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| 1 | Recent glacial retreat in High Asia in China and its impact on water resource in Northwest China显示文摘Under the impact of climatic warming, the glaciers in the High Asia in China have been retreating continuously with negative glacial mass balance in recent several decades. The retreat became more intensive in the past 10 years. The spatial pattern of the glacial retreat in the High Asia in China is that the smallest magnitude of retreat is in the inland of the Tibetan Plateau, the magnitude increases from the inland to the margin of the Tibetan Plateau, and the largest magnitude at the margin of the Tibetan Plateau. The glacial retreat in the High Asia in China has an important impact on the water resource of the arid regions in Northwest China. This study shows that the glacial retreat in the 1990s has caused an increase of 5.5% in river runoff in Northwest China. In the Tarim River basin, the increase of river runoff is higher than 5.5%. | YAO Tandong 1,2 ,WANG Youqing 2 ,LIU Shiying 2,1 ,PU Jianchen 2,1 ,SHEN Yongping 2 & LU Anxin 2,1 1.Institute of Tibetan Plateau Research,Chinese Academy of Sciences,Beijing 100029,China 2.Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou 730000,China | 2004 | Science China Earth Sciences2004，47，12： | 117 |
| 2 | Incidence and mortality of thyroid cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of thyroid cancer(TC) in China from 2008 to 2012.Methods: Incident and death cases of TC were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of TC were calculated by area(urban/rural), region(eastern, middle, western), gender and age group(0, 1-4, 5-9,…, 85+). China census in 2000 and world Segi's population were applied for age-standardized rates. Joinpoint(Version 4.6.0.0) model was used for time-trend analysis.Results: The crude incidence rate of TC was 7.56/100,000 which ranked the seventh in overall cancers. The agestandardized incidence rates by China population(ASIRC) and by World population(ASIRW) were 6.25/100,000 and 5.52/100,000, respectively. The crude mortality of TC in China was 0.52/100,000. The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were0.34/100,000 and 0.32/100,000, respectively. Incidence and mortality rates of TC were higher in females than in males and higher in urban areas than in rural areas. Eastern areas had the highest incidence followed by middle and western areas. TC incidence increased dramatically after age of 15 years, then peaked at 14.08/100,000 in the group of 50-54 years and finally decreased sharply after 55 years old. TC mortality increased with age in population,reaching the peak of 5.09/100,000 in sub-population aged 85 years or older. TC incidence increased by 4.73 times from 2.40/100,000 in 2003 to 13.75/100,000 in 2012 with an average annual increase of 20%, while TC mortality only increased slightly around 0.32/100,000 from 0.26/100,000 to 0.36/100,000.Conclusions: Appropriate targeted prevention, early detection and treatment programs can be carried out to curb the rapid growth trend of TC and control the disease burden. | Lingbin Du Runhua Li Minghua Ge Youqing Wang Huizhang Li Wanqing Chen Jie He | 2019 | Chinese Journal of Cancer Research2019，31，1： | 31 |
| 3 | Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratioin predicting survival for patients with stage Ⅰ-Ⅱgastric cancer显示文摘Background:The preoperative neutrophil-to-lymphocyte ratio(NLR) and the platelet-to-lymphocyte ratio(PLR) are associated with poor prognosis of gastric cancer.We aimed to determine whether the combination of NLR and PLR(NLR-PLR) could better predict survival of patients after curative resection for stage Ⅰ-Ⅱ gastric cancer.Methods:We collected data from the medical records of patients with stage Ⅰ-Ⅱ gastric cancer undergoing curative resection between December 2000 and November 2012 at the Sun Yat-sen Cancer Center.The preoperative NLRPLR was calculated as follows:patients with both elevated NLR(≥2.1) and PLR(≥ 120) were given a score of 2,and patients with only one or neither were given a score of 1 or 0,respectively.Results:Kaplan-Meier analysis and log-rank tests revealed significant differences in overall survival(OS) among patients with NLR-PLR scores of 0,1 and 2(P < 0.001).Multivariate analysis showed that OS was independently associated with the NLR-PLR score[hazard ratio(HR) = 1.51,95%confidence interval(CI) 