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| 1 | Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties:preparation, characterization and application in a vaginal drug delivery system显示文摘Lack of mucoadhesive properties is the major drawback to poloxamer 407(F127)-based in situ hydrogels for mucosal administration. The objective of the present study was to construct a novel mucoadhesive and thermosensitive in situ hydrogel drug delivery system based on an aminofunctionalized poloxamer for vaginal administration. First, amino-functionalized poloxamer 407(F127-NH2) was synthesized and characterized with respect to its micellization behavior and interaction with mucin. Then using acetate gossypol(AG) as model drug, AG-loaded F127-NH2-based in situ hydrogels(NFGs) were evaluated with respect to rheology, drug release, ex vivo vaginal mucosal adhesion, in vivo intravaginal retention and local irritation after vaginal administration to healthy female mice. The results show that F127-NH2 is capable of forming a thermosensitive in situ hydrogel with sustained drug release properties. An interaction between positively charged F127-NH2 and negatively charged mucin wasrevealed by changes in the particle size and zeta potential of mucin particles as well as an increase in the complex modulus of NFG caused by mucin. Ex vivo and in vivo fluorescence imaging and quantitative analysis of the amount of AG remaining in mouse vaginal lavage all demonstrated greater intravaginal retention of NFG than that of an unmodified F127-based in situ hydrogel. In conclusion, amino group functionalization confers valuable mucoadhesive properties on poloxamer 407. | Liqian Ci Zhigang Huang Yu Liub Zhepeng Liu Gang Wei Weiyue Lu | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 11 |
| 2 | Genetic characterization and linkage disequilibrium mapping of resistance to gray leaf spot in maize(Zea mays L.)显示文摘Gray leaf spot(GLS),caused by Cercospora zeae-maydis,is an important foliar disease of maize(Zea mays L.)worldwide,resistance to which is controlled by multiple quantitative trait loci(QTL).To gain insights into the genetic architecture underlying the resistance to this disease,an association mapping population consisting of 161 inbred lines was evaluated for resistance to GLS in a plant pathology nursery at Shenyang in 2010 and 2011.Subsequently,a genome-wide association study,using 41,101 single-nucleotide polymorphisms(SNPs),identified 51 SNPs significantly(P<0.001)associated with GLS resistance,which could be converted into 31 QTL.In addition,three candidate genes related to plant defense were identified,including nucleotidebinding-site/leucine-rich repeat,receptor-like kinase genes similar to those involved in basal defense.Two genic SNPs,PZE-103142893 and PZE-109119001,associated with GLS resistance in chromosome bins 3.07 and 9.07,can be used for marker-assisted selection(MAS)of GLS resistance.These results provide an important resource for developing molecular markers closely linked with the target trait,enhancing breeding efficiency. | Liyu Shi Xiangling Lv Jianfeng Weng Hanyong Zhu Changlin Liu Zhuanfang Hao Yu Zhou Degui Zhang Mingshun Li Xiaoke Ci Xinhai Li Shihuang Zhang | 2014 | The Crop Journal2014，2，Z1： | 9 |
| 3 | Confining MOF-derived SnSe nanoplatelets in nitrogen-doped graphene cages via direct CVD for durable sodium ion storage显示文摘Tin-based compounds are deemed as suitable anode candidates affording promising sodium-ion storages for rechargeable batteries andhybrid capacitors.However,synergistically tailoring the electrical conductivity and structural stability of tin-based anodes to attain durablesodium-ion storages remains challenging to date for its practical applications.Herein,metal-organic framework(MOF)derived SnSe/C wrappedwithin nitrogen-doped graphene(NG@SnSe/C)is designed targeting durable