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| 1 | Risks Associated with Misuse of Ketamine as a Rapid-Acting Antidepressant显示文摘Major depression is a serious psychiatric disorder and remains a leading cause of disability worldwide.Conventional antidepressants take at least several weeks to achieve a therapeutic response and this lag period has hindered their ability to attain beneficial effects in depressed individuals at high risk of suicide.The non-competitive Nmethyl-D-aspartate glutamate receptor antagonist ketamine has been shown to have rapid antidepressant effects in both rodents and humans.The emergence of ketamine as a fastacting antidepressant provides promising new insights into the development of a rapid treatment response in patients with clinical depression.However,its safety and toxicity remain a concern.In this review,we focus on the limitations of ketamine,including neurotoxicity,cognitive dysfunction,adverse events associated with mental status,psychotomimetic effects,cardiovascular events,and uropathic effects.Studies have shown that its safety and tolerability profiles are generally good at low doses and with short-term treatment in depressed patients.The adverse events associated with ketamine usually occur with very high doses that are administered for prolonged periods of time and can be relieved by cessation.The antidepressant actions of its two enantiomers,S-ketamine(esketamine) and R-ketamine,are also discussed.R-ketamine has greater antidepressant actions than S-ketamine,without ketamine-related sideeffects.Future treatment strategies should consider using Rketamine for the treatment of depressed patients to decrease the risk of adverse events associated with long-term ketamine use. | Weili Zhu Zengbo Ding Yinan Zhang Jie Shi Kenji Hashimoto Lin Lu | 2016 | Neuroscience Bulletin2016，32，6： | 5 |
| 2 | Hotspots of Independent and Multiple Rounds of LTR-retrotransposon Bursts in Brassica Species显示文摘Long terminal repeat retrotransposons(LTR-RTs) are a predominant group of plant transposable elements(TEs) that are an important component of plant genomes. A large number of LTR-RTs have been annotated in the genomes of the agronomically important oil and vegetable crops of the genus Brassica. Herein, full-length LTR-RTs in the genomes of Brassica and other closely related species were systematically analyzed. The full-length LTR-RT content varied greatly(from 0.43% to 23.4%) between different species, with Gypsy-like LTR-RTs constituting a primary group across these genomes. More importantly, many annotated LTR-RTs(from 10.03% to 33.25% of all detected LTR-RTs) were found to be enriched in localized hotspot regions. Furthermore, all of the analyzed species showed evidence of having experienced at least one round of a LTR-RT burst, with Raphanus sativus experiencing three or more. Moreover, these relatively ancient LTR-RT amplifications exhibited a clear expansion at specific time points. To gain a further understanding of this timing, Brassica rapa, B. oleracea, and R. sativus were examined for the presence of syntenic regions, but none were present. These findings indicate that these LTR-RT burst events were not inherited from a common ancestor,but instead were species-specific bursts that occurred after the divergence of Brassica species. This study further exemplifies the complexities of TE amplifications during the evolution of plant genomes and suggests that these LTR-RT bursts play an important role in genome expansion and divergence in Brassica species. | CAI Xu CUI Yinan ZHANG Lei WU Jian LIANG Jianli CHENG Lin WANG Xiaowu CHENG Feng | 2018 | Horticultural Plant Journal2018，4，4： | 3 |
| 3 | The synthesis of benzoxaboroles and their applications in medicinal chemistry显示文摘Benzoxaborole,as a versatile scaffold,plays important roles in organic synthesis,molecular recognition and supramolecular chemistry.It is also a privileged structure in medicinal chemistry due to its desirable physicochemical and drug-like properties.Recently,benzoxaboroles were widely applied as antifungal,antibacterial,antiviral,anti-parasite,and anti-inflammatory agents.This review covers the properties,synthetic methods and applications of benzoxaboroles in medicinal chemistry. | ZHANG Jiong ZHU MingYan LIN YiNan ZHOU HuChen | 2013 | Science China Chemistry2013，56，10： | 3 |
