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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 3 | Inhibition of signal transducer and activator of transcription 3 expression by RNA interference suppresses invasion through inducing anoikis in human colon cancer cells显示文摘AIM:To investigate the roles and mechanism of signal transducer and activator of transcription 3 (STAT3) in invasion of human colon cancer cells by RNA interference. METHODS: Small interfering RNA (siRNA) targeting Signal transducer and activator of transcription 3 (STAT3) was transfected into HT29 colon cancer cells. STAT3 protein level and DNA-binding activity of STAT3 was evaluated by western blotting and electrophoretic mobility shift assay (EMSA), respectively. We studied the anchorage-independent growth using colony formation in soft agar, and invasion using the boyden chamber model, anoikis using DNA fragmentation assay and terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL), respectively. Western blot assay was used to observe the protein expression of Bcl-xL and survivin in colon cancer HT29 cells. RESULTS: RNA interference (RNAi) mediated by siRNA leads to suppression of STAT3 expression in colon cancer cell lines. Suppression of STAT3 expression by siRNA could inhibit anchorage-independent growth, and invasion ability, and induces anoikis in the colon cancer cell line HT29. It has been shown that knockdown of STAT3 expression by siRNA results in a reduction in expression of Bcl-xL and survivin in HT29 cells. CONCLUSION: These results suggest that STAT3 siRNA can inhibit the invasion ability of colon cancer cells through inducing anoikis, which antiapoptotic genes survivin and Bcl-xL contribute to regulation of anoikis.These studies indicate STAT3 siRNA could be a useful therapeutic tool for the treatment of colon cancer. | Yu Fan You-Li Zhang Ying Wu Wei Zhang Yin-Huan Wang Zhao-Ming Cheng Hua Li | 2008 | World Journal of Gastroenterology2008，14，3： | 51 |
| 4 | Characteristics of dissolved organic matter(DOM) in leachate with different landfill ages显示文摘学习的主要目的是调查溶解有机物(DOM ) 的特征在沥滤通过化学、分光镜、元素的分析与不同垃圾堆年龄吃了。胡敏酸(哈) , fulvic (FA ) ,并且吸水(HyI ) 部分被与阳离子交换尸方法相结合的 XAD-8 树脂孤立并且净化。荧光刺激排放矩阵光谱学(EEM ) 的分析结果表明荧光山峰是为年轻垃圾堆的像蛋白质的荧光沥滤当为中等、旧的垃圾堆的荧光山峰沥滤时,吃了吃分别地是象腐殖一样和象 fulvic 一样荧光。元素的分析证明那碳,氢,和氮内容与垃圾堆年龄减少了,当氧内容增加了时。而且,在这些孤立的部分的氮内容列在后面:哈 >
HyI >
FA。元素的分析,英尺红外,和荧光 EEM 的结果也证实脂肪族的功能的组的芳香的碳和部分更充满沥滤与增加垃圾堆年龄吃了样品。 | HUO Shouliang XI Beidou YU Haichan HE Liansheng FAN Shilei LIU Hongliang | 2008 | Journal of Environmental Sciences2008，20，4： | 52 |
| 5 | Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study显示文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a safe and effective treatment for acute cerebral infarction patients,especially for moderate stroke patients.This study was approved by the Ethical Committee of Peking University Third Hospital,China(approval No.2013-068-2)on May 20,2013,and registered in the Chinese Clinical Trial Registry(registration No.ChiCTR1800017937). | Hui Zhang Chuan-Ling Li Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan | 2020 | Neural Regeneration Research2020，15，7： | 54 |
