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| 1 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 2 | Clinical study of transcatheter occlusion in treating ventricular septal defect combined with right coronary cusp bulge显示文摘Background: Perimembranous ventricular septal defect combined with right coronary cusp bulge generally should be treated with surgical thoracotomy, owing to the potential aortic regurgitation. However, the minimally invasive method of transcatheter closure has always attracted the attention of cardiologists and patients. The present study aimed to apply transcatheter occlusion in treating ventricular septal defect with right coronary cusp bulge and further evaluate the clinical effect through follow-up. Materials and methods: A total of 40 children diagnosed as having a ventricular septal defect with right coronary cusp bulge, examined using transthoracic echocardiography and cardiovascular angiography, were enrolled in this study. The ventricular septal defects were closed by placing occluders through transcatheter occlusion treatment. During the operation process, the children underwent angiography and transthoracic echocardiography examinations to check the position of the occlude and the extent of aortic regurgitation. The influence of occlusion on the conduction system was evaluated using a surface electrocardiogram. The children were followed up after their procedures. Results: All 40 patients were immediately and successfully occluded. Three patients with filament residual shunts were observed during the operations. No major surgical complications occurred during the perioperative period. During the follow-up period, the positions of all the occluders were good, the residual shunts in the three patients disappeared, and no new or aggravated aortic regurgitation occurred. Electrocardiogram did not reveal any atrioventricular blocks. Only one patient suffered from an incomplete right bundle branch block. Conclusions: Children diagnosed with ventricular septal defect combined with right coronary cusp bulge could be considered for transcatheter occlusion. With appropriate indications and methods, the effect may be favorable. | Wei Ji Zhifang Zhang Wenchuo Zhao Jie Shen Lijun Fu Lin Shi Yiwei Chen Fen Li | 2018 | Journal of Interventional Medicine2018，1，4： | 3 |
| 3 | A model-based prognostics method for fatigue crack growth in fuselage panels显示文摘This paper proposes a model-based prognostics method that couples the Extended Kalman Filter(EKF) and a new developed linearization method. The proposed prognostics method is developed in the context of fatigue crack propagation in fuselage panels where the model parameters are unknown and the crack propagation is affected by different types of uncertainties. The coupled method is composed of two steps. The first step employs EKF to estimate the unknown model parameters and the current damage state. In the second step, the proposed efficient linearization method is applied to compute analytically the statistical distribution of the damage evolution path in some future time. A numerical case study is implemented to evaluate the performance of the proposed method. The results show that the coupled EKF-linearization method provides satisfactory results: the EKF algorithm well identifies the model parameters, and the linearization method gives comparable prediction results to Monte Carlo(MC) method while leading to very significant computational cost saving. The proposed prognostics method for fatigue crack growth can be used for developing predictive maintenance strategy for an aircraft fleet, in which case, the computational cost saving is significantly meaningful. | Yiwei WANG Christian GOGU Nicolas BINAUD Christian BES Jian FU | 2019 | Chinese Journal of Aeronautics2019，32，2： | 2 |
| 4 | Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury显示文摘Compelling evidence has revealed that biased activation of G protein-coupled receptor(GPCR)signaling,including angiotensin II(AngII)receptor type 1(AT1)signaling,plays pivotal roles in vascular homeostasis and injury,but whether a clinically relevant endogenous biased antagonism of AT1 signaling exists under physiological and pathophysiological conditions has not been clearly elucidated.Here,we show that an extracellular matrix protein,cartilage oligomeric matrix protein(COMP),acts as an endogenous allosteric biased modulator of the AT1 receptor and its deficiency is clinically associated with abdominal aortic