|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy——AKT/m-TOR Pathway and Resistance to Cancer Therapy显示文摘Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy. | Liudmila V SPIRINA Irina V KONDAKOVA Natalia V TARASENKO Elena M SLONIMSKAYA Evgeny A USYNIN Alexey K GORBUNOV Zahar A YURMAZOV Svetlana Yu CHIGEVSKAYA | 2018 | 中国肺癌杂志2018，21，1： | 18 |
| 2 | JAK-STAT pathway in carcinogenesis:Is it relevant to cholangiocarcinoma progression?显示文摘The features of JAK-STAT signaling in liver cells are discussed in the current review. The role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of this pathway and alteration of its elements are compared for normal cholangiocytes, cholangiocarcinoma predisposition and development. Prolactin and interleukin-6 are described in detail as the best studied examples. In addition, the non-classical nuclear translocation of cytokine receptors is discussed in terms of its possible implication to cholangiocarcinoma development. | Olga V Smirnova Tatiana Yu Ostroukhova Roman L Bogorad | 2007 | World Journal of Gastroenterology2007，13，48： | 14 |
| 3 | 渤海海底管线溢油污染预测模型显示文摘鉴于目前的溢油模型主要是针对海面溢油的情况,本文提出了预测海底管道出现裂纹和腐蚀形成的小孔时发生溢油的模型。预测在海底管线上某一位置处的蠕孔漏油后,油的浓度超过某一规定浓度的范围,海面上形成油膜的起始位置,估计油膜是否能到达海岸线,以及被风浪携带到海岸线上的原油量。本文还给出了一个基于渤海自然状况及原油性质的算例。结果表明,该模型可以为海底管线上蠕孔溢油的污染情况预测提供参考。 | 王晶 李志军 GONCHAROV V K KLEMENT’EVA N YU | 2007 | 海洋环境科学2007，26，1： | 12 |
| 4 | High-risk corneal allografts: A therapeutic challenge显示文摘Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in 'low-risk' settings. Furthermore, although corneal graft survival in 'lowrisk' recipients is favourable, the prognosis in 'high-risk' recipients for corneal graft is poor. In 'high-risk' grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of 'high-risk' recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in 'high-risk' recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both 'low-risk' and 'high-risk' hosts. | Tian Yu Vijayalakshmi Rajendran May Griffith John V Forrester Lucia Kuffová | 2016 | World Journal of Transplantation2016，6，1： | 7 |
