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| 1 | 背根神经节Toll样受体4信号通路参与奥沙利铂诱导的周围神经病变显示文摘化疗诱发的周围神经病变(chemotherapy-induced peripheral neuropathy, CIPN)是化疗药物临床应用中的棘手问题,病人表现出持续刺痛、针刺感、深部痛和烧灼痛等各种症状。随着肿瘤治疗技术的进步和肿瘤病人生存期的延长,CIPN对肿瘤病人生活质量的影响日益突出。由于化疗药物不能通过血脑屏障,因此外周感觉神经元—背根神经节(dorsal root ganglion, DRG)被认为是化疗药物诱发CIPN的主要部位。既往研究表明,DRG组织Toll样受体4 (toll-like receptor 4, TLR4)激活参与紫杉醇诱导CIPN。但作为结直肠癌治疗的一线药物—奥沙利铂是否也通过类似的机制诱导CIPN? 2021年9月,美国德克萨斯大学MD Anderson癌症中心的Patrick M. Dougherty教授团队发表在Pain杂志的研究表明,DRG中TLR4激活同样参与奥沙利铂诱导CIPN的产生,并且可作为CIPN治疗的药物靶点。 | Illias AM Yu KJ Hwang SH 陈博(译) 张瑛(校) | 2021 | 中国疼痛医学杂志2021，27，11： | 3 |
| 2 | Bradykinin-induced reduction in collagen gene expression involve prostacyclin显示文摘 | Gallagher AM Yu H Printz MP | 1998 | Hypertension1998，32，： | 1 |
| 3 | MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP1 A BCG2) in human cancer cells显示文摘 | Pan YZ Morris ME Yu AM | 2009 | Mol Pharmacol2009，75，6： | 1 |
| 4 | Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif显示文摘 | Niewiadomska AM Yu XF | 2009 | Curr Top Microbiol Immunol2009，339，： | 1 |
| 5 | Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein显示文摘 | Huang Q Yu L Petros AM | 2004 | Biochemistry2004，43，20： | 1 |
| 6 | Macroautophagy-a novel^-amyloid peptide-generating pathway activated in Alzheimer’ sdisease 显示文摘 | Yu WH Cuervo AM Kumar A | 2005 | J Cell Biol2005，171，1： | 1 |
| 7 | The C- terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the Ct BP pathway of transcriptional repression 显示文摘 | Wu LC Bowcock AM | 1998 | J Biol Chem1998，273，25： | 1 |
| 8 | Defective antitumor responses in CX3CRl-deficient mice显示文摘 | Fong AM Combadiere C | 2007 | Int J Cancer2007，121，2： | 1 |
| 9 | In - vitro measurement of static pressure distribution in synovial joints - Part ⅡI: Retropatellar surface显示文摘 | Ahmed AM Burke DL Yu A | 1983 | J Biomech Eng1983，105，： | 1 |
| 10 | Influenza virus-in- duced glucocorticoids compromise innate host defense against a secondary bacterial infection 显示文摘 | Jamieson AM Yu S Annicelli CH | 2010 | Cell Host Microbe2010，7，2： | 1 |
| 11 | MicroRNA-328 neg- atively regulates the expression of breast cancer re-sistance protein (BCRP/ABCG2) in human cancer cells显示文摘 | Pan YZ Morris ME Yu AM | 2009 | Mol Pharmaco2009，75，6： | 1 |
| 12 | Cytochrome P450 and xenobiotic receptor humanized mice显示文摘 | Gonzalez FJ Yu AM | 2006 | Annu Rev Pharmacol Toxicol2006，46，： | 1 |
| 13 | Signal transdution by DR3,a death domain-containing receptor related to TNFR-1 and CD95显示文摘 | Chinnaiyan AM ORourke K Yu GL | 1996 | Science1996，274，： | 1 |
| 14 | Macroautophagy-a novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease显示文摘 | Yu WH Cuervo AM Kumar A | | 0，，01： | 1 |
| 15 | Keratin expression in breast cancers显示文摘 | Shao MM Chan SK Yu AM | | 0，，03： | 1 |
| 16 | Results of the influenza virus surveillance in wild birds in Western part of Mongolia显示文摘Objective:To present results of virological study of wild birds inhabiting Western Mongolia. Methods:Over a period of 2003-2008,we isolated 13 influenza A viruses:H1N1,H3N6, H13N8 and H4N6 subtypes.We did not isolate any H5N1 subtype,that still cause epizooty in wild birds and poultry.Results:We revealed taxonomic and ecological heterogeneity of the birds involved in maintenance of circulation of influenza viruses in the given territory.Influenza viruses were isolated from birds of 6 orders;among them there are species preferring water and semi-aquatic biotopes,one species preferring dry plain region,and also one species which can inhabit both dry and water biotopes.Conclusions:Representatives of all main orders of Western Mongolia avifauna are involved in support of influenza A virus circulation,highly pathogenic H5N1 influenza viruses were registered in Mongolia thus it’s necessary to continue permanent influenza virus surveillance in wild birds’ populations. | Marchenko V Yu Alekseev A Yu Tserennorov D Yurlov AK Susloparov IM Sharshov KA Ilyinykh FA Zolotykh SI Abmed D Otgonbaatar D Shestopalov AM | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，2： | 1 |
| 17 | Electrochemical behavior and simultaneous determination of vitamin B2 , B6 and C at electrochemically pretreated glassy carbon electrode 显示文摘 | Gu HY Yu AM Chen HT | 2001 | Analytical Letter2001，34，： | 1 |
| 18 | Structure of the N-terminal RNA-binding domain of the SARS-CoV nucleocapsid orotein显示文摘 | Huang Q Yu L Petros AM Gunasekera A | 2004 | Biochemistry2004，43，： | 1 |
| 19 | Small interfering RNA in drug metabolism and transport 显示文摘 | YU AM | 2007 | Curt Drug Metab2007，8，7： | 1 |
| 20 | MicroRNA-328 negatively regulates the expression of breast cancer resistance pro rein (BCRP/ABCG2) in human cancer cells ]显示文摘 | Pan YZ Morris ME Yu AM | 2009 | Mol Pharmacol2009，75，6： | 1 |
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