1.02-2.24,P = 0.039]and TNM stage(HR = 1.36,95%CI 1.01-1.83,P= 0.041).However,other systemic inflammation-based prognostic scores,including the modified Glasgow prognostic score,the prognostic nutritional index,and the combination of platelet count and NLR,were not.In TNM stage-stratified analysis,the prognostic significance of NLR-PLR was maintained in patients with stage Ⅰ(P < 0.001) and stage Ⅱ cancers(P= 0.022).In addition,the area under the receiver operating characteristic curve for the NLR-PLR score was higher than those of other systemic inflammation-based prognostic scores(P = 0.001).Conclusion:The preoperative NLR-PLR score is a useful predictor of postoperative survival in the patients with stage l-ll gastric cancer and may help identify high-risk patients for rational therapy and timely follow-up. | Xiaowei Sun Xuechao Liu Jianjun Liu Shangxiang Chen Dazhi Xu Wei Li Youqing Zhan Yuanfang Li Yingbo Chen Zhiwei Zhou | 2016 | Chinese Journal of Cancer2016，35，7： | 25 |
| 4 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 5 | Variations in air temperature during the last 100 years revealed by δ^(18)O in the Malan ice core from the Tibetan Plateau显示文摘By comprehensive analyses, it was found that the variations in d 18O recorded in Malan ice core from theKekexili Region on the Tibetan Plateau could represent thechanges in air temperature during the summer half year (from May to October) over the Kekexili Region and the northern margin of the Tibetan Plateau. The general increase trend in d18O in this ice core during the past century indicated climate warming, and it was estimated that air temperature during the summer half-year rose about 1.2C over there then. However, this ice core record documented that the study area has been cooling while most of the world has been dramatically warming since the late 1970s. A teleconnection was foundbetween the variations in d 18O in the Malan ice core and the North Atlantic Oscillation. Moreover, the variations in d 18O in this ice core were similar to that in the summer half-year air temperature over the southern Tibetan Plateau on thecenturial time scale, but opposite on the multidecadal timescale. | WANG Ninglian, YAO Tandong, PU Jianchen, ZHANG Yongliang, SUN Weizhen & WANG Youqing Key Laboratory of Ice Core and Cold Regions Environment, Cold and Arid Regions Environmental and Engineering Research Institute, ChineseAcademy of Sciences, Lanzhou 730000, China | 2003 | Chinese Science Bulletin2003，48，19： | 19 |
| 6 | Early detection of pine wilt disease in Pinus tabuliformis in North China using a field portable spectrometer and UAV-based hyperspectral imagery显示文摘Background:Pine wilt disease(PWD)is a major ecological concern in China that has caused severe damage to millions of Chinese pines(Pinus tabulaeformis).To control the spread of PWD,it is necessary to develop an effective approach to detect its presence in the early stage of infection.One potential solution is the use of Unmanned Airborne Vehicle(UAV)based hyperspectral images(HIs).UAV-based HIs have high spatial and spectral resolution and can gather data rapidly,potentially enabling the effective monitoring of large forests.Despite this,few studies examine the feasibility of HI data use in assessing the stage and severity of PWD infection in Chinese pine.Method:To fill this gap,we used a Random Forest(RF)algorithm to estimate the stage of PWD infection of trees sampled using UAV-based HI data and ground-based data(data directly collected from trees in the field).We compared relative accuracy of each of these data collection methods.We built our RF model using vegetation indices(VIs),red edge parameters(REPs),moisture indices(MIs),and their combination.Results:We report several key results.For ground data,the model that combined all parameters(OA:80.17%,Kappa:0.73)performed better than VIs(OA:75.21%,Kappa:0.66),REPs(OA:79.34%,Kappa:0.67),and MIs(OA:74.38%,Kappa:0.65)in predicting the PWD stage of individual pine tree infection.REPs had the highest accuracy(OA:80.33%,Kappa:0.58)in distinguishing trees at the early stage of PWD from healthy trees.UAV-based HI data yielded similar results:the model combined VIs,REPs and MIs(OA:74.38%,Kappa:0.66)exhibited the highest accuracy in estimating the PWD stage of sampled trees,and REPs performed best in distinguishing healthy trees from trees at early stage of PWD(OA:71.67%,Kappa:0.40).Conclusion:Overall,our results confirm the validity of using HI data to identify pine trees infected with PWD in its early stage,although its accuracy must be improved before widespread use is practical.We also show UAV-based data PWD classifications are less accurate but comparable to those of ground-based data.We believe that these results can be used to improve preventative measures in the control of PWD. | Run Yu Lili Ren Youqing Luo | 2021 | Forest Ecosystems2021，8，3： | 8 |
