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| 1 | Sciatic nerve repair using adhesive bonding and a modified conduit显示文摘When repairing nerves with adhesives, most researchers place glue directly on the nerve stumps, but this method does not fix the nerve ends well and allows glue to easily invade the nerve ends. In this study, we established a rat model of completely transected sciatic nerve injury and repaired it using a modified 1 cm-length conduit with inner diameter of 1.5 mm. Each end of the cylindrical conduit contains a short linear channel, while the enclosed central tube protects the nerve ends well. Nerves were repaired with 2-octyl-cyanoacrylate and suture, which complement the function of the modified conduit. The results demonstrated that for the same conduit, the average operation time using the adhesive method was much shorter than with the suture method. No significant differences were found between the two groups in sciatic function index, motor evoked potential latency, motor evoked potential amplitude, muscular recovery rate, number of medullated nerve fibers, axon diameter, or medullary sheath thickness. Thus, the adhesive method for repairing nerves using a modified conduit is feasible and effective, and reduces the operation time while providing an equivalent repair effect. | Xiangdang Liang Hongfei Cai Yongyu Hao Geng Sun Yaoyao Song Wen Chen | 2014 | Neural Regeneration Research2014，9，6： | 3 |
| 2 | Oxide transformation and break-up of liquid metal in boiling solutions显示文摘The non-toxic gallium-based liquid metals(LMs) are promising for various newly emerging areas due to having excellent fluidity, high electrical and heat conductivity. However, the oxide layers often affect their applications. In this paper, we disclosed a straightforward boiling strategy to efficiently remove the oxide of LM in deionized water. Meanwhile such method was also demonstrated to be capable of quickly breaking up LM into droplets(mean 0.51 mm, SD 0.20 mm) in Na Cl solution,which has important value for manufacture purpose. According to the force analysis, surface tension of LM dominates the interaction between solution bubbles and LM under the same heating conditions. Then we characterized the surface morphology and compositions of LM droplets boiled(LMDB) using scanning electron microscope(SEM), X-ray diffraction(XRD) and Xray photoelectron spectroscopy(XPS) and tested the dynamic force between a rod and LMDB. It was shown that after being boiled in water, most of Ga2O3 was transformed to scattered α-Ga OOH nanorods which has less restriction to the deformation of LM and large resistance force(0.8 mN) was tested;otherwise, after boiled in Na Cl solution, more Ga2 O3 with contact patch structure reduces the surface resistance of LM(0.2 m N) and makes it to be broken up by bubbles. The different surface products are determined by the inhibition of hydrolysis of Ga3+by Na Cl solution. This study paved a simple way for oxide removal in neutral solution and mass production of LMD. It also suggests an efficient approach for exploring mechanisms of interactions between LM and bubbles, which is difficult to study otherwise in sonication. | YANG LiXiang ZHAO Xi XU Shuo LU YongYu CHANG Hao LIU Jing | 2020 | Science China(Technological Sciences)2020，63，2： | 3 |
| 3 | Sarcaglarols A-D, Lindenane-Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks显示文摘Sarcaglarols A-D(1-4),two pairs of lindenane-monoterpene heterodimers fused by a 1,2-dioxane moiety,were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking-based strategy.Their planar structures,absolute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS,NMR spectroscopic data,ECD spectrum,and the X-ray diffraction study of isopropylidene derivatives.An intermolecular[2+2+2]cycloaddition may play a key role in the biosynthesis pathway of the 1,2-dioxane moiety fused lindenane-monoterpene heterodimer skeleton,which can be recognized as the biogenetic precursors of our previous reported lindenane-normonoterpene conjugates.In addition,compounds 1,3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid-exposed L02 cells. | Yongyue Wang Zhirong Cui Jun Chi Pengfei Tang Meihui Zhang Jixin Li Yongyi Li Hao Zhang Jun Luo Lingyi Kong | 2021 | Chinese Journal of Chemistry2021，39，1： | 1 |
| 4 | Bombyx mori U-shaped regulates the melanization cascade and immune response via binding with the Lozenge protein显示文摘Zinc finger protein,an important transcription factor,regulates gene expression associated with various physiological and pathological processes.U-shaped,belong to the Friend of GATA(FOG)transcription factor,plays a crucial role in hematopoiesis by interacting with the GATA transcription factor as a co-factor.However,little is known about its functions in insects.In the present study,a U-shaped cDNA was identified and characterized from the silkworm Bombyx mori and its potential roles in innate immunity investigated.The predicted silkworm U-shaped amino acid sequence contained a classical nuclear localization signal(NLS)motif“GESSPKRRRR”at position 45CU459,and arginine residues at position 456 and 478 are the critical sites of the NLS.U-shaped mRNA was detected in all tested tissues of the B.mori;however,the highest levels were found in the hemocytes.U-shaped mRNA expression levels were upregulated in the hemocyte after the Escherichia coli and Staphylococcus aureus challenge.Furthermore,U-shaped knockdown significantly reduced the melanization process and suppressed the expression of melanization-associated genes,including PPO1,PPO2,PPAE and BAEE.In addition,U-shaped interacts with Lozenge protein to regulate the innate immune response of the insect.Our results revealed that U-shaped binds directly to Lozenge protein to modulate the melanization process and innate immune responses in silkworm. | Kui Zhang Juan Tan Xiangwei Hao Houyi Tang Muhammad Nadeem Abbas Jingjing Su Yongyue Su Hongjuan Cui | 2022 | Insect Science2022，29，3： | 1 |
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