aneurysm(AAA)development.COMP directly interacts with the extracellular N-terminus of the AT1 via its EGF domain and inhibits AT1-β-arrestin-2 signaling,but not Gq or Gi signaling,in a selective manner through allosteric regulation of AT1 intracellular conformational states.COMP deficiency results in activation of AT1a-β-arrestin-2 signaling and subsequent exclusive AAA formation in response to AngII infusion.AAAs in COMP–/–or ApoE–/–mice are rescued by AT1a orβ-arrestin-2 deficiency,or the application of a peptidomimetic mimicking the AT1-binding motif of COMP.Explorations of the endogenous biased antagonism of AT1 receptor or other GPCRs may reveal novel therapeutic strategies for cardiovascular diseases. | Yi Fu Yaqian Huang Zhao Yang Yufei Chen Jingang Zheng Chenfeng Mao Zhiqing Li Zhixin Liu Bing Yu Tuoyi Li Meili Wang Chanjuan Xu Yiwei Zhou Guizhen Zhao Yiting Jia Wei Guo Xin Jia Tao Zhang Li Li Ziyi Liu Shengchao Guo Mingliang Ma Heng Zhang Bo Liu Junbao Du Wengong Wang Chaoshu Tang Pei Gao Qingbo Xu Xian Wang Jianfeng Liu Jinpeng Sun Wei Kong | 2021 | Cell Research2021，31，7： | 2 |
| 5 | Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability显示文摘Protein thermostability is an inherent characteristic of proteins from thermophilic microorganisms,and therefore enables these organisms to survive at extreme temperatures.Although it is well-known that thermostable proteins are critical for the growth of thermophilic organisms,the structural basis of protein thermostability is not yet fully understood.The histidine-containing phosphocarrier (HPr) protein,a phosphate shuttle protein in the phosphoenolpyruvate-dependent sugar transport system (PTS) of bacterial species,is an ideal model for investigating protein thermostability with respect to its small size and deficiency in disulphide bonds or cofactors.In this study,the HPr protein from Thermoanaerobacter tengcongensis (TtHPr) is cloned and purified.Crystal structure with good quality has been determined at 2.3 resolution,which provides a firm foundation for exploring the thermostable mechanism.However,it shows that the crystal structure is conserved and no clue can be obtained from this single structure.Furthermore,detailed comparison of sequence and structure with the homologs from mesoor thermophilic bacteria shows no obvious rule for thermostability,but the extra salt-bridge existing only in thermophilic bacteria might be a better explanation for thermostability of HPr.Thus,mutations are performed to interrupt the salt-bridge in HPrs in thermophilic bacteria.Using site-directed mutations and the circular dichroism method,thermostability is evaluated,and the mutational variations are shown to have a faster denaturing rate than for wild-type viruses,indicating that mutations cause instability in the HPrs.Understanding the higher-temperature resistance of thermophilic and hyperthermophilic proteins is essential to studies on protein folding and stability,and is critical in engineering efficient enzymes that can work at a high temperature. | FENG ChunYan GAO Feng LIU YiWei WANG GuiHua PENG Hao MA YanHe YAN JingHua GAO George Fu | 2011 | Science China(Life Sciences)2011，54，6： | 2 |
| 6 | Analysing taxi customer-search behaviour using Copula-based joint model显示文摘The drivers of vacant taxis tend to cruise the road network searching new passengers,which leads to additional traffic congestion,air pollution and other problems.This study introduces a Copula-based joint model to analyse destination selection and route choice behaviour in the customer-search process.A multinomial logit model is used to analyse the destination selection behaviour,and a path size logit model is used to explore the routes choice behaviour.Accordingly,the joint model applied Copula function is then established to analyse the correlation between these two behaviours.The destination customer generation rate,destination distance,route customer generation rate,path travel time,cumulative intersection delay,path size and route length are selected as explanatory variables.The taxis trajectory data were collected by global positioning system in Xidan District of Beijing City from September 2014 to February 2015.Using the log-likelihood,Bayesian information criterion as evaluation indexes to measure the fitting result,the joint model applied Copula function has the highest goodness-of-fit.The effect of explanatory variables on customer search behaviour is discussed based on the parameter estimation results.The results of this study are helpful to understand the customer-search behaviour of taxi drivers to reduce operating costs and improve the efficiency of the taxi operation system. | Helai Huang Zhenyuan Fang Yiwei Wang Jinjun Tang Xin Fu | 2022 | Transportation Safety and Environment2022，4，1： | 1 |
