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| 1 | Approaches to establish Q-markers for the quality standards of traditional Chinese medicines显示文摘Traditional Chinese medicine(TCM) has played a pivotal role in maintaining the health of Chinese people and is now gaining increasing acceptance around the global scope. However, TCM is confronting more and more concerns with respect to its quality. The intrinsic 'multicomponent and multitarget' feature of TCM necessitates the establishment of a unique quality and bioactivity evaluation system, which is different from that of the Western medicine. However, TCM is investigated essentially as'herbal medicine' or 'natural product', and the pharmacopoeia quality monographs are actually chemicalmarkers-based, which can ensure the consistency only in the assigned chemical markers, but, to some extent, have deviated from the basic TCM theory. A concept of 'quality marker'(Q-marker), following the 'property-effect-component' theory, is proposed. The establishment of Q-marker integrates multidisciplinary technologies like natural products chemistry, analytical chemistry, bionics, chemometrics,pharmacology, systems biology, and pharmacodynamics, etc. Q-marker-based fingerprint and multicomponent determination conduce to the construction of more scientific quality control system of TCM.This review delineates the background, definition, and properties of Q-marker, and the associated technologies applied for its establishment. Strategies and approaches for establishing Q-marker-based TCM quality control system are presented and highlighted with a few TCM examples. | Wenzhi Yang Yibei Zhang Wanying Wu Luqi Huang Dean Guo Changxiao Liu | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 51 |
| 2 | Sulfur-encapsulated in heteroatom-doped hierarchical porous carbon derived from goat hair for high performance lithium–sulfur batteries显示文摘Biomass-derived carbon materials have aroused widespread concern as host material of sulfur to enhance electrochemical performances for lithium–sulfur batteries. Herein, goat hair, as a low-cost and eco-friendly precursor, is employed to fabricate cauliflower-like in-situ nitrogen, oxygen and phosphorus tri-doped porous biomass carbon(NOPC) by a facile activation with H_3PO_4 and carbonization process.The morphology and microstructure of NOPC can be readily tuned by altering pyrolysis temperature. The as-prepared NOPC matrix material carbonized at 600 °C possesses 3D hierarchical porous structure, high specific surface area(535.352 m^2 g^(-1)), and appropriate pore size and pore size distribution. Encapsulating sulfur into the NOPC depends on a stem-melting technology as cathode materials of Li–S batteries. Due to the synergistic effect of special physical structure and inherent tri-doping of N, O and P, electrons and ions transfer and utilization of active sulfur in the materials are improved, and the shuttle behaviors of soluble lithium polysulfides are also mitigated. Consequently, the S/NOPC-600 composite exhibits excellent electrochemical performance, giving a high initial discharge capacity of 1185 mA h g^(-1) at 0.05 C and maintaining a relatively considerable capacity of 489 m A h g^(-1) at 0.2 C after 300 cycles. Our work shows that a promising candidate for cathode material of Li–S batteries can be synthesized using low-cost and renewable biomass materials by a facile process. | Juan Ren Yibei Zhou Huali Wu Fengyu Xie Chenggang Xu Dunmin Lin | 2019 | Journal of Energy Chemistry2019，28，3： | 9 |
| 3 | Processing technique of target capsule's micro inflation hole with a scanning probe显示文摘To resolve inflation of inertial confinement fusion (ICF) target and encapsulation of micro inflation hole with adhesive, a scanning probe microscope (SPM) diamond microprobe was used as the cutting tool with SPM in contact mode. Some parameters influencing the quality of micro inflation hole, such as the scanning direction of the diamond tip, the scanning rate and the contact force are discussed. Accurate taper hole was achieved whose dimension and precision could meet the requirements of inflation and encapsulation technique of micro hole. The experimental results show that using SPM diamond microprobe as the cutting tool and with special processing technique, the precision machining of target capsule's taper inflation hole can be realized. A novel operative technology for filling high Z gas to target is provided. | SUN Tao, YAN Yongda, GAO Dangzhong, TANG Yongjian, FU Yibei & DONG ShenPrecision Engineering Research Institute, Harbin Institute of Technology, Harbin 150001, China Research Centre of Laser Fusion, Chinese Academy of Engineering Plysics, Mianyang 621900, China Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics, Mianyang 621900, China | 2004 | Science China(Technological Sciences)2004，47，1： | 7 |