| 6 | Roux-en-Y choledochojejunostomy using novel magnetic compressive anastomats in canine model of obstructive jaundice显示文摘BACKGROUND:The traditional hand-sewn Roux-en-Y choledochojejunostomy is technically complicated,and the incidence of postoperative complications has remained high.A set of novel magnetic compressive anastomats was introduced to facilitate choledochojejunostomy and improve the prognosis of patients.METHODS:After ligating the common bile duct for 7 days,16 dogs were randomly divided into two groups (n=8 per group).Anastomats were used in the study group,and the traditional hand-sewn method was used in the control group for standard Roux-en-Y choledochojejunostomy.We compared the operation time,incidence of complications,gross appearance,and pathological disparity in stoma between the two groups in 1-month and 3-month follow-up examinations.RESULTS:The time spent on constructing the anastomosis for the study group was significantly shortened.Although no anastomotic stenosis occurred in the two groups,the narrowing rate of biliary-enteric anastomosis was much higher in the control group.There was one case of bile leakage in the control group,whereas no bile leakage occurred in the study group.A smoother surface,an improved layer apposition,and a lower local inflammatory response were identified in the anastomosis of the study group.CONCLUSION:The structures of the novel magnetic compressive anastomats are simple,and they are time-saving,safe and efficient for performing Roux-en-Y choledocho- jejunostomy procedures in a canine model of obstructive jaundice. | Chao Fan,Xiao-Peng Yan,Shi-Qi Liu,Chun-Bao Wang,Jian-Hui Li,Liang Yu,Zheng Wu and Yi Lv Department of Hepatobiliary Surgery and Department of Pathology,First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061,China Department of Surgical Oncology,Third Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710068,China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 49 |
| 7 | Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration显示文摘 | Yu, Y. Yao, A. H. Chen, N. Pu, L. Y. Fan, Y. Lv, L. Sun, B. C. Li, G. Q. Wang, X. H. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 45 |
| 8 | Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis显示文摘OBJECTIVE: To investigate the association of E-selectin S128R polymorphisms with ischemic stroke. DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Knowledge Infrastructure, and Wanfang Database between January 1998 and December 2010. STUDY SELECTION: Case-controlled studies addressing the association of the E-selectin polymorphism and ischemic stroke were included in this review. The genotype distribution complied with the Hardy-Weinberg genetic equilibrium. The included reports were evaluated by two authors for strict quality screening. Meta-analysis software, REVMAN 5.1, was used to investigate heterogeneity, pooled odds ratio (OR) and 95% confidence interval (CI) in individual studies. MAIN OUTCOME MEASURES: Genotype and allele distributions at the E-selectin S128R site. RESULTS: Six case-controlled studies were included after screening and application of inclusion and exclusion criteria. There was no heterogeneity in the genotype and allele frequencies, and no publication bias was found. Meta-analysis of the pooled data showed that the OR value of the (AC+CC)/AA genotype was 1.93 (95% CI: 1.55-2.41, Z = 5.80, P < 0.000 01), and the OR for the C/A allele was 1.80 (95% CI: 1.47-2.22, Z = 5.59, P < 0.000 01) in the ischemic stroke group, compared with control group. Results of pooled data in Chinese subjects showed that the OR value of (AC+CC)/AA was 2.36 (95% CI: 1.68-3.31, Z = 4.99, P < 0.000 01), and the OR value of the C/A allele was 2.25 (95% CI: 1.63-3.12, Z = 4.89, P < 0.000 01). CONCLUSION: Polymorphism of E-selectin S128R was significantly associated with susceptibility to ischemic stroke; the AC and CC genotypes as well as the C allele may be factors associated with susceptibility to ischemic stroke. | Qingli Sun Yu Fu Aping Sun Yanhong Shou Mei Zheng Xiaogang Li Dongsheng Fan | 2011 | Neural Regeneration Research2011，6，22： | 46 |