| 7 | Current status and prospects of farming the giant river prawn(Macrobrachium rosenbergii)and the oriental river prawn(Macrobrachium nipponense)in China显示文摘 | Fu Hongtuo Jiang Sufei Xiong Yiwei | 2012 | Aquaculture Research2012，，43： | 1 |
| 8 | Estimating Multiple Socioeconomic Attributes via Home Location-A Case Study in China显示文摘Inferring people’s Socioeconomic Attributes(SEAs),including income,occupation,and education level,is an important problem for both social sciences and many networked applications like targeted advertising and personalized recommendation.Previous works mainly focus on estimating SEAs from peoples’cyberspace behaviors and relationships,such as the content of tweets or the social networks between online users.Besides cyberspace data,alternative data sources about users’physical behavior,like their home location,may offer new insights.More specifically,in this paper,we study how to predict a person’s income level,family income level,occupation type,and education level from his/her home location.As a case study,we collect people’s home locations and socioeconomic attributes through a survey involving 9 provinces and 85 cities in China.We further enrich home location with the knowledge from real estate websites,government statistics websites,online map services,etc.To learn a shared representation from input features as well as attribute-specific representations for different SEAs,we propose H2SEA,a factorization machine-based multi-task learning method with attention mechanism.Extensive experiment results show that:(1)Home location can clearly improve the estimation accuracy for all SEA prediction tasks(e.g.,80.2%improvement in terms of F1-score in estimating personal income level);(2)The proposed H2SEA model outperforms alternative models for SEA inference in terms of various evaluation metrics,such as Area Under Curve(AUC),F-measure,and specificity;(3)The performance of specific SEA prediction tasks(e.g.,personal income)can be further improved if H2SEA only focuses on cities or villages due to urban-rural gap in China;(4)Compared with online crawled housing price data,the area-level average income and Points Of Interest(POI)are more important features for SEA inferences in China. | Shichang Ding Xin Gao Yufan Dong Yiwei Tong Xiaoming Fu | 2021 | Journal of Social Computing2021，2，1： | 1 |
| 9 | Angiotensin1-7 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress by preventing ROS-associated mitochondrial dysfunction and activating the Akt signaling pathway显示文摘 | Pengjun Zhao Fen Li Wei Gao Jing Wang Lijun Fu Yiwei Chen Meirong Huang | 2015 | Acta Histochemica2015，，8： | 1 |
| 10 | Realizing compact three-dimensional charge transport networks of asymmetric electron acceptors for efficient organic solar cells显示文摘Asymmetry has been demonstrated an effective approach in recent years to tune the structural and energetic orders of nonfullerene electron acceptors(NFAs)to prepare efficient organic solar cells(OSCs).In this article,five asymmetric NFAs,namely C9BTP-BO-Th Cl-2F,C9BTP-BO-Cl-2F,C9BTP-BO-2Cl-2F,C7BTP-BO-2Cl-2F and C5BTP-BO-2Cl-2F possessing varied asymmetric end-groups and alkyl chains are synthesized to tune the charge transport networks formed within these NFAs.We found that the enhanced planarity in the asymmetric NFA can facilitate closerπ-πstacking distance in either the A-to-A or A-toD type NFA dimers,whilst the larger dipole moment can promote the formation of three-dimensional(3D)charge transport networks among NFAs.Taking those advantages,C7BTP-BO-2Cl-2F exhibit a compact 3D honeycomb network with a high packing coefficient of 72.1%and molecular packing density of 0.48 g/cm^(3),contributing to a superior power conversion efficiency of 18.0%when employing PM6 as the donor,with an open-circuit voltage of 0.85 V,short-circuit current of26.7 m A cm^(-2)and fill factor of 79.3%.Our work provides guidelines in engineering the end group and side chains of asymmetric NFAs to achieve compact charge transport networks for high efficiency OSCs. | Jinlong Cai Yiwei Fu Chuanhang Guo Donghui Li Liang Wang Chen Chen Dan Liu Wei Li Tao Wang | 2023 | Science China Chemistry2023，66，2： | 1 |