| 4 | Distribution of Traditional Chinese Medicine patterns in 324 cases with hepatitis B-related acute-on-chronic liver failure:a prospective,cross-sectional survey显示文摘OBJECTIVE:To determine the distribution of Traditional Chinese Medicine(TCM) patterns in hepatitis B-related acute-on-chronic liver failure(HB-ACLF) in different stages for guiding clinical prescriptions and treatments.METHODS:A prospective,cross-sectional survey method was used in this study.A total of 324 cases with HB-ACLF in China were involved.RESULTS:The general frequency of TCM patterns in HB-ACLF were as follows:Heat Toxin Stagnation Pattern(134/324,41.36%),Damp-heat Obstruction Pattern(66/324,20.37%),Yang Qi Deficiency Pattern(52/324,16.05%),and Liver and Kidney Yin Deficiency Pattern(26/324,8.02%).In the early stage of HB-ACLF,there was a remarkably higher percentage of excessive patterns than those in the middle and late stage.The incidence of Heat Toxin Stagnation reached 58.57%(82/140) in the early stage,while it was 33.96%(36/106) in the middle stage and 20.51%(16/78) in the late stage.In the early stage of HB-ACLF,excessive patterns,such as the Heat Toxin Stagnation Pattern,were more prevalent than those in the middle and late stages(P<α ' = 0.003).However,in the late stage of HB-ACLF,deficient patterns,such as the Yang Qi Deficiency Pattern,were more prevalent than those in the early and middle stages.The Yang Qi Deficiency Pattern had a higher rate of 41.03%(32/78) in the late stage compared with that of 20.75%(22/106) in the middle stage and 8.57%(12/140,P<α ' =0.003) in the early stage.The distribution of the other patterns was not significant between the three stages(P>0.003).CONCLUSIONS:There are four major patterns of HB-ACLF,including the Heat Toxin Stagnation Pattern,the Damp-heat Obstruction Pattern,the Yang Qi Deficiency Pattern,and the Liver and Kidney Yin Deficiency Pattern.The Heat Toxin Stagnation and Yang Qi Deficiency Patterns are the representative patterns in the early and late stages of HB-ACLF.In the middle stage of HB-ACLF,the TCM patterns vary in a complicated manner,with no significant difference among the patterns.Treatment for HB-ACLF should vary with the different representative patterns in the early and late stages. | Xiaoyu Hu Yang Zhang Guo Chen Yibei Li Sen Zhong | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 6 |
| 5 | Fine-Tuned Expression of Programmed Death 1 Ligands in Mature Dendritic Cells Stimulated by CD40 Ligand is Critical for the Induction of an Efficient Tumor Specific Immune Response显示文摘During maturation,murine myeloid dendritic cells (DCs) upregulated the expressions of CD11c,CD25,CD40,CD80,CD86,MHC Ⅱ and programmed death 1 ligands 1 and 2 (PD-L1 and PD-L2). Differential expression patterns of PD-L1 and PD-L2 were found when DCs were triggered by CD40 ligand and TNF-α. PD-L1 expression was repressed and PD-L2 expression remained unchanged in mature CD40-ligated DCs,whereas TNF-α stimulated DCs kept high expression of PD-L1 and significantly enhanced PD-L2 expression on DCs. Proliferations of T lymphocytes stimulated by immature DCs were enhanced by blockade of the PD-1 and PD-1 ligand interaction. But inhibitive effects were found in T lymphocytes stimulated by CD40-ligated DCs. With the fine-tuned expressions of PD-L1 and PD-L2,CD40-ligated DCs could sustain a longer activation period and elicit a more efficient T lymphocyte activation. | Tao Gu Yibei Zhu Cheng Chen Min Li Yongjing Chen Gehua Yu Yan Ge Shiyong Zhou Huan Zhou Yong Huang Yuhua Qiu Xueguang Zhang | 2008 | Cellular & Molecular Immunology2008，5，1： | 3 |
