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| 1 | Hacking the optical diffraction limit: Review on recent developments of fluorescence nanoscopy显示文摘Subject to the diffraction limit, the resolution of conventional optical microscopy is constrained to about 200 and 500 nm in the lateral and axial planes, respectively. The advantage of optical microscopy in the life sciences over electronic microscopy, especially fluorescence microscopy, drives scientists to develop novel 'hacks' to reach nanoscale resolutions by optical means. In this review, three aspects of the techniques are discussed: (1) lateral super-resolution; (2) axial super-resolution; (3) super-resolution in three dimensions. The principles of how the methods achieve the cross-barrier resolution are discussed, and recent advances in current techniques are described. With these methods, the use of fluorescence microscopy is growing quickly toward a new era: fluorescence nanoscopy that will reveal 2 orders of magnitude more information on cellular structure and dynamics. | DING YiChen XI Peng REN QiuShi | 2011 | Chinese Science Bulletin2011，56，18： | 7 |
| 2 | Diurnal and Seasonal Variations of Thermal Stratification and Vertical Mixing in a Shallow Fresh Water Lake显示文摘Among several influential factors, the geographical position and depth of a lake determine its thermal structure. In temperate zones, shallow lakes show significant differences in thermal stratification compared to deep lakes. Here,the variation in thermal stratification in Lake Taihu, a shallow fresh water lake, is studied systematically. Lake Taihu is a warm polymictic lake whose thermal stratification varies in short cycles of one day to a few days. The thermal stratification in Lake Taihu has shallow depths in the upper region and a large amplitude in the temperature gradient,the maximum of which exceeds 5°C m–1. The water temperature in the entire layer changes in a relatively consistent manner. Therefore, compared to a deep lake at similar latitude, the thermal stratification in Lake Taihu exhibits small seasonal differences, but the wide variation in the short term becomes important. Shallow polymictic lakes share the characteristic of diurnal mixing. Prominent differences on the duration and frequency of long-lasting thermal stratification are found in these lakes, which may result from the differences of local climate, lake depth, and fetch. A prominent response of thermal stratification to weather conditions is found, being controlled by the stratifying effect of solar radiation and the mixing effect of wind disturbance. Other than the diurnal stratification and convection, the representative responses of thermal stratification to these two factors with contrary effects are also discussed. When solar radiation increases, stronger wind is required to prevent the lake from becoming stratified. A daily average wind speed greater than 6 m s–1 can maintain the mixed state in Lake Taihu. Moreover, wind-induced convection is detected during thermal stratification. Due to lack of solar radiation, convection occurs more easily in nighttime than in daytime. Convection occurs frequently in fall and winter, whereas long-lasting and stable stratification causes less convection in summer. | Yichen YANG Yongwei WANG Zhen ZHANG Wei WANG Xia REN Yaqi GAO Shoudong LIU Xuhui LEE | 2018 | Journal of Meteorological Research2018，32，2： | 3 |
| 3 | Analysis of oral microorganism diversity in healthy individuals before and after chewing areca nuts using PCR-denatured gradient gel electrophoresis显示文摘To analyze oral microbial diversity in the saliva of 8 healthy individuals before and after chewing areca nuts. Saliva samples were collected before chewing areca nuts, after chewing areca nuts for 5 min and after chewing areca nuts for 30 min. DNA was extracted, and microbial diversity was examined using PCR-denaturing gradient gel electrophoresis(PCR-DGGE). When examining DGGE profiles collectively,the bands associated with Streptococcus and Veillonella were the most intense, making them the most prevalent bacteria. Furthermore, the band intensities did not decrease after chewing areca nuts for 5 or30 min; thus, these bacteria were unaffected. However, when examining some individuals, the band intensities for Streptococcus and Veillonella became more intense after 5 min of chewing and then returned to the pre-chewing level. This difference may be attributed to the mechanical movements of the oral cavity or individual differences. Other bacteria, such as Neisseria, Actinomycetes, and Rothia dentocariosa, were also found to have an increased or decreased prevalence following areca nut-chewing.Since the predominant species that are present following areca nut-chewing include Streptococcus and Veillonella, it would seem likely that these bacteria play an important role in the periodontal diseases associated with areca chewing. | Xiong Xiong Aixiang Hou Shuhan Yi Yichen Guo Ziwei Zhao Zhongkun Wu Huan Cheng Ke Li Zongjun Li Youhua Ren Yuanliang Wang | 2018 | Animal Nutrition2018，，3： | 2 |