sodium-ion storage.NG@SnSe/C possesses favorable electricalconductivity and structure stability due to the'inner'carbon framework from the MOF thermal treatment and'outer'graphitic cage from thedirect chemical vapor deposition synthesis.Consequently,NG@SnSe/C electrode can obtain a high reversible capacity of 650 mAh·g^-1 at 0.05 A·g^1,a favorable rate performance of 287.8 mAh·g^1 at 5 A·g^1 and a superior cycle stability with a negligible capacity decay of 0.016%percycle over 3,200 cycles at 0.4 A·g^1.Theoretical calculations reveal that the nitrogen-doping in graphene can stabilize the NG@SnSe/Cstructure and improve the electrical conductivity.The reversible Na-ion storage mechanism of SnSe is further investigated by in-situ X-raydiffraction/ex-s/tu transmission electron microscopy.Furthermore,assembled sodium-ion hybrid capacitor full-cells comprising our NG@SnSe/Canode and an active carbon cathode harvest a high energy/power density of 115.5 Wh·kg^-1/5,742 W·kg^-1,holding promise for next-generationen ergy storages. | Chen Lu Zhenzhu Li Zhou Xia Haina Ci Jingsheng Cai Yingze Song Lianghao Yu Wanjian Yin Shixue Dou Jingyu Sun Zhongfan Liu | 2019 | Nano Research2019，12，12： | 7 |
| 4 | Response and adaptation to the accumulation and distribution of photosynthetic product in peanut under salt stress显示文摘To clarify the response and adaptability of peanut under salt stress,Huayu 25 was used as the material,and non-salt stress(CK),0.15% salt stress(S1),and 0.3% salt stress(S2) were applied as three treatments.The study analysed the effects of salt stress on photosynthetic characteristics,photosynthetic substances accumulation and distribution as well as the ecological adaptability of peanuts.The results showed that net photosynthetic rate(Pn),SPAD value,leaf area,and peanut yield were reduced under salt stress.Pn in CK was 13.71 and 28.72% higher than that in S1 and S2 at the 50 th day after planting,respectively.At the same growth period,the SPAD value among treatments was ranked as follows: CK>S1>S2.The 100-pod mass,100-kernel mass,kernel rate to pod,and pod mass per plant were reduced under salt stress,and the trend was CK>S1>S2.The distribution proportion of dry matter in different organs of peanut plant was changed to adapt to such stress.Roots under salt stress intensively distributed in a 0-40 cm soil layer for salt resistance.Dry mass proportion in stems and pods increased during the vegetative stage and early period of reproductive stage,respectively.The maximum growth rates of the pod volume,pod dry weight,and seed kernel dry weight all declined,and the pod and kernel volume at harvest were reduced,improving the seed plumpness under salt stress.This finding could be useful in growing peanut in saline soil. | ZHANG Guan-chu DAI Liang-xiang DING Hong CI Dun-wei NING Tang-yuan YANG Ji-shun ZHAO Xin-hua YU Hai-qiu ZHANG Zhi-meng | 2020 | Journal of Integrative Agriculture2020，19，3： | 7 |
| 5 | Carbon Monoxide: A Novel Antioxidant Against Oxidative Stress in Wheat Seedling Leaves显示文摘一氧化碳(公司) ,在动物的一个内长的发信号分子,也每氧化剂在老鼠导致的氧化包括肺类脂化合物的变细提供有势力 cytoprotective 效果。我们的最近的工作证明小麦的处理种的 0.01 亩 mol/L 血色素(一个公司施主) 在幼苗叶子减轻了导致盐的氧化损坏。在这份报告,我们进一步发现那个血色素预告的处理(<=0.1 亩 mol/L ) 能推迟小麦叶叶绿素损失由 H_2O_2 和对草快的进一步的处理调停了,二反应的氧种(ROS ) 来源, indose- 甚至时间依赖者礼貌。另外与控制样品相比,为 24 h 的 0.01 或 0.1 亩 mol/L 血色素展出了的幼苗 leavespretreatedwith H_2O_2 和 lipidperoxidation 的底层,以及叶绿素的更高的内容和抗氧化剂酶的活动。血色素施加的 Suchbeneficial 效果被抗氧化剂 butylatedhydroxytoluene (BHT ) 的预告的处理模仿,并且当 COscavenger 血红素(Hb ) ,或公司特定的合成禁止者 ZnPPIX 分别地被增加时,差别逆行。总起来说,直接在这篇论文介绍的结果第一次说明那个公司能强烈保护 ROS 的生产过剩引起的 plantsfromoxidative 损坏,并且加强公司是在各种各样的不能生活、关於生命的压力的一种有势力抗氧化剂的证据,同样类似的结果在动物组织被显示出。 | Zhi-Sheng Sa Li-Qin Huang Guo-Lin Wu Jin-Peng Ding Xiao-Yue Chen Tian Yu Ci Shi Wen-Biao Shen | 2007 | Journal of Integrative Plant Biology2007，49，5： | 4 |