| 4 | Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations显示文摘Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of cells undergoing various biological processes, the search for molecular mechanisms underlying aging of NSC/NPCs has been confronted by the enormous heterogeneity in cellular compositions of the brain and the complex cellular microenvironment where NSC/NPCs reside. Moreover, brain NSC/NPCs themselves are not a homogenous population, making it even more difficult to uncover NSC/NPC sub-type specific aging mechanisms. Here, using both population-based and single cell transcriptome analyses of young and aged mouse forebrain ependymal and subependymal regions and comprehensive “big-data” processing, we report that NSC/NPCs reside in a rather inflammatory environment in aged brain, which likely contributes to the differentiation bias towards astrocytes versus neurons. Moreover, single cell transcriptome analyses revealed that different aged NSC/NPC subpopulations, while all have reduced cell proliferation, use different gene transcription programs to regulate age-dependent decline in cell cycle. Interestingly, changes in cell proliferation capacity are not influenced by inflammatory cytokines, but likely result from cell intrinsic mechanisms. The Erk/Mapk pathway appears to be critically involved in regulating age-dependent changes in the capacity for NSC/NPCs to undergo clonal expansion. Together this study is the first example of using population and single cell based transcriptome analyses to unveil the molecular interplay between different NSC/NPCs and their microenvironment in the context of the aging brain. | Zhanpinq Shi Yanan Geng Jiping Liu Huina Zhang Liqiang Zhou Quan Lin Juehua Yu Kunshan Zhang Jie Liu Xinpei Gao Chunxue Zhang Yinan Yao Chong Zhang Yi E. Sun | 2018 | Protein & Cell2018，9，4： | 3 |
| 5 | Research on Open Block's Pedestrian System Based on the EnvironmentBehavior Theory: A Case Study of Shenzhen Oct-loft显示文摘In the context of banning gated communities, blocks returning to the human-oriented scale become the new normal, and pedestrian system design will be paid more attention in the urban planning field. Oct-Loft Creative Park is a template for open blocks in Shenzhen, with a convenient and humanized pedestrian system. This paper selects the creative park's pedestrian system as the research object, using the environment-behavior theory for analysis. Finally, optimization strategies of pedestrian system will be put forward. | LIN Jingwei ZHANG Yinan | 2017 | Journal of Landscape Research2017，9，4： | 1 |
| 6 | Accelerated In Vitro Degradation of Optically clear Low b-Sheet Silk Films by Enzyme-Mediated Pretreatment显示文摘 | Ke Shang Jelena Rnjak-Kovacina Yinan Lin | 2013 | TVST2013，2，3： | 1 |
| 7 | Quantitative estimation and spatial reconstruction of urban and rural construction land in Jiangsu Province, 1820-1985显示文摘Land cover is the most evident landscape signal to characterize the influence of human activities on terrestrial ecosystems.Since the industrial revolution,the expansion of construction land has profoundly changed the status of land use coverage and changes.This study is proposed to reconstruct the spatial pattern of construction land(urban construction land and rural settlement land)for five historical periods over the past 200 years in Jiangsu Province with 200 m′200 m grids on the basis of quantitative estimation.Urban construction land is estimated based on data about city walls,four gates along walls,and other socio-economic factors.Rural settlement land is calculated based on the rural population and per capita housing allowance.The spatial pattern of historical construction land is simulated based on the distribution of modern construction land in 1985 with a quantitative-boundarysuitability control method and thorough consideration over connectivity of different land use types.The study concludes that:(1)the amount of construction land in Jiangsu Province is estimated at 963.46 km^2 in 1820,1043.46 km^2 in 1911,1672.40 km^2 in 1936,1980.34 km^2 in1952 and 10,687.20 km^2 in 1985;and(2)the spatial distribution of construction land features the great proclivity to water bodies and main roads and the strong polarization of existent residence.The results are verified directly and indirectly by applying the trend verification of construction land changes and patterns,the correlation analysis between rural settlement land and local arable land,and quantitative accuracy test of the reconstructed construction land to actual historical survey maps covering four sample regions in 1936. | XIE Jinyuan JIN Xiaobin LIN Yinan CHENG Yinong YANG Xuhong BAI Qing ZHOU Yinkang | 2017 | Journal of Geographical Sciences2017，27，10： | 1 |