| 6 | The Abnormal High Expression of B Cell Activating Factor Belonging to TNF Superfamily (BAFF) and Its Potential Role in Kidney Transplant Recipients显示文摘B cell activating factor belonging to TNF superfamily (BAFF) is a critical regulator of B cell maturation and survival. In this present study, the expression characteristic of BAFF in kidney transplantation recipients was investigated, its potential significance was analyzed and peripheral blood of follow-up kidney transplant recipients was studied. Flow cytometric assay results showed that, cell-surface BAFF was significantly highly expressed on peripheral CD3+ T lymphocytes in ≥ 5 yrs group of kidney transplant recipients, compared with other groups (p < 0.05). BAFF expression could be found on CD4+ T cells and CD8+ T cells. The BAFF mRNA levels in peripheral mononuclear cells were consistent with the protein levels. However, serum soluble BAFF levels were inter-individually different in each group. Stratified by renal function, it was found that cell-surface BAFF levels were significantly higher in those with abnormal renal function, compared with recipients with normal renal function (p < 0.05). ELISA assay results showed that expression levels of cell surface BAFF were significantly correlated with anti-HLA Ⅰ & Ⅱ antibodies. These results indicate that BAFF may be involved in the development of graft-loss and influences the long-time outcome of kidney allograft, likely mediated by interfering with immune response. | Haiyan Xu Xiaozhou He Qing Liu Yingdi Chen Yibei Zhu Dan Shi Xueguang Zhang | 2008 | Cellular & Molecular Immunology2008，5，6： | 3 |
| 7 | Abnormally High Expression of BAFF on T Lymphocytes from Lung Cancer- associated Pleural Effusions and Its Potent Anti-tumor Effect显示文摘在现在的学习,激活从恶意的肋膜的流出( MPE )在 T 淋巴细胞上属于肿瘤坏死因素家庭( BAFF )和它的受体( BAFF-R 和 TACI )的因素的 B 房间的表情被排序的激活荧光的房间( FACS )检验分析,并且与那些相比在从非恶意的肋膜的流出( NMPE )和健康控制的 T 淋巴细胞上。它被发现那 CD3 积极 T 淋巴细胞(包括 CD25 和 CD69 积极房间的 CD4 , CD8 ,和部分)在肺的 MPE ,癌症高度并且一致地表示了 BAFF 分子,当 BAFF 的高表情能仅仅在植物凝集素(公众房产管理局)或白介素被发现时,( IL-2 ) 2 从 NMPE 或健康控制导致了 T 淋巴细胞。这些结果与从由即时 PCR 的 BAFF mRNA 察觉的结果一致。另外,当 TACI 的表达式在 CD4^+ T 房间上被增加,但是减少时,从 MPE 的 T 淋巴细胞显著地从 NMPE 或健康控制比那些表示了更多的 BAFF-R,在 CD8^+ T 房间上什么时候与控制相比。Annexin/PI 试金建议 recombinant 人 BAFF (rhBAFF ) 能从 MPE 支持 T 淋巴细胞的幸存率,当圈套受体 TACI-Fc 熔化蛋白质能支持 T 淋巴细胞的 apoptosis 率时。在 ELISA 试金检测的上层清液的 Cytokines 显示出那 rhBAFF 能显著地起来在像的 TACI-Fc-treated 组在 vitro,和 IFN-gamma 水平调整 IFN-gamma 的分泌物控制组的。所有这些结果显示从 MPE 的 T 淋巴细胞上的 BAFF 的反常地高的表示可以起反肿瘤效果的一个作用。 | Haiyan XU Xiaozhou HE Yibei ZHU Tiangzan YAN Hongbin MA Xueguang ZHANG | 2007 | Acta Biochimica et Biophysica Sinica2007，39，12： | 3 |
| 8 | Preparation of Zn/TiO_2 powder and its photocatalytic performance for oxidation of P-nitrophenol显示文摘Zn-doped TiO_2 catalysts were prepared using a sol-gel method and characterized by XPS,UV-Vis,BET, XRD in this study.Under the irradiation of simulant sunlight,the photocatalytic activity for the degradation of p-nitrophenol was studied too.After irradiation for 2.5 h,the degradation percentage of p-nitrophenol could rise to more than 80%.The results showed that the spectrum absorption band edge of Zn/TiO_2 powder does not broaden obviously comparing with pure TiO_2 powder.Zinc exists as Zn (Ⅱ).When calcined at 973 K,there is a new phase as ZnTiO_3 in Zn/TiO_2 catalyst.The order of photocatalytic activity of Zn/TiO_2 catalysts calcined at different temperatures for p-nitrophenol is 773 K>673 K>873 K>573 K>973 K and the photocatalytic activity of Zn/TiO_2 catalyst cal- cined at 773 K is better than TiO_2 catalysts heated at the same temperature,and outclasses that of commercial TiO_2 catalyst.It also showed that the photocatalytic degradation of p-nitrophenol follows first-order kinetics under the irra- diation of simulant sunlight. | LIU Xiuhua XU Yunshu ZHONG Zhijing FU Yibei DENG Yi | 2007 | Nuclear Science and Techniques2007，18，1： | 2 |
| 9 | Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance显示文摘 | Changping Wu Yibei Zhu Jingting Jiang Jiemin Zhao Xue-Guang Zhang Ning Xu | 2006 | Acta Histochemica2006，，1： | 2 |
| 10 | Traditional farming system for soil conservation on slope farmland in southwestern China显示文摘 | He Xiubin Xu Yibei Zhang Xinbao | 2007 | Soil and Tillage Research2007，94，1： | 1 |
| 11 | Analysis of Optimal Thread Pool Size显示文摘 | Yibei Ling Tracy Mullen | 2000 | ACM SIGOPS Operating Systems Review2000，34，2： | 1 |
| 12 | Hollow glass microsphere production fur laser direct-driven fusion on Shen Guang Ⅱ显示文摘 | LONGHUI Q YIBEI F YONGJLAN T | 2002 | Sci Chin Ser A2002，45，3： | 1 |