| 7 | Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy显示文摘Paclitaxel(PTX) is one of the most effective anticancer drugs for the treatment of various solid tumors, but its clinical use is limited by its poor solubility, low bioavailability, and severe systemic toxicity. Encapsulation of PTX in polymeric nanoparticles is used to overcome these problems but these micelles still need improvements in stability, pharmacokinetics, therapeutic efficacy, and safety profiles. In this study, we demonstrate a facile fabrication of a stable PTX-binding micelle made from poly(ethylene glycol)-block-dendritic polylysine, whose primary amines were reacted with phenethyl isothiocyanate(PEITC), a hydrophobic anticancer agent under clinical study. The amphiphilic conjugate(PEG-Gx-PEITC; Gx, the generation of the polylysine dendron) formed well-defined micelles whose core was composed of phenyl groups and thiourea groups binding PTX via π-π stacking and hydrogen bonding. Compared with the PTX-loaded poly(ethylene glycol)-block-poly(D,L-lactide)(PEGPDLLA/PTX) micelles in clinical use, PTX-loaded PEG-Gx-PEITC third-generation(PEG-G3-PEITC/PTX) micelles showed slowed blood clearance, enhanced tumor accumulation, and thus much improved in vivo therapeutic efficacy in both subcutaneous and orthotopic human breast cancer xenografts. Therefore, PEG-G3-PEITC is a promising drug delivery system for PTX in the treatment of breast cancer. | Jiajia Xiang Bihan Wu Zhuxian Zhou Shiqi Hu Ying Piao Quan Zhou Guowei Wang Jianbin Tang Xiangrui Liu Youqing Shen | 2018 | Science China(Life Sciences)2018，61，4： | 6 |
| 8 | Improving uniform scattering device for straw-smashing,back-throwing,no-tillage planter under complete straw mulching condition显示文摘With the objective of obtaining a completely straw-mulched field,when no-tillage mechanical sowing is implemented with straw smashing,delivering,and back-throwing approaches,it may be difficult to scatter the smashed straw uniformly during a succeeding wheat sowing step.This is because the previous rice straw is substantial in quantity and has a high humidity and toughness,which may easily result in non-uniform straw mulching and thus sparse and weak seedlings of wheat.Therefore a force-dispersing and uniform-scattering device was designed.With the number of scattering impellers,impeller angle,and impeller rotation speed as the main factors and the percentage of pass for the scattering width and non-uniformity of the straw mulching as the assessment indices,single-factor experiments and orthogonal regressive tests were performed,and a dual-index(percentage of pass for the scattering width and non-uniformity of the straw mulching)fitted regression equation was established.The test results suggested that the main factors(from primary to secondary)that influence the indices were the impeller rotation speed,number of scattering impellers,and impeller angle.The optimal parameter combination for the uniform scattering device was four rows of impellers with an angle of 15°,rotation speed of 1015 r/min,percentage of pass of 72.65%for the scattering width,and a non-uniformity of 13.8%in the straw mulching.This combination can be used to realize a uniform scattering of the smashed straw along the seedling rows on the after-sowing ground.According to the field investigation of the wheat growth,the wheat emergence rate was 90.7%.The research results can provide a reference for improving the uniform scattering device for a straw-smashing,back-throwing,no-tillage planter for obtaining a completely straw-mulched field,enhancing the quality of the machinery operation,and ensuring good and strong seedlings after sowing. | Fengwei Gu Xuemei Gao Feng Wu Zhichao Hu Youqing Chen Chong Zhang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 5 |