| 9 | Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients显示文摘胃的癌症是世界范围的第四很普通的癌症,与死亡的高率和低 5 年的幸存率。迄今为止,有为胃的癌症的有效治疗学的协议的缺乏。最近的研究建议癌症干细胞(CSC ) 为肿瘤开始,侵略,转移,和抵抗负责到 anticancer 治疗。因此,指向胃的 CSC 的治疗是吸引人的。然而,在人的胃的腺癌(GAC ) 的 CSC 没被描述。这里,我们从 GAC 病人在肿瘤纸巾和外部血识别 CSC。从肿瘤纸巾和病人的外部血被孤立的人的 GAC (GCSC ) 的 CSC 带了 CD44 和 CD54 表面标记,当注入了 immunodeficient 老鼠时,高度类似于原来的人的肿瘤的产生肿瘤,在 vitro 区分了进胃的上皮的房间,并且在 vivo 并且在 vitro 自我更新。我们的调查结果建议有效治疗学的协议必须指向 GCSC。从 GAC 病人的循环的 GCSC 的俘获也为为肿瘤转移潜在地负责的一张批评房间人口的鉴定显示出大潜力,并且为早诊断并且胃的癌症的纵的监视提供一个有效协议。 | Tie Chen Kun Yang Jianhua Yu Wentong Meng Dandan Yuan Feng Bi Fang Liu Jie Liu Bing Dai Xinzu Chen Fang Wang Fan Zeng Hong Xu Jiankun Hu Xianming Mo | 2012 | Cell Research2012，22，1： | 50 |
| 10 | Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China显示文摘长期的肝炎 B 是在中国的一个主要健康问题。自从 1992,通用种痘节目在中国改变了肝炎 B 病毒感染的传染病学从高度到中等地方性。在中国的最流行的肝炎 B 病毒种类是遗传型 B 和 C,而在西方的省的那些是遗传型 D 和 C/D 混血儿。长期的肝炎 B 在中国提出重担到社会。不同治疗策略被探索了以一种划算的方式改进耐心的结果。然而,因为通常低的收入和有限资源,有对抵抗的一个低基因障碍的抗病毒的药仍然广泛地在中国被使用。个性化的抗病毒的治疗仔细与翻译的药被联系,它在 genomics,有免疫力的 biomarkers,和纤维变性上从研究利用信息。这些研究的结果在进一步改进治疗结果是关键的。 | Rui Yu Rong Fan Jinlin Hou | 2014 | Frontiers of Medicine2014，8，2： | 43 |
| 11 | 血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的meta分析(英文)显示文摘目的:探讨普通人群血浆同型半胱氨酸水平升高是否能独立预测死亡风险。创新点:通过汇总12篇前瞻性研究,定量分析血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的关系。方法:通过检索Pub Med和Embase数据库,收集普通人群中血浆同型半胱氨酸水平与死亡关系的前瞻性观察性研究,采用STATA统计软件进行meta分析。结论:血浆同型半胱氨酸水平升高是心血管疾病及各种原因死亡风险增加的一个独立预测因素,在老年人群中尤为明显。 | Hui-yong PENG Chang-feng MAN Juan XU Yu FAN | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，1： | 46 |
| 12 | Comparative Study between Robotic Total Thyroidectomy with Central Lymph Node Dissection via Bilateral Axillo-breast Approach and Conventional Open Procedure for Papillary Thyroid Microcarcinoma显示文摘 | Qing-Qing He Jian Zhu Da-Yong Zhuang Zi-Yi Fan Lu-Ming Zheng Peng Zhou Lei Hou Fang Yu Yan-Ning Li Lei Xiao Xue-Feng Dong Gao-Feng Ni | 2016 | Chinese Medical Journal2016，，18： | 42 |
| 13 | Protein-Protein Interactions in the Regulation of WRKY Transcription Factors显示文摘自从一个 WRKY 抄写因素的第一份报告,现在是几乎 20 年, SPF1,从香甜的土豆。大进步从那以后在在植物生长,开发,和对关於生命、不能生活的应力的回答建立 WRKY 抄写因素的多样的生物角色被取得了。尽管有功能的差异,几乎所有分析 WRKY 蛋白质认出 TTGACC/T W 盒子序列并且,因此除核心 W 盒子倡导者元素的仅仅的识别以外的机制是必要的完成 WRKY 抄写因素的规章的特性。在过去的几年的研究表明了 WRKY 抄写因素身体上在发信号,抄写,并且染色质改变与角色与大量蛋白质交往。交往 WRKY 蛋白质的研究提供了重要卓见进抄写因素的重要家庭的成员的行动的规定和模式。稍微改变的 WRKY 领域和在每七个 WRKY 亚科以内保存的另外的蛋白质主题参予 proteinprotein 相互作用并且调停,这也出现了在 WRKY 蛋白质之间并且在在重要生物过程的调整的 WRKY 和另外的规章的蛋白质之间的复杂功能的相互作用。在这评论,我们为 WRKY 抄写因素总结 proteinprotein 相互作用的研究并且讨论交往的搭挡怎么作出贡献,到 WRKY 抄写因素的复杂规章、功能的网络的建立,在不同层次。 | Yingjun Chi Yan Yang Yuan Zhou Jie Zhou Baofang Fan Jing-Quan Yu Zhixiang Chen | 2013 | Molecular Plant2013，6，2： | 39 |
| 14 | Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia显示文摘 | Jian SHEN Yu ZHU Hai YU Zuo-xu FAN Feng XIAO Pan WU Qi-hui ZHANG Xiao-xing XIONG Jian-wei PAN Ren-ya ZHAN | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，3： | 36 |
| 15 | A probiotic treatment containing Lactobacillus,Bifidobacterium and Enterococcus improves IBS symptoms in an open label trial显示文摘Objective: To evaluate the efficacy and safety of live combined Bifidobacterium, Lactobacillus and Enterococcus capsules in treatment of irritable bowel syndrome. Methods: Eighty-five patients [male 32, female 53; age (45.31±11.72) years] were given live combined Bifidobacterium, Lactobacillus and Enterococcus capsules 1260 mg/d t.i.d.