by ambulatory pH monitoring,was not different between the two groups. CONCLUSION: There was no association between IEM and GPRD as well as between IEM and GERD. IEM alone cannot be considered as a definitive marker for reflux disease. | Kyung Yup Kim Gwang Ha Kim Dong Uk Kim Soo Geun Wang Byung Joo Lee Jin Choon Lee Do Youn Park Geun Am Song | 2008 | World Journal of Gastroenterology2008，14，39： | 3 |
| 6 | CRISPy-web: An online resource to design sgRNAs for CRISPR applications显示文摘CRISPR/Cas9-based genome editing has been one of the major achievements of molecular biology,allowing the targeted engineering of a wide range of genomes.The system originally evolved in prokaryotes as an adaptive immune system against bacteriophage infections.It now sees widespread application in genome engineering workflows,especially using the Streptococcus pyogenes endonuclease Cas9.To utilize Cas9,so-called single guide RNAs(sgRNAs)need to be designed for each target gene.While there are many tools available to design sgRNAs for the popular model organisms,only few tools that allow designing sgRNAs for non-model organisms exist.Here,we present CRISPy-web(http://gffzz2b22c00a04674870hcufk0n5owbpf6w0c.ffgz.tsg.suse.edu.cn/),an easy to use web tool based on CRISPy to design sgRNAs for any userprovided microbial genome.CRISPy-web allows researchers to interactively select a region of their genome of interest to scan for possible sgRNAs.After checks for potential off-target matches,the resulting sgRNA sequences are displayed graphically and can be exported to text files.All steps and information are accessible from a web browser without the requirement to install and use command line scripts. | Kai Blin Lasse Ebdrup Pedersen TilmannWeber Sang Yup Lee | 2016 | Synthetic and Systems Biotechnology2016，1，2： | 3 |
| 7 | 尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用显示文摘心肌损伤通常在经皮冠状动脉介入治疗(PCI)过程中出现,并且损伤可以通过对心肌酶的测试使之容易被监控。众所周知,尼可地尔是三磷酸腺苷ATP-敏感的K+通道的开启器,通过减小作用电位从而具有抗心律失常效应和保护心脏作用。比如,通过松弛血管平滑肌以减少微冠状动脉血流阻力。研究尼可地尔的心肌保护作用,IONA研究(尼可地尔对心绞痛的作用)即大规模对稳定型心绞痛进行的研究表明,尼可地尔口服给药能够减少冠心病致死率和非致命型心肌梗塞或胸痛意外住院治疗。目前已经对数个不稳定心绞痛(UAP)或急性心肌梗塞病人进行了尼可地尔心脏保护效应的研究评估,但还没有进行大规模研究。此研究的目的在于通过对经尼可地尔注射并PCI治疗12~48h后的不稳定心绞痛患者的心肌酶进行评估来预期考察尼可地尔的心脏保护作用。 | Ju Han Kim Myung Ho Jeong Kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup Lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬 | 2017 | 首都食品与医药2017，24，18： | 3 |
| 8 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 9 | Validation of Circulating miRNA Biomarkers for Predicting Lymph Node Metastasis in Gastric Cancer显示文摘 | Shine Young Kim Tae Yong Jeon Chang In Choi Dae Hwan Kim Dong Heon Kim Gwang Ha Kim Dong Yup Ryu Bong Eun Lee Hyung Hoi Kim | 2013 | The Journal of Molecular Diagnostics2013，，： | 2 |
| 10 | Efficient recovery of poly(γ-glutamic acid) from highly viscous culture broth显示文摘 | Jin Hwan Do Ho Nam Chang Sang Yup Lee | 2001 | Biotech and Bioeng2001，76，3： | 1 |
| 11 | Preparation and properties of water-borne polyurethanes显示文摘 | SANG YUP LEE JEONG SAM LEE BYUNG KYU KIM | 1997 | Polymer International1997，42，1： | 1 |
| 12 | Production of poly-γ-glutamic acid by fed-batch culture of Bacillus licheniformis显示文摘 | Sung Ho Yoon Jin Hwan Do Sang Yup Lee Ho Nam Chang | 2000 | Biotechnology Letters2000，，7： | 1 |
| 13 | Genome-scale reconstruction and in silico analysis of the clostridium acetobutylicum ATCC 824 metabolic network显示文摘 | Lee Joungmin Yun Hongseok Lee Sang Yup | | 0，，05： | 1 |
| 14 | Processing of gel-spun poly(β-hydroxybutyrate)fibers显示文摘 | Gordeyev SA Nekrasov YUP Shilton SJ | | 0，，09： | 1 |
| 15 | Evaluation of different Saccharomyces cerevisiae strains on the profileof volatile compounds and polyphenols in cherry wines显示文摘 | ShuYS WenGJ YuP | 2010 | Food Chemistry2010，127，： | 1 |
| 16 | Preparation and Properties of Water-Borne Polyurethanes显示文摘 | Sang Yup Lee Jeong Sam Lee Byung Kyu Kim | 1997 | Polymer International1997，42，1： | 1 |
| 17 | In silico metabolic pathway analysis and design:succinic acid production by metabolically engineered Escherichia coli as an example显示文摘 | Sang Yup Lee Soon Ho Hong Soo Yun Moon | 2002 | Genome Informatics2002，13，： | 1 |
| 18 | 显示文摘 | 俞平(YuP) 黄建业(HuangJY) 刘伟庭(LiuWT) 顾春欣(GuCX) 傅新(FuX) DarioP | 2014 | 功能材料2014，45，： | 1 |
| 19 | 显示文摘 | Kim Byung Kyu Lee Sang Yup | 1998 | Polymer1998，39，13： | 1 |
| 20 | 尼可地尔在经皮冠状动脉介入治疗不稳定心绞痛时对心肌的保护作用显示文摘2结果
在200例患者中,36例由于其胸痛不是缺血性心脏病引起的而被排除,9例由于胸痛难以控制在给药12h内需要进行紧急冠状动脉造影术,另外155例在给药12-48h间进行选择性冠状动脉造影术。在155例中,39例没有明显表现出冠状动脉狭窄,13例由于PCI没有表明因此进行了冠状动脉旁路移植术或内科治疗,结果,103例患者接受了PCI,由于没有血液回流或旁支路闭塞,6例按计划或因需要抢救服用IIb/IIIa抑制剂,1例由于完全性心脏传导阻滞需抢救而使用临时起搏器. | Ju Han Kim Myung Ho Jeong Kyung Ho Yun Kye Hun Kim Dong Koo Kang Seo Na Hong Sang Yup Lim Sang Hyun Lee Yun Sang Lee Young Joon Hong Hyung Wook Park Weon Kim Young Keun Ahn Jeong Gwang Cho Jong Chun Park Jung Chaee Kang 田玉敬(译) | 2017 | 首都食品与医药2017，24，24： | 1 |
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