| 4 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 5 | Towards win-win: weighted-Voronoi-diagram based channel quantization for security enhancement in downlink cloud-RAN with limited CSI feedback显示文摘Physical layer(PHY) security is recently proved to enable improving the security of wireless communication networks. In downlink frequency division duplex(FDD) cloud radio access network(C-RAN), the performance of PHY security highly relies on the channel state information(CSI) which is usually acquired through the codebook-quantization-based technique at the transceiver. However, the conventional quantization method aggravates the leakage of privacy information in C-RAN under the eavesdropping environment. In this paper, a novel channel quantization method is investigated to improve the secrecy-rate performance of C-RAN by exploiting the high-dimension space geometry. Based on this method, it is proved that when the statistical distribution of the channel matrices of both the legitimate user and the eavesdropper is exploited, a win-win situation can be created where secrecy-rate gains are improved without sacrificing beamforming gains from the point of view of ergodic rate. Particularly, a secrecy-oriented criterion is devised to implement the proposed method for generating codebooks. Then a weighted Voronoi diagram(WVD) is formulated on the complex Grassmann manifold and finally, a vector quantization based algorithm is proposed to build up novel quantization codebooks iteratively. Simulation results further validate the superiority of our proposed codebooks over conventional codebooks in C-RAN systems. | Dongyang XU Pinyi REN Qinghe DU Li SUN Yichen WANG | 2017 | Science China(Information Sciences)2017，60，4： | 2 |
| 6 | RESIDUAL A POSTERIORI ERROR ESTIMATE OF A NEW TWO-LEVEL METHOD FOR STEADY NAVIER-STOKES EQUATIONS显示文摘为遵守不可压缩的海军司烧方程的有限元素溶液的基于剩余的后验错误估计,与与沃尔克·约翰不同的一个新二水平的方法被计算,被导出。后验错误估计为标准有限元素方法获得的答案与估计相比包含另外的术语。在错误估计的另外的术语的重要性被学习 theirasymptotic 行为调查。为最佳的放大网孔,这些界限不比分离答案的集中具有更高的顺序。与不太计算的工作在一个粗糙的格子上解决非线性的问题的二水平的方法目的,然后在罚款上解决线性问题格子,它比在好格子上解决一个类似的非线性的问题的平常的有限元素方法优异。 | Chunfeng REN Yichen MA | 2006 | Journal of Systems Science & Complexity2006，19，4： | 2 |
| 7 | Preparation,model construction and efficacy lipid-lowering evaluation of kiwifruit juice fermented by probiotics显示文摘In this study,kiwi juice was fermented with acid-resistant and bile-resistant probiotics to screen out lactic acid bacteria that can lower cholesterol and were suitable for kiwi fermentation.A non-linear fitting equation was used to establish a kinetic model of probiotics fermenting kiwi juice(R^(2)>0.90),and then a fermented juice with special effects of lowering fat was prepared.We have studied the lipid-lowering effect of fermented fruit juice through in vivo validation experiments in mice,and determined the lipid-lowering effect of fermented fruit juice according to the mouse serum indicators and the distribution of intestinal flora.The results suggested that the juice fermented with Bifidobacterium bifidum 6169 and Lactobacillus plantarum 21805 were more effective in cholesterol degradation,and the cholesterol degradation rates were 67.57%and 64.22%,respectively.The number of viable bacteria after fermentation was significantly higher than other groups(p<0.05),and the sensory score was also higher.In addition,the serum indicators were significantly ameliorated and the number of beneficial microorganisms in the intestinal flora increased after the high-fat mice were treated with fermented kiwifruit juice.The research indicates that the fermented products have a regulatory effect on cholesterol levels in mice with hyperlipidemia. | Yu Wang Hongcai Li Yichen Ren Yaqin Wang Ren Yaopeng Wang Xiaowei Yue Tianli Wang Zhouli Gao Zhenpeng | 2022 | Food Bioscience2022，47，3： | 1 |
| 8 | A directional MAC protocol with long-range communication ability in ad hoc networks显示文摘To address the problem that long-range communication capability in ad hoc networks using directional antenna is not generally utilized,a directional media access control (DMAC) protocol with long-range communication (LRC) capability in ad hoc networks is proposed.In the LRC-DMAC,the intermediate node uses a long-range orientation (LRO) algorithm to help the transmitter obtain the directional information of the receiver which is two hops away.Consequently,the long-range link between such two hops nodes can be set up.According to whether the received power information is available or not,we propose two types of LRO algorithm:without the received power information,a basic LRO obtains the approximate directional informa-tion of the long-range receiver by a geometric relationship;however,the LRO-PI can calculate the accurate directional information of the long-range receiver using the received power.Performance analysis indicates that the LRO algorithm achieves high accuracy when the relevant parameters are properly chosen.Simulation results show that the establishment of long-range links can effectively improve the network throughput and reduce the end-to-end delay. | REN PinYi FENG Jia WANG YiChen | 2012 | Science China(Information Sciences)2012，55，4： | 0 |