| 5 | 中国成人糖尿病、血糖与结直肠癌发病率:针对50万人的前瞻性研究显示文摘背景糖尿病可致结直肠癌(CRC)的发病风险升高。糖尿病病程和非糖尿病患者的血糖与CRC发病风险之间的相关性仍不清楚。方法2004至2008年前瞻性中国Kadoofe Biobank研究从10个不同地区纳入了512 713名受试者。在10年随访期间,在基线无癌症史的510 136名受试者中共记录有3 024例新发CRC病例(1 745例结肠癌,1 716例直肠癌)。应用Cox回归分析对糖尿病(入组前诊断或筛查发现的)或无糖尿病病史者随机血糖(RPG)水平与CRC发病相关性的校正风险比(HR)进行估计。结果基线时,共有5.8%的受试者患有糖尿病。糖尿病患者发生CRC的校正HR为1.18(95%可信区间1.04~1.33),且发生结肠癌与直肠癌的风险相当[1.19(1.01~1.39)比1.14(0.96~1135)]。这些患者发生CRC的HR随糖尿病病程的延长而下降(趋势P值为0.03)。在入组前无糖尿病的受试者中,其RPG水平与CRC发病呈正相关,基线RPG每升高1 mmol/L其发生CRC的校正HR为1.04(1.02~1.05),且发生结肠癌与直肠癌的风险亦相当[1.03(1.01~1.05)比1.04(1.02~1.06)]。在男性中,糖尿病和RPG与CRC发病风险的相关性高于女性,但其差异无统计学意义(异质性检验的P值分别为0.3和0.2)。讨论在中国成年人中,未诊断糖尿病者其糖尿病和升高的血糖水平与CRC发病风险升高相关。 | Yuanjie Pang Christiana Kartsonak yu Guo Yiping Chen Ling Yang Zheng Bian Fiona Bragg Iona Y Millwood Leijia Shen Songgen Zhou Jiben Liu Junshi Chen Liming Li Michael V Holmes Zhengming Ghen 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，1： | 6 |
| 6 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 7 | 部分重力条件下气液两相流型研究显示文摘本文分析了“和平号”空间站气液两相流实验中获得的部分重力(0.1g和0.014g)条件下的流型特征及其相互转换条件,并将其和常重力与微重力两相流研究中较常用的流型转换模型的预测结果进行了比较。 | 赵建福 解京昌 林海 胡文瑞 A V Ivanov A Yu Belyaev | 2004 | 工程热物理学报2004，25，1： | 6 |
| 8 | 聚酰亚胺薄膜热膨胀系数的不稳定性研究显示文摘测量了聚酰亚胺薄膜在冷热循环过程中各温度点的热膨胀系数。结果表明:聚酰亚胺薄膜的热膨胀系数具有不稳定性。 | 王晓燕 耿洪滨 何世禹 刘勇 Yu O Pokhyl K V Koval | 2005 | 绝缘材料2005，38，2： | 4 |
| 9 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 10 | 灰鹤在天山木扎提河湿地越冬及行为观察显示文摘于2017年10月—2019年5月,采用直接计数法、瞬时扫描取样法、卫星跟踪和最小凸多边形法(MCP),对新疆阿克苏地区拜城县木扎提河流域灰鹤(Grus grus)的种群特征、活动范围、行为时间分配和行为节律进行调查和分析。结果表明,2019年越冬灰鹤种群数量超过4700只,较2016年增加1倍多,种群发展动态呈上升趋势。灰鹤主要以家庭群为主(63.90%),聚集群次之(28.62%),孤鹤最少(7.48%)。家庭群主要以2成鸟1幼鸟为主(占46.82%),聚集群以5~8只个体为主(占65.91%)。整个越冬期持续140~160 d,灰鹤越冬期活动距离为1058 km,活动区域相对固定,活动区域面积为125 km^2。日活动面积和活动距离随着气温的变化而变化,温度降低,日活动范围和活动距离降低;反之,则增加。因此,活动面积和活动距离呈凹形变化,即先增加(10—11月),再逐渐减少(12—1月),然后增加(2—3月)的变化趋势。取食和警戒是灰鹤的主要越冬行为。灰鹤的46.8%日间时间用于取食,17.8%的日间时间用于警戒,用于休息、走动、理羽和其他行为的日间时间分别占13.4%、11.4%、7.4%和3.2%。日取食高峰呈双凸型,出现在8:00—9:00和17:00—18:00,分别达到57.0%和58.5%。休息高峰出现在11:00—15:00,占24.6%,呈单峰型。研究区灰鹤种群面临着放牧、农耕、天敌、道路车辆、低温和人为驱赶等诸多威胁因素。 | 李军伟 马鸣 孟凡娟 E I Ilyashenko V Yu Ilyashenko O V Belyalov A E Gavrilov S Kh Zaripova N Batbayar 曹垒 | 2020 | 生态与农村环境学报2020，36，5： | 4 |
| 11 | 放电脉冲重频准分子激光器在不同应用领域的发展现状(英文)显示文摘研究了脉冲宽度为25~40 ns的放电脉冲XeCl准分子激光器的工作参数。结果显示,激光器产生的脉冲能量为0.2~0.7 J,重复频率为100 Hz,表明在泵浦功率为2.8~3.3 MW/cm3时,激光器实现了2.6%的激光效率和3.8%的本征效率。 | LOSEV V F PANCHENKO Yu N DUDAREV V V IVANOV N G KONOVALOV I N PAVLINSKY A V PUCHIKIN A V | 2011 | 中国光学2011，4，1： | 3 |
| 12 | High-pressure synthesis and characterization of diamond from a sulfur–carbon system显示文摘 | Yu Pal’yanov Yu Borzdov I Kupriyanov V Gusev A Khokhryakov A Sokol | 2001 | Diamond & Related Materials2001，，： | 2 |
