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| 1 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | Controlling Morphology of Active Layer by Tuning Coplanarity of the Centrality in Acceptor-Donor-Acceptor Small Molecules for Photovoltaic Application显示文摘一系列 acceptor-donor-acceptor 选择小分子被综合包含 phenothiazine, 2,7-carbazole 和 thieno 的捐赠电子的中央大楼一半[3,4-b ] thiophene 和双方上的 tetrazine 的接受电子的一半。中央块的各种各样的符合构造,与在 phenothiazine 的一份订单的共面 < 2,7-carbazole < thieno [3,4-b ] thiophene,在光、电气化学的性质和小分子的 crystallinity 上有明显的影响。另外,混合在小分子之间拍摄,从制服变化并且(6,6 )-phenyl-C61-butyric 酸甲基酉旨提供了 signi ? cantly 各种各样的形态学出现到贯穿的网络。作为结果,光电的设备基于三个小分子提供了的体积异质接面改变了性能,并且最高共面的分子基于展出的设备最好的光电的表演。 | Pan Zhang Chao Li Yue Zhao Yaowen Li Yingfeng Tu | 2013 | Chinese Journal of Chemistry2013，31，11： | 2 |
| 3 | Numerical Simulation for Damping-Controlled Deployment of Z-Folded Inflatable Tube显示文摘The damping-controlled deployment technology of flexible Z-folded inflatable tube is one of the key technologies of space inflatable structures.Constraint failure between couple nodes is proposed to simulate the damping-controlled deployment.And the equation of constraint failure is established.Inflation process of Z-folded tube is simulated with control volume method.Compared with uncontrolled method,it is indicated that the new method can effectively solve the disordered deployment problem of the slender Z-folded inflatable tube.By analyzing the displacement of the apical of the folded tube with different constraint forces during deployment process,the concept of effective constraint force is proposed.In the effective region of constraint force,the folded tube deploys with little retraction and fluctuation.Otherwise,The flexible folded tube would deploy disorderly or even cannot deploy.The simulation method and numerical results have a theoretical and instructive significance to the research on the space inflatable structures. | Yu Li Zhan Yanan Shi Yingfeng Zhao Xiaoshun Liu Xin | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 2 |
| 4 | Multi-Branch Cable Harness Layout Design Based on Genetic Algorithm with Probabilistic Roadmap Method显示文摘Current studies on cable harness layouts have mainly focused on cable harness route planning.However,the topological structure of a cable harness is also extremely complex,and the branch structure of the cable harness can affect the route of the cable harness layout.The topological structure design of the cable harness is a key to such a layout.In this paper,a novel multi-branch cable harness layout design method is presented,which unites the probabilistic roadmap method(PRM)and the genetic algorithm.First,the engineering constraints of the cable harness layout are presented.An obstacle-based PRM used to construct non-interference and near to the surface roadmap is then described.In addition,a new genetic algorithm is proposed,and the algorithm structure of which is redesigned.In addition,the operation probability formula related to fitness is proposed to promote the efficiency of the branch structure design of the cable harness.A prototype system of a cable harness layout design was developed based on the method described in this study,and the method is applied to two scenarios to verify that a quality cable harness layout can be efficiently obtained using the proposed method.In summary,the cable harness layout design method described in this study can be used to quickly design a reasonable topological structure of a cable harness and to search for the corresponding routes of such a harness. | Yingfeng Zhao Jianhua Liu Jiangtao Ma Linlin Wu | 2021 | Chinese Journal of Mechanical Engineering2021，34，2： | 2 |