| 8 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 9 | Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice显示文摘Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly population.Given the increased incidence of cancer and the population ageing trend globally,it is very important to explore how ageing impairs tissue wound healing and spontaneous cancer.In a murine model of DSS-induced acute colitis and AOM/DSS-induced colitis-associated cancer(CAC),we found ageing significantly decreases intestinal wound healing and simultaneous CAC initiation,although ageing does not affect the incidence of AOM-induced,sporadic non-inflammatory CRC.Mechanistically,reduced fibroblasts were observed in the colitis microenvironment of ageing mice.Through conditional lineage tracing,an important source of fibroblasts potentially derived from intestinal smooth muscle cells(ISMCs)was identified orchestrating intestinal wound healing and CAC initiation in young mice.However,the number of transformed fibroblasts from ISMCs significantly decreased in ageing mice,accompanied by decreased intestinal wound healing and decreased CAC initiation.ISMCs-fibroblasts transformation in young mice and reduction of this transformation in ageing mice were also confirmed by ex-vivo intestinal muscular layer culture experiments.We further found that activation of YAP/TAZ in ISMCs is required for the transformation of ISMCs into fibroblasts.Meanwhile,the reduction of YAP/TAZ activation in ISMCs during intestinal wound healing was observed in ageing mice.Conditional knockdown of YAP/TAZ in ISMCs of young mice results in reduced fibroblasts in the colitis microenvironment,decreased intestinal wound healing and decreased CAC initiation,similar to the phenotype of ageing mice.In addition,the data from intestine samples derived from inflammatory bowel disease(IBD)patients show that activation of YAP/TAZ also occurs in ISMCs from these patients.Collectively,our work reveals an important role of the ageing stromal microenvironment in intestinal wound healing and CAC initiation.Furthermore,our work also identified a potential source of fibroblasts involved in colitis and CAC. | Yi Liu Yanhong Ji Ruiyi Jiang Chao Fang Gang Shi Lin Cheng Yinan Zuo Yixin Ye Xiaolan Su Junshu Li Huiling Wang Yuan Wang Yi Lin Lei Dai Shuang Zhang Hongxin Deng | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 10 | Urban Renewal Practice Based on the Activation Use of Greenbelts: A Case Study of Greenways in Taichung显示文摘The greenway system in Taichung is a successful case that regenerates urban greenbelts through various activation strategies. This paper takes greenways in Taichung for example, analyzes their renewal plans, and finds out their experience of regeneration. The greenways in Taichung were first designed to control urban sprawl and then became idle greenbelts. Afterwards, the greenways were transformed into an urban vitality belt with the joint efforts of multiple parties. The existing greenbelt model in many cities does have some deficiencies. Therefore, it is recommended that there be room for growth in urban development in these cities and they can draw lessons from Taichung. | ZHANG Yinan LIN Jingwei | 2018 | Journal of Landscape Research2018，10，4： | 0 |
| 11 | Porous polymeric ligand promoted copper-catalyzed C-N coupling of(hetero)aryl chlorides under visible-light irradiation显示文摘A porous polymeric ligand(PPL)has been synthesized and complexed with copper to generate a heterogeneous catalyst(Cu@PPL)that has facilitated the efficient C-N coupling with various(hetero)aryl chlorides under mild conditions of visiblelight irradiation at 80°C(58 examples,up to 99%yields).This method could be applied to both aqueous ammonia and substituted amines,and is compatible to a variety of functional groups and heterocycles,as well as allows tandem C-N couplings with conjunctive dihalides.Furthermore,the heterogeneous characteristic of Cu@PPL has enabled a straightforward catalyst separation in multiple times of recycling with negligible catalytic efficiency loss by simple filtration,affording reaction mixtures containing less than 1 ppm of Cu residue. | Erfei Wang Kaixuan Chen Yinan Chen Jiawei Zhang Xinrong Lin Mao Chen | 2021 | Science China Chemistry2021，64，1： | 0 |
