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| 1 | Syndecan-2, negatively regulated by miR-20b-5p, contributes to 5-fluorouracil resistance of colorectal cancer cells via the JNK/ERK signaling pathway显示文摘5-Fluorouracil (5-FU) resistance has been long considered as an obstacle to the efficacy of chemotherapy in colorectal cancer (CRC). In this study, we demonstrated the role of miR-20b-5p-regulated syndecan-2 (SDC2) in 5-FU resistance of CRC cells. 5-FU-resistant SW480 CRC cells were established by treatment of SW480 cells with stepwise increase of 5-FU concentration. The results showed that SDC2 was expressed significantly higher in SW480/5-FU cells than in SW480/WT cells as revealed by quantitative real-time polymerase chain reaction and western blot analysis. MTT assay and BrdU assay showed that SDC2 overexpression led to increased cell survival rate, while SDC2 knockdown reversed the drug resistance of SW480/5-FU cells. Wound healing and transwell invasion assays revealed that knockdown of SDC2 inhibited the migratory and invasive ability of SW480/5-FU cells. Moreover, animal experiments indicated that si-SDC2 plays a suppressive role in tumor growth in vivo. We also confirmed that miR-20b-5p interacted with SDC2, which reversed the effect of SDC2 in SW480/5-FU cells via the c-Jun N-terminal kinase (JNK)/extracellular regulated protein kinases (ERK) signaling pathway. These findings showed that JNK/ERK signaling pathway is involved in miR-20b-5p/SDC2 axis-mediated 5-FU resistance in SW480/5-FU cells, indicating that the miR-20b-5p/SDC2 axis is a potential target for reversing 5-FU resistance in CRC. | Ruheng Hua Yan Zhang Xiyue Yan Dong Tang Xiaolong Li Qingfeng Ni Daorong Wang Jianwei Zhu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 4 |
| 2 | Effects of temperature and strain rate on dynamic properties of concrete显示文摘 | Bin Jia Junlin Tao Zhengliang Li Ruheng Wang Yu Zhang | 2008 | Transactions of Tianjin University2008，，1： | 1 |
| 3 | A Combined Method for Triplex Pump Fault Diagnosis Based on Wavelet Transform,Fuzzy Logic and Neuro-Networks显示文摘 | Fansen Kong Ruheng Chen | 2004 | Mechanical Systems and Signal Processing2004，18，： | 1 |
| 4 | A Study on Nanoscale Infrared Absorbent Working in Waveband Range of 1300-400 cm^(-1)显示文摘Nanoscale powder of SiO_2/Al_2O_3/TiO_2 composite was prepared by sol-gel method.Microstructure and mor- phology of the obtained samples were characterized by infrared(IR),X-ray diffraction(XRD)analysis and transmission electron microscopy(TEM).It is proved that infrared absorbing peaks of the samples are in waveband range of 1300-400 cm^(-1),and the peak shape changes with their component.Mechanism of the in- frared peak's positions and shapes which changes with the size and morphology of the prepared nano-particles has been tentatively discussed. | Yongmao HU Jinzhong XIANG Xueqing ZHANG Ruheng LI Xinghui WU | 2008 | Journal of Materials Science & Technology2008，24，5： | 1 |
| 5 | A combined method for triplex pump fault diagnosis based on wavelet transform, fuzzy logic and neuron-net-works显示文摘 | Kong Fansen Chen Ruheng | 2004 | Mechanical Systems and Signal Processing2004，，18： | 1 |
| 6 | A combined method for triplex pump fault diagnosis based on wavelet transform, fuzzy logic and neuro-networks 显示文摘 | KONG Fansen CHEN Ruheng | 2004 | Mechanical Systems and Signal Processing2004，18，1： | 1 |
| 7 | A combined method for triplex pump fault diagnosis based on wavelet transform, fuzzy logic and neuro-networks 显示文摘 | Fansen Konga Ruheng Chen | 2004 | Mechanical Systems and Signal Processing2004，18，： | 1 |
| 8 | A Combined Method for Triplex Pump Fault Diagnosis Based on Wavelet Transform,Fuzzy Logic and Neuro-networks显示文摘 | Kong Fansen Chen Ruheng | 2004 | Mechanical Systems and Signal Processing2004，18，1： | 1 |
| 9 | A combined method for triplex pump fault diagnosis based on wavelet transform,fuzzy logic and neuro-networks显示文摘 | Fansen Kong Ruheng Chen | 2004 | Mechanical Systems and Signal Processing2004，，18： | 1 |
| 10 | A Multi-level En- gineering Talents Cultivating System 显示文摘 | Xie Yong Ha Jincheol Li Ruheng | 2012 | Journal of Engi- neering Education Research2012，15，4： | 1 |
| 11 | A combined method for triplex pump fault diagnosis based on wavelet transform fuzzy logic and neuro-networks显示文摘 | KONG Fansen CHEN Ruheng | 2004 | Mechanical Systems and Signal Processing2004，，18： | 1 |
| 12 | erbB4/HER4在非小细胞NSCLC中的表达研究(英文)显示文摘Objective: To test the expression of HER4 in non-small cell lung cancer (NSCLC) and elucidate the relationship between its over-expression and the clinical pathology of NSCLC. Methods: 70 cases of paraffin-embedded tissues from informative NSCLC were tested for the expression of HER4 by means of immunohistochemical assay. Results: HER4 were overexpressed in NSCLC in 91.4%. The overexpression of HER4 correlated only with the lymph node metastasis, TNM staging and survival after operation. Conclusion: ErbB4 is one of the genes to regulate the growth of NSCLC in advanced stages and artificial interference of the overexpression of HER4 in NSCLC might be a good way for the treatment of NSCLC in advanced stages. | Zaichun Deng Wenying Yu Guoping Hu Ruheng Zheng Dunhua Zhang Yunshan Tan Yonghua Xu Wanli Jiang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 0 |