| 9 | Management Strategies and Research Orientations of Forest Diseases and Pests in China显示文摘Forest diseases and pests are perceived as a growing hazard to China economy. It is a common conclusion that the actualities of forest pests in china are no effective measures to the old important pests, some secondary pests are ascending to chief pests, increasing devastation from exotic pests, frequent ecological pest eruption induced by environmental detriment and host-leading diseases to threaten the 'Western Development Project 'in China, which is the most important economical strategy to China; th... | ZHANG Xingyao LIANG Jun LU Quan YAN Donghui LUO Youqing XU Zhichun WEN Junbao1. Research Institute of Forest Ecology. Environment and Protection. Chinese Academy of Forestry. Beijing, 100091. P R China:2. College of Biological Sciences and Technology. Beiiine Forestry University. Beiiine. 100083. P R China | 2002 | Chinese Forestry Science and Technology2002，1，2： | 4 |
| 10 | An investigation of the influence of near-fault ground motion parameters on the pile's response in liquefiable soil显示文摘The performance of a soil-pile system can be significantly influenced by ground motion parameters. However, few research efforts have been performed to provide a complete description of the influence of key ground motion parameters on the pile's behavior in liquefiable soil. In this study, a three-dimensional finite element(FE) model, incorporating a multisurface plasticity solid-fluid fully coupled formulation soil constitutive model, is developed and calibrated based on centrifuge test data. Seventy-two near-fault non-pulse-like(NF-NP) and seventy-two near-fault pulse-like(NF-P) ground motion records are studied with the calibrated FE model to distinguish the effects of several common ground motion parameters soon afterwards. Base on the parametric study results, a simple index, RPGV/PGA(i.e., the ratio of peak ground velocity(PGV) to peak ground acceleration(PGA)), shows its capability on characterizing the pile behavior under both NF-NP and NF-P ground motions. Furthermore, two equations are developed to characterize the relationships between the RPGV/PGA as well as the maximum pile's moments and displacements. In general, this study can be helpful to gain new insights on the influence of typical index parameters for near-field ground motions on the response of the pile foundation in liquefiable soil. | Hui Shuqing Tang Liang Zhang Xiaoyu Wang Youqing Ling Xianzhang Xu Bowen | 2018 | Earthquake Engineering and Engineering Vibration2018，17，4： | 4 |
| 11 | RELATIONSHIP OF LENNARD-JONES POTENTIAL ANDMORSE POTENTIAL WITH W_x(r) POTENTIAL显示文摘RELATIONSHIPOFLENNARD-JONESPOTENTIALANDMORSEPOTENTIALWITHW_x(r)POTENTIALXie,Youqing(DepartementofMaterialsScienceandEngineein... | Xie , Youqing(Departement of Materials Science and Engineeing ,Central South University of Technology ,Changsha 410083) | 1994 | 中国有色金属学会会刊:英文版1994，4，3： | 4 |
| 12 | Combining WV-2 images and tree physiological factors to detect damage stages of Populus gansuensis by Asian longhorned beetle (Anoplophora glabripennis) at the tree level显示文摘Background:Anoplophora glabripennis(Motschulsky),commonly known as Asian longhorned beetle(ALB),is a wood-boring insect that can cause lethal infestation to multiple borer leaf trees.In Gansu Province,northwest China,ALB has caused a large number of deaths of a local tree species Populus gansuensis.The damaged area belongs to Gobi desert where every single tree is artificially planted and is extremely difficult to cultivate.Therefore,the monitoring of the ALB infestation at the individual tree level in the landscape is necessary.Moreover,the determination of an abnormal phenotype that can be obtained directly from remote-sensing images to predict the damage degree can greatly reduce the cost of field investigation and management.Methods:Multispectral WorldView-2(WV-2)images and 5 tree physiological factors were collected as experimental materials.One-way ANOVA of the tree’s physiological factors helped in determining the phenotype to predict damage degrees.The original bands of WV-2 and derived vegetation indices were used as reference data to construct the dataset of a prediction model.Variance inflation factor and stepwise regression analyses were used to eliminate collinearity and redundancy.Finally,three machine learning algorithms,i.e.,Random Forest(RF),Support Vector Machine(SVM),Classification And Regression Tree(CART),were applied and compared to find the best classifier for predicting the damage stage of individual P.gansuensis.Results:The confusion