| 13 | Application of coal gel-forming solution in prevention of coal self-ignition显示文摘 | Evwseev V S Yu A | 1985 | Ugol1985，，9： | 2 |
| 14 | Augmented interferon-γ, interleukin-4and transforming growth factor-β mRNA expression in blood mononuclear cell in myasthenia gravis显示文摘 | Link J Navikas V Yu M | 1994 | J Neuroimmunol1994，51，： | 2 |
| 15 | 高功率重频电化学HF激光器(英文)显示文摘研制了高功率、高重频非链式HF激光器,并研究了脉冲模式和重频模式下在SF6的混合气中增加电极边缘电场强度而不使用其它措施即可实现自持体引发放电的可能性,得到了重复频率为20 Hz,脉冲能量为67 J,转换效率为3%的激光输出。 | BULAEV V D GUSEV V S FIRSOV K N KAZANTSEV S Yu KONONOV I G LYSENKO S L MOROSOV Yu B POZNYSHEV A N | 2011 | 中国光学2011，4，1： | 2 |
| 16 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hpbxv0wkwb9cf6bco.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 17 | Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker显示文摘Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was characterized by GPC and 1H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. | SUN JianGuo GRAETER Stefan V TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong | 2014 | Science China Chemistry2014，57，4： | 2 |
| 18 | 基于XeF(C-A)放大器的混合(固态/气态)超高功率飞秒激光系统(英文)显示文摘提出了基于前端发生器和终端放大器,使用光泵浦XeF(C-A)激活介质的太瓦级混合激光器(THL-100)系统。前端发生器由长532 nm的连续激光泵浦的钛宝石飞秒脉冲振荡器,脉冲展宽机构,532 nm的脉冲激光泵浦的再生多通道放大器,衍射光栅压缩器和二次谐波发生器(KDP)组成。其光束输出参数为:脉冲持续时间50 fs,二次谐波(475 nm)辐射能量5 mJ。前端发生器以10 Hz的单脉冲模式工作。XeF(C-A)放大器由双高压脉冲发生器(线性变压器),爆炸式阴极发射真空二极管,电子束注入系统,充满Xe的气室转换器和激光单元组成。高压发生器包括12个变压器,每个变压器有8个电容(40 nF)和火花隙,电容可以充电至100 kV。真空二极管中的电子束参数为:总电流300 kA,峰值电压550kV,脉冲持续时间约150 ns。穿透金属箔片到达Xe转换器的6个100 cm×12 cm电子束的总能量为67 kJ。激光系统通过泵浦能量的级联处理导致Xe2*的快速形成,并在(172±5)nm连续辐射。真空紫外辐射通过CaF2窗口辐射到含有XeF2蒸汽和氮气缓冲气体的激光单元中,使XeF2光解,形成XeF*准分子。由真空紫外辐射泵浦的放大器激活介质长110 cm,直径为24 cm。文中通过数值模拟给出了输出参数和第一实验结果,根据XeF(C-A)放大器参数模型和增益测量结果,得到的输出能量高达23 J,这意味着50 fs脉冲的峰值功率高达4060 TW。 | LOSEV V ALEKSEEV S IVANOV N KOVALCHUK B MIKHEEVL MESYATS G PANCHENKO Yu PUCHIKIN A RATAKHIN N YASTREMSKY A | 2011 | 光学精密工程2011，19，2： | 2 |
| 19 | Lymphangioleiomyomatosis (LAM) :a review of clinical and morphological features显示文摘 | Ferrans V J Yu ZX Nelson WK | 2000 | J Nippon Med Sch2000，67，5： | 1 |
| 20 | An experimental investigation of propagation of hydrogen-air premixed flames in a filling of metal balls in a tube显示文摘 | Korolchenko A Ya Trunev A V Tsarichenko S G Prostov E N | 1995 | Fire-and-Explosion Safety1995，4，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员