| 6 | Evolutionary transition between invertebrates and vertebrates via methylation reprogramming in embryogenesis显示文摘Major evolutionary transitions are enigmas,and the most notable enigma is between invertebrates and vertebrates,with numerous spectacular innovations.To search for the molecular connections involved,we asked whether global epigenetic changes may offer a clue by surveying the inheritance and reprogramming of parental DNA methylation across metazoans.We focused on gametes and early embryos,where the methylomes are known to evolve divergently between fish and mammals.Here,we find that methylome reprogramming during embryogenesis occurs neither in pre-bilaterians such as cnidarians nor in protostomes such as insects,but clearly presents in deuterostomes such as echinoderms and invertebrate chordates,and then becomes more evident in vertebrates.Functional association analysis suggests that DNA methylation reprogramming is associated with development,reproduction and adaptive immunity for vertebrates,but not for invertebrates.Interestingly,the single HOX cluster of invertebrates maintains unmethylated status in all stages examined.In contrast,the multiple HOX clusters show dramatic dynamics of DNA methylation during vertebrate embryogenesis.Notably,the methylation dynamics of HOX clusters are associated with their spatiotemporal expression in mammals.Our study reveals that DNA methylation reprogramming has evolved dramatically during animal evolution,especially after the evolutionary transitions from invertebrates to vertebrates,and then to mammals. | Xiaocui Xu Guoqiang Li Congru Li Jing Zhang Qiang Wang David KSimmons Xuepeng Chen Naveen Wijesena Wei Zhu Zhanyang Wang Zhenhua Wang Bao Ju Weimin Ci Xuemei Lu Daqi Yu Qian-fei Wang Neelakanteswar Aluru Paola Oliveri Yong EZhang Mark QMartindale Jiang Liu | 2019 | National Science Review2019，6，5： | 2 |
| 7 | Large-sized bone defect repair by combining a decalcified bone matrix framework and bone regeneration units based on photo-crosslinkable osteogenic microgels显示文摘Physiological repair of large-sized bone defects is great challenging in clinic due to a lack of ideal grafts suitable for bone regeneration.Decalcified bone matrix(DBM)is considered as an ideal bone regeneration scaffold,but low cell seeding efficiency and a poor osteoinductive microenvironment greatly restrict its application in large-sized bone regeneration.To address these problems,we proposed a novel strategy of bone regeneration units(BRUs)based on microgels produced by photo-crosslinkable and microfluidic techniques,containing both the osteogenic ingredient DBM and vascular endothelial growth factor(VEGF)for accurate biomimic of an osteoinductive microenvironment.The physicochemical properties of microgels could be precisely controlled and the microgels effectively promoted adhesion,proliferation,and osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)in vitro.BRUs were successfully constructed by seeding BMSCs onto microgels,which achieved reliable bone regeneration in vivo.Finally,by integrating the advantages of BRUs in bone regeneration and the advantages of DBM scaffolds in 3D morphology and mechanical strength,a BRU-loaded DBM framework successfully regenerated bone tissue with the desired 3D morphology and effectively repaired a large-sized bone defect of rabbit tibia.The current study developed an ideal bone biomimetic microcarrier and provided a novel strategy for bone regeneration and large-sized bone defect repair. | Junxiang Hao Baoshuai Bai Zheng Ci Jincheng Tang Guanhuai Hu Chengxiang Dai Mengyuan Yu Meng Li Wei Zhang Yixin Zhang Wenjie Ren Yujie Hua Guangdong Zhou | 2022 | Bioactive Materials2022，7，8： | 2 |
| 8 | Establishment and Application of Early Risk Stratification Method for Acute Abdominal Pain in Adults显示文摘 | Yu Wang Hong Zhao Zhen Zhou Ci Tian Hong-Li Xiao Bao-En Wang | 2017 | Chinese Medical Journal2017，，5： | 2 |