| 9 | Synthesis of Cs_(2.5)H_(0.5)PW_(12)O_(40)/TiO_(2) Nanocomposites with Dominant TiO_(2){001}Facets and Related Photocatalytic Properties显示文摘TiO_(2) nanosheets with dominant{001}facets,coupled with Cs_(2.5)H_(0.5)PW_(12)O_(40),were successfully synthesized by a one-step hydrothermal reaction.The photocatalytic activity of nanocatalysts was evaluated by the degradation of Rhodamine B under UV light irradiation.The results showed that both the addition of Cs_(2.5)H_(0.5)PW_(12)O_(40) and the exposed{001}facets of TiO_(2) have a positive effect on the photocatalytic activity.The improved photoactivity of nanocomposites in comparison with that of TiO_(2) nanosheets could be attributed to the synergistic effect between Cs_(2.5)H_(0.5)PW_(12)O_(40) and TiO_(2) which facilitates the separation of photo-induced hole-electron pairs. | Yichen Hu Yuanhang Ren Gangfeng Tang Cheng Wang Min Tang Bin Yue Heyong He | 2014 | Chinese Journal of Chemistry2014，32，11： | 0 |
| 10 | TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma显示文摘Objective:Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma(HCC).The precise prediction of post-transplant lung metastasis in the early phase is of great value.Methods:The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways.We enrolled 241 HCC patients who underwent liver transplantation from three centers.Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor(TNF),tumor necrosis factor receptor 1(TNFR1),and TNFR2,particularly for post-transplant lung metastasis.Results:Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC.The expression of TNF was degraded in comparison to that in para-tumor tissues(P<0.001).The expression of key receptors in the TNF-dependent signaling pathway,TNFR1 and TNFR2,was higher in HCC tissues than in para-tumor tissues(P<0.001).TNF and TNFR1 showed no relationship with patients’outcomes,whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival(OS)and increased recurrence risk(5-year OS rate:31.9%vs.62.5%,P<0.001).Notably,elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis(hazard ratio:1.146;P<0.001).Cox regression analysis revealed that TNFR2,Hangzhou criteria,age,and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis,and a novel nomogram was established accordingly.The nomogram achieved excellent prognostic efficiency(area under time-dependent receiver operating characteristic=0.755,concordance-index=0.779)and was superior to conventional models,such as the Milan criteria.Conclusions:TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC.A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC. | Huigang Li Zuyuan Lin Jianyong Zhuo Modan Yang Wei Shen Zhihang Hu Yichen Ding Hao Chen Chiyu He Xinyu Yang Siyi Dong Xuyong Wei Beicheng Sun Shusen Zheng Ren Lang Di Lu Xiao Xu | 2023 | Chinese Journal of Cancer Research2023，35，1： | 0 |
| 11 | Enhancing physical-layer security via big-data-aided hybrid relay selection显示文摘The explosive growth in data trac presents new challenges to the new generation of wireless communication systems,such as computing capabilities,spectrum eciency and security.In this paper,we use the network structure,which is adaptable for the big data trac,to improve the security of wireless networks.Speci cally,a big-data aided hybrid relay selection scheme is designed and analyzed to enhance physical layer security.First,considering the ideal situation that an eavesdropper's CSI(Channel State Information)is known to the legal nodes,we propose an optimal hybrid relay selection scheme consisting of the optimal mode selection scheme and the optimal relay selection scheme.In this case,we analyze the upper bound of an eavesdropper's capacity in FD(Full-Duplex)mode and the secrecy outage probabilities of the optimal HD(Half-Duplex),FD,and hybrid relay selection schemes.Through the analysis of data,it is clear that the mode selection is decided by the self-interference of the FD technique.However,the instantaneous CSI of an eavesdropper is dicult to obtain due to the passive characteristic of eavesdroppers in practice.Therefore,a more practical hybrid relay selection scheme with only the channel distribution information of an eavesdropper is further studied,where a weighting factor is employed to guarantee that the hybrid mode is no worse than either the FD mode or HD mode when the self-interference grows.Finally,the simulation results show the improved security of our proposed scheme. | Hongliang He Pinyi Ren Qinghe Du Li Sun Yichen Wang | 2017 | Journal of Communications and Information Networks2017，2，1： | 0 |
| 12 | Synthesis and orientational assemblies of MgO nanosheets with exposed(111) facets显示文摘MgO nanosheets with exposed(111) facets were obtained through the preparation of Mg(OH)2 precursor by a hydrothermal method in the presence of oleylamine and subsequent calcination in air. The different preferred orientational assemblies of Mg O nanosheets, achieved by adjusting the polarity of dispersing solvents(ethanol and cyclohexane) during the sample preparation, show different structural and spectral features. | Min Tang Yuanhang Ren Yichen Hu Lin Ye Bin Yue Heyong He | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
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