| 12 | Progress in Studies of Geomagnetic Navigation of Animals显示文摘The geomagnetic field may play a key role in orientation and navigation of many long-distance mi- gratory animals. Taking homing and migrating birds as examples, this paper reviews recent progress in studies of geomagnetic 'compass' of animals. Moreover, we propose to address two aspects in future geomagnetic orientation research :(1) what are the true components of the 'map'? ( 2 ) What are the magneto-receptors and which brain areas acquire and process the geomagnetic field informa- tion ? | Tian Lanxiang Pan Yongxin Lin Wei Wang Yinan Zhang Shuyi | 2005 | Science Foundation in China2005，13，1： | 0 |
| 13 | Oncolytic virotherapy:basic principles,recent advances and future directions显示文摘Oncolytic viruses(OVs)have attracted growing awareness in the twenty-first century,as they are generally considered to have direct oncolysis and cancer immune effects.With the progress in genetic engineering technology,OVs have been adopted as versatile platforms for developing novel antitumor strategies,used alone or in combination with other therapies.Recent studies have yielded eye-catching results that delineate the promising clinical outcomes that OVs would bring about in the future.In this review,we summarized the basic principles of OVs in terms of their classifications,as well as the recent advances in OV-modification strategies based on their characteristics,biofunctions,and cancer hallmarks.Candidate OVs are expected to be designed as“qualified soldiers”first by improving target fidelity and safety,and then equipped with“cold weapons”for a proper cytocidal effect,“hot weapons”capable of activating cancer immunotherapy,or“auxiliary weapons”by harnessing tactics such as anti-angiogenesis,reversed metabolic reprogramming and decomposing extracellular matrix around tumors.Combinations with other cancer therapeutic agents have also been elaborated to show encouraging antitumor effects.Robust results from clinical trials using OV as a treatment congruously suggested its significance in future application directions and challenges in developing OVs as novel weapons for tactical decisions in cancer treatment. | Danni Lin Yinan Shen Tingbo Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 14 | Structural plasticity-based hydrogel optical Willshaw model for one-shot on-the-fly edge learning显示文摘Autonomous one-shot on-the-fly learning copes with the high privacy,small dataset,and in-stream data at the edge.Implementing such learning on digital hardware suffers from the well-known von-Neumann and scaling bottlenecks.The optical neural networks featuring large parallelism,low latency,and high efficiency offer a promising solution.However,ex-situ training of conventional optical networks,where optical path configuration and deep learning model optimization are separated,incurs hardware,energy and time overheads,and defeats the advantages in edge learning.Here,we introduced a bio-inspired material-algorithm co-design to construct a hydrogel-based optical Willshaw model(HOWM),manifesting Hebbian-rule-based structural plasticity for simultaneous optical path configuration and deep learning model optimization thanks to the underlying opto-chemical reactions.We first employed the HOWM as an all optical in-sensor AI processor for one-shot pattern classification,association and denoising.We then leveraged HOWM to function as a ternary content addressable memory(TCAM)of an optical memory augmented neural network(MANN)for one-shot learning the Omniglot dataset.The HOWM empowered one-shot on-the-fly edge learning leads to 1000boost of energy efficiency and 10boost of speed,which paves the way for the next-generation autonomous,efficient,and affordable smart edge systems. | Dingchen Wang Dingyao Liu Yinan Lin Anran Yuan Woyu Zhang Yaping Zhao Shaocong Wang Xi Chen Hegan Chen Yi Zhang Yang Jiang Shuhui Shi Kam Chi Loong Jia Chen Songrui Wei Qing Wang Hongyu Yu Renjing Xu Dashan Shang Han Zhang Shiming Zhang Zhongrui Wang | 2023 | InfoMat2023，5，4： | 0 |
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