| 13 | Effect of Pingan Fang, a Traditional Chinese Medicine compound, on behavioral sensitization and conditioned place preference induced by ethanol in mice显示文摘OBJECTIVE:To observe the effect of Pingan Fang(PG)on behavioral sensitization and conditioned place preference(CPP)induced by ethanol in mice,and to determine the intervention mechanism of PG on alcohol addiction.METHODS:A behavioral sensitization mouse model induced by ethanol was established to observe the effect of PG on the development and expression of behavioral sensitization induced by ethanol by recording the spontaneous activity of mice.The resident time of mice in a white box was measured to evaluate the effect of PG on developing CPP induced by ethanol.Concentrations of dopamine(DA),Glutamate(Glu),and?-aminobutyric acid(GABA)in the corresponding mesolimbic region of mice were determined by enzyme-linked immunosorbent assay.RESULTS:Although PG did not alter spontaneous activity in mice,it reduced the growth of spontaneous activity stimulated by ethanol.The residence time in the white box after-ethanol-training of mice in CPP experiments was decreased.CONCLUSION:Our data suggested that PG blocked the development and expression of behavioral sensitization induced by ethanol and the development of CPP in mice.The mechanism might be related to the decreased content of DA and Glu and increased content of GABA in the mesolimbic dopamine system.This suggests that PG might be useful for the prevention and treatment of alcohol addiction. | Jia Lingyan Li Yibei Hu Xiaoyu Lin Wu Wen Dachao Zhong Sen | 2016 | Journal of Traditional Chinese Medicine2016，36，2： | 1 |
| 14 | Controlling Discrete Time T- S Fuzzy Chaotic Systems via Adaptive Adjustment 显示文摘 | Yibei Nian Yongai Zheng | 2012 | Physics Procedia2012，24，： | 1 |
| 15 | Hollow glass microsphere production for laser direct-driven fusion targets on Shen Guang II显示文摘 | Qiu Longhui Fu Yibei Tang Yongjian Wei Yun Zheng Yongming Shi Tao Yao Shujiu | 2002 | Science in China Series A: Mathematics2002，，3： | 1 |
| 16 | Analysis of Optimal Thr-ead Pool Size显示文摘 | Ling Yibei Mullen T Lin Xiaola | 2000 | ACM SIGOPS Operating System Review2000，34，2： | 1 |
| 17 | Analysis of Optimal Thread Pool Size显示文摘 | Ling Yibei Mullen T Lin Xiaola | 2000 | ACM SIGOPS Operating Systeni Review2000，34，2： | 1 |
| 18 | Discrete-time inverse linear quadratic optimal control over fnite time-horizon under noisy output measurements显示文摘In this paper,the problem of inverse quadratic optimal control over fnite time-horizon for discrete-time linear systems is considered.Our goal is to recover the corresponding quadratic objective function using noisy observations.First,the identifability of the model structure for the inverse optimal control problem is analyzed under relative degree assumption and we show the model structure is strictly globally identifable.Next,we study the inverse optimal control problem whose initial state distribution and the observation noise distribution are unknown,yet the exact observations on the initial states are available.We formulate the problem as a risk minimization problem and approximate the problem using empirical average.It is further shown that the solution to the approximated problem is statistically consistent under the assumption of relative degrees.We then study the case where the exact observations on the initial states are not available,yet the observation noises are known to be white Gaussian distributed and the distribution of the initial state is also Gaussian(with unknown mean and covariance).EM-algorithm is used to estimate the parameters in the objective function.The efectiveness of our results are demonstrated by numerical examples. | Han Zhang Yibei Li Xiaoming Hu | 2021 | Control Theory and Technology2021，19，4： | 1 |
| 19 | Capacity-aware multicast algorithms on heterogeneous overlay networks显示文摘 | Zhang Zhan Chen Shigang Ling Yibei | 2006 | IEEE Trans on Parallel and Distributed Systems2006，17，2： | 1 |
| 20 | Hollow glass microsphere production for laser direct-driven fusion targets on Shen Guang II显示文摘 | Qiu Longhui Fu Yibei Tang Yongjian Wei Yun Zheng Yongming Shi Tao Yao Shujiu | 2002 | Science in China Series A: Mathematics2002，，3： | 1 |
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