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| 1 | miR-27b-3p/MARCH7 regulates invasion and metastasis of endometrial cancer cells through Snail-mediated pathway显示文摘Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7(MARCH7),also known as axotrophin,was originally identified in mouse embryonic stem cells.MARCH7 is involved in T-cell proliferation,neuronal development,and the immune system.However,its role in endometrial cancer(EC)remains unclear.This study aimed to investigate the role of MARCH7 in EC.Quantitative polymerase chain reaction,immunohistochemistry,and western blot analysis were used to examine the expression of MARCH7,E-cadherin,Snail,and Vimentin in EC cell lines or clinical specimens.The role of MARCH7 in maintaining EC cell malignant phenotype was determined by transwell assay and using xenograft tumor model.Dual-luciferase reporter gene assay was performed to determine whether MARCH7 is an authentic target of miR-27b-3p.Our data showed that the expression level of MARCH7 in EC tissues was higher than that in normal endometrium tissues.The level of MARCH7 was positively associated with that of Snail and Vimentin,clinical stage,and histological grade,while negatively associated with that of E-cadherin.Knockdown of MARCH7 inhibited the invasion and metastasis of EC cells in vitro and in vivo.The opposite effect was observed after overexpressing MARCH7.MARCH7 promoted invasion and metastasis of EC cells via the Snail-mediated pathway.Furthermore,MARCH7 was demonstrated to be an authentic target of miR-27b-3p,and miR-27b-3p decreased the stimulus effect induced by MARCH7.These data indicate that MARCH7 may be an oncogenic factor and a therapeutic target for EC.miR-27b-3p/MARCH7 may also regulate EC cell invasion and metastasis via the Snail-mediated pathway. | Ling Liu Jianguo Hu Tinghe Yu Shuang You Yulin Zhang Lina Hu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 6 |
| 2 | The review of research into the uses of low level ultrasound in cancer therapy显示文摘 | Yu Tinghe Wang Zhibiao Mason T J | 2004 | Ultrasonics Sonochemistry2004，11，： | 1 |
| 3 | BTLA,a New Inhibitory B7 Family Receptor with a TNFR Family Ligand显示文摘B and T lymphocyte attenuator (BTLA), identified as an immune inhibitory receptor recently, plays widespreadroles on T and B cells. Emerging evidence has generated plentiful information on the mechanisms which BTLA mediates negative regulation in immune responses and involves in a variety of physiological and pathological processes. The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases. | Chun Zeng Tinghe Wu Yu Zhen Xuepei Xia Yong Zhao | 2005 | Cellular & Molecular Immunology2005，2，6： | 1 |
| 4 | A microbubble agent improves the therapeutic efficiency of high intensity focused ultrasound : a rabbit kidney study显示文摘 | Tinghe Yu Guoyun Wang Kai Hu | 2004 | Urol Res2004，32，1： | 1 |
| 5 | Amierobubble agent improves the therapeutic efficiency of high intentsity focused ultrasound:A rabbit kidney study显示文摘 | Yu Tinghe Wang Guoyun Hu Kai etal | 2004 | Urol Res2004，32，1： | 1 |
| 6 | A microbubble agent improves the therapeutic efficiency of highintensity focused ultrasound:a rabbit kidney study显示文摘 | Tinghe Yu Guoyun Wang Kai Hu | 2004 | Urol Res2004，32，： | 1 |
| 7 | A review of research into the uses of low level ult rasound in cancer therapy显示文摘 | Yu Tinghe Wang Zhibiao Mason T J | 2004 | Ultrasonics Sonochemistry2004，11，2： | 1 |
| 8 | Hyperecho as the Indicator of Tissue Necrosis During Microbubble-Assisted High Intensity Focused Ultrasound: Sensitivity, Specificity and Predictive Value显示文摘 | Tinghe Yu Chuanshan Xu | 2008 | Ultrasound in Medicine & Biology2008，，8： | 1 |
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