×4 weeks. Syndrome scales were used to evaluate the efficacy in gastrointestinal syndrome. Fecal flora was also measured before and after the treatment. Six bacteria were cultured and the colony forming units were counted in stool. SPSS was used for data analysis. Results: Seventy-four patients finished the follow-up. No side-effect was found. For treatment of irritable bowel syndrome, the effective rate of live combined Bifidobacterium, Lactobacillus and Enterococcus capsules was 56.8% in the second week, 74.3% in the fourth week and 73.0% in the sixth week. Single symptom was improved, especially in abdominal pain and stool character. The probiotica con- taining live combined Bifidobacterium, Lactobacillus and Enterococcus could increase bifidobacterium count (P<0.01) and lac- tobacillus count (P<0.05); decrease bacteroides count (P<0.05) and enterococci count (P<0.01); No obvious changes were ob- served in clostridium difficile colonitis and enterobacteriaceae (P>0.05). Conclusion: The result of the study indicated that the administration of live combined Bifidobacterium, Lactobacillus and Enterococcus improved the symptom of irritable bowel syndrome and that there was a gradual increase of this effect. Thereafter conditions remained stable for 2 weeks. That improve- ment may be associated with alterations in gastrointestinal flora. | FAN yu-jing CHEN Shu-jie YU Ying-cong SI Jian-min LIU Bin | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，12： | 33 |
| 16 | Geochronology and significance of volcanic rocks in the Ning-Wu Basin of China显示文摘The Ning-Wu(Nanjing-Wuhu) Basin is one of the most important volcanic basins in the Middle-Lower Yangtze River Valley,eastern China.It consists of four volcanic units,i.e.,the Longwangshan,Dawangshan,Gushan,and Niangniangshan Formations.Their LA-ICP MS U-Pb zircon ages are 134.8±1.8,132.2±1.6,129.5±0.8,and 126.8±0.6 Ma,respectively.Results of this study indicate that all volcanic rocks in the Ning-Wu Basin were formed in the Early Cretaceous from 135 to 127 Ma,lasting 8-10 m.y.No Jurassic volcanic activities occurred in any of the volcanic basins of the Middle-Lower Yangtze River Valley,including the Ning-Wu Basin.These new chronological results provide significant evidence for further study of this region to improve our understanding of Mesozoic tectonic,magmatic,and metallogenic processes of eastern China. | ZHOU TaoFa FAN Yu YUAN Feng ZHANG LeJun QIAN Bin MA Liang YANG XiFei David R COOKE | 2011 | Science China Earth Sciences2011，54，2： | 33 |
| 17 | Clinicopathologic significance of HER-2/neu protein expression and gene amplification in gastric carcinoma显示文摘AIM:To study the HER-2/neu protein expression and gene amplification in gastric carcinoma and their relation.METHODS:One hundred and forty-five formalin-fixed and paraffin-embedded tumor tissue samples from Chinese gastric carcinoma patients were studied with immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH)methods.Clinicopathologic data about all patients were collected.RESULTS:The levels of HER-2 3+,HER-2 2+and HER21+were measurable in 6.9%,8.3%and 17.2%of the samples,respectively.No HER-2 was stained in 67.6% of the samples.FISH showed that HER-2 gene was amplified in 18 samples,10 HER-2 3+samples,5 HER-2 2+samples,and 3 HER-2 1+samples with IHC staining.HER-2 status was not correlated with the sex and age of patients,and tumor size,location or differentiation,but with the depth of invasion,TNM stage,lymph node and distant metastasis as well as histopathological classification of gastric cancer(P<0.05).CONCLUSION:All samples with IHC as HER-2 expression should be analyzed with FISH.Detection of HER-2 gene amplification can assess the malignant biological behaviors and prognosis of gastric cancer. | Shi-Yan Yan Ying Hu Jian-Gao Fan Guo-Quan Tao Yong-Ming Lu Xu Cai Bao-Hua Yu Yi-Qun Du | 2011 | World Journal of Gastroenterology2011，17，11： | 34 |