| 13 | Video-assisted Thoracoscopic Surgery in Early Evaluation of First Time Spontaneous Pneumothorax: A Retrospective Study显示文摘 | Lijie Tan Qun Wang Zhenglang Xu Ruheng Zheng | 2005 | Journal of US-China Medical Science2005，2，4： | 0 |
| 14 | Enhanced collection of scattered photons in nonlinear fluorescence microscopy by extended epi-detection with a silicon photomultiplier array显示文摘To maximize signal collection in nonlinear optical microscopy,non-descanned epi-detection is generally adopted for in vivo imaging.However,because of severe scattering in biological samples,most of the emitted fluorescence photons go beyond the collection angles of objectives and thus cannot be detected.Here,we propose an extended detection scheme to enhance the collection of scattered photons in nonlinear fluorescence microscopy using a silicon photomultiplier array ahead of the front apertures of objectives.We perform numerical simulations to demonstrate the enhanced fluorescence collection via extended epi-detection in the multi-photon fluorescence imaging of human skin and mouse brain through craniotomy windows and intact skulls.For example,with red fluorescence emission at a depth of 600μm in human skin,the increased collection can be as much as about 150%with a 10×,0.6-NA objective.We show that extended epi-detection is a generally applicable,feasible technique for use in nonlinear fluorescence microscopy to enhance signal detection. | Ruheng SHI Cheng JIN Chi LIU Lingjie KONG | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，10： | 0 |
| 15 | A Cu-modified active carbon fiber significantly promoted H_(2)S and PH_(3) simultaneous removal at a low reaction temperature显示文摘Poisonous gases,such as H_(2)S and PH3,produced by industrial production harm humans and damage the environment.In this study,H_(2)S and PH3 were simultaneously removed at low temperature by modified activated carbon fiber(ACF)catalysts.We have considered the active metal type,content,precursor,calcination,and reaction temperature.Experimental results exhibited that ACF could best perform by loading 15%Cu from nitrate.The optimized calcination temperature and reaction temperature separately were 550℃ and 90℃.Under these conditions,the most removal capacity could reach 69.7 mg/g and 132.1 mg/g,respectively.Characterization results showed that moderate calcination temperature(550℃)is suitable for the formation of the copper element on the surface of ACF,lower or higher temperature will generate more cuprous oxide.Although both can exhibit catalytic activity,the role of the copper element is significantly greater.Due to the exceptional dispersibility of copper(oxide),the ACF can still maintain the advantages of larger specific surface area and pore volume after loading copper,which is the main reason for better performance of related catalysts.Finally,increasing the copper loading amount can significantly increase the crystallinity and particle size of copper(oxide)on the ACF,thereby improving its catalytic performance.In situ IR found that the reason for the deactivation of the catalyst should be the accumulation of generated H_(2)PO_(4)^(-) and S0_(4)^(2-)(H_(2)0)^(6) which could poison the catalyst. | Yingwu Wang Ping Ning Ruheng Zhao Kai Li Chi Wang Xin Sun Xin Song Qiang Lin | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 0 |
| 16 | Improving signal-to-background ratio by orders of magnitude in high-speed volumetric imaging in vivo by robust Fourier light field microscopy显示文摘Fourier light field microscopy(FLFM)shows great potential in high-speed volumetric imaging of biodynamics.However,due to the inherent disadvantage of wide-field illumination,it suffers from intense background,arising from out of the depth-of-field signal and tissue scattered noise.The background will not only deteriorate the image contrast,making quantitative measurement difficult,but also introduce artifacts,especially in functional imaging of the neuronal network activity in vivo.Here,we propose the robust Fourier light field microscopy(RFLFM),which suppresses the background in FLFM by introducing structured illumination and computational reconstruction based on HiLo.The superior performance of RFLFM is verified by volumetric imaging of biological dynamics in larval zebrafish and mouse in vivo,at a volumetric imaging rate up to 33.3 Hz.The statistical results show that the fluorescence background can be significantly depressed,with the signal-to-background ratio improved by orders of magnitude and the whole image contrast improved by as much as~10.4 times.Moreover,we stress that,in functional imaging of neuronal network activity in turbid brain tissues,our system can avoid artifacts resulting from background fluctuations,while conventional light field microscopy fails.As a simple but powerful tool,we anticipate our technique to be widely adopted in robust,high-contrast,high-speed volumetric imaging. | JIAZHEN ZHAI RUHENG SHI LINGJIE KONG | 2022 | Photonics Research2022，10，5： | 0 |
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