| 11 | Direct laser writing breaking diffraction barrier based on two-focus parallel peripheralphotoinhibition lithography显示文摘Direct laser writing(DLW)enables arbitrary three-dimensional nanofabrication.However,the diffraction limit poses a major obstacle for realizing nanometer-scale features.Furthermore,it is challenging to improve the fabrication efficiency using the currently prevalent single-focal-spot systems,which cannot perform high-throughput lithography.To overcome these challenges,a parallel peripheral-photoinhibition lithography system with a sub-40-nm two-dimensional feature size and a sub-20-nm suspended line width was developed in our study,based on two-photon polymerization DLW.The lithography efficiency of the developed system is twice that of conventional systems for both uniform and complex structures.The proposed system facilitates the realization of portable DLW with a higher resolution and throughput. | Dazhao Zhu Liang Xu Chenliang Ding Zhenyao Yang Yiwei Qiu Chun Cao Hongyang He Jiawei Chen Mengbo Tang Lanxin Zhan Xiaoyi Zhang Qiuyuan Sun Chengpeng Ma Zhen Wei Wenjie Liu Xiang Fu Cuifang Kuang Haifeng Li Xu Liu | 2022 | Advanced Photonics2022，4，6： | 1 |
| 12 | Semi-analytical Stiffness Model of Bolted Joints in Machine Tools Considering the Coupling Effect显示文摘This study proposes an improved semi-analytical approach for contact stiffness modeling of bolted joints in a machine tool system.First,nonlinear contact stress distribution within a single-bolted joint is obtained from the simulation results of finite element analysis software.Second,employing the Hertz contact theory and fractal theory,the contact stiffness model of a single asperity is formulated,affording analytical expressions for normal and tangential contact stiffnesses of a single-bolted joint by integrating multi-asperities in the contact area.Subsequently,considering two test specimens as illustrations,the mode shapes and natural frequencies of the proposed model and modal analysis tests are compared,and the influence of coupling effects between two adjacent bolts is illustrated.The maximum error in the natural frequencies of the proposed approach is<2.73%relative to the experimental results.Finally,the measurements of frequency response functions on a box-in-box precision horizontal machine tool are conducted to demonstrate the accuracy and efficiency of the proposed model.The proposed model is highly efficient in revealing the influence of microcontact factors on the contact stiffness of bolted joints and in guiding the optimal functional design of bolt arrangements under the framework of virtual machine tools. | Yiwei Ma Yutao Fu Yanling Tian Xianping Liu | 2023 | Nanomanufacturing and Metrology2023，6，2： | 0 |
| 13 | Research on Ecological Space Planning Oriented Urban River Landscape Planning显示文摘Based on the generalized landscape perspective, regional connotation of urban river landscape is expanded. The area connotation of urban river landscape is expanded based on the generalized landscape perspective. In addition to natural and functional attributes, river landscape should be regarded as a regional space element based on heterogeneous space scale. First, as for research method system, the space research models(including ecological footprint, space planning, and landscape pattern index, etc.) coupled with different angle scales and interdisciplinary theory, are utilized to study different correlations and results formed by urban river landscape elements and other regional space elements from the perspective of the regional ecological space, and the overall development goal of the urban river landscape pattern based on the goals of the regional ecological space planning is obtained. Second, the oriented urban river landscape planning and the 'M' type close-tonature design strategy are evaluated through the city function zoning orientation and micro-scale urban river landscape pattern index. The research realizes the compatibility of overall goals in terms of the regional ecology, the development of urban functional areas, and the river landscape planning, without losing micro difference and maneuverability based on the urban river landscape planning and design oriented strategy, which innovates the new approach of urban river landscape planning and design with sustainable and balanced development of regional resources, multi-scale, and multiple objectives. | FU Fei CHEN Yiwei | 2014 | Journal of Landscape Research2014，6，5： | 0 |
