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| 1 | Evolution of boundary layer ozone in Shijiazhuang,a suburban site on the North China Plain显示文摘The structure of the boundary layer affects the evolution of ozone(O3), and research into this structure will provide important insights for understanding photochemical pollution.In this study, we conducted a one-month observation(from June 15 to July 14, 2016) of the boundary layer meteorological factors as well as O3 and its precursors in Luancheng County,Shijiazhuang(37°53′N, 114°38′E). Our research showed that photochemical pollution in Shijiazhuang is serious, and the mean hourly maximum and mean 8-hr maximum O3 concentrations are 97.9 ± 26.1 and 84.4 ± 22.4 ppbV, respectively. Meteorological factors play a significant role in the formation of O3. High temperatures and southeasterly winds lead to elevated O3 values, and at moderate relative humidity(40%–50%) and medium boundary layer heights(1200–1500 m), O3 production sensitivity occurred in the transitional region between volatile organic compounds(VOC) and nitrogen oxides(NOx) limitations,and the O3 concentration was the highest. The vertical profiles of O3 were also measured by a tethered balloon. The results showed that a large amount of O3 was stored in the residual layer, and the concentration was positively correlated with the O3 concentration measured the previous day. During the daytime of the following day, the contribution of O3 stored in the residual layer to the boundary layer reached 27%± 7% on average. | Wei Zhao Guiqian Tang Huan Yu Yang Yang Yinghong Wang Lili Wang Junlin An Wenkang Gao Bo Hu Mengtian Cheng Xingqin An Xin Li Yuesi Wang | 2019 | Journal of Environmental Sciences2019，31，9： | 15 |
| 2 | Development of Genomic Microsatellite Multiplex PCR Using Dye-Labeled Universal Primer and Its Validation in Pedigree Analysis of Pacific Oyster(Crassostrea gigas)显示文摘There is an increasing requirement for traceability of aquaculture products, both for consumer protection and for food safety. There are high error rates in the conventional traceability systems depending on physical labels. Genetic traceability technique depending on DNA-based tracking system can overcome this problem. Genealogy information is essential for genetic traceability, and microsatellite DNA marker is a good choice for pedigree analysis. As increasing genotyping throughput of microsatellites, microsatellite multiplex PCR has become a fast and cost-effective technique. As a commercially important cultured aquatic species, Pacific oyster Crassostrea gigas has the highest global production. The objective of this study was to develop microsatellite multiplex PCR panels with dye-labeled universal primer for pedigree analysis in C. gigas, and these multiplex PCRs were validated using 12 full-sib families with known pedigrees. Here we developed six informative multiplex PCRs using 18 genomic microsatellites in C. gigas. Each multiplex panel contained a single universal primer M13(-21) used as a tail on each locus-specific forward primer and a single universal primer M13(-21) labeled with fluorophores. The polymorphisms of the markers were moderate, with an average of 10.3 alleles per locus and average polymorphic information content of 0.740. The observed heterozygosity per locus ranged from 0.492 to 0.822. Cervus simulations revealed that the six panels would still be of great value when massive families were analysed. Pedigree analysis of real offspring demonstrated that 100% of the offspring were unambiguously allocated to their parents when two multiplex PCRs were used. The six sets of multiplex PCRs can be an important tool for tracing cultured individuals, population genetic analysis, and selective breeding program in C. gigas. | LIU Ting LI Qi SONG Junlin YU Hong | 2017 | Journal of Ocean University of China2017，16，1： | 5 |