matrix of RF achieved the highest overall classification accuracy(86.2%)and the highest Kappa index value(0.804),indicating the potential of using WV-2 imaging to accurately detect damage stages of individual trees.In addition,the canopy color was found to be positively correlated with P.gansuensis’damage stages.Conclusions:A novel method was developed by combining WV-2 and tree physiological index for semi-automatic classification of three damage stages of P.gansuensis infested with ALB.The canopy color was determined as an abnormal phenotype that could be directly assessed using remote-sensing images at the tree level to predict the damage degree.These tools are highly applicable for driving quick and effective measures to reduce damage to pure poplar forests in Gansu Province,China. | Quan Zhou Xudong Zhang Linfeng Yu Lili Ren Youqing Luo | 2021 | Forest Ecosystems2021，8，3： | 3 |
| 13 | Water cooling radiator for solid state power supply in fast-axial-flow C02 laser显示文摘 | Heng ZHAO Bo LI Wenjin WANG Yi HU Youqing WANG | 2016 | Frontiers of Optoelectronics2016，9，4： | 3 |
| 14 | Interlayer coupling in anisotropic/isotropic van der Waals heterostructures of ReS2 and MoS2 monolayers显示文摘在里面飞机对称是到二维的分层的材料,以及原子地薄的异质接面的物理性质的一个重要贡献者。这里,在夹层联合相互作用和费用分离被观察由的地方,我们表明物件 2 和瞬间 2 单层的各向异性 / 各向同性的货车 der Waals (vdW ) heterostructures 在 situ Raman 光致发光光谱学,电,并且 photoelectrical 大小。我们相信这些结果能对理解原子地薄的 vdW heterostructures 的基本物理并且创造电子的小说和 optoelectronic 设备有用。 | Mei Zhao Wenting Zhang Manman Liu Chao Zou Keqin Yang Yun Yang Youqing Dong Lijie Zhang Shaoming Huang | 2016 | Nano Research2016，9，12： | 3 |
| 15 | Enhanced learning and memory in GAT1 heterozygous mice显示文摘-Aminobutyric 酸(伽马氨基丁酸) 是在中央神经系统的主要禁止的 neurotransmitter。伽马氨基丁酸传播的结束通过膜蛋白质的一个家庭的行动,叫的伽马氨基丁酸 transporters (GAT14 ) 。伽马氨基丁酸系统涉及存储器的调整,这很好被建立。我们的以前的学习显示出老鼠展出了损害马头鱼尾的怪兽依赖者学习和记忆的那同型结合的 GAT1/ 。在鼠标上评估内长的减少的伽马氨基丁酸举起的影响认知行为,学习和异质接合的 GAT1+/ 鼠标的存储器的能力被被动回避范例和莫利斯舞水迷宫检测。洞板范例也被用来在如此的老鼠在焦虑相关的行为或探索行为测量变化。作为 synaptic 粘性的一种形式,长期的 potentiation 在老鼠被记录海马趾的 CA1 区域。我们发现了显示的老鼠增加了的那 GAT1+/ 学习并且记忆,减少的像焦虑的行为,和与野类型、同型结合的 GAT1/ 老鼠相比的最高的 synaptic 粘性。我们的结果建议在 GAT1 活动的中等减小引起在鼠标学习和记忆的改进。 | Jun Shi Youqing Cai Guoxiang Liu Neng Gong Zhenze Liu Tianle Xu Zhugang Wang Jian Fei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，4： | 3 |
| 16 | Computation of concentrations of characteristic atoms of alloys in BCC structure显示文摘In this paper,taking Nb-Mo alloy system as an example,the equations of concentration of characteristic atoms of alloys in BCC structure were obtained on the basis of the idea of systematic science of alloys and the number of coordination atoms.The concentrations of characteristic atoms in B2-NbMo type ordered alloys were calculated as functions of ordering degree(s) and composition xMo.When s=smax,the concentrations of characteristic atoms of stoichiometric B2-NbMo intermetallic compound are equal to that of alloys,that is,Nb 8 x0.5 at.,Mo 0 x0.5 at.As ordering degree decreases,characteristic atoms Nb 8A andM o 0A of B2-NbMo type ordered alloy split.And the degree of splitting of characteristic atoms increases with the ordering degree decreasing.Therefore,disordered alloys and various types of ordered alloys can be designed. | PENG HongJian WU Qing LI XiaoBo XIE YouQing | 2011 | Science China(Technological Sciences)2011，54，9： | 3 |
| 17 | Expression, purification of a synthetic fuse-protein-TSF from PF4 and TSP1 fragments and its effect on angio-genesis and tumor growth显示文摘Sequences encoding PF4 (58-70) and TSP1 (429-459) were linked to yield a single gene TSF which encodes the fuse-protein of TSF. The gene was cloned into a pGEX-2T expression vector to generate a protein GST-TSF, which was strongly expressed in E. coli. The purified GST-TSF was degraded with thrombin to generate the protein TSF. With the methods of MTT and wound repair assay, the effects of TSF on the proliferation and migration of EC were detected, respectively. The results showed that TSF significantly suppressed BAEC proliferation and migration in a dose-dependent manner. The fuse protein GST-TSF, and the peptides PF4 (58-70) and TSP1 (429-459) also inhibited BAEC proliferation and migration, respectively, but their inhibition rates were not as high as TSF. Using the CAM assay, it was shown that TSF, GST-TSF, PF4 (58-70) and TSP1 (429-459) inhibited angiogenesis in chick CAM potentially, the effect of TSF was the highest. In vivo, the growth of Lewis lung carcinoma was potently inhibited by TSF | SHEN Xianrong JI Dongmei HU Youqing JIA Fuxing DENG Xinxian WANG Ling CHU Zhiyong JIANG Dingwen LEI Chengxiang HUANG Jiansheng HU Xinran REN Darning | 2001 | Chinese Science Bulletin2001，46，24： | 2 |