| 18 | Volumetric-modulated arc therapy vs c-IMRT in esophageal cancer:A treatment planning comparison显示文摘AIM:To compare the volumetric-modulated arc therapy AT plans ith conventional sliding indo intensity-modulated radiotherapy c-I RT plans in esophageal cancer EC . METHODS:Tenty patients ith EC ere selected, including 5 cases located in the cervical, the upper, the middle and the lo er thorax, respectively. Five plans ere generated ith the eclipse planning system:three using c-IMRT with 5 fields (5F), 7 fields (7F) and 9 fields (9F), and two using VMAT with a single arc 1A and double arcs 2A . The treatment plans ere designed to deliver a dose of 60 Gy to the plan-ning target volume Tith the same constrains in a 2.0 Gy daily fraction, 5 d a eek. lans ere normalized to 95% of the T that received 100% of the prescribed dose. We examined the dose-volume histogram parameters of T and the organs at risk OAR such as lungs, spinal cord and heart. onitor units U and normal tissue complication probability NTC of OAR ere also reported. RESULTS:Both c-I RT and AT plans resulted in abundant dose coverage of T for EC of different locations. The dose conformity to T as improved as the number of field in c-IMRT or rotating arc in VMAT as increased. The doses to T and OAR in AT plans ere not statistically different in comparison ith c-I RT plans, ith the follo ing exceptions:in cervical and upper thoracic EC, the conformity index CI as higher in VMAT (1A 0.78 and 2A 0.8) than in c-IMRT (5F 0.62, 7F 0.66 and 9F 0.73) and homogeneity was slightly better in c-IMRT (7F 1.09 and 9F 1.07) than in VMAT (1A 1.1 and 2A 1.09). Lung V30 was lower in VMAT (1A 12.52 and 2A 12.29) than in c-IMRT (7F 14.35 and 9F 14.81). The humeral head doses were significantly increased in AT as against c-I RT. In the middle and lower thoracic EC, CI in VMAT (1A 0.76 and 2A 0.74) was higher than in c-IMRT (5F 0.63 Gy and 7F 0.67 Gy), and homogeneity was almost similar bet een AT and c-I RT. 20 2A 21.49 Gy vs 7F 24.59 Gy and 9F 24.16 Gy) and V30 (2A 9.73 Gy vs 5F 12.61 Gy, 7F 11.5 Gy and 9F 11.37 Gy) of lungs in AT ere lo er than in c-I RT, but lo doses to lungs (V5 and V10) were increased. V30 (1A 48.12 Gy vs 5F 59.2 Gy, 7F 58.59 Gy and 9F 57.2 Gy), V40 and 50 of heart in AT as lo er than in c-I RT. Us in AT plans ere significantly reduced in comparison ith c-I RT, maximum doses to the spinal cord and mean doses of lungs ere similar bet een the t o techniques. NTC of spinal cord as 0 for all cases. NTC of lungs and heart in AT ere lo er than inc-I RT. The advantage of AT plan as enhanced by doubling the arc. CONCLUSION:Compared ith c-I RT, AT, especially the 2A, slightly improves the OAR dose sparing, such as lungs and heart, and reduces NTC and U ith a better T coverage. | Li Yin Hao Wu Jian Gong Jian-Hao Geng Fan Jiang An-Hui Shi Rong Yu Yong-Heng Li Shu-Kui Han Bo Xu Guang-Ying Zhu | 2012 | World Journal of Gastroenterology2012，18，37： | 34 |
| 19 | High-density Linkage Map of Cultivated Allotetraploid Cotton Based on SSR, TRAP, SRAP and AFLP Markers显示文摘一张高密度的连锁图为从在 Gossypium hirsutum L 之间的 cultivatedallotetraploid 种类的一个种间的十字导出的一张 F_2 人口被构造。并且 G.barbadense L。从种间的十字的 186 个 F_2 个人的一个总数“ CRI36 x 哈尔 7124' 是在包括一个新奇标记系统的 1 252 多态的 loci 的 genotyped,目标区域扩大多型性(陷井) 。地图由 1 097 个标记组成,包括 697 简单顺序重复(SSR ) , 171 个陷井, 129 顺序相关的放大多型性, 98 放大 fragmentlengthpolymorphisms,和二个词法标记,并且跨越了 4 有 4.1cM 的平均遗传距离的 536.7 厘米每标记。用在染色体之中的 45 复制 SSR loci, 13 同源染色体中的 11 个在四倍体棉花被识别。这张地图将为量的特点 loci 并且在棉花的分子的繁殖印射的高分辨率提供一个必要资源。 | Jiwen Yu Shuxun Yu Cairui Lu Wu Wang Shuli Fan Meizhen Song Zhongxu Lin Xianlong Zhang Jinfa Zhang | 2007 | Journal of Integrative Plant Biology2007，49，5： | 29 |
| 20 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
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