| 3 | CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment显示文摘Clinical sorafenib treatment could activate C-X-C receptor type 4(CXCR4)/stromal source factor-1α(SDF-1α)axis to aggravate intra-tumoral hypoxia of hepatocellular carcinoma(HCC),which further leads to progression,invasion,metastasis,and immunosuppression of tumors and in return causes resistance to sorafenib therapy.Therefore,a multi-functional oxygen delivery nanoplatform was rationally constructed based on an oxygen-saturated perfluorohexane(PFH)-cored liposome,with the CXCR4 antagonist LFC131 peptides modifying on the surface to simultaneously deliver sorafenib and the CSF1/CSF1R inhibitor PLX3397(named PFH@LSLP)for sorafenib-resistant HCC treatment.The PFH@LSLP was developed to overcome sorafenib resistance by syner-gistic effects of the following 3 roles:1)the O_(2)-saturated PFH core could alleviate the tumor hypoxia by O_(2) supply;2)the LFC131 peptide recognized the hypoxia-related overexpressed CXCR4 and then blocked SDF-1α/CXCR4 axis to re-sensitize the HCC cells to sorafenib;3)PLX3397 activated the immune responses via inhibiting the CSF1/CSF1R pathway in TAMs,further enhanced CD8^(+)T cell infiltration to reverse immunosuppression in tumors.Antitumor performance on H22 tumor-bearing mice and HCC patient-derived tumor xenograft(PDX)model showed that PFH@LSLP could overcome sorafenib resistance by synergistic effect of hypoxia attenuation,resistance-related gene regulation,and immune-microenvironment modification. | Yuehua Wang Zhenjie Wang Fei Jia Qing Xu Zhilin Shu Junlin Deng Aimin Li Meng Yu Zhiqiang Yu | 2022 | Bioactive Materials2022，7，11： | 3 |
| 4 | Cep57, a NEDDl-binding pericentriolar material component, is essential for spindle pole integrity显示文摘 | Qixi Wu Runsheng He Haining Zhou Albert CH Yu Bo Zhang Junlin Teng Jianguo Chen | 2012 | Cell Research2012，22，9： | 2 |
| 5 | Fabrication and characterization of glass–ceramics materials developed from steel slag waste显示文摘 | Feng He Yu Fang Junlin Xie Jun Xie | 2012 | Materials and Design2012，，： | 2 |
| 6 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 2 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 1 |
| 9 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 1 |
| 10 | Fabrication and characterization of glass-ceramics materials developed from steel slagwaste 显示文摘 | He Feng Fang Yu Xie Junlin Xie Jun | 2012 | Materials and Design2012，42，： | 1 |
| 11 | A non-viral vector for potential DMD gene therapy study by targeting a minidystrophin-GFP fusion gene into the hrDNA locus显示文摘基因治疗为 Duchenne 肌肉发达的营养障碍(DMD ) 的致命的混乱作为一条有希望的途径出现了。用一个新奇非病毒的交货系统,指向向量的人的 ribosomal DNA (hrDNA ) ,我们与 10 的高地点特定的综合效率指向了 minidystrophin-GFP 熔化基因进 HT1080 房间的 hrDNA 地点 ? 5,在里面 transgene 能高效地并且连续地表示它。minidystrophin-GFP 熔化蛋白质容易被发现在 HT1080 房间的血浆膜上本地化,显示它的可能的生理的表演。我们的调查结果证明指向 hrDNA 向量可能为 DMD 基因治疗学习是高度有用的。 | Junlin Yang Xionghao Liu Jiaoling Yu Liang Sheng Yan Shi Zhuo Li Youjin Hu Jinfeng Xu Lingqian Wu Yu Liang Jiahui Xia Desheng Liang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，12： | 1 |
| 12 | Effects of temperature and strain rate on dynamic properties of concrete显示文摘 | Bin Jia Junlin Tao Zhengliang Li Ruheng Wang Yu Zhang | 2008 | Transactions of Tianjin University2008，，1： | 1 |
| 13 | Citrus yield estima- tion based on images processed by an Android mobile phone 显示文摘 | Gong Aiping Yu Junlin He Yong | 2013 | Biosystems Engineering2013，115，2： | 1 |
| 14 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 1 |
| 15 | Characteristics and source apportionment of VOCs measured in Shanghai, China显示文摘 | Changjie Cai Fuhai Geng Xuexi Tie Qiong Yu Junlin An | 2010 | Atmospheric Environment2010，，38： | 1 |
| 16 | Fabrication and Characterization of Glass-ceramics Materials Developed from Steel Slag Waste显示文摘 | He Feng Fang Yu Xie Junlin | 2012 | Materials and Design2012，42，： | 1 |
| 17 | Citrus yield estimation based on images processed by an Android mobile phone显示文摘 | Gong Aiping Yu Junlin He Yong | 2013 | Biosystems Engineering2013，115，2： | 1 |
| 18 | Fabrication and characterization of glass-ceramics materials developed from steel slag waste 显示文摘 | Feng He Yu Fang Junlin Xie | 2012 | Materials and Design2012，42，： | 1 |
| 19 | Time course of cerebral hemodynamics in aneurysmal subarachnoid hemorrhage显示文摘 | Hung‐ChenWang Wei‐CheLin Tzu‐MingYang Wu‐FuChen Yu‐JunLin Nai‐WenTsai Wen‐NengChang Cheng‐HsienLu | 2012 | Ultrasound2012，，2： | 1 |
| 20 | 5-20 Preliminary Results of In-orbit test for Plastic Scintillator Detector of DAMPE显示文摘As a key subdetector of dark matter particles explorer(DAMPE), Plastic Scintillator Detector(PSD) play an important role in distinguishing electrons and photons events and probing heavy ion species up to Z=20[1]. DAMPE satellite was launched on Dec.17th2015 successfully, after that DAMPE powered up for front end electronics(FEEs) and for photomultiplier tubes(PMTs) with high voltage of payload on Dec.20th and Dec.24th, respectively. | Zhang Yongjie Sun Zhiyu Yu Yuhong Zhou Yong Fang Fang Wang Zhaoming Chen Junlin Liu Jie | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
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