| 5 | Real-time pore structure evolution difference between deep and shallow coal during gas adsorption:A study based on synchrotron radiation small-angle X-ray scattering显示文摘Coal seam CO2 sequestration is an important option to address global warming.A better knowledge on coal pore structure evolution during gas adsorption can provide guidance for coal seams CO2 seques-tration.However,few investigations on the pore structure evolution differences between the deep and shallow coal were conducted during gas adsorption.In this study,based on the real-time synchrotron radiation small-angle X-ray scattering(SAXS)observation,the average pore diameter and pore surface fractal dimension evolution differences between deep and shallow coal were investigated from the as-pects of coal compositions and stress history.Two types of coal deformation(inner-swelling and outer-swelling)coexist during gas adsorption.Coal compositions have significant impact on the dominance of deformation type.The dominance of inner-swelling in deep coal is induced by the higher ash contents,and there is the decrease of average pore diameter during gas adsorption.The impact of stress-history(burial depth)on adsorption-induced deformation is more prominent than that of gas adsorption ca-pacity.In deep coal,the surface fractal dimension evolution presents a negative correlation with the evolution of pore diameters.In shallow coal,the surface fractal dimension evolution presents a Langmuir-type correlation with the adsorption time. | Yingfeng Sun Shuaipeng Zhu Fei Xie Chujian Han Yixin Zhao Zetian Zhang | 2024 | Particuology2024，87，4： | 0 |
| 6 | Nano-to micro-pore characterization by synchrotron radiation SAXS and nano-CT for bituminous coals显示文摘Considering the complementarity of synchrotron radiation SAXS and nano-CT in the pore structure detection range,synchrotron radiation SAXS and nano-CT methods were combined to characterize the nano-to micropore structure of two bituminous coal samples.In mesopores,the pore size distribution curves exhibit unimodal distribution and the average pore diameters are similar due to the affinity of metamorphic grades of the two samples.In macropores,the sample with higher mineral matter content,especially clay mineral content,has a much higher number of pores.The fractal dimensions representing the pore surface irregularity and the pore structure heterogeneity were also characterized by synchrotron radiation SAXS and nano-CT.The fractal dimensions estimated by both methods for different pore sizes show consistency and the sample with smaller average pore diameters has a more complex pore structure within the full tested range. | Yixin ZHAO Chujian HAN Yingfeng SUN Nima Noraei DANESH Tong LIU Yirui GAO | 2021 | Frontiers of Earth Science2021，15，2： | 0 |
| 7 | KDM4C与ATF4协同作用转录调控氨基酸代谢显示文摘组蛋白赖氨酸甲基转移酶(KNITs)和去甲基化酶(KDMs)通过控制组蛋白赖氨酸的甲基化状态,在转录调控中起着重要的作用。 | Erhu Zhao Jane Ding Yingfeng Xia Mengling Liu Bingwei Ye Jeong-Hyeon Choi Chunhong Yan Zheng Dong Shuang Huang Yunhong Zha Liqun Yang 崔红娟 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
| 8 | 转录分析显示高危险的人类神经母细胞瘤和小鼠神经母细胞瘤的球形细胞中有共同的代谢调节显示文摘高危险性的神经母细胞瘤(neuroblastoma)仍然是一种最致命的幼童癌症之一,而识别驱动或维持高危险性的神经母细胞瘤的代谢途径则可能开辟新的治疗方针。 | Mengling Liu Yingfeng Xia Jane Ding Bingwei Ye Erhu Zhao Jeong-Hyeon Choi Ahmet Alptekin Chunhong Yan Zheng Dong Shuang Huang Liqun Yang Hongjuan Cui 查运红 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
| 9 | RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis显示文摘Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)pathway.However,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains unclear.Here,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 phosphorylation.RNA-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral replication.RIPK3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I IFNs.Conversely,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV replication.RIPK3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune responses.Mechanistically,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase activity.Overall,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV. | Yue Si Haijun Zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang Zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv Xijing Zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，5： | 0 |