| 18 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 19 | Shugan Huoxue Huayu Fang(疏肝活血化瘀方)attenuates carbon tetrachloride-induced hepatic fibrosis in rats by inhibiting transforming growth factor-β1/Smad signaling显示文摘OBJECTIVE:To investigate the potential mechanism by which Shugan Huoxue Huayu Fang(疏肝活血化瘀方,SGHXHYF)ameliorates liver fibrosis.METHODS:Liver fibrosis was induced in rats by intraperitoneal injection of carbon tetrachloride(CCl_(4))in peanut oil solution(40%,3 m L/kg body weight)twice a week for 8 weeks.A normal control group received the same volume of peanut oil alone.During weeks 5-8,the CCl_(4)-injected rat groups were administered saline(vehicle control),colchicine(0.1 mg/mL,1 mg/kg,positive control),or SGHXHYF(0.1 mg/mL;0.3,0.6 and 1.2 mg/kg)once daily by oral gavage.Rats were sacrificed 24 h after the last treatment.Blood samples were collected for measurement of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),albumin(ALB),collagenⅠ,and collagenⅢlevels.Liver samples were analyzed by histopathological staining,Masson's staining of extracellular matrix proteins,and immune-ohistochemical staining ofα-smooth muscle actin(α-SMA).TGF-β1/Smad protein and mRNA levels were analyzed by Western blot and quantitative reverse transcription-polymerase chain reaction analysis,respectively.In vitro experiments were also performed using rat hepatic stellate cells(HSCs).RESULTS:Compared with the control animals,CCl_(4)-exposed rats exhibited elevated serum levels of ALT,AST,ALP,collagenⅠ,and collagenⅢ;reduced serum levels of ALB;and increased collagen deposition andα-SMA expression in liver sections,reflecting liver fibrosis.CCl_(4) also increased expression of TGF-β1 and the activated(phosphorylated)forms of Smad2 and Smad3 but reduced expression of the negative regulator Smad7 in the liver.Notably,concomitant administration of SGHXHYF to CCl_(4)-exposed rats was found to significantly reverse or abolish the pro-fibrotic effects of CCl_(4) in the liver and reduced serum transferase levels.Analysis of HSCs in vitro confirmed that,mechanistically,SGHXHYF inhibited activation of the TGF-β1/Smad signaling pathway by downregulating phosphorylated Smad2 and Smad3 and upregulating Smad7 levels.CONCLUSION:SGHXHYF ameliorated CCl_(4)-induced liver fibrosis by inhibiting the TGF-β1/Smad signaling pathway.These findings suggest that SGHXHYF may have clinical utility for the treatment or prevention of liver fibrosis. | LIU Lei GUO Hanbin SHAO Cuiping WANG Lin XU Youqing ZHOU Yiming | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 2 |
| 20 | Determination of damaged wheat kernels with hyperspectral imaging analysis显示文摘Hyperspectral imaging was applied to classify the damaged wheat kernels and healthy kernels.The spectral information was extracted from damaged wheat kernels and healthy kernels samples.The effective wavelengths were obtained from spectral of 865-1711 nm by X-loadings of principal component analysis(PCA)and successive projection algorithm(SPA)method,respectively.Partial least square method(PLS)and least square-support vector machine(LS-SVM)were then used to build classification models on full spectral data and effective wavelengths dataset,respectively.The results showed that the classification accuracy of every LS-SVM model was the best,being 100%.While the accuracy of the PLS model was slightly lower,still over 97%.The confusion matrix showed that several damaged wheat kernels samples were misclassified as healthy samples,while all healthy samples were correctly classified.The overall results indicated that hyperspectral imaging could be used for discriminating the damaged wheat kernels and could provide a reference for detecting other grain kernels grading degrees.Further,this study can provide a research basis for the development of online or portable detectors on grain damaged kernels recognition,which will be beneficial for grain grading or post-harvest quality processing of other grains. | Yuanyuan Shao Chong Gao Guantao Xuan Xuemei Gao Youqing Chen Zhichao Hu | 2020 | International Journal of Agricultural and Biological Engineering2020，13，5： | 2 |
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