| 14 | 气动优化设计和计算流体力学在无人机设计中的应用显示文摘In the past two decades,the world’s unmanned aerial vehicle(UAV)industry has developed rapidly.Various kinds of UAVs have been used in military and civilian fields.Based on the characteristics of UAVs and the development of aerodynamics,this article analyzes the development of aerodynamic optimization design and dynamic numerical simulation technology,then lists engineering applications.Both aerodynamic optimization design and dynamic numerical simulation have greatly shortened the UAV design period and reduced the research and design cost.These two methods gradually replace traditional methods such as wind tunnel test. | SUN Kaijun YU Yueyang FU Yiwei | 2020 | Aerospace China2020，21，3： | 0 |
| 15 | Analytical Representation of Data-driven Transient Stability Constraint and Its Application in Preventive Control显示文摘Accurate transient stability assessment(TSA) and effective preventive control are important for the stable operation of power systems. With the superiorities in precision and efficiency, data-driven methods are widely used in TSA nowadays. Data-driven TSA model can be adopted in the stability constraints of preventive control optimization, but existing methods are mostly iteration-based ones, which may result in low efficiency, sometimes even non-convergence. In this paper,an analytical representation method of data-driven transient stability constraint is proposed based on a non-parametric regression model built for TSA. Key feature extraction and dominant sample selection are proposed to reduce the scale of the TSA model, and bi-level linearization is applied to further modify it.Optimal preventive control model is then formulated as a mixed-integer linear program(MILP) problem with the linearized analytical data-driven transient stability constraint, which can be solved without iterations. An overall procedure of datadriven TSA and preventive control is finally developed. Case studies show that the proposed method has high accuracy in TSA and can achieve effective preventive control of power system with high efficiency. | Yiwei Fu Xiaohua Zhang Lei Chen Zengyao Tian Kaiyuan Hou Haikuan Wang | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 0 |
| 16 | SiRAP2-12,a Positive Regulatory Factor,Effectively Improves the Waterlogging Tolerance of Foxtail Millet(Setaria italica)显示文摘Foxtail millet(Setaria italica)growth was inhibited because of waterlogging stress,which has caused yield reduc-tion.ERF family plays an important role to plant adversity tolerance.In our study,we obtained 19,819 differential expressed genes(DEGs)between the two treatments based on the RNA-seq sequencing of foxtail millet of water-logging stress.Furthermore,a total of 28 ERF family members were obtained,which have a complete open read-ing frame.We studied the evolution and function of SiERF family and how they affected the waterlogging tolerance.It was found that SiERF1A/B/C(GenBank ID:OR775217,OR775219,OR775218)and SiRAP2-12(GenBank ID:OR775216)have similar functions to the known waterlogging tolerance genes of other plants.Among them,the SiRAP2-12 expression was obviously significantly up-regulated in foxtail millet after 5d water-logging stress.After SiRAP2-12 was silenced,the activity of defense enzymes in millet decreased significantly.In details,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),the osmotic regulator proline(Pro),and the activity of the anaerobic respiratory enzyme alcohol dehydrogenase(ADH)content were decreased by 78.61%,29.52%,79.95%,19.41%and 54.77%,respectively.In contrast,the relative electrical conductivity contents(REC),malondialdehyde(MDA),and hydrogen peroxide(H_(2)O_(2))of the foxtail millet subjected to virus-induced gene silencing clearly increased by 1.03-fold,36.09%,and 15.21%,respectively.The content of sodium(Na^(+))in the SiRAP2-12-silenced foxtail millet also increased,but that of potassium(K^(+))decreased.Interestingly,we found that ethylene content was significantly reduced.Further,the SiAOC1 expression,an essential gene for ethylene synthesis,was inhibited in SiRAP2-12-silenced foxtail millet after waterlogging stress.Taken together,we hypothesized that SiRAP2-12 might be a positive regulator of millet tolerance to waterlogging stress. | Xueyan Xia Xiaohong Fu Yu Zhao Jihan Cui Nuoya Xiao Jingxin Wang Yiwei Lu Meihong Huang Cheng Chu Jia Zhang Mengxin Yang Shunguo Li Jianfeng Liu | 2024 | Phyton-International Journal of Experimental Botany2024，93，3： | 0 |
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