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| 1 | Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy显示文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: 'intervascular background coloration'; 'proliferation of intrapapillary capillary loops(IPCL)'; and 'dilation', 'tortuosity', 'change in caliber', and 'various shapes(VS)' of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME. | Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya Masayuki Kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 3 | Expression of cyclooxy-genase-2 in prostate carcinoma显示文摘 | Yoshimura R Sano H Masuda C | 2000 | Cancer2000，89，3： | 1 |
| 4 | A case of late-onset Tourette's disorder successfully treated with aripiprazole:View from blood levels of catecholamine metabolites and brain-derived neurotrophic factor (BDNF)显示文摘 | Ikenouchi-Sugita A Yoshimura R Hayashi K | 2009 | World Journal of Biological Psychiatry2009，10，43： | 1 |
| 5 | Expressin of cyclooxygenase-2 in patients with bladder carcinoma 显示文摘 | Yoshimura R Sano H Mitsuhashi M | 2001 | Uro12001，165，5： | 1 |
| 6 | Expression of cyclooxygenase in prostate carcinoma显示文摘 | Yoshimura R Sano H Masuda C | 2000 | Cancer(Phila)2000，89，3： | 1 |
| 7 | 显示文摘 | Mikami M Funahashi R Yoshimura M | 2003 | Journal of Applied Physics2003，94，10： | 1 |
| 8 | Quantita- tive Evaluation of Flow-induced Structural Vibration and Noise in Turbo Machinery by Full-scale Weakly Coupled Simulation 显示文摘 | JIANG Y Y YOSHIMURA S IMAI R | 2007 | Journal of Fluids and Structures2007，23，4： | 1 |
| 9 | Preparation of PA-MAM-and PPI-Metal (silver,platinum,and palladium) ano-composites and their eatalytic activities for reduction of 4-Nitrophenol显示文摘 | ISONO R YOSHIMURA T | 2004 | Langmuir2004，，20： | 1 |
| 10 | Thymidine phosphorylase levels as a prognostic factor in renal cell carcinoma显示文摘 | Wada S Yoshimura R Naganuma T | 2003 | BJU Int2003，91，： | 1 |
| 11 | 显示文摘 | Chiba R Yoshimura F Sakurai Y | 2002 | Solid State Ionics2002，，： | 1 |
| 12 | Relationship between bone marrow cellularity and apparent diffusion coefficient 显示文摘 | Nonomura Y Yasumoto M Yoshimura R | 2001 | J Magn Reson Imaging2001，39，5： | 1 |
| 13 | Blood levels ofbrain--derived neurotrophic factor (BDNF)in major depressive dis order 显示文摘 | Yoshimura R Ikenouchi Sugita A Hori H | 2010 | Seishin Shinkeigaku Zasshi2010，112，98： | 1 |
| 14 | Plasma levels of eatecholamine merabolites predict the response to sulpiri- de or fluvoxamine in major depression显示文摘 | Ueda N Yoshimura R Shinkai K et a/ | 2002 | Pharmacopsyehi- atry2002，35，5： | 1 |
| 15 | Identification of ThreeExercise-induced Mortality Risk Factors in Patients with COPD显示文摘 | Yoshimura K Maekura R Hiraga T | 2014 | COPD2014，11，6： | 1 |
| 16 | Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model显示文摘 | Morishita R Hayashi K | 2002 | Hypertension2002，39，： | 1 |
| 17 | Relationship between bone marrow cellularity and apparent diffusion coefficient 显示文摘 | Nonomura Y Yasumoto M Yoshimura R el al | 2001 | Magn Reson Imaging2001，13，5： | 1 |
| 18 | Quantitative evaluation of flow-induced structural vibration and noise in turbo machinery by full-scale weakly coupled simulation 显示文摘 | Jiang Y Y Yoshimura S Imai R | 2007 | Journal of Fluids and Structures2007，23，： | 1 |
| 19 | Prediction method of speech recognition performance based on HMM-based speech synthesis technique 显示文摘 | Terashima R Yoshimura T Wakita T | 2010 | IEEJ Transactions on Electronics Information and Systems2010，130，： | 1 |
| 20 | The cognitive profile of aripiprazole differs from that of other atypical antipsychotics in schizophrenia patients显示文摘 | Hori H Yoshimura R Katsuki A | | 0，，06： | 1 |
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