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| 1 | Structure feature and antitumor activity of a novel polysaccharide isolated from Lactarius deliciosns Gray显示文摘 | DING Xiang HOU Yiling HOU Wanru | 2012 | Carbohydrate Polymers2012，89，2： | 1 |
| 2 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 3 | Structuralfeature and antitumor activity of a novel polysaccharideisolated from Lactarius deliciosus Gray显示文摘 | DING Xiang HOU Yiling HOU Wanru | 2012 | CarbohydPolym2012，89，： | 1 |
| 4 | Structure feature and antitumor activity of a novel polysaccharide isolated from Lactarius deliciosus Gray显示文摘 | Xiang Ding Yiling Hou Wanru Hou | 2012 | Carbohydrate Polymers2012，，2： | 1 |
| 5 | Impact of urbanization on local climate change of Mega city Shanghai and its surroundings显示文摘 | Chen Baode Hou Yiling | | J0，，： | 1 |
| 6 | Cloning and sequence analysis of translocase of inner mitochondrial membrane 10 homolog(yeast) gene (TIMM10) from the giant panda显示文摘 | Hou Yiling Du Yujie Hou Wanru | 2009 | J Cell Anita Biol2009，3，1： | 1 |
| 7 | eDNA cloning and overexpression of ribosomal protein S19gene (rpS19) fromthe Giant Panda显示文摘 | Hou Yiling Hou Wanru Hao Yanzhe | 2009 | DNA and Cell Biology2009，28，1： | 1 |
| 8 | eDNA, genomic sequence and overexpression of crystallin alpha- B Gene (CRYAB) of the Giant Panda显示文摘 | Hou Yiling Hou Wanru Ren Zhenglong | 2008 | Int J Biol Sci2008，4，6： | 1 |
| 9 | Structure elucidation,immunomodulatory activity,antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff显示文摘A new water-soluble heteropolysaccharide with a molecular weight of 15 k Da was isolated from the fruiting bodies of Boletus reticulatus Schaeff.Structural characterization results revealed that B.reticulatus Schaeff polysaccharide(BRS-X)had a backbone of 1,6-linkedα-D-galactose and 1,2,6-linkedα-D-galactose which branches were mainly composed of a terminal 4-linkedβ-D-glucose and the ratio of D-galactose and D-glucose was 5:1.Bioactivity assays indicated that BRS-X displayed a strong proliferative activity in T cells and B cells and promoted the secretion of immunoglobulin G(Ig G),Ig E,Ig D and Ig M.In addition,BRS-X could facilitate the proliferation and phagocytosis of RAW264.7 cells and could significantly inhibit the growth of tumors in S180-bearing mice.The results of transcriptome sequencing analysis illustrated that total 46 genes enriched in MAPK and total 34 genes enriched in PI3 K/Akt signaling pathways in BRS-X group.The protein VEGF and VEGFR expression were significantly reduced under the treatment with BRS-X.These findings provide a scientific basis for the edible and medicinal value of BRS-X. | Siyuan Su Xiang Ding Yiling Hou Binbin Liu Zhouhe Du Junfeng Liu | 2023 | Food Science and Human Wellness2023，12，2： | 1 |
| 10 | Observed surface warming induced by urbanization in east China显示文摘 | Yang Xuchao Hou Yiling Chen Baode | 2011 | Atmospheres2011，，14： | 1 |
| 11 | Anti-microorganism,anti-tumor,and immune activities of a novel polysaccharide isolated from Tricholoma matsutake显示文摘 | Hou Yiling Ding Xiang Hou Wanru | 2013 | Pharmacognosy Magazine2013，35，9： | 1 |
| 12 | Status Quo of Maker Spaces in Main Urban Area of Chengdu显示文摘This paper, based on the literature review and field investigation, studied the status quo of maker spaces in main urban district of Chengdu at a time when the development of the maker spaces has received strong support from national and local governments. In addition to introducing the related concepts and policy support of the maker space, it summarized its distribution characteristics, audience characteristics, and status quo as well as problems and presented the direction for the development of the maker space in main urban area of Chengdu grounded on a survey of the status quo of national maker spaces in main urban area of Chengdu. | GAO Wei LIU Pan LIANG Zihan HOU Junzheng LUO Tianze LU Baorong WANG Xufei YU Xinyu FENG Yajin REN Zijie DU Jinqiang BAI Yile WANG Kejie SUN Zhentong | 2017 | Journal of Landscape Research2017，9，4： | 0 |
| 13 | Physical exercise protects muscle from accelerated aging induced by high-salt intake and muscle CG2196(salt)gene overexpression in Drosophila显示文摘Aging decreases muscle mass,strength,and functional capacity.High-salt stress seems to promote muscle aging and decrease lifespan.However,exercise delays muscle aging and increases longevity,and it may protect muscle from rapid aging induced by high-salt intake(HSI),but the molecular mechanisms are poorly understood.In this study,the flies were fed a high-salt diet and trained to exercise.Muscle CG2196(salt)gene and dSir2 gene were over-expressed by building mef2-gal4/UAS system.The results showed that both physical exercise and muscle dSir2 gene overexpression prevented HSI-induced and muscle salt overexpression-induced accelerated age-related decline of climbing index,climbing endurance,muscle NAD^(+)level,SOD activity level,dSir2 expression,and dFOXO expression,and they also prevented HSI-induced and muscle salt overexpression-induced accelerated age-related increase in muscle ROS level,MDA level,and salt gene expression.Physical exercise improved lifespan decrease induced by HSI and muscle salt overexpression.Therefore,current results indicated that high-salt stress accelerated muscle aging by decreasing muscular NAD^(+)/dSir2/dFOXO pathway activity and increasing oxidative stress.Physical exercise protected muscle from accelerated aging induced by high-salt stress through activating muscle NAD^(+)/dSir2/dFOXO pathway and enhancing muscle oxidation resistance.The combination of exercise and muscle dSir2 overexpression had the best protective effect on muscle aging and lifespan in flies. | Dengtai Wen Yiling Chen Xu Tian Wenqi Hou | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
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