| 9 | Role of intracellular calcium in contraction of internal anal sphincter显示文摘INTRODUCTIONInternalanalsphincter(IAS)isacontinuationofthesmoothcircularmusclelayerthickenedattherectum,innervatedbyvegetativ... | NIU Wei Xin 1, QIN Xin Yu 1, LU Ying Qing 2, SHI Nian Ci 2 and WANG Cheng Pei 1 | 1999 | World Journal of Gastroenterology1999，5，2： | 2 |
| 10 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 11 | Suppressors of cytokine-signaling proteins induce insulin resistance in the retina and promote survival of retinal cells 显示文摘 | Liu X Mameza MG Lee YS Eseonu CI Yu CR Kang Derwent JJ | 2008 | Diabetes2008，57，6： | 1 |
| 12 | CD2 distinguishes two subsets of human plasmacytoid dendritic cells with distinct phenotype and functions显示文摘 | Matsui T Connolly JE Michnevitz M Chaussabel D Yu CI Glaser C Tindle S Pypaert M Freitas H Piqueras B Banchereau J Palucka AK | 2009 | J Immunol2009，182，11： | 1 |
| 13 | Dynamic regulation of axon guidance显示文摘 | Yu TW Bargmann CI | 2001 | Nature Neurosci Suppl2001，4，： | 1 |
| 14 | Hyperinsulinaemia possible risk factors of cancer among diabetic patients显示文摘 | Wu X Yu H Amos CI | | 0，，9： | 1 |
| 15 | Dominant role of in situ native cartilage niche for determining the cartilage type regenerated by BMSCs显示文摘Tissue-engineered cartilage regeneration by bone marrow stromal cells(BMSCs)is considered an ideal method.However,how to regulate BMSCs to regenerate specific types of cartilage remains unclear,which significantly limits its clinical translation and leads to suboptimal clinical effects.Herein,we systematically explored the role of native ear and articular cartilage niches on the differentiation fate of BMSCs and the type of regenerated cartilage.First,we prepared two types of acellular cartilage sheets(ACSs)and two types of chondrocytes.Then green fluorescent protein-labeled BMSCs were seeded on two types of ACSs with or without corresponding types of chondrocytes using a sandwich model and directed or cross-implanted them into native cartilage niches.After one year of in vivo culture,cell tracking and the results of histological results showed that the native cartilage niches were capable of regulating BMSCs regeneration into specific types of cartilage that were consistent with the cartilage types of the implanted sites.Furthermore,even when the type of niche formed by ACSs or the biomimetic cartilage niche constructed by specific types of ACSs and specific types of chondrocytes did not match with the native cartilage niche,the native cartilage niche continued to determine the type of cartilage regenerated by implanted BMSCs and chondrocytes.All our results provide sufficient evidence for specific types of cartilage regeneration using chondrogenic potential cells,such as mesenchymal stem cells and chondrocytes. | Mengjie Hou Baoxing Tian Baoshuai Bai Zheng Ci Yu Liu Yixin Zhang Guangdong Zhou Yilin Cao | 2022 | Bioactive Materials2022，7，7： | 1 |
| 16 | Dynamic regulation of axon guidance 显示文摘 | Yu TW Bargmann CI | 2001 | Nat Neurosci2001，，： | 1 |
| 17 | Coexistence and relationship of antikeratinocyte an antimelanocyte antibodies in patientswith nonsegmental-type vitiligo显示文摘 | YuHS Kao CH Yu CI | 1993 | J Invest Dermatol1993，100，6： | 1 |
| 18 | Investigation of the Interracial Reaction between Multi Walled Carbon Nanotubes and Aluminum显示文摘 | L Ci Z R Yu N Yun | 2006 | Acta Materialia2006，54，： | 1 |
| 19 | Alterations of insulin - like growth factor - 1 receptor gene copy number and protein expression are common in non- small cell lung cancer显示文摘 | Tran TN Selinger CI Yu B | 2014 | J Clin Patho12014，67，11： | 1 |
| 20 | construction of single chain interleukin 12DNA plasmid totreat airway hyperresponsive- ness in an animal model of asthma显示文摘 | LEE YL YE YL YU CI etal | 2001 | Hum Gene Ther2001，12，6： | 1 |
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