| 10 | Development of the expressed immunoglobulinμchain repertoire during maturation of mice B cells显示文摘In the bone marrow and spleen,the developing B cell populations undergo both negative and positive selections to shape their B cell receptor repertoire.To gain insight into the shift of the immunoglobulin heavy(IgH)chain repertoire during B cell development,we undertook large scale Igμchain repertoire analysis of pre-B,immature B and spleen B cell populations.We found that the majority of VH gene segments,VH families,JH and D gene segments,were observed to have significantly different usage frequencies when three B cell populations were compared,but the usage profile of the VH,D,and JH genes between different B cell populations showed high correlations.In both productive and nonproductive rearrangements,the length of CDRH3 shortened significantly on average when B cells entered the periphery.However,the CDRH3 length distribution of nonproductive rearrangements did not follow a Gaussian distribution,but decreased successively in the order 3n–2,3n–1 and 3n,suggesting a direct correlation between mRNA stability and CDRH3 length patterns of nonproductive rearrangements.Further analysis of the individual components comprising CDRH3 of productive rearrangements indicated that the decrease in CDRH3 length was largely due to the reduction of N addition at the 5′and 3′junctions.Moreover,with development,the amino acid content of CDRH3 progressed toward fewer positively charged and nonpolar residues but more polar residues.All these data indicated that the expressed Igμchain repertoire,especially the repertoire of CDRH3,was fine-tuned when B cells passed through several checkpoints of selection during the process of maturation. | Jingwen LIANG Yingfeng LUO Yi SUN Meng LEI Bing ZHANG Songnian HU Yaofeng ZHAO | 2014 | Frontiers of Agricultural Science and Engineering2014，1，3： | 0 |
| 11 | Immunomodulatory and Antiviral Therapy Improved Functional Cure Rate in CHB Patients with High HBsAg Level Experienced NA显示文摘Background and Aims:A functional cure,or hepatitis B virus(HBV)surface antigen(HBsAg)loss,is difficult to achieve in patients with hepatitis B virus e antigen(HBeAg)-positive chronic hepatitis B.The HBV vaccine and granulocyte-macrophage colony-stimulating factor(GM-CSF)have been reported to help reduce HBsAg levels and promote HBsAg loss.In this prospective randomized trial,we evaluated HBsAg loss in patients receiving pegylated interferon α2b(PEGIFN-α2b)and tenofovir disoproxil fumarate(TDF),with and without GM-CSF and HBV vaccination.Methods:A total of 287 patients with HBeAg positive chronic hepati-tis B and seroconversion after nucleot(s)ide analog treat-ment were assigned randomly to three treatment groups for 48 weeks,TDF alone(control),PEGIFN-α2b+TDF,and PEGIFN-α2b+TDF+GM-CSF+HBV vaccine.The prima-ry endpoints were the proportions of patients with HBsAg loss and seroconversion at 48 and 72 weeks.Resu/ts:The cumulative HBsAg loss rates in the control,PEGIFN-α2b+TDF,and PEGIFN-α2b+TDF+GM-CSF+HBV vaccine groups at week 48 were 0.0%,28.3%,and 41.1%,respec-tively.The cumulative HBsAg seroconversion rates in these groups at week 48 were 0.0%,21.7%,and 33.9%,respec-tively.Multivariate regression analysis showed that GM-CSF use plus HBV vaccination was significantly associated with HBsAg loss(p=0.017)and seroconversion(p=0.030).Con-clusions:In patients with HBeAg-positive chronic hepatitis B and seroconversion after nucleot(s)ide analog treatment,immunomodulatory/antiviral treatment regimens effective-ly improved HBsAg loss,and the regimen including GM-CSF and HBV vaccination was most effective. | Hongyu Jia Guodong Yu Jiong Yu Xiaoli Zhang Lisha Yang Bin Wang Jiming Zhang Lang Bai Xinxin Zhang Kai Wang Ping Zhao Dongliang Yang Yingren Zhao Yanyan Yu Yimin Zhang Jueqing Gu Chanyuan Ye Huan Cai Yingfeng Lu Dairong Xiang Liang Yu Jiangshan Lian Jianhua Hu Shanyan Zhang Ciliang Jin Yida Yang | 2023 | Journal of Clinical and Translational Hepatology2023，11，5： | 0 |
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